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Aliases for AADACL4 Gene

Aliases for AADACL4 Gene

  • Arylacetamide Deacetylase Like 4 2 3 5
  • EC 3.1.1.- 4

External Ids for AADACL4 Gene

Previous GeneCards Identifiers for AADACL4 Gene

  • GC01P011857

Summaries for AADACL4 Gene

GeneCards Summary for AADACL4 Gene

AADACL4 (Arylacetamide Deacetylase Like 4) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity and carboxylic ester hydrolase activity. An important paralog of this gene is AADACL3.

Additional gene information for AADACL4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AADACL4 Gene

Genomics for AADACL4 Gene

Regulatory Elements for AADACL4 Gene

Enhancers for AADACL4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H012432 1.9 FANTOM5 Ensembl ENCODE dbSUPER 13.7 -207.9 -207896 7 HDGF PKNOX1 FOXA2 ARNT ARID4B FEZF1 DMAP1 ZNF2 YY1 FOS LINC01784 PRAMEF12 PRAMEF11 PRAMEF30P HNRNPCL1 PRAMEF4 PRAMEF29P PRAMEF6 LOC102724659 RNU5E-1
GH01H012423 0.9 Ensembl ENCODE dbSUPER 10.6 -220.5 -220452 1 TFDP1 PRDM1 RNU6ATAC18P AADACL4 SNORA59A GC01P012422 GC01M012433
GH01H012400 0.9 dbSUPER 10.2 -242.3 -242284 3 ELF3 FOXA2 ATF1 MLX ARID4B RAD21 ZSCAN9 RARA CREM THAP11 RNU6ATAC18P AADACL4 SNORA59A GC01P012422 PIR35697 GC01P012251
GH01H012375 0.7 Ensembl ENCODE 10.7 -267.8 -267821 1 CEBPA RAD21 DHRS3 RNU6ATAC18P AADACL4 SNORA59A GC01P012422 GC01P012251 PIR35697
GH01H012315 0.6 ENCODE dbSUPER 11.5 -328.2 -328204 1 ZNF133 DHRS3 AADACL4 RNU6ATAC18P SNORA59A GC01P012251 PIR35697 GC01P012422
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around AADACL4 on UCSC Golden Path with GeneCards custom track

Genomic Location for AADACL4 Gene

Chromosome:
1
Start:
12,644,547 bp from pter
End:
12,667,086 bp from pter
Size:
22,540 bases
Orientation:
Plus strand

Genomic View for AADACL4 Gene

Genes around AADACL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AADACL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AADACL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AADACL4 Gene

Proteins for AADACL4 Gene

  • Protein details for AADACL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VUY2-ADCL4_HUMAN
    Recommended name:
    Arylacetamide deacetylase-like 4
    Protein Accession:
    Q5VUY2

    Protein attributes for AADACL4 Gene

    Size:
    407 amino acids
    Molecular mass:
    46082 Da
    Quaternary structure:
    No Data Available

neXtProt entry for AADACL4 Gene

Post-translational modifications for AADACL4 Gene

  • Glycosylation at posLast=168168 and Asn269
  • Modification sites at PhosphoSitePlus

Other Protein References for AADACL4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AADACL4 Gene

Domains & Families for AADACL4 Gene

Gene Families for AADACL4 Gene

Protein Domains for AADACL4 Gene

Suggested Antigen Peptide Sequences for AADACL4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5VUY2

UniProtKB/Swiss-Prot:

ADCL4_HUMAN :
  • Belongs to the GDXG lipolytic enzyme family.
Family:
  • Belongs to the GDXG lipolytic enzyme family.
genes like me logo Genes that share domains with AADACL4: view

Function for AADACL4 Gene

Enzyme Numbers (IUBMB) for AADACL4 Gene

Phenotypes From GWAS Catalog for AADACL4 Gene

Gene Ontology (GO) - Molecular Function for AADACL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IBA --
GO:0052689 carboxylic ester hydrolase activity IEA --
genes like me logo Genes that share ontologies with AADACL4: view
genes like me logo Genes that share phenotypes with AADACL4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for AADACL4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AADACL4 Gene

Localization for AADACL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AADACL4 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AADACL4 gene
Compartment Confidence
plasma membrane 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for AADACL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with AADACL4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for AADACL4 Gene

Pathways & Interactions for AADACL4 Gene

SuperPathways for AADACL4 Gene

No Data Available

Interacting Proteins for AADACL4 Gene

Gene Ontology (GO) - Biological Process for AADACL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009056 catabolic process IBA --
genes like me logo Genes that share ontologies with AADACL4: view

No data available for Pathways by source and SIGNOR curated interactions for AADACL4 Gene

