AADACL3 Gene
protein-coding GIFtS: 37
GCID: GC01P012776
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arylacetamide deacetylase-like 3
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Aliases
for AADACL3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Arylacetamide Deacetylase-Like 31 2 | | OTTHUMG000000018871 | | EC 3.1.1.-3 |
Export aliases for AADACL3 gene to outside databasesPrevious GC identifers: GC01P012698 GC01P011931 |
Summaries
for AADACL3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for AADACL3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_021937.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the AADACL3 gene promoter:
HOXA9B HOXA9 AML1a STAT1beta STAT1alpha Meis-1b STAT3 LyF-1 ATF6 Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for AADACL3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AADACL3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.21 Ensembl cytogenetic band: 1p36.21 HGNC cytogenetic band: 1p36.21AADACL3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P012776: view genomic region
(about GC identifiers)
Start:
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12,776,118 bp from pter |
End:
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12,788,726 bp from pter |
Size:
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12,609 bases |
Orientation:
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plus strand |
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Proteins
for AADACL3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ADCL3_HUMAN, Q5VUY0 (See
protein sequence)Recommended Name: Arylacetamide deacetylase-like 3 Size: 350 amino acids; 39743 Da
Secondary accessions: B3KXR9 Q5VUY1Alternative splicing: 2 isoforms: Q5VUY0-1 Q5VUY0-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for AADACL3: NX_Q5VUY0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5VUY0
AADACL3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001096639.1 NP_001096640.1
ENSEMBL proteins: ENSP00000333352 ENSP00000352268
Human Recombinant Protein Products for AADACL3:
AADACL3 Antibody Products:
Assay Products for AADACL3: |
Protein
Domains /
Families
for AADACL3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
AADACL3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q5VUY0ProtoNet protein and cluster: Q5VUY0 1 Blocks protein family: IPB013094 Alpha/beta hydrolase fold-3
UniProtKB/Swiss-Prot: ADCL3_HUMAN, Q5VUY0Similarity: Belongs to the 'GDXG' lipolytic enzyme family |
Function
for AADACL3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Enzyme Number (IUBMB): EC 3.1.1.-1
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016787 | hydrolase activity |
IEA | -- |
AADACL3 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AADACL3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AADACL3 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): AADACL3 (NM_001103169) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AADACL3 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat AADACL3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AADACL3 |
|
Pathways & Interactions
for AADACL3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AADACL3
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for AADACL3 (ENSP000003522684) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for AADACL3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for AADACL3
Search CenterWatch for drugs/clinical trials and news about AADACL3 / ADCL3
|
Transcripts
for AADACL3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for AADACL3 gene (2 alternative transcripts): NM_001103169.1 NM_001103170.1 Unigene Cluster for AADACL3: Arylacetamide deacetylase-like 3 Hs.464705 [show with all ESTs]Unigene Representative Sequence: NM_0011031702 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000332530(uc009vnn.1 uc001aug.1) ENST00000359318
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AADACL3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AADACL3 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): AADACL3 (NM_001103169) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AADACL3 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat AADACL3 |
Additional cDNA sequence: AK127828.1 2 DOTS entries: DT.95147510 DT.91653713 6 AceView cDNA sequences: BG698756 BG697255 BG674993 AK127828 BG739916 BG696600
GeneLoc Exon Structure
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Expression
for AADACL3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| AADACL3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGAATGTCTA
About this image
See AADACL3 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.464705
SABiosciences Custom PCR Arrays for AADACL3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AADACL3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat AADACL3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AADACL3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AADACL3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AADACL3 |
Orthologs
for AADACL3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for AADACL3 gene from 5/17 species (see all 17) About this table
ENSEMBL Gene Tree for AADACL3 (if available)
TreeFam Gene Tree for AADACL3 (if available) |
Paralogs
for AADACL3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for AADACL3 gene
- AADAC2 AADACL42 LIPE2 NCEH12 AADACL22
4 SIMAP similar genes for AADACL3 using alignment to 1 protein entry: ADCL3_HUMAN:AADACL4 AADAC NCEH1 AADACL2
AADACL3 for paralogs About GeneDecksing
|
Genomic Variants
for AADACL3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for AADACL3 (12776118 - 12788726 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for AADACL3
3 CNVs: 2298 4403 3283 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AADACL3 |
|
Disorders
/ Diseases
for AADACL3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
AADACL3 for disorders About GeneDecksing
4  diseases for AADACL3: About MalaCardshermaphroditism infertility tuberculosis mycobacterium tuberculosis
Export disorders for AADACL3 gene to outside databases
|
Publications
for AADACL3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for AADACL3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with AADACL3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
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External Searches for AADACL3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing AADACL3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing AADACL3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing AADACL3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for AADACL3 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for AADACL3 gene:
Search GeneIP for patents involving AADACL3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for AADACL3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for AADACL3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AADACL3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AADACL3 | | | OriGene Protein Over-expression Lysate for AADACL3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for AADACL3 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AADACL3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AADACL3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AADACL3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AADACL3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AADACL3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AADACL3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AADACL3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AADACL3 |
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 | | | AADACL3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AADACL3 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for AADACL3 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat AADACL3 |
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