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AADACL2 Gene

protein-coding GIFtS: 46

GC03P152936

arylacetamide deacetylase-like 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
EC 3.1.1.- ^³
MGC72001 ^¹, ²

Descriptions
arylacetamide deacetylase-like 2 ^²

External Ids
HGNC: 24427¹
Entrez Gene: 344752²
UniProtKB: Q6P093³
Ensembl: ENSG00000197953⁷

Search outside databases for aliases for AADACL2 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the AADACL2 gene

Entrez Gene cytogenetic band: 3q25.1 Ensembl cytogenetic band: 3q25.1 HGNC cytogenetic band: 3q25.1

AADACL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P152936: (about GC identifiers)

Start:	152,934,405 bp from pter
End:	152,958,242 bp from pter
Size:	23,838 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000003.10 NT_005612.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ADCL2_HUMAN, Q6P093 (See protein sequence)

Recommended Name: Arylacetamide deacetylase-like 2 precursor

Size: 401 amino acids; 46100 Da

Subcellular location: Secreted

Secondary accessions: Q5HYJ4

Alternative splicing: 2 isoforms: Q6P093-1 Q6P093-2

REFSEQ proteins: NP_997248.2

ENSEMBL proteins:

ENSP00000348911

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (AADACL2)
	Human Recombinant Proteins from Abnova (AADACL2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--

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Antibodies for AADACL2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (AADACL2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (AADACL2)
	Novus Biologicals Antibodies for AADACL2

Assays for AADACL2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q6P093

ProtoNet protein and cluster: Q6P093

2 Blocks protein families:

IPB002168 Lipolytic enzyme

IPB013094 Alpha/beta hydrolase fold-3

UniProtKB/Swiss-Prot: ADCL2_HUMAN, Q6P093

Similarity: Belongs to the 'GDXG' lipolytic enzyme family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AADACL2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_207365

Applied Biosystems Silencer® siRNAs for AADACL2

Sigma-Aldrich siRNA for AADACL2

Sigma-Aldrich shRNA for AADACL2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for AADACL2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_207365
Myc/DDK tagged cDNA clone in CMV expression vector: NM_207365
untagged cDNA clones in CMV expression vector (see all 2): NM_207365

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_207365

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016787	hydrolase activity	IEA	--

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(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008152	metabolic process	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for AADACL2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AADACL2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_207365

Sigma-Aldrich siRNA for AADACL2

Sigma-Aldrich shRNA for AADACL2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_207365

REFSEQ mRNAs for AADACL2 gene:

NM_207365.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_207365

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_207365
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_207365
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_207365

Additional cDNA sequence:

BC065724.1 BX647585.1

2 DOTS entries:

DT.210964 DT.99979342

17 AceView cDNA sequences:

AI130823 AA045911 BX118873 NM_207365 AA045966 AI122615 AA027036 BC065724

BX647585 AL599128 AA045778 AA122302 CB851186 AA122299 AA027115 AA045832

AA122269

highest scoring ESTs for AADACL2:

AA122302 AA027115 AA045778 AA045832 AA045911 AA045966 AA122269 AI130823 BC065724 BX118873

Unigene Cluster for AADACL2:

Arylacetamide deacetylase-like 2

Hs.144710 [show with all ESTs]

Unigene Representative Sequence: BX647585

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000356517

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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AADACL2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for AADACL2

¹ / ² / ³

3 probe-sets matching AADACL2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
49872_at²^{, 3}	U95-B	1	1.00	1.00	1.00	1.00	AA122302	1.00	1.00	1.00	1
240420_at²^{, 3}	U133-B	1	0.91	1.00	--	--	AA027115	0.80	1.00	0.91	1
240420_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ACTTCACCAT

SOURCE GeneReport for Unigene cluster: Hs.144710

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for AADACL2 gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	AADACL2¹	--	arylacetamide deacetylase-like 2	82.58(n) 75.71(a)	609872 XM_847596.1 XP_852689.1
chimpanzee (Pan troglodytes)	AADACL2¹	--	arylacetamide deacetylase-like 2	99.56(n) 99.74(a)	470969 XM_526352.2 XP_526352.2
rat (Rattus norvegicus)	Aadacl2¹	--	arylacetamide deacetylase-like 2	80.47(n) 78.89(a)	295076 XM_227188.3 XP_227188.2
mouse (Mus musculus)	Aadacl2^{1, 5}	3⁵	arylacetamide deacetylase-like 2^{1, 5}	81.18(n)¹ 79.68(a)¹	639634¹ XM_986184.1¹ XP_991278.1¹ BC147724⁵ BC147728⁵

About this table Species with no ortholog for AADACL2

ENSEMBL Gene Tree for AADACL2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for AADACL2 gene

