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Aliases for AADAC Gene

Aliases for AADAC Gene

  • Arylacetamide Deacetylase 2 3 5
  • Arylacetamide Deacetylase (Esterase) 2 3
  • DAC 3 4
  • EC 3.1.1.79 56
  • EC 3.1.1.3 4
  • EC 3.1.1 56
  • CES5A1 3

External Ids for AADAC Gene

Previous GeneCards Identifiers for AADAC Gene

  • GC03P148473
  • GC03P152364
  • GC03P152813
  • GC03P152852
  • GC03P153014
  • GC03P151515
  • GC03P151531
  • GC03P148922

Summaries for AADAC Gene

Entrez Gene Summary for AADAC Gene

  • Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens [provided by RefSeq, Jul 2008]

GeneCards Summary for AADAC Gene

AADAC (Arylacetamide Deacetylase) is a Protein Coding gene. Diseases associated with AADAC include Chanarin-Dorfman Syndrome and Gilles De La Tourette Syndrome. Among its related pathways are Metabolism and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include hydrolase activity and triglyceride lipase activity. An important paralog of this gene is AADACL2.

UniProtKB/Swiss-Prot for AADAC Gene

  • Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity.

Gene Wiki entry for AADAC Gene

Additional gene information for AADAC Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AADAC Gene

Genomics for AADAC Gene

GeneHancer (GH) Regulatory Elements for AADAC Gene

Promoters and enhancers for AADAC Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I151813 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 595 +1.6 1645 4.4 ELF3 FOXA2 ZNF48 RAD21 RARA YY1 FOS CREM MIXL1 SMARCA5 AADAC IGSF10 LOC105374160 ENSG00000243273 SUCNR1 AADACL2-AS1
GH03I151765 Enhancer 1.2 Ensembl ENCODE 41.4 -44.4 -44443 7.7 FOXA2 MLX ARID4B SIN3A DMAP1 ETS1 YY1 FOS RXRA MXD4 AADACP1 AADAC LINC02066 LOC105374160 ENSG00000242097 AADACL2-AS1
GH03I151790 Enhancer 0.7 ENCODE 35.7 -23.7 -23737 0.2 SOX13 FOXA2 NEUROD1 ZBTB40 CTBP1 GATA3 TCF7L2 GATAD2A SMARCE1 FOXA3 AADAC IGSF10 LOC105374160 AADACP1 AADACL2-AS1
GH03I151836 Enhancer 1.1 Ensembl ENCODE 15.3 +23.3 23336 1.2 PKNOX1 ATF1 ARNT SIN3A TCF12 FOS ATF7 REST MAFF SMARCA4 AADAC SUCNR1 AADACL2-AS1
GH03I151875 Enhancer 1.4 FANTOM5 Ensembl ENCODE 7.4 +62.3 62318 1.7 HDAC1 ATF1 PKNOX1 ARNT ZNF133 ZBTB40 ZNF766 SIRT6 ETV6 ATF7 AADAC SUCNR1 LOC105374159 AADACL2-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around AADAC on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the AADAC gene promoter:

Genomic Locations for AADAC Gene

Genomic Locations for AADAC Gene
chr3:151,814,025-151,828,488
(GRCh38/hg38)
Size:
14,464 bases
Orientation:
Plus strand
chr3:151,531,825-151,546,276
(GRCh37/hg19)

Genomic View for AADAC Gene

Genes around AADAC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AADAC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AADAC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AADAC Gene

Proteins for AADAC Gene

  • Protein details for AADAC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22760-AAAD_HUMAN
    Recommended name:
    Arylacetamide deacetylase
    Protein Accession:
    P22760
    Secondary Accessions:
    • A8K3L3
    • D3DNJ6
    • Q8N1A9

    Protein attributes for AADAC Gene

    Size:
    399 amino acids
    Molecular mass:
    45734 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Can hydrolyze a number of clinical drugs such as flutamide, an antiandrogen drug used for the treatment of prostate cancer; phenacetin, an analgesic antipyretic which has been withdrawn from the market due to its links with renal failure; and rifamycins which have been used as antituberculosis drugs.
    SequenceCaution:
    • Sequence=AAA35551.1; Type=Frameshift; Positions=53, 56; Evidence={ECO:0000305};

neXtProt entry for AADAC Gene

Selected DME Specific Peptides for AADAC Gene

P22760:
  • GDSAGGNL
  • LRRGLFYIHGGGWC
  • DPDVKIKLK
  • RFWSEYFTTDR

Post-translational modifications for AADAC Gene

Other Protein References for AADAC Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for AADAC Gene

