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AAK1 Gene

protein-coding GIFtS: 51

GC02M069561

AP2 associated kinase 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
DKFZp686F03202 ^²
DKFZp686K16132 ^¹, ²
EC 2.7.11.1 ^³
FLJ23712 ^²
FLJ25931 ^²
FLJ31060 ^²
FLJ42882 ^²
FLJ45252 ^²
KIAA1048 ^¹, ², ³
MGC138170 ^²
MGC164568 ^²
MGC164570 ^²

Descriptions
AP2 associated kinase 1 ^²
Adaptor-associated kinase 1 ^², ³

External Ids
HGNC: 19679¹
Entrez Gene: 22848²
UniProtKB: Q2M2I8³
Ensembl: ENSG00000115977⁷

Search outside databases for aliases for AAK1 gene

Previous GC identifers: GC02M069717 GC02M069899 GC02M069683 GC02M069619

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for AAK1:

Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis

to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic

accessory factors. This gene encodes a member of the SNF1 subfamily of Ser/Thr protein kinases.

The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes

binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor

endocytosis. Its kinase activity is stimulated by clathrin. Alternatively spliced transcript

variants have been described, but their biological validity has not been determined. [provided by

RefSeq]

UniProtKB/Swiss-Prot: AAK1_HUMAN, Q2M2I8

Function: Phosphorylates the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2). May play a

role in regulating aspects of clathrin-mediated endocytosis (By similarity)

Gene Wiki entry for AAK1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the AAK1 gene

Entrez Gene cytogenetic band: 2p14 Ensembl cytogenetic band: 2p14 HGNC cytogenetic band: 2p24.3-p14

AAK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M069561: (about GC identifiers)

Start:	69,538,631 bp from pter
End:	69,724,481 bp from pter
Size:	185,851 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000002.10 NT_022184.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: AAK1_HUMAN, Q2M2I8 (See protein sequence)

Recommended Name: AP2-associated protein kinase 1

Size: 863 amino acids; 93578 Da

Subunit: Interacts with alpha-adaptin and AP-2 (By similarity)

Subcellular location: Membrane; Peripheral membrane protein (By similarity). Cell membrane;

Peripheral membrane protein (By similarity). Membrane, clathrin-coated pit (By similarity).

Note=Active when found in clathrin-coated pits at the plasma membrane (By similarity)

Secondary accessions: Q4ZFZ3 Q53RX6 Q9UPV4

Post-translational modifications:

Autophosphorylated (By similarity)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_055726.3

ENSEMBL proteins:

ENSP00000386342 ENSP00000386456 ENSP00000375072 ENSP00000385181

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (AAK1)
	Human Recombinant Proteins from Abnova (AAK1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0005905	coated pit	IEA	--

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Antibodies for AAK1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for AAK1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (AAK1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (AAK1)
	Novus Biologicals Antibodies for AAK1

Assays for AAK1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q2M2I8

ProtoNet protein and cluster: Q2M2I8

UniProtKB/Swiss-Prot: AAK1_HUMAN, Q2M2I8

Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family

Similarity: Contains 1 protein kinase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AAK1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (AAK1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC002695

Applied Biosystems Silencer® siRNAs for AAK1

Sigma-Aldrich siRNA and siRNA Panels for AAK1

Sigma-Aldrich shRNA Panels and shRNA for AAK1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for AAK1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_014911
Myc/DDK tagged cDNA clone in CMV expression vector: NM_014911
untagged cDNA clones in CMV expression vector (see all 3): BC002695

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_014911

UniProtKB/Swiss-Prot: AAK1_HUMAN, Q2M2I8

Function: Phosphorylates the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2). May play a

role in regulating aspects of clathrin-mediated endocytosis (By similarity)

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme regulation: Stimulated by clathrin (By similarity)

Enzyme Number (IUBMB): EC 2.7.11.1

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004674	protein serine/threonine kinase activity	IEA	--
GO:0005524	ATP binding	IEA	--
GO:0016740	transferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for AAK1 (Your Favorite Gene powered by Ingenuity)

Clathrin-mediated Endocytosis

GeneDecks AAK1 for the pathways selected above

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1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006468	protein amino acid phosphorylation	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for AAK1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AAK1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (AAK1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC002695

Sigma-Aldrich siRNA and siRNA Panels for AAK1

Sigma-Aldrich shRNA Panels and shRNA for AAK1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_014911

REFSEQ mRNAs for AAK1 gene:

NM_014911.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_014911

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_014911
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_014911
                                 untagged cDNA clones in CMV expression vector (see all 3): BC002695

Additional cDNA sequence:

AF090100.1 AF090101.1 AK055622.1 AK056043.1 AK074292.1 AK098797.1 AK124229.1 AK124872.1

AK127187.1 AK310951.1 BC002695.2 BC073953.1 BC090950.1 BC104842.1 BC111965.1 BC132937.1

BC132939.1 BC143710.1 BX640963.1 BX641060.1 CR599899.1 CR624904.1

24/25 DOTS entries (see all 25 ):

