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Aliases for AADAC Gene

Aliases for AADAC Gene

  • Arylacetamide Deacetylase 2 3 5
  • Arylacetamide Deacetylase (Esterase) 2 3
  • DAC 3 4
  • EC 3.1.1.79 61
  • EC 3.1.1.3 4
  • EC 3.1.1 61
  • CES5A1 3

External Ids for AADAC Gene

Previous GeneCards Identifiers for AADAC Gene

  • GC03P148473
  • GC03P152364
  • GC03P152813
  • GC03P152852
  • GC03P153014
  • GC03P151515
  • GC03P151531
  • GC03P148922

Summaries for AADAC Gene

Entrez Gene Summary for AADAC Gene

  • Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens [provided by RefSeq, Jul 2008]

GeneCards Summary for AADAC Gene

AADAC (Arylacetamide Deacetylase) is a Protein Coding gene. Diseases associated with AADAC include Neutral Lipid Storage Disease. Among its related pathways are cytochrome P450 and Metabolism. GO annotations related to this gene include hydrolase activity and triglyceride lipase activity. An important paralog of this gene is AADACL2.

UniProtKB/Swiss-Prot for AADAC Gene

  • Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity.

Gene Wiki entry for AADAC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AADAC Gene

Genomics for AADAC Gene

Regulatory Elements for AADAC Gene

Enhancers for AADAC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around AADAC on UCSC Golden Path with GeneCards custom track

Genomic Location for AADAC Gene

Chromosome:
3
Start:
151,814,025 bp from pter
End:
151,828,488 bp from pter
Size:
14,464 bases
Orientation:
Plus strand

Genomic View for AADAC Gene

Genes around AADAC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AADAC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AADAC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AADAC Gene

Proteins for AADAC Gene

  • Protein details for AADAC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22760-AAAD_HUMAN
    Recommended name:
    Arylacetamide deacetylase
    Protein Accession:
    P22760
    Secondary Accessions:
    • A8K3L3
    • D3DNJ6
    • Q8N1A9

    Protein attributes for AADAC Gene

    Size:
    399 amino acids
    Molecular mass:
    45734 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Can hydrolyze a number of clinical drugs such as flutamide, an antiandrogen drug used for the treatment of prostate cancer; phenacetin, an analgesic antipyretic which has been withdrawn from the market due to its links with renal failure; and rifamycins which have been used as antituberculosis drugs.
    SequenceCaution:
    • Sequence=AAA35551.1; Type=Frameshift; Positions=53, 56; Evidence={ECO:0000305};

neXtProt entry for AADAC Gene

Selected DME Specific Peptides for AADAC Gene

Post-translational modifications for AADAC Gene

Other Protein References for AADAC Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for AADAC Gene

Gene Families for AADAC Gene

Suggested Antigen Peptide Sequences for AADAC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P22760

UniProtKB/Swiss-Prot:

AAAD_HUMAN :
  • Belongs to the GDXG lipolytic enzyme family.
Family:
  • Belongs to the GDXG lipolytic enzyme family.
genes like me logo Genes that share domains with AADAC: view

