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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AADAC Gene

protein-coding   GIFtS: 59
GCID: GC03P151531

Arylacetamide Deacetylase

(Previous name: arylacetamide deacetylase (esterase))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Arylacetamide Deacetylase1 2     EC 3.1.1.33
DAC2 3 5     EC 3.1.18
Arylacetamide Deacetylase (Esterase)1 2     EC 3.1.1.798
CES5A12     

External Ids:    HGNC: 171   Entrez Gene: 132   Ensembl: ENSG000001147717   OMIM: 6003385   UniProtKB: P227603   

Export aliases for AADAC gene to outside databases

Previous GC identifers: GC03P148473 GC03P152364 GC03P152813 GC03P152852 GC03P153014 GC03P151515 GC03P148922


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for AADAC Gene:
Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase,
which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens
(provided by RefSeq, Jul 2008)

GeneCards Summary for AADAC Gene: 
AADAC (arylacetamide deacetylase) is a protein-coding gene. Diseases associated with AADAC include neutral lipid storage disease, and lipid storage disease. GO annotations related to this gene include triglyceride lipase activity and catalytic activity. An important paralog of this gene is AADACL4.

UniProtKB/Swiss-Prot: AAAD_HUMAN, P22760
Function: Arylacetamide deacetylation is an important enzyme activity in the metabolic activation of arylamine
substrates to ultimate carcinogens. Displays major serine hydrolase activity in liver microsomes. Hydrolyzes also
flutamide, which is an antiandrogen drug used for the treatment of prostate cancer that occasionally causes
severe hepatotoxicity. Displays cellular triglyceride lipase activity in liver. Increases intracellular fatty
acids derived from hydrolysis of newly formed triglyceride stores

Gene Wiki entry for AADAC Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AADAC gene promoter:
         MEF-2A   TBP   POU2F1   POU2F1a   FOXO4   aMEF-2   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAADAC promoter sequence
   Search SABiosciences Chromatin IP Primers for AADAC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AADAC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q25.1   Ensembl cytogenetic band:  3q25.1   HGNC cytogenetic band: 3q25.1

AADAC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AADAC gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P151531:  view genomic region     (about GC identifiers)

Start:
151,531,825 bp from pter      End:
151,546,276 bp from pter
Size:
14,452 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AAAD_HUMAN, P22760 (See protein sequence)
Recommended Name: Arylacetamide deacetylase  
Size: 399 amino acids; 45734 Da
Subcellular location: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Microsome membrane;
Single-pass type II membrane protein
Sequence caution: Sequence=AAA35551.1; Type=Frameshift; Positions=53, 56;
Secondary accessions: A8K3L3 D3DNJ6 Q8N1A9

Explore the universe of human proteins at neXtProt for AADAC: NX_P22760

Explore proteomics data for AADAC at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P22760

  • 4 DME Specific Peptides for AADAC (P22760)
     GDSAGGNL  DPDVKIKLK  RFWSEYFTTDR  LRRGLFYIHGGGWC 

    AADAC Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    AADAC Protein Expression
    REFSEQ proteins: NP_001077.2  
    ENSEMBL proteins: 
     ENSP00000232892   ENSP00000419620  

    Human Recombinant Protein Products for AADAC: 
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    Cloud-Clone Corp. Proteins for AADAC 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IDA10318829
    GO:0016021integral to membrane IEA--

    AADAC for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR017157 Arylacetamide_deacetylase
     IPR013094 AB_hydrolase_3
     IPR002168 Lipase_GDXG_AS

    Graphical View of Domain Structure for InterPro Entry P22760

    ProtoNet protein and cluster: P22760

    2 Blocks protein domains:
    IPB002168 Lipolytic enzyme
    IPB013094 Alpha/beta hydrolase fold-3


    UniProtKB/Swiss-Prot: AAAD_HUMAN, P22760
    Similarity: Belongs to the 'GDXG' lipolytic enzyme family


    AADAC for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AAAD_HUMAN, P22760
    Function: Arylacetamide deacetylation is an important enzyme activity in the metabolic activation of arylamine
    substrates to ultimate carcinogens. Displays major serine hydrolase activity in liver microsomes. Hydrolyzes also
    flutamide, which is an antiandrogen drug used for the treatment of prostate cancer that occasionally causes
    severe hepatotoxicity. Displays cellular triglyceride lipase activity in liver. Increases intracellular fatty
    acids derived from hydrolysis of newly formed triglyceride stores
    Catalytic activity: Triacylglycerol + H(2)O = diacylglycerol + a carboxylate
    Biophysicochemical properties: Kinetic parameters: KM=0.8 mM for flutamide; Vmax=1.1 nmol/min/mg enzyme toward
    flutamide;