Gene Families for AADAC Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for AADAC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P22760

UniProtKB/Swiss-Prot:

AAAD_HUMAN :
  • Belongs to the GDXG lipolytic enzyme family.
Family:
  • Belongs to the GDXG lipolytic enzyme family.
genes like me logo Genes that share domains with AADAC: view

Function for AADAC Gene

Molecular function for AADAC Gene

GENATLAS Biochemistry:
arylacetamide deacetylase,microsomal,liver
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.8 mM for flutamide {ECO:0000269 PubMed:19339378, ECO:0000269 PubMed:22207054, ECO:0000269 PubMed:22415931, ECO:0000269 PubMed:24125761}; KM=0.6 mM for flutamide {ECO:0000269 PubMed:19339378, ECO:0000269 PubMed:22207054, ECO:0000269 PubMed:22415931, ECO:0000269 PubMed:24125761}; KM=0.472 mM for flutamide {ECO:0000269 PubMed:19339378, ECO:0000269 PubMed:22207054, ECO:0000269 PubMed:22415931, ECO:0000269 PubMed:24125761}; KM=3.05 mM for phenacetin {ECO:0000269 PubMed:19339378, ECO:0000269 PubMed:22207054, ECO:0000269 PubMed:22415931, ECO:0000269 PubMed:24125761}; KM=1.8 mM for phenacetin {ECO:0000269 PubMed:19339378, ECO:0000269 PubMed:22207054, ECO:0000269 PubMed:22415931, ECO:0000269 PubMed:24125761}; KM=1.42 mM for phenacetin {ECO:0000269 PubMed:19339378, ECO:0000269 PubMed:22207054, ECO:0000269 PubMed:22415931, ECO:0000269 PubMed:24125761}; KM=0.2 mM for rifampicin {ECO:0000269 PubMed:19339378, ECO:0000269 PubMed:22207054, ECO:0000269 PubMed:22415931, ECO:0000269 PubMed:24125761}; KM=0.154 mM for rifampicin {ECO:0000269 PubMed:19339378, ECO:0000269 PubMed:22207054, ECO:0000269 PubMed:22415931, ECO:0000269 PubMed:24125761}; Vmax=1.1 nmol/min/mg enzyme toward flutamide {ECO:0000269 PubMed:19339378, ECO:0000269 PubMed:22207054, ECO:0000269 PubMed:22415931, ECO:0000269 PubMed:24125761}; Vmax=0.617 nmol/min/mg enzyme toward flutamide {ECO:0000269 PubMed:19339378, ECO:0000269 PubMed:22207054, ECO:0000269 PubMed:22415931, ECO:0000269 PubMed:24125761}; Vmax=1.34 nmol/min/mg enzyme toward phenacetin {ECO:0000269 PubMed:19339378, ECO:0000269 PubMed:22207054, ECO:0000269 PubMed:22415931, ECO:0000269 PubMed:24125761}; Vmax=6.4 nmol/min/mg enzyme toward phenacetin {ECO:0000269 PubMed:19339378, ECO:0000269 PubMed:22207054, ECO:0000269 PubMed:22415931, ECO:0000269 PubMed:24125761}; Vmax=1.42 nmol/min/mg enzyme toward phenacetin {ECO:0000269 PubMed:19339378, ECO:0000269 PubMed:22207054, ECO:0000269 PubMed:22415931, ECO:0000269 PubMed:24125761}; Vmax=0.149 nmol/min/mg enzyme toward rifampicin {ECO:0000269 PubMed:19339378, ECO:0000269 PubMed:22207054, ECO:0000269 PubMed:22415931, ECO:0000269 PubMed:24125761}; Vmax=0.060 nmol/min/mg enzyme toward rifampicin {ECO:0000269 PubMed:19339378, ECO:0000269 PubMed:22207054, ECO:0000269 PubMed:22415931, ECO:0000269 PubMed:24125761};
UniProtKB/Swiss-Prot CatalyticActivity:
Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.
UniProtKB/Swiss-Prot Function:
Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity.
UniProtKB/Swiss-Prot Induction:
Down-regulated following infection with hepatis C virus which results in impaired triacylglycerol lipolysis and impaired assembly of very low density lipoproteins. This may represent a cellular adaptation to infection that is aimed at limiting viral production.

