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AAGAB Gene

protein-coding   GIFtS: 54
GCID: GC15M067493

Alpha- And Gamma-Adaptin Binding Protein

  See AAGAB-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Alpha- And Gamma-Adaptin Binding Protein1 2
KPPP12 5
PPKP12 5
PPKP1A2 5
p342 5
Alpha- And Gamma-Adaptin-Binding Protein P342

External Ids:    HGNC: 256621   Entrez Gene: 797192   Ensembl: ENSG000001035917   OMIM: 6148885   UniProtKB: Q6PD743   

Export aliases for AAGAB gene to outside databases

Previous GC identifers: GC15M065282 GC15M044327


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AAGAB Gene:
The protein encoded by this gene interacts with the gamma-adaptin and alpha-adaptin subunits of complexes involved
in clathrin-coated vesicle trafficking. Mutations in this gene are associated with type I punctate palmoplantar
keratoderma. Alternatively spliced transcript variants have been found for this gene. (provided by RefSeq, Dec
2012)

GeneCards Summary for AAGAB Gene:
AAGAB (alpha- and gamma-adaptin binding protein) is a protein-coding gene. Diseases associated with AAGAB include keratoderma, palmoplantar, punctate type ia, and keratoderma.

UniProtKB/Swiss-Prot: AAGAB_HUMAN, Q6PD74
Function: May be involved in endocytic recycling of growth factor receptors such as EGFR

Gene Wiki entry for AAGAB (FLJ11506) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for AAGAB
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for AAGAB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AAGAB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22.33-q23   Ensembl cytogenetic band:  15q23   HGNC cytogenetic band: 15q22.33-q23

AAGAB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AAGAB gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M067493:  view genomic region     (about GC identifiers)

Start:
67,493,366 bp from pter      End:
67,547,533 bp from pter
Size:
54,168 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: AAGAB_HUMAN, Q6PD74 (See protein sequence)
Recommended Name: Alpha- and gamma-adaptin-binding protein p34  
Size: 315 amino acids; 34594 Da
Subunit: Associated with AP-1 and AP-2 complexes
Secondary accessions: Q6FI86 Q7Z5X9 Q9H0P1 Q9HAK0

Explore the universe of human proteins at neXtProt for AAGAB: NX_Q6PD74

Explore proteomics data for AAGAB at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See AAGAB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001258814.1  NP_001258815.1  NP_078942.3  

    ENSEMBL proteins: 
     ENSP00000261880   ENSP00000453263   ENSP00000440735   ENSP00000453059  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR019341 Alpha/Gamma-adaptin-bd_p34

    Graphical View of Domain Structure for InterPro Entry Q6PD74

    ProtoNet protein and cluster: Q6PD74


    Find genes that share domains with AAGAB           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AAGAB_HUMAN, Q6PD74
    Function: May be involved in endocytic recycling of growth factor receptors such as EGFR

    Phenotypes:
         1 GenomeRNAi human phenotype for AAGAB:

     Decreased cell number 

    Animal Models:
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    hsa-mir-93-3p (MIRT038743), hsa-mir-92a-3p (MIRT049395)

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    Selected qRT-PCR Assays for microRNAs that regulate AAGAB (see all 9):
    hsa-miR-34c-5p hsa-miR-548am hsa-miR-449b hsa-miR-551b* hsa-miR-449a hsa-miR-34a hsa-miR-548x hsa-miR-3119
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AAGAB_HUMAN, Q6PD74: Cytoplasm, cytosol
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    extracellular3
    endoplasmic reticulum1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol IEA--

    Find genes that share ontologies with AAGAB           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AAGAB
    Interactions:

        Search GeneGlobe Interaction Network for AAGAB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for AAGAB (Q6PD742, 3 ENSP000002618804) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EIF3CQ996132, 3, ENSP000003326044MINT-64673 I2D: score=5 STRING: ENSP00000332604
    UNC119Q134322, 3MINT-64672 I2D: score=4 
    AP2A2O949733I2D: score=1 
    ATF7IPENSP000002611684STRING: ENSP00000261168
    AP1G2ENSP000003124424STRING: ENSP00000312442
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015031protein transport IEA--

    Find genes that share ontologies with AAGAB           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for AAGAB



