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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

AADAT Gene

protein-coding GIFtS: 56
GCID: GC04M170981

aminoadipate aminotransferase

Explore 7 diseases affiliated with
AADAT via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Aminoadipate Aminotransferase¹ ²		2-Aminoadipate Aminotransferase² ³
KAT2¹ ² ³ ⁵		2-Aminoadipate Transaminase² ³
KATII¹ ²		KAT/AadAT² ³
Alpha-Aminoadipate Aminotransferase² ³		Kynurenine/Alpha-Aminoadipate Aminotransferase, Mitochondrial²
Kynurenine Aminotransferase II² ³		L Kynurenine/Alpha Aminoadipate Aminotransferase²
Kynurenine--Oxoglutarate Aminotransferase II² ³		AadAT³
Kynurenine--Oxoglutarate Transaminase 2² ³		EC 2.6.1.39³
Kynurenine--Oxoglutarate Transaminase II² ³		EC 2.6.1.7³

External Ids:	HGNC: 17929¹	Entrez Gene: 51166²	Ensembl: ENSG00000109576⁷	OMIM: 611754⁵	UniProtKB: Q8N5Z0³

Export aliases for AADAT gene to outside databases

Previous GC identifers: GC00U991148 GC04M171565 GC04M171677 GC04M171356 GC04M171218 GC04M166736

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for AADAT:

This gene encodes a protein that is highly similar to mouse and rat kynurenine aminotransferase II. The rat protein is

a homodimer with two transaminase activities. One activity is the transamination of alpha-aminoadipic acid, a final

step in the saccaropine pathway which is the major pathway for L-lysine catabolism. The other activity involves the

transamination of kynurenine to produce kynurenine acid, the precursor of kynurenic acid which has neuroprotective

properties. Two alternative transcripts encoding the same isoform have been identified, however, additional

alternative transcripts and isoforms may exist. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: AADAT_HUMAN, Q8N5Z0

Function: Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine,

methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety

of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and

alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.1 NT_016354.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the AADAT gene promoter:
SREBP-1a SREBP-1c Tal-1beta E47 SREBP-1b
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: AADAT promoter sequence

Search SABiosciences Chromatin IP Primers for AADAT

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AADAT

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q33 Ensembl cytogenetic band: 4q33 HGNC cytogenetic band: 4q33

AADAT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AADAT gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M170981: view genomic region (about GC identifiers)

Start:	170,981,373 bp from pter	End:	171,012,850 bp from pter
Size:	31,478 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: AADAT_HUMAN, Q8N5Z0 (See protein sequence)

Recommended Name: Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial precursor

Size: 425 amino acids; 47352 Da

Cofactor: Pyridoxal phosphate

Subunit: Homodimer

Subcellular location: Mitochondrion (Potential)

6/10 PDB 3D structures from and Proteopedia for AADAT (see all 10):

2QLR (3D)

2R2N (3D)

2VGZ (3D)

2XH1 (3D)

3DC1 (3D)

3UE8 (3D)

Secondary accessions: B3KP84 Q9UL02

Alternative splicing: 2 isoforms: Q8N5Z0-1 Q8N5Z0-2 (May be due to a competing donor splice site)

Explore the universe of human proteins at neXtProt for AADAT: NX_Q8N5Z0

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8N5Z0

AADAT Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_057312.1 NP_872603.1

ENSEMBL proteins:

ENSP00000336808 ENSP00000423190 ENSP00000423341 ENSP00000226840 ENSP00000425067

ENSP00000421389 ENSP00000423843

Reactome Protein details: Q8N5Z0
Human Recombinant Protein Products for AADAT:

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	Uscn Proteins for AADAT

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	--	--
GO:0005759	mitochondrial matrix	TAS	--

AADAT for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

AADAT for domains About GeneDecksing

4 InterPro domains/families:

IPR004839 Aminotransferase_I/II

IPR015424 PyrdxlP-dep_Trfase

IPR015421 PyrdxlP-dep_Trfase_major_sub1

IPR015422 PyrdxlP-dep_Trfase_major_sub2

Graphical View of Domain Structure for InterPro Entry Q8N5Z0

ProtoNet protein and cluster: Q8N5Z0

UniProtKB/Swiss-Prot: AADAT_HUMAN, Q8N5Z0

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: AADAT_HUMAN, Q8N5Z0

Function: Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine,

methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety

of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and

alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro)