DT.40236651 DT.212178 DT.423892 DT.91770925 DT.97835469 DT.97840143 DT.406526 DT.120967885

DT.75100760 DT.120967810 DT.91681853 DT.101955018 DT.91657368 DT.92048762 DT.40269460 DT.40316488

DT.91709840 DT.95157451 DT.120967884 DT.91874433 DT.95169277 DT.95370485 DT.99973978 DT.75173194

24/158 AceView cDNA sequences (see all 158 ):

BU616599 AW150262 BM708925 AI417784 BX496298 BQ448135 BF056409 AW005687

AI092715 BM683347 BX643479 BE502816 AK127187 BG167887 CR599899 AI561048

AI393040 AI215790 BX954097 AW183814 BE673248 BQ706876 AA311378 BQ021694

highest scoring ESTs for AAK1:

BE703934 BE934586 BF846035 BF944389 BF955425 BG014392 BG946376 NM_014911 AB028971 AA425256

Unigene Cluster for AAK1:

AP2 associated kinase 1

Hs.468878 [show with all ESTs]

Unigene Representative Sequence: NM_014911

GeneLoc Exon Structure

4 Ensembl transcripts including schematic representations:

ENST00000409068 ENST00000409085 ENST00000390657 ENST00000406297

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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AAK1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for AAK1

¹ / ² / ³

23 probe-sets matching AAK1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
34949_at²^{, 3}	U95-A	1	1.00	1.00	0.05	1.07	AB028971	0.80	0.83	0.82	1
40572_at²^{, 3}	U95-A	1	1.00	1.00	0.92	0.34	N51314	0.20	1.00	0.72	1
39456_at²^{, 3}	U95-A	1	1.00	1.00	0.72	0.33	AF090100	0.20	1.00	0.72	1
77290_at²^{, 3}	U95-E	1	1.00	1.00	0.91	1.26	AL120721	0.20	1.00	0.72	1
40628_at²^{, 3}	U95-A	1	1.00	1.00	0.93	0.83	AA322648	0.20	1.00	0.72	1
39463_at²^{, 3}	U95-A	1	1.00	1.00	0.58	0.19	AF090101	0.20	1.00	0.72	1
66046_at²	U95-C	1	1.00	1.00	0.78	0.34	--	--	--	--	--
52124_at²	U95-B	1	0.94	1.00	0.25	1.59	--	--	--	--	--
67665_f_at²^{, 3}	U95-E	384	0.38	0.02	0.49	1.87	R02298	0.20	0.50	0.38	1
238100_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI820626	0.20	1.00	0.72	1
214998_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF090100	0.20	1.00	0.72	1
214956_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF090101	0.20	1.00	0.72	1
205435_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_014911	0.60	1.00	0.82	1
225522_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
211186_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC002695	0.40	0.67	0.55	1
205434_s_at²^{, 3}	U133-A	2	1.00	0.91	--	--	AW451954	0.60	0.83	0.73	1
238100_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
214998_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
214956_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
205435_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
225522_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211186_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
205434_s_at²	U133Plus2	2	1.00	0.91	--	--	--	--	--	--	--

GeneDecks AAK1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AAAGTCAATC

SOURCE GeneReport for Unigene cluster: Hs.468878
Expression variation in blood from EXPOLDB for AAK1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for AAK1 gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	AAK1¹	--	AP2 associated kinase 1	93.48(n) 97.63(a)	474625 XM_531855.2 XP_531855.2
chimpanzee (Pan troglodytes)	AAK1¹	--	AP2 associated kinase 1	99.69(n) 99.69(a)	736127 XM_001138098.1 XP_001138098.1
cow (Bos taurus)	AAK1¹	--	AP2 associated kinase 1	91.6(n) 95.17(a)	532546 XM_611658.3 XP_611658.3
rat (Rattus norvegicus)	Aak1¹	--	AP2 associated kinase 1	89.95(n) 92.73(a)	500244 XM_575594.2 XP_575594.2
mouse (Mus musculus)	Aak1^{1, 5}	6 (35.50 cM)⁵	AP2 associated kinase 1^{1, 5}	90.13(n)¹ 93.05(a)¹	269774¹ NM_001040106.2¹ NP_001035195.1¹ AI324201⁵ AI462552⁵ (see all 34)

About this table Species with no ortholog for AAK1

ENSEMBL Gene Tree for AAK1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for AAK1 gene