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for AAGAB gene (3 alternative transcripts): 
    NM_001271885.1  NM_001271886.1  NM_024666.4  

    Unigene Cluster for AAGAB:

    Alpha- and gamma-adaptin binding protein
    Hs.254642  [show with all ESTs]
    Unigene Representative Sequence: NM_001271886
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261880(uc002aqk.4 uc010uju.2) ENST00000538028 ENST00000561452
    ENST00000542650 ENST00000558725 ENST00000560362 ENST00000561229
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate AAGAB (see all 9):
    hsa-miR-34c-5p hsa-miR-548am hsa-miR-449b hsa-miR-551b* hsa-miR-449a hsa-miR-34a hsa-miR-548x hsa-miR-3119
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    Additional mRNA sequence: 

    AK021568.1 AK294402.1 AL136715.1 AL832256.1 BC001975.1 BC035852.1 BC047026.1 BC058886.1 
    CR533540.1 

    9 DOTS entries:

    DT.92050314  DT.114988  DT.100811320  DT.40212182  DT.121065308  DT.100811321  DT.100036122  DT.121065200 
    DT.121065287 

    Selected AceView cDNA sequences (see all 234):

    N89887 W73913 CD672099 CA430118 AI825596 BC058886 CA312633 BF062455 
    BQ188160 BQ214285 AI910479 CR614587 BU608106 BE882300 AA551994 BI834717 
    AA857846 CR620129 AI828332 BQ425900 BP357531 BQ877979 BC047026 AI758798 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for AAGAB    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:              -     -     -                                                                     
    SP2:                    -     -                                                                     
    SP3:                                                                                                
    SP4:                          -                                                                     
    SP5:                          -                                                                     


    ECgene alternative splicing isoforms for AAGAB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AAGAB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGAAATTCT
    AAGAB Expression
    About this image


    AAGAB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    AAGAB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AAGAB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.254642

    UniProtKB/Swiss-Prot: AAGAB_HUMAN, Q6PD74
    Tissue specificity: Widely expressed, including in skin and keratinocytes, with highest levels in adrenal gland,
    rectum and thymus

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for AAGAB gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aagab1 , 5 alpha- and gamma-adaptin binding protein1, 5 84.23(n)1
    85.71(a)1
      9 (34.19 cM)5
    669391  NM_025857.21  NP_080133.11 
     636026555 
    chicken
    (Gallus gallus)
    Aves AAGAB1 alpha- and gamma-adaptin binding protein 74.63(n)
    74.52(a)
      415553  NM_001271528.1  NP_001258457.1 
    lizard
    (Anolis carolinensis)
    Reptilia AAGAB6
    alpha- and gamma-adaptin binding protein
    64(a)
    1 ↔ 1
    GL343467.1(341515-356810)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.105812 Xenopus laevis transcribed sequence with weak similarity more 74.41(n)    48055118 
    zebrafish
    (Danio rerio)
    Actinopterygii aagab1 alpha- and gamma-adaptin binding protein 62.31(n)
    59.48(a)
      436696  NM_001002423.1  NP_001002423.1 


    ENSEMBL Gene Tree for AAGAB (if available)
    TreeFam Gene Tree for AAGAB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AAGAB gene
    2 SIMAP similar genes for AAGAB using alignment to 3 protein entries:     AAGAB_HUMAN (see all proteins):
    DKFZp667D2317    DKFZp686G08119

    Find genes that share paralogs with AAGAB           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AAGAB (see all 1081)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs114116311,2
    C--44332599(+) AAAAA-/ACTTGC 3 -- int11Minor allele frequency- A:0.50CSA 2
    rs1116563791,2
    C--44334566(+) TTTTTC/TTTCTT 3 -- int10--------
    rs121017931,2
    C--44369055(+) gaaccC/G/Tgggaa 3 -- int10--------
    rs1932681481,2
    --47548729(+) CATACG/TCTGGC 3 -- ds50010--------
    rs1382097021,2
    C--47548794(+) TATTAC/TATAAC 3 -- ds50010--------
    rs71726451,2
    C,F--47548909(+) CATACT/CTTACA 3 -- ds500112Minor allele frequency- C:0.33NA WA CSA EA 510
    rs121482821,2
    C,H--47548959(+) CCAAAC/TACTAT 3 -- ds50014Minor allele frequency- T:0.02EA NS NA 384
    rs1417678521,2
    --47548981(+) CAAGAA/GATGTT 3 -- ds50010--------
    rs1847528911,2
    --47549055(+) ACTTGC/TGGTAG 3 -- ut310--------
    rs1890830551,2
    --47549100(+) ATTACC/TGTAGT 3 -- ut310--------

