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Aliases for AADACL3 Gene

Aliases for AADACL3 Gene

  • Arylacetamide Deacetylase-Like 3 2 3
  • EC 3.1.1.- 4

External Ids for AADACL3 Gene

Previous GeneCards Identifiers for AADACL3 Gene

  • GC01P012698
  • GC01P011931

Summaries for AADACL3 Gene

GeneCards Summary for AADACL3 Gene

AADACL3 (Arylacetamide Deacetylase-Like 3) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is AADAC.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AADACL3 Gene

Genomics for AADACL3 Gene

Regulatory Elements for AADACL3 Gene

Genomic Location for AADACL3 Gene

Start:
12,716,115 bp from pter
End:
12,728,759 bp from pter
Size:
12,645 bases
Orientation:
Plus strand

Genomic View for AADACL3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AADACL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AADACL3 Gene

Proteins for AADACL3 Gene

  • Protein details for AADACL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VUY0-ADCL3_HUMAN
    Recommended name:
    Arylacetamide deacetylase-like 3
    Protein Accession:
    Q5VUY0
    Secondary Accessions:
    • B3KXR9
    • Q5VUY1

    Protein attributes for AADACL3 Gene

    Size:
    350 amino acids
    Molecular mass:
    39743 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for AADACL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AADACL3 Gene

Proteomics data for AADACL3 Gene at MOPED

Post-translational modifications for AADACL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AADACL3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AADACL3 Gene

Domains for AADACL3 Gene

Protein Domains for AADACL3 Gene

Suggested Antigen Peptide Sequences for AADACL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5VUY0

UniProtKB/Swiss-Prot:

ADCL3_HUMAN :
  • Q5VUY0
Family:
  • Belongs to the GDXG lipolytic enzyme family.
genes like me logo Genes that share domains with AADACL3: view

No data available for Gene Families for AADACL3 Gene

Function for AADACL3 Gene

Enzyme Numbers (IUBMB) for AADACL3 Gene

Gene Ontology (GO) - Molecular Function for AADACL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with AADACL3: view

Animal Model Products

CRISPR Products

miRNA for AADACL3 Gene

miRTarBase miRNAs that target AADACL3

No data available for Molecular function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for AADACL3 Gene

Localization for AADACL3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AADACL3 Gene COMPARTMENTS Subcellular localization image for AADACL3 gene
Compartment Confidence
endoplasmic reticulum 1
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for AADACL3 Gene

Pathways for AADACL3 Gene

SuperPathways for AADACL3 Gene

No Data Available

Interacting Proteins for AADACL3 Gene

Gene Ontology (GO) - Biological Process for AADACL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with AADACL3: view

No data available for Pathways by source for AADACL3 Gene

Transcripts for AADACL3 Gene

mRNA/cDNA for AADACL3 Gene

(6) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AADACL3 Gene

Arylacetamide deacetylase-like 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AADACL3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for AADACL3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AADACL3 Gene

No ASD Table

Relevant External Links for AADACL3 Gene

GeneLoc Exon Structure for
AADACL3
ECgene alternative splicing isoforms for
AADACL3

Expression for AADACL3 Gene

mRNA expression in normal human tissues for AADACL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AADACL3 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (33.9) and Skin - Sun Exposed (Lower leg) (14.2).

SOURCE GeneReport for Unigene cluster for AADACL3 Gene Hs.464705

genes like me logo Genes that share expressions with AADACL3: view

In Situ Assay Products

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for AADACL3 Gene

Orthologs for AADACL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for AADACL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AADACL3 35
  • 98.57 (n)
  • 97.71 (a)
AADACL3 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AADACL3 36
  • 60 (a)
OneToOne
LOC530613 35
  • 76.86 (n)
  • 70.29 (a)
dog
(Canis familiaris)
Mammalia AADACL3 35
  • 76.67 (n)
  • 70.57 (a)
AADACL3 36
  • 60 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Aadacl3 35
  • 70.79 (n)
  • 64.08 (a)
Aadacl3 16
Aadacl3 36
  • 55 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 44 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 37 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Aadacl3 35
  • 70.02 (n)
  • 61.21 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 37 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 37 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 40 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii aadacl4 36
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F16F9.4 36
  • 19 (a)
ManyToMany
T09B9.1 36
  • 20 (a)
ManyToMany
trcs-1 36
  • 20 (a)
ManyToMany
Y43F8A.3 36
  • 20 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
OneToMany
Species with no ortholog for AADACL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for AADACL3 Gene

ENSEMBL:
Gene Tree for AADACL3 (if available)
TreeFam:
Gene Tree for AADACL3 (if available)

Paralogs for AADACL3 Gene

Paralogs for AADACL3 Gene

Selected SIMAP similar genes for AADACL3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with AADACL3: view

Variants for AADACL3 Gene

Sequence variations from dbSNP and Humsavar for AADACL3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs3000856 -- 12,718,596(-) tctct(A/T)gaacc intron-variant
rs3000857 -- 12,717,928(-) aattg(A/G)aagtt intron-variant
rs3000858 -- 12,717,317(-) TGAGC(A/G)TCAAG intron-variant
rs3000859 - 12,716,341(-) ACCCA(A/T)GTCAA synonymous-codon, reference, nc-transcript-variant
rs3000860 -- 12,716,215(-) AACAC(G/T)CAGGC stop-gained, reference, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for AADACL3 Gene

Variant ID Type Subtype PubMed ID
essv17144 CNV CNV 17122850
dgv20e1 CNV Complex 17122850
dgv21e1 CNV Complex 17122850
nsv428410 CNV Gain+Loss 18775914
nsv466394 CNV Gain 19166990
nsv871119 CNV Gain 21882294
essv3598 CNV CNV 17122850
dgv22e1 CNV Complex 17122850

Relevant External Links for AADACL3 Gene

HapMap Linkage Disequilibrium report
AADACL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AADACL3 Gene

Disorders for AADACL3 Gene

No disorders were found for AADACL3 Gene.

No data available for UniProtKB/Swiss-Prot for AADACL3 Gene

Publications for AADACL3 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4

Products for AADACL3 Gene

Sources for AADACL3 Gene

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