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AADACL4 Gene

protein-coding   GIFtS: 37

GC01P012627
arylacetamide deacetylase-like 4
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
EC 3.1.1.- 3
OTTHUMG00000001889 1
OTTHUMP00000001872 2
Descriptions
arylacetamide deacetylase-like 4 2
External Ids
HGNC: 320381
Entrez Gene: 3430662
UniProtKB: Q5VUY23
Ensembl: ENSG000002045187
Search outside databases for aliases for AADACL4 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the AADACL4 gene  

Entrez Gene cytogenetic band: 1p36.21   Ensembl cytogenetic band:  1p36.21   HGNC cytogenetic band: 1p36.21

AADACL4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P012627:     (about GC identifiers)

Start:
12,627,153 bp from pter
End:
12,649,684 bp from pter
Size:
22,532 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000001.9  NT_021937.18  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ADCL4_HUMAN, Q5VUY2 (See protein sequence)
Recommended Name: Arylacetamide deacetylase-like 4  
Size: 407 amino acids; 46082 Da
Subcellular location: Membrane; Single-pass type II membrane protein (Potential)

REFSEQ proteins: NP_001013652.1  

ENSEMBL proteins: 
ENSP00000365395 


Human Recombinant Proteins 
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Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0016020 membrane IEA--
GO:0016021 integral to membrane IEA--
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Antibodies for AADACL4: 
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Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
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Search Novus for antibodies for AADACL4

Assays for AADACL4: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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3 InterPro domains/families:
 IPR017157 Arylacetamide_deacetylase
 IPR013094 AB_hydrolase_3
 IPR002168 Lipase_GDXG_AS


   GeneDecks  AADACL4 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q5VUY2

ProtoNet protein and cluster: Q5VUY2

1 Blocks protein family: IPB013094 Alpha/beta hydrolase fold-3

UniProtKB/Swiss-Prot: ADCL4_HUMAN, Q5VUY2
Similarity: Belongs to the 'GDXG' lipolytic enzyme family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (AADACL4)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001013630

              Applied Biosystems Silencer® siRNAs for AADACL4

              Sigma-Aldrich siRNA for AADACL4  
                     Sigma-Aldrich shRNA for AADACL4  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001013630
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001013630
                                 untagged cDNA clone in CMV expression vector: NM_001013630 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_001013630

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0004091 carboxylesterase activity IEA--
GO:0016787 hydrolase activity IEA--
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(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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  --

1 Gene Ontology (GO) biological process term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0008152 metabolic process IEA--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for AADACL4

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (AADACL4)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001013630

              Sigma-Aldrich siRNA for AADACL4  
                     Sigma-Aldrich shRNA for AADACL4  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001013630  

REFSEQ mRNAs for AADACL4 gene: 

NM_001013630.1   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001013630  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001013630
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001013630
                                 untagged cDNA clone in CMV expression vector: NM_001013630 

1 DOTS entry:

DT.75183998 

2 AceView cDNA sequences:

BX096582 AI804040 

highest scoring ESTs for AADACL4:

AI804040 BX096582 NM_001013630 DV080085 

Unigene Cluster for AADACL4:

Arylacetamide deacetylase-like 4
Hs.209954  [show with all ESTs]
Unigene Representative Sequence: NM_001013630


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000376221  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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AADACL4 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for AADACL4

1Data from GNF BioGPS
    About these images

About these images

CGAP SAGE TAG: TTCCCTGAAG

SOURCE GeneReport for Unigene cluster: Hs.209954
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for AADACL4 gene from 5/6 species (see all 6 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
AADACL41   -- arylacetamide deacetylase-like 4 77.66(n)
68.8(a)
607688  XM_844461.1  XP_849554.1 
chimpanzee
(Pan troglodytes)
AADACL41   -- arylacetamide deacetylase-like 4 99.26(n)
99.02(a)
469815  XM_525200.2  XP_525200.2 
rat
(Rattus norvegicus)
RGD15657611   -- similar to novel protein similar to esterases 71.74(n)
64.13(a)
313688  XM_233640.4  XP_233640.4 
mouse
(Mus musculus)
OTTMUSG000000107471   -- predicted gene, OTTMUSG00000010747 71.99(n)
65.11(a)
435815  NM_001081248.1  NP_001074717.1 
chicken
(Gallus gallus)
AADACL41   -- arylacetamide deacetylase-like 4 58.5(n)
50.71(a)
768457  XM_001231393.1  XP_001231394.1 
About this table        Species with no ortholog for AADACL4

ENSEMBL Gene Tree for AADACL4
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for AADACL4 gene
AADACL12  AADACL32  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/129 NCBI SNPs in AADACL4 are shown (see all 129 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 63)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 1 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs120785431,2
F,H12626567(+) GGACCC/ACAGAA 1 -- ng514Minor allele frequency- A:0.01EU EA WA 418
rs66875771,2
F,H12627053(+) AGAGAG/CTGAGG 1 -- ng513Minor allele frequency- C:0.01EU EA 298
--
rs96629081,2
H12625458(+) aacaaC/Tgacaa 1 -- ng514Minor allele frequency- T:0.00EU EA WA 398
rs30008881,2
A,C,F,H,O12644921(-) CCTGTA/GTCTAT 1 -- int18Minor allele frequency- G:0.01NA EU EA WA 740
rs20275891,2
A,C,F,H,O12647518(-) TTTGGC/TTTCCG 1 -- int18Minor allele frequency- T:0.18EA WA NA 692
rs15397011,2
A,C,F,H12634960(-) AAGGGT/CATCTT 1 -- int14Minor allele frequency- C:0.12EA WA 478
rs111219551,2
A,C,F,H12645771(+) TACCCG/AAACTC 1 -- int15Minor allele frequency- A:0.02EU EA WA 578
rs65410501,2
A,C,F,H12632454(+) TTGGGG/TTCAGA 1 -- int13Minor allele frequency- T:0.03EU EA 300
rs22569011,2
A,C,F,H12641798(-) AACAGA/GTCCAG 1 -- int19Minor allele frequency- G:0.01EU EA WA 1008
rs22570171,2
A,C,F,H12641402(-) TGAAGT/CCGGGG 1 -- int14Minor allele frequency- C:0.16EU EA WA 420
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HapMap Linkage Disequilibrium images for AADACL4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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  --

(Possibly Related Articles in Doctor's Guide)
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  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
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1 PubMed article for AADACL4 gene:
(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 343066 HGNC: 32038 AceView: LOC343066 Ensembl:ENSG00000204518 euGenes: HUgn343066
ECgene: AADACL4 H-InvDB: AADACL4
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
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  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for AADACL4:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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