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Aliases for AADAT Gene

Aliases for AADAT Gene

  • Aminoadipate Aminotransferase 2 3
  • Kynurenine Aminotransferase II 2 3 4
  • KAT2 3 4 6
  • L Kynurenine/Alpha Aminoadipate Aminotransferase 2 3
  • Kynurenine--Oxoglutarate Aminotransferase II 3 4
  • Kynurenine--Oxoglutarate Transaminase II 3 4
  • Kynurenine--Oxoglutarate Transaminase 2 3 4
  • Alpha-Aminoadipate Aminotransferase 3 4
  • 2-Aminoadipate Aminotransferase 3 4
  • 2-Aminoadipate Transaminase 3 4
  • KAT/AadAT 3 4
  • Kynurenine/Alpha-Aminoadipate Aminotransferase, Mitochondrial 3
  • EC 2.6.1.39 4
  • EC 2.6.1.7 4
  • KATII 3
  • AadAT 4

External Ids for AADAT Gene

Previous GeneCards Identifiers for AADAT Gene

  • GC00U991148
  • GC04M171565
  • GC04M171677
  • GC04M171356
  • GC04M171218
  • GC04M170981
  • GC04M166736

Summaries for AADAT Gene

Entrez Gene Summary for AADAT Gene

  • This gene encodes a protein that is highly similar to mouse and rat kynurenine aminotransferase II. The rat protein is a homodimer with two transaminase activities. One activity is the transamination of alpha-aminoadipic acid, a final step in the saccaropine pathway which is the major pathway for L-lysine catabolism. The other activity involves the transamination of kynurenine to produce kynurenine acid, the precursor of kynurenic acid which has neuroprotective properties. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

GeneCards Summary for AADAT Gene

AADAT (Aminoadipate Aminotransferase) is a Protein Coding gene. Among its related pathways are Metabolism and Carbon metabolism. GO annotations related to this gene include protein homodimerization activity and kynurenine-oxoglutarate transaminase activity.

UniProtKB/Swiss-Prot for AADAT Gene

  • Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AADAT Gene

Genomics for AADAT Gene

Regulatory Elements for AADAT Gene

Genomic Location for AADAT Gene

Start:
170,060,222 bp from pter
End:
170,091,699 bp from pter
Size:
31,478 bases
Orientation:
Minus strand

Genomic View for AADAT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AADAT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AADAT Gene

Proteins for AADAT Gene

  • Protein details for AADAT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5Z0-AADAT_HUMAN
    Recommended name:
    Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
    Protein Accession:
    Q8N5Z0
    Secondary Accessions:
    • B3KP84
    • Q9UL02

    Protein attributes for AADAT Gene

    Size:
    425 amino acids
    Molecular mass:
    47352 Da
    Cofactor:
    Name=pyridoxal 5-phosphate; Xref=ChEBI:CHEBI:597326;
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for AADAT Gene

    Alternative splice isoforms for AADAT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AADAT Gene

Proteomics data for AADAT Gene at MOPED

Post-translational modifications for AADAT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AADAT Gene

No data available for DME Specific Peptides for AADAT Gene

Domains for AADAT Gene

Graphical View of Domain Structure for InterPro Entry

Q8N5Z0

UniProtKB/Swiss-Prot:

AADAT_HUMAN :
  • Q8N5Z0
Family:
  • Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
genes like me logo Genes that share domains with AADAT: view

No data available for Gene Families for AADAT Gene

Function for AADAT Gene

Molecular function for AADAT Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=0.9 mM for aminoadipate {ECO:0000269 PubMed:18620547}; KM=4.7 mM for kynurenine {ECO:0000269 PubMed:18620547}; KM=1.7 mM for methionine {ECO:0000269 PubMed:18620547}; KM=1.6 mM for glutamate {ECO:0000269 PubMed:18620547}; KM=1.8 mM for tyrosine {ECO:0000269 PubMed:18620547}; KM=1.2 mM for 2-oxoglutarate {ECO:0000269 PubMed:18620547}; KM=1.5 mM for 2-oxocaproic acid {ECO:0000269 PubMed:18620547}; KM=1.8 mM for phenylpyruvate {ECO:0000269 PubMed:18620547}; KM=1.4 mM for ino-3-pyruvate {ECO:0000269 PubMed:18620547}; pH dependence: Optimum pH is 7-9. {ECO:0000269 PubMed:18620547}; Temperature dependence: Optimum temperature is 50 degrees Celsius. {ECO:0000269 PubMed:18620547};
UniProtKB/Swiss-Prot CatalyticActivity: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate
UniProtKB/Swiss-Prot CatalyticActivity: L-2-aminoadipate + 2-oxoglutarate = 2-oxoadipate + L-glutamate
UniProtKB/Swiss-Prot EnzymeRegulation: Kynurenine transaminase activity is competitively inhibited by aminoadipate, asparagine, glutamate, histidine, cysteine, lysine, 3-hydroxy-kynurenine and phenylalanine.
UniProtKB/Swiss-Prot Function: Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).

