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Aliases for AADACL4 Gene

Aliases for AADACL4 Gene

  • Arylacetamide Deacetylase-Like 4 2 3
  • EC 3.1.1.- 4

External Ids for AADACL4 Gene

Summaries for AADACL4 Gene

GeneCards Summary for AADACL4 Gene

AADACL4 (Arylacetamide Deacetylase-Like 4) is a Protein Coding gene. An important paralog of this gene is AADAC.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AADACL4 Gene

Genomics for AADACL4 Gene

Genomic Location for AADACL4 Gene

Start:
12,644,547 bp from pter
End:
12,667,086 bp from pter
Size:
22,540 bases
Orientation:
Plus strand

Genomic View for AADACL4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AADACL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AADACL4 Gene

Regulatory Elements for AADACL4 Gene

Proteins for AADACL4 Gene

  • Protein details for AADACL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VUY2-ADCL4_HUMAN
    Recommended name:
    Arylacetamide deacetylase-like 4
    Protein Accession:
    Q5VUY2
    Secondary Accessions:

    Protein attributes for AADACL4 Gene

    Size:
    407 amino acids
    Molecular mass:
    46082 Da
    Quaternary structure:
    No Data Available

neXtProt entry for AADACL4 Gene

Proteomics data for AADACL4 Gene at MOPED

Post-translational modifications for AADACL4 Gene

  • Glycosylation at Asn168 and Asn269

Other Protein References for AADACL4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AADACL4 Gene

Domains for AADACL4 Gene

Protein Domains for AADACL4 Gene

UniProtKB/Swiss-Prot:

ADCL4_HUMAN
Family:
  • Belongs to the GDXG lipolytic enzyme family.:
    • Q5VUY2
genes like me logo Genes that share domains with AADACL4: view

No data available for Gene Families for AADACL4 Gene

Function for AADACL4 Gene

Enzyme Numbers (IUBMB) for AADACL4 Gene

Gene Ontology (GO) - Molecular Function for AADACL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity --
GO:0052689 carboxylic ester hydrolase activity IEA --
genes like me logo Genes that share ontologies with AADACL4: view

Phenotypes for AADACL4 Gene

genes like me logo Genes that share phenotypes with AADACL4: view

No data available for Molecular function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for AADACL4 Gene

Localization for AADACL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AADACL4 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AADACL4 Gene COMPARTMENTS Subcellular localization image for AADACL4 gene
Compartment Confidence
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for AADACL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with AADACL4: view

Pathways for AADACL4 Gene

SuperPathways for AADACL4 Gene

No Data Available

Interacting Proteins for AADACL4 Gene

Gene Ontology (GO) - Biological Process for AADACL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with AADACL4: view

No data available for Pathways by source for AADACL4 Gene

Transcripts for AADACL4 Gene

mRNA/cDNA for AADACL4 Gene

(5) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AADACL4 Gene

Arylacetamide deacetylase-like 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AADACL4 Gene

No ASD Table

Relevant External Links for AADACL4 Gene

GeneLoc Exon Structure for
AADACL4
ECgene alternative splicing isoforms for
AADACL4

Expression for AADACL4 Gene

mRNA expression in normal human tissues for AADACL4 Gene

mRNA differential expression in normal tissues according to GTEx for AADACL4 Gene

This gene is overexpressed in Vagina (8.2), Adipose - Visceral (Omentum) (6.3), Kidney - Cortex (4.9), and Prostate (4.3).

SOURCE GeneReport for Unigene cluster for AADACL4 Gene Hs.209954

genes like me logo Genes that share expressions with AADACL4: view

Orthologs for AADACL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for AADACL4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AADACL4 36
  • 99.26 (n)
  • 99.02 (a)
AADACL4 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AADACL4 36
  • 79.03 (n)
  • 69.78 (a)
dog
(Canis familiaris)
Mammalia AADACL4 36
  • 77.58 (n)
  • 68.54 (a)
AADACL4 37
  • 63 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 9430007A20Rik 37
  • 61 (a)
OneToMany
Gm13124 37
  • 59 (a)
OneToMany
Gm13177 36
  • 71.99 (n)
  • 65.11 (a)
Gm13177 16
Gm13177 37
  • 65 (a)
OneToMany
Gm13178 37
  • 64 (a)
OneToMany
Gm436 37
  • 65 (a)
OneToMany
Gm438 37
  • 61 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 53 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 41 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Aadacl4 36
  • 71.74 (n)
  • 64.13 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 42 (a)
ManyToMany
-- 37
  • 44 (a)
ManyToMany
-- 37
  • 40 (a)
ManyToMany
-- 37
  • 46 (a)
ManyToMany
-- 37
  • 40 (a)
ManyToMany
AADACL4 36
  • 56.73 (n)
  • 48.52 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 42 (a)
ManyToMany
-- 37
  • 41 (a)
ManyToMany
-- 37
  • 42 (a)
ManyToMany
-- 37
  • 42 (a)
ManyToMany
-- 37
  • 41 (a)
ManyToMany
-- 37
  • 40 (a)
ManyToMany
-- 37
  • 44 (a)
ManyToMany
-- 37
  • 42 (a)
ManyToMany
-- 37
  • 41 (a)
ManyToMany
-- 37
  • 42 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492051 36
  • 53.78 (n)
  • 49.22 (a)
zebrafish
(Danio rerio)
Actinopterygii aadacl4 36
  • 49.92 (n)
  • 38.92 (a)
aadacl4 37
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F16F9.4 37
  • 23 (a)
ManyToMany
T09B9.1 37
  • 21 (a)
ManyToMany
trcs-1 37
  • 20 (a)
ManyToMany
Y43F8A.3 37
  • 22 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 24 (a)
OneToMany
Species with no ortholog for AADACL4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AADACL4 Gene

ENSEMBL:
Gene Tree for AADACL4 (if available)
TreeFam:
Gene Tree for AADACL4 (if available)

Paralogs for AADACL4 Gene

Paralogs for AADACL4 Gene

Selected SIMAP similar genes for AADACL4 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for AADACL4 Gene

genes like me logo Genes that share paralogs with AADACL4: view

Variants for AADACL4 Gene

Sequence variations from dbSNP and Humsavar for AADACL4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1419298 -- 12,665,932(-) ACTAC(A/G)CCAGT intron-variant
rs1539699 -- 12,662,400(-) CTTGC(C/G)CATCA intron-variant
rs1539700 -- 12,652,416(-) GGGAC(A/T)GTTGA intron-variant
rs1539701 -- 12,652,354(-) AAGGG(C/T)ATCTT intron-variant
rs1539702 -- 12,651,751(-) ctggg(A/G)tgcaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AADACL4 Gene

Variant ID Type Subtype PubMed ID
essv17144 CNV CNV 17122850
dgv20e1 CNV Complex 17122850
dgv145n71 CNV Gain 21882294
dgv21e1 CNV Complex 17122850
nsv428410 CNV Gain+Loss 18775914
nsv871219 CNV Gain 21882294
nsv515525 CNV Loss 19592680

Relevant External Links for AADACL4 Gene

HapMap Linkage Disequilibrium report
AADACL4

Disorders for AADACL4 Gene

Relevant External Links for AADACL4

Genetic Association Database (GAD)
AADACL4
genes like me logo Genes that share disorders with AADACL4: view

No data available for UniProtKB/Swiss-Prot for AADACL4 Gene

Publications for AADACL4 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  2. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3

Products for AADACL4 Gene

  • antibodies-online peptides for AADACL4
  • antibodies-online antibodies for AADACL4
  • antibodies-online kits for AADACL4

Sources for AADACL4 Gene

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