         Genatlas biochemistry entry for AADAC:
    arylacetamide deacetylase,microsomal,liver

         Enzyme Numbers (IUBMB): EC 3.1.1.31 EC 3.1.12 EC 3.1.1.792

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity TAS8063807
    GO:0004091carboxylesterase activity IEA--
    GO:0004806triglyceride lipase activity ISS--
    GO:0016298lipase activity TAS11481320
    GO:0016787hydrolase activity ----
         
    AADAC for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for AADAC:
     Decreased viability with pacli 

    Animal Models:
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AADAC

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for AADAC (ENSP000002328924) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HDAC2ENSP000003813314STRING: ENSP00000381331
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008152metabolic process ----
    GO:0010898positive regulation of triglyceride catabolic process ISS--

    AADAC for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    AADAC for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AADAC (AAAD)

    3 HMDB Compounds for AADAC    About this table
    CompoundSynonyms CAS #PubMed Ids
    3-Aminosalicylic acid3-Amino Salicylate (see all 16)570-23-0--
    AnilineAminobenzene (see all 16)62-53-3--
    Ecgonine(2R,3S)-3-hydroxy-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid (see all 5)481-37-8--

    1 Novoseek inferred chemical compound relationship for AADAC gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arylamine 76.3 3 8063807 (2)

    Search CenterWatch for drugs/clinical trials and news about AADAC / AAAD

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for AADAC gene: 
    NM_001086.2  

    Unigene Cluster for AADAC:

    Arylacetamide deacetylase
    Hs.506908  [show with all ESTs]
    Unigene Representative Sequence: NM_001086
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000232892(uc003eze.3) ENST00000488869
    miRNA
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    Inhib. RNA
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    Additional mRNA sequence: 

    AK290628.1 BC020706.1 BC032309.1 L32179.1 

    6 DOTS entries:

    DT.415010  DT.95156022  DT.101980759  DT.92460876  DT.99957497  DT.434029 

    24/68 AceView cDNA sequences (see all 68):

    CR624107 AV685871 CB148233 BC032309 CB156860 BG542396 BG569285 BI760687 
    CB105350 NM_001086 AA045221 AA045320 BG567565 N76857 AV685841 BX443932 
    BX431750 AV703616 AA702700 AA700863 BC020706 BQ695358 AA777647 AV705031 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AADAC expression in normal human tissues (normalized intensities)      AADAC embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGCATAATT
    AADAC Expression
    About this image


    AADAC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/24 selected tissues (see all 24) fully expand
     
     Kidney (Urinary System)    fully expand to see all 9 entries
             Presumptive Podocytes Podocyte Layer
             Proximal Tubule
             visceral organ/metanephros/renal medulla   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 4 entries
             visceral organ   
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Intestine (Gastrointestinal Tract)    fully expand to see all 2 entries
             small intestine   
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             sensory organ/ear/inner ear   

    See AADAC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AADAC

    SOURCE GeneReport for Unigene cluster: Hs.506908

    UniProtKB/Swiss-Prot: AAAD_HUMAN, P22760
    Tissue specificity: Mainly expressed in liver, small intestine, colon and adrenal gland

        SABiosciences Expression via Pathway-Focused PCR Array including AADAC: 
              Drug Metabolism: Phase I Enzymes in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for AADAC gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aadac1 , 5 arylacetamide deacetylase (esterase)1, 5 72.73(n)1
    69.95(a)1
      3 (29.17 cM)5
    677581  NM_023383.11  NP_075872.11 
     600317635 
    chicken
    (Gallus gallus)
    Aves AADACL21 arylacetamide deacetylase-like 2 61.49(n)
    57.89(a)
      425034  XM_422836.3  XP_422836.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    61(a)
    1 → many
    3(17851732-17873020)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1001489121 arylacetamide deacetylase-like 54.25(n)
    50.51(a)
      100148912  XM_001923679.3  XP_001923714.2 
    worm
    (Caenorhabditis elegans)
    Secernentea trcs-16
    Y43F8A.36
    (see all 3)
    Protein Y43F8A.3, isoform a
    (see all 3)
    24(a)
    24(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    IV(9587098-9588834)
    V(19377444-19381031)


    ENSEMBL Gene Tree for AADAC (if available)
    TreeFam Gene Tree for AADAC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AADAC gene
    AADACL42  AADACL32  NCEH12  AADACL22  
    4 SIMAP similar genes for AADAC using alignment to 2 protein entries:     AAAD_HUMAN (see all proteins):
    AADACL2    NCEH1    AADACL3    AADACL4