Catalytic activity: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate

Catalytic activity: L-2-aminoadipate + 2-oxoglutarate = 2-oxoadipate + L-glutamate

Enzyme regulation: Kynurenine transaminase activity is competitively inhibited by aminoadipate, asparagine, glutamate,

histidine, cysteine, lysine, 3-hydroxy-kynurenine and phenylalanine

Biophysicochemical properties: Kinetic parameters: KM=0.9 mM for aminoadipate; KM=4.7 mM for kynurenine; KM=1.7 mM for

methionine; KM=1.6 mM for glutamate; KM=1.8 mM for tyrosine; KM=1.2 mM for 2-oxoglutarate; KM=1.5 mM for 2-oxocaproic

acid; KM=1.8 mM for phenylpyruvate; KM=1.4 mM for ino-3-pyruvate; pH dependence: Optimum pH is 7-9; Temperature

dependence: Optimum temperature is 50 degrees Celsius;

Enzyme Numbers (IUBMB): EC 2.6.1.39¹ EC 2.6.1.7¹

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016212	kynurenine-oxoglutarate transaminase activity	TAS	--
GO:0016740	transferase activity	--	--
GO:0030170	pyridoxal phosphate binding	IEA	--
GO:0042803	protein homodimerization activity	IPI	18620547
GO:0047536	2-aminoadipate transaminase activity	IDA	18620547

AADAT for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for AADAT:

Synthetic lethal with c-Myc af

3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Aadat):

behavior/neurological

nervous system

vision/eye

AADAT for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Aadat^tm1Tag for AADAT

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AADAT

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Metabolism

Metabolism

1.00

Metabolic pathways

0.38

Tryptophan metabolism

Tryptophan metabolism

1.00

Tryptophan metabolism

0.47

Metabolism of amino acids and derivatives

Metabolism of amino acids and derivatives

1.00

Lysine catabolism

Lysine catabolism

1.00

Lysine degradation

Lysine degradation

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for AADAT

Tryptophan metabolism

4 Reactome Pathways for AADAT

	Tryptophan catabolism
	Lysine catabolism
	Metabolism
	Metabolism of amino acids and derivatives

4 Kegg Pathways (Kegg details for AADAT):

	Lysine biosynthesis
	Lysine degradation
	Tryptophan metabolism
	Metabolic pathways

UniProtKB/Swiss-Prot: AADAT_HUMAN, Q8N5Z0

Pathway: Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 4/6

AADAT for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for AADAT

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

5/96 Interacting proteins for AADAT (Q8N5Z0³ ENSP00000226840⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 96)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NME1-NME2	P22392³	I2D: score=1
NME2	P22392³	I2D: score=1
UBC	P0CG48³, ENSP00000344818⁴	I2D: score=1 STRING: ENSP00000344818
WARS	P23381³, ENSP00000347495⁴	I2D: score=1 STRING: ENSP00000347495
ALDH18A1	P54886³	I2D: score=2

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006103	2-oxoglutarate metabolic process	IDA	18620547
GO:0006536	glutamate metabolic process	IDA	18620547
GO:0006554	lysine catabolic process	TAS	--
GO:0006569	tryptophan catabolic process	TAS	--
GO:0009058	biosynthetic process	IEA	--

AADAT for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

AADAT for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for AADAT

Browse Tocris compounds for AADAT

10 HMDB Compounds for AADAT About this table

Compound	Synonyms	CAS #	PubMed Ids
4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid	4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate (see all 2)	--	--
4-(2-Aminophenyl)-2,4-dioxobutanoic acid	4-(2-aminophenyl)-2,4-dioxobutanoate (see all 4)	--	--
Aminoadipic acid	(+/-)-2-Aminoadipate (see all 24)	542-32-5	--
Famotidine	Amfamox (see all 83)	76824-35-6	--
Hydroxykynurenine	3-(3-hydroxyanthraniloyl)-Alanine (see all 7)	484-78-6	--
L-Glutamic acid	(2S)-2-Aminopentanedioate (see all 49)	56-86-0	--
L-Kynurenine	(S)-alpha,2-diamino-3-hydroxy-gamma-oxo-Benzenebutanoate (see all 15)	343-65-7	--
Oxoadipic acid	alpha-ketoadipic acid (see all 19)	3184-35-8	--
Oxoglutaric acid	2-Ketoglutarate (see all 9)	328-50-7	--
Pyridoxal 5'-phosphate	Apolon B6 (see all 27)	54-47-7	--

