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Aliases for AADACL2 Gene

Aliases for AADACL2 Gene

  • Arylacetamide Deacetylase-Like 2 2 3
  • EC 3.1.1.- 4

External Ids for AADACL2 Gene

Previous GeneCards Identifiers for AADACL2 Gene

  • GC03P152936
  • GC03P151451
  • GC03P148843

Summaries for AADACL2 Gene

GeneCards Summary for AADACL2 Gene

AADACL2 (Arylacetamide Deacetylase-Like 2) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity and carboxylic ester hydrolase activity. An important paralog of this gene is AADAC.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AADACL2 Gene

Genomics for AADACL2 Gene

Regulatory Elements for AADACL2 Gene

Genomic Location for AADACL2 Gene

Chromosome:
3
Start:
151,733,916 bp from pter
End:
151,761,339 bp from pter
Size:
27,424 bases
Orientation:
Plus strand

Genomic View for AADACL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AADACL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AADACL2 Gene

Proteins for AADACL2 Gene

  • Protein details for AADACL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P093-ADCL2_HUMAN
    Recommended name:
    Arylacetamide deacetylase-like 2
    Protein Accession:
    Q6P093
    Secondary Accessions:
    • Q5HYJ4

    Protein attributes for AADACL2 Gene

    Size:
    401 amino acids
    Molecular mass:
    46099 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH65724.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI46075.1; Type=Miscellaneous discrepancy; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for AADACL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AADACL2 Gene

Proteomics data for AADACL2 Gene at MOPED

Post-translational modifications for AADACL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AADACL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AADACL2 Gene

Domains & Families for AADACL2 Gene

Gene Families for AADACL2 Gene

Suggested Antigen Peptide Sequences for AADACL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P093

UniProtKB/Swiss-Prot:

ADCL2_HUMAN :
  • Belongs to the GDXG lipolytic enzyme family.
Family:
  • Belongs to the GDXG lipolytic enzyme family.
genes like me logo Genes that share domains with AADACL2: view

Function for AADACL2 Gene

Enzyme Numbers (IUBMB) for AADACL2 Gene

Gene Ontology (GO) - Molecular Function for AADACL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity --
GO:0052689 carboxylic ester hydrolase activity IEA --
genes like me logo Genes that share ontologies with AADACL2: view
genes like me logo Genes that share phenotypes with AADACL2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AADACL2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AADACL2 Gene

Localization for AADACL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AADACL2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AADACL2 Gene COMPARTMENTS Subcellular localization image for AADACL2 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for AADACL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with AADACL2: view

Pathways & Interactions for AADACL2 Gene

SuperPathways for AADACL2 Gene

No Data Available

Interacting Proteins for AADACL2 Gene

Gene Ontology (GO) - Biological Process for AADACL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with AADACL2: view

No data available for Pathways by source and SIGNOR curated interactions for AADACL2 Gene

Drugs & Compounds for AADACL2 Gene

(2) Drugs for AADACL2 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Gibberellin A3 Experimental Pharma Target 0
GIBBERELLIN A4 Experimental Pharma Target 0
genes like me logo Genes that share compounds with AADACL2: view

Transcripts for AADACL2 Gene

mRNA/cDNA for AADACL2 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AADACL2 Gene

Arylacetamide deacetylase-like 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AADACL2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AADACL2 Gene

No ASD Table

Relevant External Links for AADACL2 Gene

GeneLoc Exon Structure for
AADACL2
ECgene alternative splicing isoforms for
AADACL2

Expression for AADACL2 Gene

mRNA expression in normal human tissues for AADACL2 Gene

mRNA differential expression in normal tissues according to GTEx for AADACL2 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x25.4) and Skin - Not Sun Exposed (Suprapubic) (x22.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for AADACL2 Gene



SOURCE GeneReport for Unigene cluster for AADACL2 Gene Hs.144710

genes like me logo Genes that share expression patterns with AADACL2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for AADACL2 Gene

Orthologs for AADACL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for AADACL2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AADACL2 35
  • 74.23 (n)
  • 63.59 (a)
AADACL2 36
  • 63 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AADACL2 35
  • 81.96 (n)
  • 74.06 (a)
AADACL2 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Aadacl2 35
  • 81.05 (n)
  • 79.05 (a)
Aadacl2 16
Aadacl2 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AADACL2 35
  • 99.58 (n)
  • 99.5 (a)
AADACL2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Aadacl2 35
  • 80.47 (n)
  • 78.3 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 50 (a)
OneToMany
-- 36
  • 49 (a)
OneToMany
-- 36
  • 33 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 60 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 47 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 49 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii aadac 36
  • 43 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F16F9.4 36
  • 20 (a)
ManyToMany
T09B9.1 36
  • 20 (a)
ManyToMany
trcs-1 36
  • 21 (a)
ManyToMany
Y43F8A.3 36
  • 25 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
OneToMany
Species with no ortholog for AADACL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for AADACL2 Gene

ENSEMBL:
Gene Tree for AADACL2 (if available)
TreeFam:
Gene Tree for AADACL2 (if available)

Paralogs for AADACL2 Gene

Paralogs for AADACL2 Gene

(3) SIMAP similar genes for AADACL2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with AADACL2: view

Variants for AADACL2 Gene

Sequence variations from dbSNP and Humsavar for AADACL2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs986227 -- 151,743,828(-) CTATT(G/T)TAATA intron-variant
rs1120606 -- 151,746,343(-) actag(A/C/T)gttat intron-variant
rs1120607 -- 151,746,185(-) aaata(C/G)ctcag intron-variant
rs1401961 -- 151,744,877(-) GTAGA(A/C)CAGTA intron-variant
rs1401962 -- 151,742,744(-) CTAAT(C/T)AGGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AADACL2 Gene

Variant ID Type Subtype PubMed ID
nsv511102 CNV Complex 20534489
nsv522472 CNV Loss 19592680
nsv877651 CNV Loss 21882294
dgv1521e1 CNV Complex 17122850

Variation tolerance for AADACL2 Gene

Residual Variation Intolerance Score: 78.15% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.61; 30.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AADACL2 Gene

HapMap Linkage Disequilibrium report
AADACL2
Human Gene Mutation Database (HGMD)
AADACL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AADACL2 Gene

Disorders for AADACL2 Gene

Relevant External Links for AADACL2

Genetic Association Database (GAD)
AADACL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AADACL2
genes like me logo Genes that share disorders with AADACL2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AADACL2 Gene

Publications for AADACL2 Gene

  1. Isolation and characterization of arylacetamide deacetylase in cynomolgus macaques. (PMID: 25715734) Uno Y. … Imai T. (J. Vet. Med. Sci. 2015) 2 67
  2. Large-scale identification of human genes implicated in epidermal barrier function. (PMID: 17562024) Toulza E. … Guerrin M. (Genome Biol. 2007) 67
  3. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 67
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 67
  5. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 67

Products for AADACL2 Gene

Sources for AADACL2 Gene

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