Function for AADAC Gene

Molecular function for AADAC Gene

GENATLAS Biochemistry:
arylacetamide deacetylase,microsomal,liver
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.8 mM for flutamide {ECO:0000269 PubMed:19339378, ECO:0000269 PubMed:22207054, ECO:0000269 PubMed:22415931, ECO:0000269 PubMed:24125761}; KM=0.6 mM for flutamide {ECO:0000269 PubMed:19339378, ECO:0000269 PubMed:22207054, ECO:0000269 PubMed:22415931, ECO:0000269 PubMed:24125761}; KM=0.472 mM for flutamide {ECO:0000269 PubMed:19339378, ECO:0000269 PubMed:22207054, ECO:0000269 PubMed:22415931, ECO:0000269 PubMed:24125761}; KM=3.05 mM for phenacetin {ECO:0000269 PubMed:19339378, ECO:0000269 PubMed:22207054, ECO:0000269 PubMed:22415931, ECO:0000269 PubMed:24125761}; KM=1.8 mM for phenacetin {ECO:0000269 PubMed:19339378, ECO:0000269 PubMed:22207054, ECO:0000269 PubMed:22415931, ECO:0000269 PubMed:24125761}; KM=1.42 mM for phenacetin {ECO:0000269 PubMed:19339378, ECO:0000269 PubMed:22207054, ECO:0000269 PubMed:22415931, ECO:0000269 PubMed:24125761}; KM=0.2 mM for rifampicin {ECO:0000269 PubMed:19339378, ECO:0000269 PubMed:22207054, ECO:0000269 PubMed:22415931, ECO:0000269 PubMed:24125761}; KM=0.154 mM for rifampicin {ECO:0000269 PubMed:19339378, ECO:0000269 PubMed:22207054, ECO:0000269 PubMed:22415931, ECO:0000269 PubMed:24125761}; Vmax=1.1 nmol/min/mg enzyme toward flutamide {ECO:0000269 PubMed:19339378, ECO:0000269 PubMed:22207054, ECO:0000269 PubMed:22415931, ECO:0000269 PubMed:24125761}; Vmax=1.1 nmol/min/mg enzyme toward flutamide {ECO:0000269 PubMed:19339378, ECO:0000269 PubMed:22207054, ECO:0000269 PubMed:22415931, ECO:0000269 PubMed:24125761}; Vmax=0.617 nmol/min/mg enzyme toward flutamide {ECO:0000269 PubMed:19339378, ECO:0000269 PubMed:22207054, ECO:0000269 PubMed:22415931, ECO:0000269 PubMed:24125761}; Vmax=1.34 nmol/min/mg enzyme toward phenacetin {ECO:0000269 PubMed:19339378, ECO:0000269 PubMed:22207054, ECO:0000269 PubMed:22415931, ECO:0000269 PubMed:24125761}; Vmax=6.4 nmol/min/mg enzyme toward phenacetin {ECO:0000269 PubMed:19339378, ECO:0000269 PubMed:22207054, ECO:0000269 PubMed:22415931, ECO:0000269 PubMed:24125761}; Vmax=1.42 nmol/min/mg enzyme toward phenacetin {ECO:0000269 PubMed:19339378, ECO:0000269 PubMed:22207054, ECO:0000269 PubMed:22415931, ECO:0000269 PubMed:24125761}; Vmax=0.149 nmol/min/mg enzyme toward rifampicin {ECO:0000269 PubMed:19339378, ECO:0000269 PubMed:22207054, ECO:0000269 PubMed:22415931, ECO:0000269 PubMed:24125761}; Vmax=0.060 nmol/min/mg enzyme toward rifampicin {ECO:0000269 PubMed:19339378, ECO:0000269 PubMed:22207054, ECO:0000269 PubMed:22415931, ECO:0000269 PubMed:24125761};
UniProtKB/Swiss-Prot CatalyticActivity:
Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.
UniProtKB/Swiss-Prot Function:
Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity.
UniProtKB/Swiss-Prot Induction:
Down-regulated following infection with hepatis C virus which results in impaired triacylglycerol lipolysis and impaired assembly of very low density lipoproteins. This may represent a cellular adaptation to infection that is aimed at limiting viral production.

Enzyme Numbers (IUBMB) for AADAC Gene

Gene Ontology (GO) - Molecular Function for AADAC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity TAS 8063807
GO:0004806 triglyceride lipase activity IEA,ISS --
GO:0016298 lipase activity TAS 11481320
GO:0017171 serine hydrolase activity IEA,IDA 17936933
GO:0019213 deacetylase activity TAS --
genes like me logo Genes that share ontologies with AADAC: view
genes like me logo Genes that share phenotypes with AADAC: view

Animal Model Products

  • Taconic Biosciences Mouse Models for AADAC

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AADAC Gene

Localization for AADAC Gene

Subcellular locations from UniProtKB/Swiss-Prot for AADAC Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein. Microsome membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AADAC Gene COMPARTMENTS Subcellular localization image for AADAC gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 3
extracellular 2
cytosol 1

Gene Ontology (GO) - Cellular Components for AADAC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA,TAS --
GO:0016021 integral component of membrane IEA --
GO:0031090 organelle membrane IEA --
genes like me logo Genes that share ontologies with AADAC: view