Enzyme Numbers (IUBMB) for AADAC Gene

Phenotypes From GWAS Catalog for AADAC Gene

Gene Ontology (GO) - Molecular Function for AADAC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity TAS 8063807
GO:0004806 triglyceride lipase activity ISS,IBA --
GO:0016298 lipase activity TAS 11481320
GO:0016787 hydrolase activity IEA --
GO:0017171 serine hydrolase activity IEA,IDA 17936933
genes like me logo Genes that share ontologies with AADAC: view
genes like me logo Genes that share phenotypes with AADAC: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AADAC Gene

Localization for AADAC Gene

Subcellular locations from UniProtKB/Swiss-Prot for AADAC Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein. Microsome membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AADAC gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 3
extracellular 2
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for AADAC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031090 organelle membrane IEA --
genes like me logo Genes that share ontologies with AADAC: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for AADAC Gene

Pathways & Interactions for AADAC Gene

genes like me logo Genes that share pathways with AADAC: view

Pathways by source for AADAC Gene

Interacting Proteins for AADAC Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000232892%0d%0a9606.ENSP00000326804%0d%0a9606.ENSP00000286428%0d%0a9606.ENSP00000334188%0d%0a9606.ENSP00000356729%0d%0a9606.ENSP00000209929%0d%0a
Selected Interacting proteins: ENSP00000232892 P22760-AAAD_HUMAN for AADAC Gene via STRING IID

Gene Ontology (GO) - Biological Process for AADAC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0008152 metabolic process IEA --
GO:0009056 catabolic process IBA --
GO:0010898 positive regulation of triglyceride catabolic process ISS,IEA --
genes like me logo Genes that share ontologies with AADAC: view

No data available for SIGNOR curated interactions for AADAC Gene

Drugs & Compounds for AADAC Gene

(3) Drugs for AADAC Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Aniline Experimental Pharma 0
Ecgonine Experimental, Illicit Pharma 0

(3) Additional Compounds for AADAC Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Aminosalicylic acid
  • 3-Amino Salicylate
  • 3-Amino Salicylic acid
  • 3-Amino-(8CI)salicylate
  • 3-Amino-(8CI)salicylic acid
  • 3-Amino-2-hydroxy-(9CI)benzoate
570-23-0
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
genes like me logo Genes that share compounds with AADAC: view

Transcripts for AADAC Gene

mRNA/cDNA for AADAC Gene

Unigene Clusters for AADAC Gene

Arylacetamide deacetylase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for AADAC Gene

No ASD Table

Relevant External Links for AADAC Gene

GeneLoc Exon Structure for
AADAC
ECgene alternative splicing isoforms for
AADAC

Expression for AADAC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AADAC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AADAC Gene

This gene is overexpressed in Adrenal Gland (x26.7) and Liver (x17.4).

Protein differential expression in normal tissues from HIPED for AADAC Gene

This gene is overexpressed in Gallbladder (28.7), Liver (20.6), Adrenal (9.3), and Fetal Liver (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for AADAC Gene



Protein tissue co-expression partners for AADAC Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of AADAC Gene:

AADAC

SOURCE GeneReport for Unigene cluster for AADAC Gene:

Hs.506908

mRNA Expression by UniProt/SwissProt for AADAC Gene:

P22760-AAAD_HUMAN
Tissue specificity: Detected in liver (at protein level). Mainly expressed in liver, small intestine, colon, adrenal gland and bladder.

Evidence on tissue expression from TISSUES for AADAC Gene

  • Liver(4.7)
  • Intestine(4.5)
  • Heart(4)
genes like me logo Genes that share expression patterns with AADAC: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for AADAC Gene

Orthologs for AADAC Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AADAC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AADAC 33 34
  • 99.5 (n)
dog
(Canis familiaris)
Mammalia AADAC 33 34
  • 81.12 (n)
cow
(Bos Taurus)
Mammalia AADAC 33 34
  • 76.94 (n)
rat
(Rattus norvegicus)
Mammalia Aadac 33
  • 73.87 (n)
mouse
(Mus musculus)
Mammalia Aadac 33 16 34
  • 72.73 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 67 (a)
OneToMany
-- 34
  • 67 (a)
OneToMany
-- 34
  • 64 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia AADAC 34
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves AADACL2 33
  • 61.49 (n)
-- 34
  • 57 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 61 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia aadac 33
  • 60.15 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100148912 33
  • 54.39 (n)
aadac 34
  • 49 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea trcs-1 34
  • 25 (a)
ManyToMany
F16F9.4 34
  • 24 (a)
ManyToMany
T09B9.1 34
  • 23 (a)
ManyToMany
Y43F8A.3 34
  • 23 (a)
ManyToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1039.03 33
  • 44.78 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 29 (a)
OneToMany
Species where no ortholog for AADAC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AADAC Gene

