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Aliases & Descriptions for AADAT
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases AadAT 3 EC 2.6.1.7,EC 2.6.1.39 3 KAT/AadAT 3 KAT2 1 , 2 , 3 , 5 KATII 1 , 2
Descriptions 2-aminoadipate aminotransferase 3 2-aminoadipate transaminase 3 Alpha-aminoadipate aminotransferase 3 Kynurenine aminotransferase II 2 , 3 Kynurenine--oxoglutarate aminotransferase II 3 Kynurenine--oxoglutarate transaminase II 3 L kynurenine/alpha aminoadipate aminotransferase 2 aminoadipate aminotransferase 2
Search outside databases for aliases for AADAT genePrevious GC identifers: GC00U991148 GC04M171565 GC04M171677 GC04M171356
Summaries for AADAT (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for AADAT : This gene encodes a protein that is highly similar to mouse and rat kynurenine aminotransferase II.The rat protein is a homodimer with two transaminase activities. One activity is thetransamination of alpha-aminoadipic acid, a final step in the saccaropine pathway which is themajor pathway for L-lysine catabolism. The other activity involves the transamination ofkynurenine to produce kynurenine acid, the precursor of kynurenic acid which has neuroprotectiveproperties. Two alternative transcripts encoding the same isoform have been identified, however,additional alternative transcripts and isoforms may exist. [provided by RefSeq] UniProtKB/Swiss-Prot: AADAT_HUMAN, Q8N5Z0 Function : Shows activity also towards tryptophan, aspartate and hydroxykinurenine
Genomic Location for AADAT
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the AADAT gene Entrez Gene cytogenetic band: 4q33 Ensembl cytogenetic band: 4q33 HGNC cytogenetic band: 4q33 AADAT Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure
GeneLoc location for GC04M171218:
(about GC identifiers )
Start:
171,217,948 bp from pter
End:
171,247,947 bp from pter
Size:
30,000 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000004.10 NT_022792.17 Proteins for AADAT
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: AADAT_HUMAN, Q8N5Z0 (See
protein sequence )Recommended Name: Kynurenine/alpha-aminoadipate aminotransferase mitochondrial precursor Size : 425 amino acids; 47352 Da
Cofactor : Pyridoxal phosphate
Subunit : Homodimer (By similarity)
Subcellular location : Mitochondrion (Potential)
PDB structures from and Proteopedia : 2QLR (3D)
 2R2N (3D)
 2VGZ (3D)
 3DC1 (3D)
 
Secondary accessions : Q9UL02Alternative splicing : 2 isoforms : Q8N5Z0-1 Q8N5Z0-2
REFSEQ proteins (2 alternative transcripts):
NP_057312.1 NP_872603.1 ENSEMBL proteins: ENSP00000336808 ENSP00000226840 Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: AADAT 2 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for AADAT: Assays for AADAT:
Protein
Domains/ Families for AADAT(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q8N5Z0 ProtoNet protein and cluster: Q8N5Z0
UniProtKB/Swiss-Prot: AADAT_HUMAN, Q8N5Z0 Similarity : Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family
Gene Function for AADAT
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
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Clones , and
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SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_182662 Applied Biosystems Silencer ® siRNAs for AADAT Sigma-Aldrich siRNA for AADAT Sigma-Aldrich shRNA for AADAT Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_016228                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_016228                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_016228  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_182662 UniProtKB/Swiss-Prot: AADAT_HUMAN, Q8N5Z0 Function : Shows activity also towards tryptophan, aspartate and hydroxykinurenineCatalytic activity : L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate +L-glutamate Catalytic activity : L-2-aminoadipate + 2-oxoglutarate = 2-oxoadipate + L-glutamateEnzyme Number (IUBMB): EC 2.6.1.7,EC
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Aadat) :3 Gene Ontology (GO) molecular function terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0016212 kynurenine-oxoglutarate transaminase activity
IEA -- GO:0030170 pyridoxal phosphate binding
IEA -- GO:0047536 2-aminoadipate transaminase activity
IEA --
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Pathways & Interactions for AADAT
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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3 Sigma-Aldrich "Your Favorite Gene" Pathways for AADAT (Your Favorite Gene powered by Ingenuity) UniProtKB/Swiss-Prot: AADAT_HUMAN, Q8N5Z0 Pathway : Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA fromL-lysine: step 4/6
5/11 Interacting proteins for AADAT (ENSP00000336808 3 ) via UniProtKB, MINT, and/or STRING (see all 11
)About this table 1 Gene Ontology (GO) biological process term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0009058 biosynthetic process
IEA --
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Drugs & Compounds for AADAT (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
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Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for AADAT 1 Novoseek chemical compound relationship for AADAT gene