    AADAC for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for AADAC
    PGOHUM00000238233 PGOHUM00000238234


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/461 SNPs in AADAC are shown (see all 461)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs622728851,2
    C,F--151529878(+) ACCCAT/CAGCAC 1 -- us2k14Minor allele frequency- C:0.04NA CSA WA 242
    rs1862160561,2
    --151529933(+) CCATTC/TGACTT 1 -- us2k10--------
    rs346387341,2
    C,F--151529999(+) GAATAC/ACTCCC 1 -- us2k19Minor allele frequency- A:0.18NA WA EA 372
    rs1915129221,2
    --151530007(+) CCCAAC/TACTCT 1 -- us2k10--------
    rs21209821,2
    C,F,O,A,H--151530121(-) TGTTGA/GTTTTT 1 -- us2k1 tfbs338Minor allele frequency- N:0.00NS EA NA WA CSA 3398
    rs1393849501,2
    --151530144(+) AAGTGC/TGAAAT 1 -- us2k10--------
    rs1833436301,2
    --151530145(+) AGTGCA/GAAATC 1 -- us2k10--------
    rs730164051,2
    C,F--151530259(+) CACCAG/ACTAAC 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1910209881,2
    --151530301(+) CTCTTC/GTCAGA 1 -- us2k10--------
    rs168339351,2
    C,F,H--151530313(+) CAATTC/TGACTC 1 -- us2k127Minor allele frequency- T:0.16NA EA NS WA CSA 2390

    HapMap Linkage Disequilibrium report for AADAC (151531825 - 151546276 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for AADAC (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2672544CNV Deletion23128226
    dgv622n27CNV Loss19166990
    dgv5276n71CNV Loss21882294
    nsv514175CNV Loss21397061
    nsv522472CNV Loss19592680
    nsv517155CNV Loss19592680
    dgv621n27CNV Loss19166990
    nsv877654CNV Loss21882294
    nsv877655CNV Loss21882294
    esv25716CNV Loss19812545


    Human Gene Mutation Database (HGMD): AADAC
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600338    OMIM disorders: --

    9 diseases for AADAC:    About MalaCards
    neutral lipid storage disease    lipid storage disease    ectropion    cytochrome p450
    infertility    tuberculosis    prostate cancer    prostatitis
    hepatitis

    2 diseases from the University of Copenhagen DISEASES database for AADAC:
    Neutral lipid storage disease     Ectropion

    AADAC for disorders           About GeneDecksing

    Genetic Association Database (GAD): AADAC
    Human Genome Epidemiology (HuGE) Navigator: AADAC (2 documents)

    Export disorders for AADAC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AADAC gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with AADAC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human liver arylacetamide deacetylase. Molecular cloning of a novel esterase involved in the metabolic activation of arylamine carcinogens with high sequence similarity to hormone-sensitive lipase. (PubMed id 8063807)1, 2, 3, 9 Probst M.R.... Gasser R. (1994)
    2. Human arylacetamide deacetylase is a principal enzyme in flutamide hydrolysis. (PubMed id 19339378)1, 2, 9 Watanabe A.... Yokoi T. (2009)
    3. Purification and characterization of a human liver arylacetamide deacetylase. (PubMed id 2043131)1, 2, 9 Probst M.R.... Meyer U.A. (1991)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. Association of IFIH1 and other autoimmunity risk alle les with selective IgA deficiency. (PubMed id 20694011)1, 4 Ferreira R.C....HammarstrAPm L. (2010)
    6. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1, 4 Saito A....Kamatani N. (2009)
    7. Human carboxylesterases and their role in xenobiotic and endobiotic metabolism. (PubMed id 17936933)1, 2 Ross M.K. and Crow J.A. (2007)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Catalog of 680 variations among eight cytochrome p450 (CYP) genes, nine esterase genes, and two other genes in the Japanese population. (PubMed id 12721789)1, 2 Saito S....Nakamura Y. (2003)
    10. Radiation hybrid mapping of human arylacetamide deacetylase (AADAC) locus to chromosome 3. (PubMed id 9299245)1, 9 Yamazaki K....Tanaka I. (1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 13 HGNC: 17 AceView: AADAC Ensembl:ENSG00000114771 euGenes: HUgn13
    ECgene: AADAC H-InvDB: AADAC

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AADAC Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for AADAC Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for AADAC gene:
    Search GeneIP for patents involving AADAC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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