Drugs & Compounds for AADACL4 Gene

No Compound Related Data Available

Transcripts for AADACL4 Gene

mRNA/cDNA for AADACL4 Gene

(3) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AADACL4 Gene

Arylacetamide deacetylase-like 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for AADACL4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for AADACL4 Gene

No ASD Table

Relevant External Links for AADACL4 Gene

GeneLoc Exon Structure for
AADACL4
ECgene alternative splicing isoforms for
AADACL4

Expression for AADACL4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AADACL4 Gene

mRNA differential expression in normal tissues according to GTEx for AADACL4 Gene

This gene is overexpressed in Vagina (x8.2), Adipose - Visceral (Omentum) (x6.3), Kidney - Cortex (x4.9), and Prostate (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of AADACL4 Gene:

AADACL4

SOURCE GeneReport for Unigene cluster for AADACL4 Gene:

Hs.209954
genes like me logo Genes that share expression patterns with AADACL4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for AADACL4 Gene

Orthologs for AADACL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for AADACL4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AADACL4 33 34
  • 99.26 (n)
cow
(Bos Taurus)
Mammalia AADACL4 33
  • 79.03 (n)
dog
(Canis familiaris)
Mammalia AADACL4 33 34
  • 77.58 (n)
mouse
(Mus musculus)
Mammalia Gm13177 33 34
  • 71.99 (n)
Gm436 34
  • 65 (a)
OneToMany
Gm13178 34
  • 64 (a)
OneToMany
9430007A20Rik 34
  • 61 (a)
OneToMany
Gm438 34
  • 61 (a)
OneToMany
Gm13124 34
  • 59 (a)
OneToMany
Aadacl4 16
rat
(Rattus norvegicus)
Mammalia Aadacl4 33
  • 71.74 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 53 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 41 (a)
OneToMany
chicken
(Gallus gallus)
Aves AADACL4 33
  • 56.73 (n)
-- 34
  • 46 (a)
ManyToMany
-- 34
  • 44 (a)
ManyToMany
-- 34
  • 42 (a)
ManyToMany
-- 34
  • 40 (a)
ManyToMany
-- 34
  • 40 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 44 (a)
ManyToMany
-- 34
  • 42 (a)
ManyToMany
-- 34
  • 42 (a)
ManyToMany
-- 34
  • 42 (a)
ManyToMany
-- 34
  • 42 (a)
ManyToMany
-- 34
  • 42 (a)
ManyToMany
-- 34
  • 41 (a)
ManyToMany
-- 34
  • 41 (a)
ManyToMany
-- 34
  • 41 (a)
ManyToMany
-- 34
  • 40 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492051 33
  • 53.78 (n)
zebrafish
(Danio rerio)
Actinopterygii aadacl4 33 34
  • 49.92 (n)
worm
(Caenorhabditis elegans)
Secernentea F16F9.4 34
  • 23 (a)
ManyToMany
Y43F8A.3 34
  • 22 (a)
ManyToMany
T09B9.1 34
  • 21 (a)
ManyToMany
trcs-1 34
  • 20 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 24 (a)
OneToMany
Species where no ortholog for AADACL4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AADACL4 Gene

ENSEMBL:
Gene Tree for AADACL4 (if available)
TreeFam:
Gene Tree for AADACL4 (if available)

Paralogs for AADACL4 Gene

Paralogs for AADACL4 Gene

(3) SIMAP similar genes for AADACL4 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for AADACL4 Gene

genes like me logo Genes that share paralogs with AADACL4: view

Variants for AADACL4 Gene

Sequence variations from dbSNP and Humsavar for AADACL4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000070273 -- 12,662,374(+) TGGCA(C/T)GATGG intron-variant
rs1000108427 -- 12,643,497(+) TGTTG(C/T)CCAGG upstream-variant-2KB
rs1000129460 -- 12,665,348(+) CTCCT(A/G)AGTAG intron-variant
rs1000194867 -- 12,665,585(+) ACTTT(A/G)GTGTT intron-variant
rs1000310995 -- 12,665,803(+) ACATG(C/T)TCATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AADACL4 Gene

Variant ID Type Subtype PubMed ID
esv3585236 CNV loss 21293372
nsv1011540 CNV loss 25217958
nsv515525 CNV loss 19592680

Variation tolerance for AADACL4 Gene

Residual Variation Intolerance Score: 56.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.41; 27.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AADACL4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AADACL4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AADACL4 Gene

Disorders for AADACL4 Gene

Relevant External Links for AADACL4

Genetic Association Database (GAD)
AADACL4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AADACL4

No disorders were found for AADACL4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AADACL4 Gene

Publications for AADACL4 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  2. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie AG … Butte NF (PloS one 2012) 3 60

Products for AADACL4 Gene

Sources for AADACL4 Gene

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