Enzyme Numbers (IUBMB) for AADAT Gene

Gene Ontology (GO) - Molecular Function for AADAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0016212 kynurenine-oxoglutarate transaminase activity TAS --
GO:0030170 pyridoxal phosphate binding IEA --
GO:0042803 protein homodimerization activity IPI 18620547
GO:0047536 2-aminoadipate transaminase activity IDA 18620547
genes like me logo Genes that share ontologies with AADAT: view

Phenotypes for AADAT Gene

genes like me logo Genes that share phenotypes with AADAT: view

Animal Models for AADAT Gene

MGI Knock Outs for AADAT:

miRNA for AADAT Gene

miRTarBase miRNAs that target AADAT

No data available for Transcription Factor Targeting and HOMER Transcription for AADAT Gene

Localization for AADAT Gene

Subcellular locations from UniProtKB/Swiss-Prot for AADAT Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AADAT Gene COMPARTMENTS Subcellular localization image for AADAT gene
Compartment Confidence
mitochondrion 4
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for AADAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with AADAT: view

Pathways for AADAT Gene

genes like me logo Genes that share pathways with AADAT: view

Pathways by source for AADAT Gene

UniProtKB/Swiss-Prot Q8N5Z0-AADAT_HUMAN

  • Pathway: Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 4/6

Interacting Proteins for AADAT Gene

Gene Ontology (GO) - Biological Process for AADAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006103 2-oxoglutarate metabolic process IDA 18620547
GO:0006536 glutamate metabolic process IDA 18620547
GO:0006554 lysine catabolic process TAS --
GO:0006569 tryptophan catabolic process TAS --
GO:0009058 biosynthetic process IEA --
genes like me logo Genes that share ontologies with AADAT: view

Compounds for AADAT Gene

(10) HMDB Compounds for AADAT Gene

Compound Synonyms Cas Number PubMed IDs
4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid
  • 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
Not Available
4-(2-Aminophenyl)-2,4-dioxobutanoic acid
  • 4-(2-aminophenyl)-2,4-dioxobutanoate
Not Available
Aminoadipic acid
  • (+/-)-2-Aminoadipate
542-32-5
Famotidine
  • Amfamox
76824-35-6
Hydroxykynurenine
  • 3-(3-hydroxyanthraniloyl)-Alanine
484-78-6

(2) Drugbank Compounds for AADAT Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
L-Glutamic Acid
  • (2S)-2-Aminopentanedioic acid
56-86-0 target
Pyridoxal Phosphate
  • Codecarboxylase
54-47-7 target cofactor

(3) Novoseek inferred chemical compound relationships for AADAT Gene

Compound -log(P) Hits PubMed IDs
kynurenine 93.1 18
kynurenic acid 89.8 8
alpha-aminoadipate 82.9 2
genes like me logo Genes that share compounds with AADAT: view

Transcripts for AADAT Gene

Unigene Clusters for AADAT Gene

Aminoadipate aminotransferase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AADAT Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^
SP1: - - - -
SP2: - - -
SP3: - - -
SP4: - - - - - - - -
SP5: - - - -
SP6:
SP7: - - - - - -
SP8:

ExUns: 16 ^ 17 ^ 18a · 18b · 18c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for AADAT Gene

GeneLoc Exon Structure for
AADAT
ECgene alternative splicing isoforms for
AADAT

Expression for AADAT Gene

mRNA expression in normal human tissues for AADAT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AADAT Gene

