AAED1 Gene
protein-coding GIFtS: 38
GCID: GC09M099404
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AhpC/TSA antioxidant enzyme domain containing 1(Previous name: chromosome 9 open reading frame 21 )
(Previous symbol: C9orf21)
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Aliases
for AAED1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| AhpC/TSA Antioxidant Enzyme Domain Containing 11 2 | | C9orf211 2 3 | | AhpC/TSA Antioxidant Enzyme Domain-Containing Protein 12 3 | | Chromosome 9 Open Reading Frame 211 | | Thioredoxin-Like Protein AAED12 | | UPF0308 Protein C9orf212 |
Export aliases for AAED1 gene to outside databases |
Summaries
for AAED1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for AAED1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008470.19
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for AAED1
Other transcription factors
Search SABiosciences Chromatin IP Primers for AAED1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AAED1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q22.32 Ensembl cytogenetic band: 9q22.33 HGNC cytogenetic band: 9q22.32AAED1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M099404: view genomic region
(about GC identifiers)
Start:
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99,401,859 bp from pter |
End:
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99,417,599 bp from pter |
Size:
|
15,741 bases |
Orientation:
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minus strand |
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Proteins
for AAED1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: AAED1_HUMAN, Q7RTV5 (See
protein sequence)Recommended Name: Thioredoxin-like protein AAED1 Size: 226 amino acids; 24857 Da
Secondary accessions: B2RMW4 Q5JU02Explore the universe of human proteins at neXtProt for AAED1: NX_Q7RTV5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q7RTV5
AAED1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_714542.1
ENSEMBL proteins: ENSP00000398933 ENSP00000364382 ENSP00000412378
Human Recombinant Protein Products:
AAED1 Antibody Products:
Assay Products for AAED1: |
Protein
Domains /
Families
for AAED1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
AAED1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q7RTV5ProtoNet protein and cluster: Q7RTV5 UniProtKB/Swiss-Prot: AAED1_HUMAN, Q7RTV5Similarity: Belongs to the AAED1 family |
Function
for AAED1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AAED1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AAED1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for AAED1 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AAED1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AAED1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AAED1 |
2 GenomeRNAi human phenotypes for AAED1:
|
Pathways & Interactions
for AAED1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AAED1
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for AAED1 (ENSP000003643824) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for AAED1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for AAED1
Search CenterWatch for drugs/clinical trials and news about AAED1
|
Transcripts
for AAED1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for AAED1 gene: NM_153698.1 Unigene Cluster for AAED1: AhpC/TSA antioxidant enzyme domain containing 1 Hs.44640 [show with all ESTs]Unigene Representative Sequence: NM_1536984 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000446045 ENST00000375234(uc004awm.3) ENST00000411939 ENST00000464512
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AAED1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AAED1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for AAED1 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AAED1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AAED1 |
Additional cDNA sequence: BC136501.1 BC136503.1 6 DOTS entries: DT.413946 DT.100810778 DT.100810777 DT.100018439 DT.91744085 DT.91744087 24/83 AceView cDNA sequences (see all 83): BM310469 AA253265 AW517509 BM843088 AA974101 BE218052 BM843533 AW590923 AW779132 CA413692 BG219878 AW207287 CA438799 CA419879 AI914117 BG201014 AI568733 AI655189 AI251742 BE467790 BK000255 CA412848 AI394211 AI140317
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for AAED1 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b |
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| SP1: | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | | - | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for AAED1
|
Expression
for AAED1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| AAED1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGGGAAGCA
About this image
See AAED1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AAED1
SOURCE GeneReport for Unigene cluster: Hs.44640
SABiosciences Custom PCR Arrays for AAED1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AAED1
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat AAED1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AAED1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AAED1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AAED1 |
Orthologs
for AAED1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for AAED1 gene from 5/12 species (see all 12) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Aaed11 , 5 |
RIKEN cDNA 1110018J18 gene5
AhpC/TSA antioxidant enzyme domain containing 11 |
86.79(n)1
90.09(a)1 |
|
13 (33.26 cM)5
661291 NM_025370.21 NP_079646.11
642918365 |
chicken
(Gallus gallus) |
Aves |
AAED11 |
AhpC/TSA antioxidant enzyme domain containing 1 |
73.05(n)
75(a) |
|
427472 XM_003643010.1 XP_003643058.1 |
lizard
(Anolis carolinensis) |
Reptilia |
C9orf216 |
-- |
63(a) |
1 ↔ 1 |
2(39875707-39884367) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.46552 |
Transcribed sequence with weak similarity to protein more |
75.69(n) |
|
CF223750.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.167122 |
Transcribed sequence with weak similarity to protein more |
77.08(n) |
|
BI980704.1 |
ENSEMBL Gene Tree for AAED1 (if available)
TreeFam Gene Tree for AAED1 (if available) |
Paralogs
for AAED1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for AAED1 gene
1 SIMAP similar gene for AAED1 using alignment to 3 protein entries: AAED1_HUMAN (see all proteins):C9orf21
AAED1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for AAED1
PGOHUM00000241356
|
Genomic Variants
for AAED1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for AAED1 (99401859 - 99417599 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for AAED1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AAED1 |
|
Disorders
/ Diseases
for AAED1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for AAED1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for AAED1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with AAED1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
- Fugu and human sequence comparison identifies novel human genes and conserved non-coding sequences. (PubMed id 12234665)1, 2 Gilligan P.... Venkatesh B. (2002)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
- Reconsidering the evolution of eukaryotic selenoprote ins: a novel nonmammalian family with scattered phylogenetic distribution. (PubMed id 14710190)1 Castellano S....GuigA^ R. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for AAED1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing AAED1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing AAED1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing AAED1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for AAED1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for AAED1 gene:
Search GeneIP for patents involving AAED1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for AAED1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for AAED1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AAED1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AAED1 | | | OriGene Protein Over-expression Lysate for AAED1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for AAED1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AAED1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AAED1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for AAED1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | Search Tocris compounds for AAED1 |
| |  |  |  |  | | | | |
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 |
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 | | | AAED1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AAED1 |
|  |  |  | | | | Search ThermoFisher Antibodies for AAED1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AAED1 |
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