Pathways & Interactions for AADAC Gene

genes like me logo Genes that share pathways with AADAC: view

Pathways by source for AADAC Gene

Interacting Proteins for AADAC Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 20)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000232892%0d%0a9606.ENSP00000430432%0d%0a9606.ENSP00000380718%0d%0a9606.ENSP00000302968%0d%0a9606.ENSP00000250838%0d%0a9606.ENSP00000303178%0d%0a
Selected Interacting proteins: ENSP00000232892 P22760-AAAD_HUMAN for AADAC Gene via STRING IID

Gene Ontology (GO) - Biological Process for AADAC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0010898 positive regulation of triglyceride catabolic process IEA,ISS --
genes like me logo Genes that share ontologies with AADAC: view

No data available for SIGNOR curated interactions for AADAC Gene

Drugs & Compounds for AADAC Gene

(3) Drugs for AADAC Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Aniline Experimental Pharma 0
Ecgonine Experimental, Illicit Pharma 0

(3) Additional Compounds for AADAC Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Aminosalicylic acid
  • 3-Amino Salicylate
  • 3-Amino Salicylic acid
  • 3-Amino-(8CI)salicylate
  • 3-Amino-(8CI)salicylic acid
  • 3-Amino-2-hydroxy-(9CI)benzoate
570-23-0
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
genes like me logo Genes that share compounds with AADAC: view

Transcripts for AADAC Gene

mRNA/cDNA for AADAC Gene

Unigene Clusters for AADAC Gene

Arylacetamide deacetylase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AADAC Gene

No ASD Table

Relevant External Links for AADAC Gene

GeneLoc Exon Structure for
AADAC
ECgene alternative splicing isoforms for
AADAC

Expression for AADAC Gene

mRNA expression in normal human tissues for AADAC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AADAC Gene

This gene is overexpressed in Adrenal Gland (x26.7) and Liver (x17.4).

Protein differential expression in normal tissues from HIPED for AADAC Gene

This gene is overexpressed in Gallbladder (28.7), Liver (20.6), Adrenal (9.3), and Fetal Liver (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for AADAC Gene



Protein tissue co-expression partners for AADAC Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of AADAC Gene:

AADAC

SOURCE GeneReport for Unigene cluster for AADAC Gene:

Hs.506908

mRNA Expression by UniProt/SwissProt for AADAC Gene:

P22760-AAAD_HUMAN
Tissue specificity: Detected in liver (at protein level). Mainly expressed in liver, small intestine, colon, adrenal gland and bladder.
genes like me logo Genes that share expression patterns with AADAC: view

Primer Products

Orthologs for AADAC Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AADAC Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AADAC 34
  • 76.94 (n)
  • 71.18 (a)
AADAC 35
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AADAC 34
  • 81.12 (n)
  • 75.44 (a)
AADAC 35
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Aadac 34
  • 72.73 (n)
  • 69.95 (a)
Aadac 16
Aadac 35
  • 70 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AADAC 34
  • 99.5 (n)
  • 99.25 (a)
AADAC 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Aadac 34
  • 73.87 (n)
  • 68.09 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 67 (a)
OneToMany
-- 35
  • 64 (a)
OneToMany
-- 35
  • 67 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia AADAC 35
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves AADACL2 34
  • 61.49 (n)
  • 57.89 (a)
-- 35
  • 57 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 61 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia aadac 34
  • 60.15 (n)
  • 53.63 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100148912 34
  • 54.39 (n)
  • 50.13 (a)
aadac 35
  • 49 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F16F9.4 35
  • 24 (a)
ManyToMany
T09B9.1 35
  • 23 (a)
ManyToMany
trcs-1 35
  • 25 (a)
ManyToMany
Y43F8A.3 35
  • 23 (a)
ManyToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1039.03 34
  • 44.78 (n)
  • 27.61 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 29 (a)
OneToMany
Species where no ortholog for AADAC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AADAC Gene

ENSEMBL:
Gene Tree for AADAC (if available)
TreeFam:
Gene Tree for AADAC (if available)