2 DrugBank Compounds for AADAT About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
L-Glutamic Acid	(2S)-2-Aminopentanedioic acid (see all 15)	56-86-0	target	--	17139284 17016423 12850557
Pyridoxal Phosphate	Codecarboxylase (see all 9)	54-47-7	target	cofactor	12126930 15016471

3 Novoseek chemical compound relationships for AADAT gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
kynurenine	93.1	26	8350986 (2), 10441733 (2), 18056995 (2), 16511030 (2) (see all 14)
kynurenic acid	89.8	14	10441733 (1), 14559362 (1), 16099455 (1), 18056995 (1) (see all 8)
alpha-aminoadipate	82.9	2	14559362 (1), 8087205 (1)

Search CenterWatch for drugs/clinical trials and news about AADAT

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for AADAT gene (2 alternative transcripts):

NM_016228.3 NM_182662.1

Unigene Cluster for AADAT:

Aminoadipate aminotransferase

Hs.529735 [show with all ESTs]

Unigene Representative Sequence: AF481738

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000337664(uc003isr.3) ENST00000509167(uc003ist.3) ENST00000515480

ENST00000353187(uc003iss.3) ENST00000505906 ENST00000510340 ENST00000507375

ENST00000502392

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Additional cDNA sequence:

AF481738.1 AK055952.1 AK314729.1 BC031068.1

10 DOTS entries:

DT.310471 DT.100019700 DT.40299440 DT.95259621 DT.91865689 DT.95245901 DT.100719445 DT.87046874

DT.95340712 DT.108019

24/80 AceView cDNA sequences (see all 80):

AI580846 W05694 CA436887 BQ287909 AA568464 BC031068 AI024796 BX281257

CD722938 AI819354 AI393635 NM_182662 N54512 H92545 CB215768 H72204

BU154412 NM_016228 AK055952 AW472959 F11219 F08882 BP375293 BG195687

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for AADAT (see all 8) About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4a	·	4b	·	4c	^	5a	·	5b	·	5c	^	6	^	7	^	8a	·	8b	·	8c	^	9	^	10a	·	10b	·	10c	·	10d	^	11a	·	11b	^	12	^	13	^	14	^	15	^
SP1:															-				-		-																						-
SP2:															-						-																						-
SP3:																			-		-																						-
SP4:					-		-		-		-		-		-				-		-
SP5:													-		-				-		-

ExUns:	16	^	17	^	18a	·	18b	·	18c
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for AADAT

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

AADAT expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCTATCTGT

About this image
See AADAT Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AADAT

SOURCE GeneReport for Unigene cluster: Hs.529735

UniProtKB/Swiss-Prot: AADAT_HUMAN, Q8N5Z0

Tissue specificity: Higher expression in the liver. Also found in heart, brain, kidney, pancreas, prostate, testis and

ovary

SABiosciences Expression via Pathway-Focused PCR Arrays including AADAT:

Amino Acid Metabolism II in human mouse rat

Amino Acid Metabolism I in human mouse rat

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for AADAT gene from 6/26 species (see all 26) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Aadat^{1 , 5}	aminoadipate aminotransferase^{1, 5}	79.14(n)¹ 73.41(a)¹		8 (30.85 cM)⁵ 23923¹ NM_011834.2¹ NP_035964.1¹ 60506124⁵
chicken (Gallus gallus)	Aves	AADAT¹	aminoadipate aminotransferase	70.98(n) 68.94(a)		428728 XM_426286.3 XP_426286.3
lizard (Anolis carolinensis)	Reptilia	AADAT⁶	--	69(a)	1 ↔ 1	GL343216.1(939292-955373)
African clawed frog (Xenopus laevis)	Amphibia	MGC68542²	hypothetical protein MGC68542	72.17(n)		BC059968.1
zebrafish (Danio rerio)	Actinopterygii	LOC557979¹	kynurenine/alpha-aminoadipate aminotransferase, mitochondrial-like	62.76(n) 63.78(a)		557979 XM_681142.5 XP_686234.5
fruit fly (Drosophila melanogaster)	Insecta	CG6321⁶	--	18(a)	1 ↔ 1	3L(11052537-11054324)

