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AADACL3 Gene

protein-coding   GIFtS: 38

GC01P012698
arylacetamide deacetylase-like 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for AADACL3

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
EC 3.1.1.- 3
OTTHUMG00000001887 1
OTTHUMP00000001868 2
OTTHUMP00000001869 2
Descriptions
arylacetamide deacetylase-like 3 2
External Ids
HGNC: 320371
Entrez Gene: 1267672
UniProtKB: Q5VUY03
Ensembl: ENSG000001889847
Search outside databases for aliases for AADACL3 gene

Summaries
for AADACL3

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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   --

Genomic Location
for AADACL3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the AADACL3 gene  

Entrez Gene cytogenetic band: 1p36.21   Ensembl cytogenetic band:  1p36.21   HGNC cytogenetic band: 1p36.21

AADACL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P012698:     (about GC identifiers)

Start:
 12,698,705 bp from pter
End:
 12,711,313 bp from pter
Size:
 12,609 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000001.9  NT_021937.18  

Proteins
for AADACL3

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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 UniProtKB/Swiss-Prot: ADCL3_HUMAN, Q5VUY0 (See protein sequence)
Recommended Name: Arylacetamide deacetylase-like 3  
Size: 407 amino acids; 46101 Da
Subcellular location: Membrane; Single-pass type II membrane protein (Potential)
Sequence caution: Sequence=CAH74175.1; Type=Erroneous gene model prediction; Sequence=CAH74176.2;
Type=Erroneous gene model prediction;
Secondary accessions: Q5VUY1

REFSEQ proteins (2 alternative transcripts): 
NP_001096639.1  NP_001096640.1  


ENSEMBL proteins: 
ENSP00000352268 ENSP00000333352 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
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                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0016020 membrane IEA--
GO:0016021 integral to membrane IEA--
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Antibodies for AADACL3: 
Browse Antibodies Central at Invitrogen
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Browse Antibodies at Sigma-Aldrich
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Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
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Search Novus for antibodies for AADACL3

Assays for AADACL3: 
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Browse Kits and Assays available from Millipore
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Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for AADACL3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
2 InterPro domains/families:
 IPR013094 AB_hydrolase_3
 IPR002168 Lipase_GDXG_AS


   GeneDecks  AADACL3 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q5VUY0

ProtoNet protein and cluster: Q5VUY0

1 Blocks protein family: IPB013094 Alpha/beta hydrolase fold-3

UniProtKB/Swiss-Prot: ADCL3_HUMAN, Q5VUY0
Similarity: Belongs to the 'GDXG' lipolytic enzyme family

Gene Function
for AADACL3

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (AADACL3)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
                Browse Origene for 29mer shRNA kit in GFP-retroviral vector

              Applied Biosystems Silencer® siRNAs for AADACL3

              Sigma-Aldrich siRNA for AADACL3  
                     Browse shRNA at Sigma-Aldrich  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001103169
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001103169
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001103169 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_001103170

1 Gene Ontology (GO) molecular function term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0016787 hydrolase activity IEA--
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Pathways & Interactions
for AADACL3

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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  --

1 Gene Ontology (GO) biological process term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0008152 metabolic process IEA--
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Drugs & Compounds
for AADACL3

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for AADACL3

Transcripts
for AADACL3

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (AADACL3)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
                Browse Origene for 29mer shRNA kit in GFP-retroviral vector

              Sigma-Aldrich siRNA for AADACL3  
                     Browse shRNA at Sigma-Aldrich  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001103169  NM_001103170  

REFSEQ mRNAs for AADACL3 gene (2 alternative transcripts): 

NM_001103169.1   NM_001103170.1   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001103169  NM_001103170  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001103169
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001103169
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001103169 

Additional cDNA sequence: AK127828.1 

2 DOTS entries:

DT.95147510  DT.91653713 

6 AceView cDNA sequences:

BG698756 BG697255 BG674993 AK127828 BG739916 BG696600 

highest scoring ESTs for AADACL3:

AK127828 BG674993 BG696600 BG697255 BG698756 BG739916 CR747481 DA851937 BG674779 XM_928294 

Unigene Cluster for AADACL3:

Arylacetamide deacetylase-like 3
Hs.464705  [show with all ESTs]
Unigene Representative Sequence: NM_001103170


GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:
ENST00000359318  ENST00000332530  

Expression
for AADACL3

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

AADACL3 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for AADACL3

1Data from GNF BioGPS
    About these images

About these images

CGAP SAGE TAG: GGAATGTCTA

SOURCE GeneReport for Unigene cluster: Hs.464705

Orthologs
for AADACL3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for AADACL3 gene from 5 species
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 AADACL31   -- arylacetamide deacetylase-like 3 76.67(n)
70.57(a)		 487435  XM_544560.2  XP_544560.2 
chimpanzee
(Pan troglodytes)		 AADACL31   -- arylacetamide deacetylase-like 3 98.57(n)
97.71(a)		 457970  XM_514407.2  XP_514407.2 
cow
(Bos taurus)		 AADACL31   -- arylacetamide deacetylase-like 3 76.86(n)
70.29(a)		 530613  XM_609088.2  XP_609088.2 
rat
(Rattus norvegicus)		 Aadacl31   -- arylacetamide deacetylase-like 3 70.02(n)
61.21(a)		 313686  XM_233636.4  XP_233636.4 
mouse
(Mus musculus)		 Aadacl31, 5 45
 arylacetamide deacetylase-like 31, 5 70.79(n)1
64.08(a)1		 2308831  XM_144109.11  XP_144109.11 
 AL6070735 
About this table        Species with no ortholog for AADACL3

ENSEMBL Gene Tree for AADACL3

Paralogs
for AADACL3

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for AADACL3 gene
AADACL42  AADACL12  

SNPs/Variants
for AADACL3

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/97 NCBI SNPs in AADACL3 are shown (see all 97 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 53)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 1 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
rs30108881,2
A,C,F,H,O12710219(+) TCCCAT/CTGGGT 2 -- ut31 ese312Minor allele frequency- C:0.24NA EU EA WA 1160
--
rs30009291,2
A,C,F,H12710993(-) gtacaT/Cgcttt 2 -- ut31 ese38Minor allele frequency- C:0.16EU EA WA 836
rs42409041,2
A,C,F,H12708910(+) ACTTTC/TGTCCA 2 -- ut31 ese317Minor allele frequency- N:0.00EU EA WA NA 1654
rs30108911,2
A,C,F,H12711377(+) tgttcA/Tatagc 2 -- ng314Minor allele frequency- T:0.24EU EA WA 420
rs30108861,2
A,C,F,H12708950(+) CATCAT/CGTACT 2 -- ut31 ese312Minor allele frequency- C:0.24NA EU EA WA 1160
rs30108871,2
A,C,F,H12709004(+) GCTCTG/AGGCTG 2 -- ut318Minor allele frequency- A:0.23NA EU EA WA 716
rs30108741,2
A,C,F,H12698721(+) GGTTTA/CCACTG 2 -- ut51 ese34Minor allele frequency- C:0.33EU EA WA 420
rs30008611,2
A,C,F,H12698438(-) ATAAAC/TACGAT 2 -- ng5112Minor allele frequency- T:0.36NA EU EA WA 1134
rs30009301,2
A,C,F,H12708657(-) CTACCC/TCCTCC 2 -- ut31 ese3 trp38Minor allele frequency- T:0.20NA EU EA WA 704
rs30108851,2
A,C,F,H12708860(+) GCCTCC/TCTAAG 2 -- ut31 ese38Minor allele frequency- T:0.23NA EU EA WA 734
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HapMap Linkage Disequilibrium images for AADACL3 (up to first 250kb)

Disorders & Mutations
for AADACL3

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

   --

Medical News
for AADACL3

(Possibly Related Articles in Doctor's Guide)
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   --

Publications
for AADACL3

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
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1 PubMed article for AADACL3 gene:

Search for AADACL3

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing AADACL3

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section
Entrez Gene: 126767 HGNC: 32037 AceView: LOC126767 Ensembl:ENSG00000188984 euGenes: HUgn126767
ECgene: AADACL3 H-InvDB: AADACL3

Other Databases showing AADACL3

(According to HUGE)
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   --

Specialized Databases showing AADACL3

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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   --

Licensable Technologies
for AADACL3

(Available from WIS Yeda, Salk, Tufts)
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  --

Services
for AADACL3

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for AADACL3:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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