BMP2KL² BMP2K² STK16²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/941 NCBI SNPs in AAK1 are shown (see all 941 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 284)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1396795^1,2	A,C,F,H	69726066(+)	`TTGAAG/ACAGAT`	1	--	ng3¹		8	EU EA WA	836
	rs4852898^1,2	A,C,F,H	69726301(+)	`TTAAGG/ATAGCT`	1	--	ng3¹		4	EU EA WA	418
--	rs9309428^1,2	A,C,F,H	69546510(+)	`ACGGCC/TCGCGG`	1	--	ut3¹		8	EU EA WA	838
--	rs4441525^1,2	A,C,F,H	69540728(+)	`CCTCTC/TATCAA`	1	--	ut3¹		12	EU EA WA NA	1046
--	rs3552^1,2	A,C,F,H	69551662(+)	`TTCACA/GTTTTT`	1	--	ut3¹		8	MN NA EU EA WA	738
	rs1396797^1,2	A,C,F,H	69726161(+)	`TTAAAC/GAAGCT`	1	--	ng3¹		11	EU EA WA NA	972
--	rs7577689^1,2	A,C,F,H	69539790(+)	`GGAAAG/AGTACC`	1	--	ut3¹		11	EU EA WA NA	978
	rs12151791^1,2	C,F,H	69556132(+)	`GGAGGC/TCATTC`	1	--	ut3¹		8	EU EA WA	836
--	rs7420531^1,2	C,F,H	69549505(+)	`TGGTCA/GAGAAC`	1	--	ut3¹		4	EU EA WA	418
--	rs13427243^1,2	A,F,H	69543691(+)	`AAAGTG/ATTGAA`	1	--	ut3¹		1	WA	112

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HapMap Linkage Disequilibrium images for AAK1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/24 PubMed articles for AAK1 gene (see all 24 ):

A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{3, 4} Beausoleil S.A.... Gygi S.P. (2006)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{3, 4} Hillier L.W....Wilson R.K. (2005)
Global phosphoproteome of HT-29 human colon adenocarcinoma cells. (PubMed id 16083285)^{3, 4} Kim J.-E.... White F.M. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)^{3, 4} Beausoleil S.A....Gygi S.P. (2004)
The protein kinase complement of the human genome. (PubMed id 12471243)^{2, 3} Manning G....Sudarsanam S. (2002)
Identification of an adaptor-associated kinase, AAK1, as a regulator of clathrin-mediated endocytosis. (PubMed id 11877461)^{2, 3} Conner S.D. and Schmid S.L. (2002)
Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)^{3, 4} Kikuno R....Ohara O. (1999)
AAK1-mediated micro2 phosphorylation is stimulated by assembled clathrin. (PubMed id 14617351)^{1, 3} Conner S.D....Schmid S.L. (2003)
Differential requirements for AP-2 in clathrin-mediated endocytosis. (PubMed id 12952931)^{1, 3} Conner S.D. and Schmid S.L. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 22848	HGNC: 19679	AceView: AAK1	Ensembl:ENSG00000115977	euGenes: HUgn22848
ECgene: AAK1	H-InvDB: AAK1

(According to HUGE)
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HUGE: KIAA1048

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for AAK1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for AAK1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for AAK1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for AAK1		Antibodies for AAK1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for AAK1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Antibodies for AAK1

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AAK1 Gene

protein-coding GIFtS: 51

Aliases &
Descriptions
for AAK1

Summaries
for AAK1

Genomic Location
for AAK1

Proteins
for AAK1

Protein Domains/
Families
for AAK1

Gene Function
for AAK1

Pathways & Interactions
for AAK1

Drugs & Compounds
for AAK1

Transcripts
for AAK1

Expression
for AAK1

Orthologs
for AAK1

Paralogs
for AAK1

SNPs/Variants
for AAK1

Disorders & Mutations
for AAK1

Medical News
for AAK1

Publications
for AAK1

Search for AAK1

Genome Databases showing AAK1

Other Databases showing AAK1

Specialized Databases showing AAK1

Licensable Technologies
for AAK1

Services
for AAK1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

AAK1 Gene

protein-coding GIFtS: 51

Aliases & Descriptionsfor AAK1

Summariesfor AAK1

Genomic Locationfor AAK1

Proteinsfor AAK1

Protein Domains/Familiesfor AAK1

Gene Functionfor AAK1

Pathways & Interactionsfor AAK1

Drugs & Compoundsfor AAK1

Transcriptsfor AAK1

Expression for AAK1

Orthologsfor AAK1

Paralogsfor AAK1

SNPs/Variantsfor AAK1

Disorders & Mutationsfor AAK1

Medical Newsfor AAK1

Publicationsfor AAK1

Search for AAK1

Genome Databases showing AAK1

Other Databases showing AAK1

Specialized Databases showing AAK1

Licensable Technologiesfor AAK1

Servicesfor AAK1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for AAK1

Summaries
for AAK1

Genomic Location
for AAK1

Proteins
for AAK1

Protein Domains/
Families
for AAK1

Gene Function
for AAK1

Pathways & Interactions
for AAK1

Drugs & Compounds
for AAK1

Transcripts
for AAK1

Expression
for AAK1

Orthologs
for AAK1

Paralogs
for AAK1

SNPs/Variants
for AAK1

Disorders & Mutations
for AAK1

Medical News
for AAK1

Publications
for AAK1

Licensable Technologies
for AAK1

Services
for AAK1