ENSEMBL Gene Tree for AADAT (if available)
TreeFam Gene Tree for AADAT (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs140084198^1,2		--	170980974(+)	`ATGAAC/TACAGG`	2	--	ds500¹		0	--	--	--	--
rs141310286^1,2	C	--	170981198(+)	`AAAAA-/ATAGTTA`	2	--	ds500¹		0	--	--	--	--
rs150485838^1,2		--	170981222(+)	`TAATAC/TCTTAA`	2	--	ds500¹		0	--	--	--	--
rs187964064^1,2		--	170981232(+)	`AAGGGC/TTGTAG`	2	--	ds500¹		0	--	--	--	--
rs116971062^1,2	F	--	170981306(+)	`CAATGT/CAGTAA`	2	--	ds500¹		1		EA	120
rs138302195^1,2		--	170981425(+)	`CATAAC/GGTTTA`	2	--	ut3¹		0	--	--	--	--
rs144018711^1,2		--	170981431(+)	`GTTTAG/TGGTAC`	2	--	ut3¹		0	--	--	--	--
rs181473131^1,2		--	170981433(+)	`TTATGG/TTACTT`	2	--	ut3¹		0	--	--	--	--
rs34588185^1,2	C	--	170981469(+)	`AAATT-/ATAACA`	2	--	ut3¹		2		NA	4
rs146704043^1,2		--	170981568(+)	`TCTCAA/GAATAA`	2	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for AADAT (170981373 - 171012850 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for AADAT: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AADAT

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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AADAT for disorders           About GeneDecksing

OMIM gene information: 611754    OMIM disorders: --

7 diseases for AADAT:    About MalaCards

huntington's disease down syndrome meningitis pneumonia

schizophrenia prostatitis neuronitis

1 disease from the University of Copenhagen DISEASES database for AADAT:

Huntington's disease

1 Novoseek disease relationship for AADAT gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
huntington disease	41.3	1	10441733 (1)

Human Genome Epidemiology (HuGE) Navigator: AADAT (1 document)

Export disorders for AADAT gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for AADAT gene, integrated from 9 sources (see all 30):
(articles sorted by number of sources associating them with AADAT)

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Characterization of the human gene encoding alpha-aminoadipate aminotransferase (AADAT). (PubMed id 12126930)^{1, 2, 3, 7} Goh D.L.M.... Geraghty M.T. (2002)
Substrate specificity and structure of human aminoadipate aminotransferase/kynurenine aminotransferase II. (PubMed id 18620547)^{1, 2, 9} Han Q.... Li J. (2008)
Crystal structure of human kynurenine aminotransferase II. (PubMed id 18056995)^{1, 2, 9} Han Q.... Li J. (2008)
Genomic organization and expression analysis of mouse kynurenine aminotransferase II, a possible factor in the pathophysiology of Huntington's disease. (PubMed id 10441733)^{1, 3, 9} Yu P....Tagle D.A. (1999)
Crystal structure of human kynurenine aminotransferase II, a drug target for the treatment of schizophrenia. (PubMed id 18056996)^{1, 2, 9} Rossi F.... Rizzi M. (2008)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
2-Aminoadipate-2-oxoglutarate aminotransferase isoenzymes in human liver: a plausible physiological role in lysine and tryptophan metabolism. (PubMed id 8087205)^{1, 9} Okuno E....Kido R. (1993)
Association of kynurenine aminotransferase II gene C4 01T polymorphism with immune response in patients with meningitis. (PubMed id 21473761)¹ de Souza F.R....Agnez-Lima L.F. (2011)
Somatization, but not depression, is characterized by disorders in the tryptophan catabolite (TRYCAT) pathway, indicating increased indoleamine 2,3-dioxygenase and lowered kynurenine aminotransferase activity. (PubMed id 21712776)¹ Maes M....Rief W. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 51166	HGNC: 17929	AceView: AADAT	Ensembl:ENSG00000109576	euGenes: HUgn51166
ECgene: AADAT	Kegg: 51166	H-InvDB: AADAT

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for AADAT	Pharmacogenomics, SNPs, Pathways

Intellectual Property for AADAT gene
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Patent Information for AADAT gene:
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GeneCards and IP:
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