AADAC²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/148 NCBI SNPs in AADACL2 are shown (see all 148 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 59)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1972977^1,2	C,F,H	152946111(-)	`TCCCGA/CAATGC`	1	A/S	mis¹ ese³		12		EU EA WA NA	1050
--	rs9843521^1,2	C,F,H	152933505(+)	`TATGTT/CGAAAC`	1	--	ng5¹ tfbs³		7		EU EA WA NA	548
--	rs2009669^1,2	A,C	152932486(-)	`tatagA/Gtatat`	1	--	ng5¹		0	--	--	--	--
--	rs1584387^1,2	C	152932873(-)	`acataC/Tgcata`	1	--	ng5¹		0	--	--	--	--
	rs1052562^1,2	H	152957893(+)	`ATCTCT/ATAAGA`	1	I/L	mis¹ ese³		5		MN EU EA WA	588
--	rs1584386^1,2	C	152932875(-)	`acacaC/Tatgca`	1	--	ng5¹		0	--	--	--	--
	rs1401961^1,2	A,C,F,H,O	152945355(-)	`GTAGAC/ACAGTA`	1	--	int¹		17		EA EU WA NA	1578
	rs1401965^1,2	A,C,F,H,O	152942197(-)	`ACCTCG/ATAAAA`	1	--	int¹		18		NS NA EU EA WA	1268
	rs1401966^1,2	A,C,F,H,O	152942099(-)	`TTAACG/ACATGA`	1	--	int¹		13		NS NA EU EA WA	786
	rs1401962^1,2	A,C,F,H,O	152943222(-)	`CTAATC/TAGGGT`	1	--	int¹		11		NA EA EU WA	922

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HapMap Linkage Disequilibrium images for AADACL2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

5 PubMed articles for AADACL2 gene:

Large-scale identification of human genes implicated in epidermal barrier function. (PubMed id 17562024)³ Toulza E.... Guerrin M. (2007)
The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005)⁴ Bechtel S....Schupp I. (2007)
The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)⁴ Muzny D.M....Gibbs R.A. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 344752	HGNC: 24427	AceView: MGC72001	Ensembl:ENSG00000197953	euGenes: HUgn344752
ECgene: AADACL2	H-InvDB: AADACL2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for AADACL2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for AADACL2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for AADACL2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for AADACL2		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for AADACL2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (AADACL2)
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Search OriGene for AADACL2

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Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

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AADACL2 Gene

protein-coding GIFtS: 46

Aliases &
Descriptions
for AADACL2

Summaries
for AADACL2

Genomic Location
for AADACL2

Proteins
for AADACL2

Protein Domains/
Families
for AADACL2

Gene Function
for AADACL2

Pathways & Interactions
for AADACL2

Drugs & Compounds
for AADACL2

Transcripts
for AADACL2

Expression
for AADACL2

Orthologs
for AADACL2

Paralogs
for AADACL2

SNPs/Variants
for AADACL2

Disorders & Mutations
for AADACL2

Medical News
for AADACL2

Publications
for AADACL2

Search for AADACL2

Genome Databases showing AADACL2

Other Databases showing AADACL2

Specialized Databases showing AADACL2

Licensable Technologies
for AADACL2

Services
for AADACL2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

AADACL2 Gene

protein-coding GIFtS: 46

Aliases & Descriptionsfor AADACL2

Summariesfor AADACL2

Genomic Locationfor AADACL2

Proteinsfor AADACL2

Protein Domains/Familiesfor AADACL2

Gene Functionfor AADACL2

Pathways & Interactionsfor AADACL2

Drugs & Compoundsfor AADACL2

Transcriptsfor AADACL2

Expression for AADACL2

Orthologsfor AADACL2

Paralogsfor AADACL2

SNPs/Variantsfor AADACL2

Disorders & Mutationsfor AADACL2

Medical Newsfor AADACL2

Publicationsfor AADACL2

Search for AADACL2

Genome Databases showing AADACL2

Other Databases showing AADACL2

Specialized Databases showing AADACL2

Licensable Technologiesfor AADACL2

Servicesfor AADACL2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for AADACL2

Summaries
for AADACL2

Genomic Location
for AADACL2

Proteins
for AADACL2

Protein Domains/
Families
for AADACL2

Gene Function
for AADACL2

Pathways & Interactions
for AADACL2

Drugs & Compounds
for AADACL2

Transcripts
for AADACL2

Expression
for AADACL2

Orthologs
for AADACL2

Paralogs
for AADACL2

SNPs/Variants
for AADACL2

Disorders & Mutations
for AADACL2

Medical News
for AADACL2

Publications
for AADACL2

Licensable Technologies
for AADACL2

Services
for AADACL2