ENSEMBL:
Gene Tree for AADAC (if available)
TreeFam:
Gene Tree for AADAC (if available)

Paralogs for AADAC Gene

Paralogs for AADAC Gene

(4) SIMAP similar genes for AADAC Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for AADAC Gene

genes like me logo Genes that share paralogs with AADAC: view

Variants for AADAC Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for AADAC Gene

AAAD_HUMAN-P22760
Three alleles are known: AADAC*1, AADAC*2 and AADAC*3. The sequence shown is that of AADAC*1 which is found in European American, African American, Japanese and Korean populations at allelic frequencies of 39.3 to 47.4%. The AADAC*2 allele is found in European American, African American, Korean, and Japanese populations at allelic frequencies of 52.6 to 63.5% whereas the AADAC*3 allele is found in European American (1.3%) and African American (2.0%) samples but not in Japanese or Korean samples.

Sequence variations from dbSNP and Humsavar for AADAC Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000171717 -- 151,813,706(+) A/C upstream_transcript_variant
rs1000238313 -- 151,813,840(+) T/G upstream_transcript_variant
rs1000306220 -- 151,813,864(+) C/T upstream_transcript_variant
rs1000839586 -- 151,813,693(+) AAGATT/ upstream_transcript_variant
rs1000995062 -- 151,825,877(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for AADAC Gene

Variant ID Type Subtype PubMed ID
dgv1419e212 CNV loss 25503493
dgv4919n100 CNV loss 25217958
dgv4920n100 CNV loss 25217958
dgv4921n100 CNV loss 25217958
dgv621n27 CNV loss 19166990
dgv622n27 CNV loss 19166990
dgv8652n54 CNV loss 21841781
dgv8653n54 CNV loss 21841781
dgv8654n54 CNV loss 21841781
dgv8655n54 CNV loss 21841781
esv25716 CNV loss 19812545
esv2672544 CNV deletion 23128226
esv2759189 CNV loss 17122850
esv2763771 CNV loss 21179565
esv3562727 CNV deletion 23714750
esv3598188 CNV loss 21293372
esv3893786 CNV loss 25118596
nsv514175 CNV loss 21397061
nsv517155 CNV loss 19592680
nsv522472 CNV loss 19592680
nsv592056 CNV loss 21841781
nsv592069 CNV loss 21841781
nsv592070 CNV loss 21841781
nsv592072 CNV loss 21841781

Variation tolerance for AADAC Gene

Residual Variation Intolerance Score: 75.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.15; 38.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AADAC Gene

Human Gene Mutation Database (HGMD)
AADAC
SNPedia medical, phenotypic, and genealogical associations of SNPs for
AADAC

Disorders for AADAC Gene

MalaCards: The human disease database

(2) MalaCards diseases for AADAC Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
chanarin-dorfman syndrome
  • cds
gilles de la tourette syndrome
  • gts
- elite association - COSMIC cancer census association via MalaCards
Search AADAC in MalaCards View complete list of genes associated with diseases

Additional Disease Information for AADAC

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with AADAC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AADAC Gene

Publications for AADAC Gene

  1. Human liver arylacetamide deacetylase. Molecular cloning of a novel esterase involved in the metabolic activation of arylamine carcinogens with high sequence similarity to hormone-sensitive lipase. (PMID: 8063807) Probst MR … Gasser R (The Journal of biological chemistry 1994) 2 3 4 22 58
  2. Human arylacetamide deacetylase is a principal enzyme in flutamide hydrolysis. (PMID: 19339378) Watanabe A … Yokoi T (Drug metabolism and disposition: the biological fate of chemicals 2009) 3 4 22 58
  3. Purification and characterization of a human liver arylacetamide deacetylase. (PMID: 2043131) Probst MR … Meyer UA (Biochemical and biophysical research communications 1991) 3 4 22 58
  4. N-Glycosylation during translation is essential for human arylacetamide deacetylase enzyme activity. (PMID: 24125761) Muta K … Yokoi T (Biochemical pharmacology 2014) 3 4 58
  5. Arylacetamide deacetylase: a novel host factor with important roles in the lipolysis of cellular triacylglycerol stores, VLDL assembly and HCV production. (PMID: 23542347) Nourbakhsh M … Kneteman NM (Journal of hepatology 2013) 3 4 58

Products for AADAC Gene

Sources for AADAC Gene

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