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Aliases & Descriptions for AADACL1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EC 3.1.1.- 3 | | KIAA1363 1, 3 | | NCEH 2, 3 |
| | | Descriptions |
|---|
| Neutral cholesterol ester hydrolase 2, 3 | | arylacetamide deacetylase-like 1 2 |
|
| | Search outside databases for aliases for AADACL1 gene |
Summaries for AADACL1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: ADCL1_HUMAN, Q6PIU2Function: Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsible for cholesterol ester hydrolysis in macrophages, thereby contributing to the development of atherosclerosis. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds. May contribute to cancer pathogenesis by promoting tumor cell migration |
Genomic Location for AADACL1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the AADACL1 gene 
Entrez Gene cytogenetic band: 3q26.31 Ensembl cytogenetic band: 3q26.31 HGNC cytogenetic band: 3q26.31AADACL1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M173832:
(about GC identifiers)
Start:
|
173,831,129 bp from pter |
End:
|
173,911,702 bp from pter |
Size:
|
80,574 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000003.10 NT_005612.15
| Proteins for AADACL1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: ADCL1_HUMAN, Q6PIU2 (See
protein sequence)Recommended Name: Arylacetamide deacetylase-like 1 Size: 408 amino acids; 45808 Da
Subcellular location: Membrane; Single-pass type II membrane protein (Probable). Microsome (By similarity)
Secondary accessions: B7Z2K4 B7Z3A1 B7Z5U2 B7Z906 B7ZAW6 Q86WZ1 Q9P2I4Alternative splicing: 3 isoforms: Q6PIU2-1 Q6PIU2-2 Q6PIU2-3 Post-translational modifications:
N-glycosylated1
REFSEQ proteins (4 alternative transcripts):
NP_001139748.1 NP_001139749.1 NP_001139750.1 NP_065843.3
ENSEMBL proteins: ENSP00000273512
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
4 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for AADACL1: Assays for AADACL1: | Protein
Domains/ Families for AADACL1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q6PIU2
ProtoNet protein and cluster: Q6PIU2 2 Blocks protein families: IPB002168 Lipolytic enzyme IPB013094 Alpha/beta hydrolase fold-3
UniProtKB/Swiss-Prot: ADCL1_HUMAN, Q6PIU2Similarity: Belongs to the 'GDXG' lipolytic enzyme family | Gene Function for AADACL1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_020792
Applied Biosystems Silencer® siRNAs for AADACL1
Sigma-Aldrich siRNA and siRNA Panels for AADACL1  Sigma-Aldrich shRNA for AADACL1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_020792                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_020792                                  untagged cDNA clone in CMV expression vector: NM_020792 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_020792
UniProtKB/Swiss-Prot: ADCL1_HUMAN, Q6PIU2Function: Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsible for cholesterol ester hydrolysis in macrophages, thereby contributing to the development of atherosclerosis. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds. May contribute to cancer pathogenesis by promoting tumor cell migrationEnzyme Number (IUBMB): EC 3.1.1.- 1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Aadacl1):
2 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004091 | carboxylesterase activity |
IEA | -- | | GO:0016787 | hydrolase activity |
IEA | -- | About this table | Pathways & Interactions for AADACL1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| --2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008152 | metabolic process |
IEA | -- | | GO:0016042 | lipid catabolic process |
IEA | -- | About this table
|
Drugs & Compounds for AADACL1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for AADACL1
|
Transcripts for AADACL1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_020792
Sigma-Aldrich siRNA and siRNA Panels for AADACL1  Sigma-Aldrich shRNA for AADACL1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_020792 REFSEQ mRNAs for AADACL1 gene (4 alternative transcripts): NM_001146276.1 NM_001146277.1 NM_001146278.1 NM_020792.4
Applied Biosystems TaqMan ® Gene Expression Assays: NM_020792               OriGene GFP tagged cDNA clone in CMV expression vector: NM_020792                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_020792                                  untagged cDNA clone in CMV expression vector: NM_020792  Additional cDNA sequence: AB037784.1 AK294811.1 AK295641.1 AK299422.1 AK304253.1 AK316431.1 AL512752.1 BC028734.1 BC047588.1 9 DOTS entries: DT.446475 DT.100774528 DT.95302321 DT.97777363 DT.100774526 DT.100774527 DT.120896588 DT.120896590 DT.120896610 24/97 AceView cDNA sequences (see all 97
):BQ009207 AI859996 AI052302 BM968147 AA625233 AI419800 BX281107 BE218940 BX378214 AI192253 AW192003 AW188964 AI962960 AA971330 BM128997 NM_020792 CA423166 BG778641 AI948947 BF435737 AA548653 BE877591 BM712744 CB138758
highest scoring ESTs for AADACL1:AB037784 AI769531 AI948947 AL119157 BC028734 BC047588 BG701753 BI666603 BM922259 U46357 Unigene Cluster for AADACL1: Arylacetamide deacetylase-like 1 Hs.444099 [show with all ESTs]Unigene Representative Sequence: BC028734
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000273512
|
Expression for AADACL1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| AADACL1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for AADACL1
1 / 2 / 3 5 probe-sets matching AADACL1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TTTGGAAATA
SOURCE GeneReport for Unigene cluster: Hs.444099 UniProtKB/Swiss-Prot: ADCL1_HUMAN, Q6PIU2Tissue specificity: Expressed in monocyte-derived macrophages. Up-regulated in invasive melanoma and breast carcinoma cell lines |
Orthologs for AADACL1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for AADACL1 gene from 5/9 species (see all 9
)
About this table Species with no ortholog for AADACL1
ENSEMBL Gene Tree for AADACL1 | Paralogs for AADACL1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for AADACL1 gene
- AADACL42 AADACL32
|
SNPs/Variants for AADACL1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for AADACL1 (up to first 250kb)
|
Disorders & Mutations for AADACL1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
| -- |
Medical News for AADACL1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for AADACL1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10 PubMed articles for AADACL1 gene:- Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)2, 3, 4 Nagase T....Ohara O. (2000)
- Identification of neutral cholesterol ester hydrolase, a key enzyme removing cholesterol from macrophages. (PubMed id 18782767)3, 4 Okazaki H....Ishibashi S. (2008)
- An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling. (PubMed id 17052608)3, 4 Chiang K.P....Cravatt B.F. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)4 Chen R.... Zou H. (2009)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)3 Kimura K.... Sugano S. (2006)
- Enzyme annotation with chemical tools. (PubMed id 17052604)3 Herman A.G. and Stockwell B.R. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)4 Ota T....Sugano S. (2004)
- Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness. (PubMed id 12149457)4 Jessani N.... Cravatt B.F. (2002)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
|
Search for AADACL1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing AADACL1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing AADACL1
(According to HUGE)
About This Section
| |
Specialized Databases showing AADACL1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for AADACL1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for AADACL1:

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Incremental update: 13 Oct 2009
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