SOURCE GeneReport for Unigene cluster for AADAT Gene Hs.529735

mRNA Expression by UniProt/SwissProt for AADAT Gene

Q8N5Z0-AADAT_HUMAN
Tissue specificity: Higher expression in the liver. Also found in heart, brain, kidney, pancreas, prostate, testis and ovary
genes like me logo Genes that share expressions with AADAT: view

No data available for mRNA differential expression in normal tissues for AADAT Gene

Orthologs for AADAT Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AADAT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AADAT 35
  • 99.37 (n)
  • 99.29 (a)
AADAT 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AADAT 35
  • 85.25 (n)
  • 80.24 (a)
AADAT 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AADAT 35
  • 87.06 (n)
  • 83.06 (a)
AADAT 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Aadat 35
  • 79.14 (n)
  • 73.41 (a)
Aadat 16
Aadat 36
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 44 (a)
OneToMany
-- 36
  • 70 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia AADAT 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Aadat 35
  • 77.23 (n)
  • 72.1 (a)
chicken
(Gallus gallus)
Aves AADAT 35
  • 70.98 (n)
  • 68.94 (a)
AADAT 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 59 (a)
OneToMany
-- 36
  • 68 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia MGC68542 35
tropical clawed frog
(Silurana tropicalis)
Amphibia aadat 35
  • 66.12 (n)
  • 62.88 (a)
Str.16644 35
zebrafish
(Danio rerio)
Actinopterygii AADAT 36
  • 62 (a)
OneToOne
LOC557979 35
  • 62.68 (n)
  • 63.61 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARO8 36
  • 27 (a)
OneToMany
ARO8 38
ARO9 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4740 36
  • 54 (a)
OneToOne
Species with no ortholog for AADAT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AADAT Gene

ENSEMBL:
Gene Tree for AADAT (if available)
TreeFam:
Gene Tree for AADAT (if available)

Paralogs for AADAT Gene

No data available for Paralogs for AADAT Gene

Variants for AADAT Gene

Sequence variations from dbSNP and Humsavar for AADAT Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs716822 -- 170,086,353(-) GTTCC(A/G)GGAAC intron-variant
rs963660 -- 170,073,915(-) GCCCC(A/G)AATTT intron-variant
rs991245 -- 170,088,637(+) CATTA(C/T)AGTCA intron-variant
rs991246 -- 170,088,715(+) cagat(A/T)catac intron-variant
rs991247 -- 170,088,754(+) taaca(A/G)gtggg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AADAT Gene

Variant ID Type Subtype PubMed ID
nsv4601 CNV Loss 18451855
nsv830150 CNV Gain 17160897

Relevant External Links for AADAT Gene

HapMap Linkage Disequilibrium report
AADAT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AADAT Gene

Disorders for AADAT Gene

(1) University of Copenhagen DISEASES for AADAT Gene

(1) Novoseek inferred disease relationships for AADAT Gene

Disease -log(P) Hits PubMed IDs
huntington disease 41.3 1

Relevant External Links for AADAT

Genetic Association Database (GAD)
AADAT
Human Genome Epidemiology (HuGE) Navigator
AADAT
genes like me logo Genes that share disorders with AADAT: view

No data available for UniProtKB/Swiss-Prot for AADAT Gene

Publications for AADAT Gene

  1. Characterization of the human gene encoding alpha-aminoadipate aminotransferase (AADAT). (PMID: 12126930) Goh D.L.M. … Geraghty M.T. (Mol. Genet. Metab. 2002) 2 3 4 25
  2. Genomic organization and expression analysis of mouse kynurenine aminotransferase II, a possible factor in the pathophysiology of Huntington's disease. (PMID: 10441733) Yu P. … Tagle D.A. (Mamm. Genome 1999) 2 3 23
  3. Crystal structure of human kynurenine aminotransferase II. (PMID: 18056995) Han Q. … Li J. (J. Biol. Chem. 2008) 3 4 23
  4. Crystal structure of human kynurenine aminotransferase II, a drug target for the treatment of schizophrenia. (PMID: 18056996) Rossi F. … Rizzi M. (J. Biol. Chem. 2008) 3 4 23
  5. Substrate specificity and structure of human aminoadipate aminotransferase/kynurenine aminotransferase II. (PMID: 18620547) Han Q. … Li J. (Biosci. Rep. 2008) 3 4 23

Products for AADAT Gene

Sources for AADAT Gene

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