    HapMap Linkage Disequilibrium report for AAGAB (67493366 - 67547533 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for AAGAB:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv3519CNV Deletion18987735
    esv2749800CNV Deletion23290073
    esv999184CNV Deletion20482838
    nsv827371CNV Loss20364138
    nsv819309CNV Loss19587683
    esv8158CNV Loss19470904

    Human Gene Mutation Database (HGMD): AAGAB
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AAGAB
    DNA2.0 Custom Variant and Variant Library Synthesis for AAGAB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614888   
    OMIM disorders: 148600  
    UniProtKB/Swiss-Prot: AAGAB_HUMAN, Q6PD74
  • Keratoderma, palmoplantar, punctate 1A (PPKP1A) [MIM:148600]: An autosomal dominant dermatological
    disorder characterized by multiple hyperkeratotic, centrally indented, papules that develop in early adolescence,
    or later, and are irregularly distributed on the palms and soles (other palmoplantar keratoses have mostly
    diffuse hyperkeratinization). In mechanically irritated areas, confluent plaques can be found. Interfamilial and
    intrafamilial severity shows broad variation. In some cases, PPKP1 is associated with the development of early-
    and late-onset malignancies, including squamous cell carcinoma. Note=The disease is caused by mutations affecting
    the gene represented in this entry

  • 3 diseases for AAGAB:    
    About MalaCards
    keratoderma, palmoplantar, punctate type ia    keratoderma    palmoplantar keratosis

    1 disease from the University of Copenhagen DISEASES database for AAGAB:
    Palmoplantar keratosis

    Find genes that share disorders with AAGAB           About GenesLikeMe

    Genetic Association Database (GAD): AAGAB
    Human Genome Epidemiology (HuGE) Navigator: AAGAB (1 document)

    Export disorders for AAGAB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AAGAB gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with AAGAB)
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    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (Genome Res. 2001)
    2. Nonsense mutations in AAGAB cause punctate palmoplantar keratoderma type Buschke-Fischer-Brauer. (PubMed id 23000146)1, 2 Giehl K.A.... Strom T.M. (Am. J. Hum. Genet. 2012)
    3. Haploinsufficiency for AAGAB causes clinically heterogeneous forms of punctate palmoplantar keratoderma. (PubMed id 23064416)1, 2 Pohler E.... McLean W.H. (Nat. Genet. 2012)
    4. Polymorphisms in predicted miRNA binding sites and osteoporosis. (PubMed id 20641033)1, 4 Lei S.F....Deng H.W. (J. Bone Miner. Res. 2011)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Gamma-synergin: an EH domain-containing protein that interacts with gamma-adaptin. (PubMed id 10477754)1, 3 Page L.J.... Robinson M.S. (J. Cell Biol. 1999)
    8. Heterozygous mutations in AAGAB cause type 1 punctate palmoplantar keratoderma with evidence for increased growth factor signaling. (PubMed id 23743648)1 PAPhler E....Brown S.J. (J. Invest. Dermatol. 2013)
    9. Loss-of-function mutation in AAGAB in Chinese families with punctuate palmoplantar keratoderma. (PubMed id 23448244)1 Li M....Zhang G. (Br. J. Dermatol. 2013)
    10. Six mutations in AAGAB confirm its pathogenic role in Chinese punctate palmoplantar keratoderma patients. (PubMed id 23633024)1 Cui H....Zhang X. (J. Invest. Dermatol. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79719 HGNC: 25662 AceView: FLJ11506 Ensembl:ENSG00000103591 euGenes: HUgn79719
    ECgene: AAGAB H-InvDB: AAGAB

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for AAGAB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AAGAB gene:
    Search GeneIP for patents involving AAGAB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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