Paralogs for AADAC Gene

Paralogs for AADAC Gene

(4) SIMAP similar genes for AADAC Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for AADAC Gene

genes like me logo Genes that share paralogs with AADAC: view

Variants for AADAC Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for AADAC Gene

AAAD_HUMAN-P22760
Three alleles are known: AADAC*1, AADAC*2 and AADAC*3. The sequence shown is that of AADAC*1 which is found in European American, African American, Japanese and Korean populations at allelic frequencies of 39.3 to 47.4%. The AADAC*2 allele is found in European American, African American, Korean, and Japanese populations at allelic frequencies of 52.6 to 63.5% whereas the AADAC*3 allele is found in European American (1.3%) and African American (2.0%) samples but not in Japanese or Korean samples.

Sequence variations from dbSNP and Humsavar for AADAC Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_014798 -

Structural Variations from Database of Genomic Variants (DGV) for AADAC Gene

Variant ID Type Subtype PubMed ID
dgv1419e212 CNV loss 25503493
dgv4919n100 CNV loss 25217958
dgv4920n100 CNV loss 25217958
dgv4921n100 CNV loss 25217958
dgv621n27 CNV loss 19166990
dgv622n27 CNV loss 19166990
dgv8652n54 CNV loss 21841781
dgv8653n54 CNV loss 21841781
dgv8654n54 CNV loss 21841781
dgv8655n54 CNV loss 21841781
esv25716 CNV loss 19812545
esv2672544 CNV deletion 23128226
esv2759189 CNV loss 17122850
esv2763771 CNV loss 21179565
esv3562727 CNV deletion 23714750
esv3598188 CNV loss 21293372
esv3893786 CNV loss 25118596
nsv514175 CNV loss 21397061
nsv517155 CNV loss 19592680
nsv522472 CNV loss 19592680
nsv592056 CNV loss 21841781
nsv592069 CNV loss 21841781
nsv592070 CNV loss 21841781
nsv592072 CNV loss 21841781

Variation tolerance for AADAC Gene

Residual Variation Intolerance Score: 75.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.15; 38.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AADAC Gene

Human Gene Mutation Database (HGMD)
AADAC
SNPedia medical, phenotypic, and genealogical associations of SNPs for
AADAC

Disorders for AADAC Gene

MalaCards: The human disease database

(1) MalaCards diseases for AADAC Gene - From: DISEASES

Disorder Aliases PubMed IDs
neutral lipid storage disease
  • chanarin-dorfman syndrome
- elite association - COSMIC cancer census association via MalaCards
Search AADAC in MalaCards View complete list of genes associated with diseases

Relevant External Links for AADAC

Genetic Association Database (GAD)
AADAC
Human Genome Epidemiology (HuGE) Navigator
AADAC
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AADAC
genes like me logo Genes that share disorders with AADAC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AADAC Gene

Publications for AADAC Gene

  1. Human liver arylacetamide deacetylase. Molecular cloning of a novel esterase involved in the metabolic activation of arylamine carcinogens with high sequence similarity to hormone-sensitive lipase. (PMID: 8063807) Probst M.R. … Gasser R. (J. Biol. Chem. 1994) 2 3 4 22 65
  2. Human arylacetamide deacetylase is a principal enzyme in flutamide hydrolysis. (PMID: 19339378) Watanabe A. … Yokoi T. (Drug Metab. Dispos. 2009) 3 4 22 65
  3. Purification and characterization of a human liver arylacetamide deacetylase. (PMID: 2043131) Probst M.R. … Meyer U.A. (Biochem. Biophys. Res. Commun. 1991) 3 4 22 65
  4. N-Glycosylation during translation is essential for human arylacetamide deacetylase enzyme activity. (PMID: 24125761) Muta K. … Yokoi T. (Biochem. Pharmacol. 2014) 3 4 65
  5. Arylacetamide deacetylase: a novel host factor with important roles in the lipolysis of cellular triacylglycerol stores, VLDL assembly and HCV production. (PMID: 23542347) Nourbakhsh M. … Kneteman N.M. (J. Hepatol. 2013) 3 4 65

Products for AADAC Gene

Sources for AADAC Gene

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