Free for academic non-profit institutions. Other users need a Commercial license

Aliases for AAED1 Gene

Aliases for AAED1 Gene

  • AhpC/TSA Antioxidant Enzyme Domain Containing 1 2 3 5
  • AhpC/TSA Antioxidant Enzyme Domain-Containing Protein 1 3 4
  • C9orf21 3 4
  • Chromosome 9 Open Reading Frame 21 2
  • UPF0308 Protein C9orf21 3

External Ids for AAED1 Gene

Previous HGNC Symbols for AAED1 Gene

  • C9orf21

Previous GeneCards Identifiers for AAED1 Gene

  • GC09M099404

Summaries for AAED1 Gene

GeneCards Summary for AAED1 Gene

AAED1 (AhpC/TSA Antioxidant Enzyme Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity and antioxidant activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AAED1 Gene

Genomics for AAED1 Gene

Regulatory Elements for AAED1 Gene

Enhancers for AAED1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around AAED1 on UCSC Golden Path with GeneCards custom track

Promoters for AAED1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around AAED1 on UCSC Golden Path with GeneCards custom track

Genomic Location for AAED1 Gene

96,639,577 bp from pter
96,655,323 bp from pter
15,747 bases
Minus strand

Genomic View for AAED1 Gene

Genes around AAED1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AAED1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AAED1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AAED1 Gene

Proteins for AAED1 Gene

  • Protein details for AAED1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Thioredoxin-like protein AAED1
    Protein Accession:
    Secondary Accessions:
    • B2RMW4
    • Q5JU02

    Protein attributes for AAED1 Gene

    226 amino acids
    Molecular mass:
    24857 Da
    Quaternary structure:
    No Data Available

neXtProt entry for AAED1 Gene

Proteomics data for AAED1 Gene at MOPED

Post-translational modifications for AAED1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AAED1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AAED1 Gene

Domains & Families for AAED1 Gene

Protein Domains for AAED1 Gene

Suggested Antigen Peptide Sequences for AAED1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the AAED1 family.
  • Belongs to the AAED1 family.
genes like me logo Genes that share domains with AAED1: view

No data available for Gene Families for AAED1 Gene

Function for AAED1 Gene

Phenotypes for AAED1 Gene

genes like me logo Genes that share phenotypes with AAED1: view

Animal Model Products

miRNA for AAED1 Gene

miRTarBase miRNAs that target AAED1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AAED1 Gene

Localization for AAED1 Gene

Subcellular locations from

Jensen Localization Image for AAED1 Gene COMPARTMENTS Subcellular localization image for AAED1 gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for AAED1 Gene

Pathways & Interactions for AAED1 Gene

SuperPathways for AAED1 Gene

No Data Available

Interacting Proteins for AAED1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000364382 for AAED1 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for AAED1 Gene


No data available for Pathways by source and SIGNOR curated interactions for AAED1 Gene

Drugs & Compounds for AAED1 Gene

No Compound Related Data Available

Transcripts for AAED1 Gene

Unigene Clusters for AAED1 Gene

AhpC/TSA antioxidant enzyme domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AAED1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: -
SP2: - - -

Relevant External Links for AAED1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AAED1 Gene

mRNA expression in normal human tissues for AAED1 Gene

Protein differential expression in normal tissues from HIPED for AAED1 Gene

This gene is overexpressed in Islet of Langerhans (53.4) and Bone (15.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for AAED1 Gene

SOURCE GeneReport for Unigene cluster for AAED1 Gene Hs.44640

genes like me logo Genes that share expression patterns with AAED1: view

Protein tissue co-expression partners for AAED1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for AAED1 Gene

Orthologs for AAED1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AAED1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia AAED1 35
  • 90.86 (n)
  • 91.15 (a)
AAED1 36
  • 89 (a)
(Canis familiaris)
Mammalia AAED1 35
  • 90.62 (n)
  • 87.95 (a)
AAED1 36
  • 86 (a)
(Mus musculus)
Mammalia Aaed1 35
  • 86.79 (n)
  • 90.09 (a)
Aaed1 16
Aaed1 36
  • 88 (a)
(Pan troglodytes)
Mammalia AAED1 35
  • 99.41 (n)
  • 99.12 (a)
AAED1 36
  • 99 (a)
(Gallus gallus)
Aves C9ORF21 35
  • 73.05 (n)
  • 75 (a)
AAED1 36
  • 66 (a)
(Anolis carolinensis)
Reptilia AAED1 36
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia aaed1 35
  • 61.65 (n)
  • 54.87 (a)
Str.4655 35
(Danio rerio)
Actinopterygii Dr.16712 35
LOC100332791 35
  • 58.86 (n)
  • 55.41 (a)
AAED1 36
  • 54 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.215 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G37240 35
  • 45.34 (n)
  • 32.26 (a)
(Oryza sativa)
Liliopsida Os03g0284600 35
  • 42.56 (n)
  • 31.28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10381 36
  • 32 (a)
Species with no ortholog for AAED1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AAED1 Gene

Gene Tree for AAED1 (if available)
Gene Tree for AAED1 (if available)

Paralogs for AAED1 Gene

(1) SIMAP similar genes for AAED1 Gene using alignment to 3 proteins: Pseudogenes for AAED1 Gene

genes like me logo Genes that share paralogs with AAED1: view

No data available for Paralogs for AAED1 Gene

Variants for AAED1 Gene

Sequence variations from dbSNP and Humsavar for AAED1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs9886834 - 96,654,718(+) AACTC(C/T)TGGGG reference, missense
rs1129517 -- 96,641,272(+) TTTGG(G/T)GTTTA utr-variant-3-prime
rs7847700 -- 96,644,006(+) caggc(A/G)cctgt intron-variant
rs7847716 -- 96,643,349(+) tcaag(C/G/T)gatta intron-variant
rs7848633 -- 96,644,064(+) ggagg(C/T)ggagg intron-variant

Variation tolerance for AAED1 Gene

Residual Variation Intolerance Score: 90.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.06; 68.83% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for AAED1 Gene

Disorders for AAED1 Gene

Relevant External Links for AAED1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for AAED1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AAED1 Gene

Publications for AAED1 Gene

  1. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  4. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh J.H. … Kim N.S. (Mamm. Genome 2005) 3
  5. Reconsidering the evolution of eukaryotic selenoproteins: a novel nonmammalian family with scattered phylogenetic distribution. (PMID: 14710190) Castellano S. … GuigA^ R. (EMBO Rep. 2004) 3

Products for AAED1 Gene

Sources for AAED1 Gene