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Transcripts for AADAT(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_182662 Sigma-Aldrich siRNA for AADAT Sigma-Aldrich shRNA for AADAT Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_016228 NM_182662
REFSEQ mRNAs for AADAT gene (2 alternative transcripts): NM_016228.3 NM_182662.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_016228 NM_182662
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_016228                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_016228                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_016228  
Additional cDNA sequence: AF481738.1 AK055952.1 AK314729.1 BC031068.1
10 DOTS entries : DT.310471 DT.100019700 DT.40299440 DT.95259621 DT.91865689 DT.95245901 DT.100719445 DT.108019 DT.87046874 DT.95340712
24/80 AceView cDNA sequences (see all 80
):F08882 CB215768 BU154412 CD722938 AI819354 H92545 NM_182662 AI393635 BQ287909 W05694 BC031068 AA568464 N54512 AI024796 BX281257 H72204 AK055952 F11219 AW472959 AI580846 NM_016228 CA436887 BU741977 BI597437
highest scoring ESTs for AADAT :AI819354 AK055952 BC031068 BM478854 AA059063 AA121140 AA333897 AA401238 AA404282 AA434578
Unigene Cluster for AADAT: Aminoadipate aminotransferase Hs.529735 [show with all ESTs ] Unigene Representative Sequence: AF481738 GeneLoc Exon Structure 5/8 Alternative Splicing Database (ASD) splice patterns (SP) for AADAT (see all 8
) ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ SP1 :               -     -   -                       -           SP2 :               -       -                       -           SP3 :                   -   -                       -           SP4 :     -   -   -   -   -   -     -   -                                 SP5 :             -   -     -   -                                
ExUns: 16 ^ 17 ^ 18a · 18b · 18c SP1 :           SP2 :           SP3 :           SP4 :           SP5 :          
About this scheme ECgene alternative splicing isoforms for AADAT 2 Ensembl transcripts including schematic representations : ENST00000337664
ENST00000353187
Expression for AADAT
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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AADAT expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for AADAT 1 / 2 / 3
3 probe-sets matching AADAT gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: TCCTATCTGTSOURCE GeneReport for Unigene cluster: Hs.529735 UniProtKB/Swiss-Prot: AADAT_HUMAN, Q8N5Z0 Tissue specificity : Higher expression in the liver. Also found in heart, brain, kidney, pancreas,prostate, testis and ovary
Orthologs for AADAT
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for AADAT gene from 5/12 species (see all 12
)
About this table Species with no ortholog for AADAT ENSEMBL Gene Tree for AADAT Paralogs for AADAT (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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SNPs/Variants for AADAT (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for AADAT (up to first 250kb)
Disorders & Mutations for AADAT
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 611754 1 Novoseek disease relationship for AADAT gene
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Medical News for AADAT (Possibly Related Articles in
Doctor's Guide )
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Publications for AADAT (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/21 PubMed articles for AADAT gene (see all 21
): Characterization of the human gene encoding alpha-aminoadipate aminotransferase (AADAT). (PubMed id 12126930) 2, 3, 4 Goh D.L.M.... Geraghty M.T. (2002) Genomic organization and expression analysis of mouse kynurenine aminotransferase II, a possible factor in the pathophysiology of Huntington's disease. (PubMed id 10441733) 1, 2, 3 Yu P....Tagle D.A. (1999) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 3, 4 Ota T....Sugano S. (2004) Crystal structure of human kynurenine aminotransferase II. (PubMed id 18056995) 1, 3 Han Q....Li J. (2008) Crystal structure of human kynurenine aminotransferase II, a drug target for the treatment of schizophrenia. (PubMed id 18056996) 1, 3 Rossi F....Rizzi M. (2008) 2-Aminoadipate-2-oxoglutarate aminotransferase isoenzymes in human liver: a plausible physiological role in lysine and tryptophan metabolism. (PubMed id 8087205) 1, 3 Okuno E....Kido R. (1993) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 3 Strausberg R.L....Marra M.A. (2002) Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id ) 4 Aoki H.... Hino O. (2000) Purification and properties of alpha-aminoadipate aminotransferase from rat liver and kidney mitochondria. (PubMed id 1798692) 3 Mawal M.R....Deshmukh D.R. (1991)
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Genome Databases showing AADAT
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing AADAT
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Specialized Databases showing AADAT (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for AADAT (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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