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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AADAC Gene

protein-coding   GIFtS: 57
GCID: GC03P151531

arylacetamide deacetylase

(Previous name: arylacetamide deacetylase (esterase) )
 Explore 8 diseases affiliated with
AADAC via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for AADAC    

Aliases
for AADAC gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Arylacetamide Deacetylase1 2     EC 3.1.1.33
DAC1 2 3 5     EC 3.1.18
CES5A11 2     EC 3.1.1.798
Arylacetamide Deacetylase (Esterase)1 2     

External Ids:    HGNC: 171   Entrez Gene: 132   Ensembl: ENSG000001147717   OMIM: 6003385   UniProtKB: P227603   

Export aliases for AADAC gene to outside databases

Previous GC identifers: GC03P148473 GC03P152364 GC03P152813 GC03P152852 GC03P153014 GC03P151515 GC03P148922


Summaries
for AADAC gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for AADAC:
Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which
catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: AAAD_HUMAN, P22760
Function: Arylacetamide deacetylation is an important enzyme activity in the metabolic activation of arylamine
substrates to ultimate carcinogens. Displays major serine hydrolase activity in liver microsomes. Hydrolyzes also
flutamide, which is an antiandrogen drug used for the treatment of prostate cancer that occasionally causes severe
hepatotoxicity. Displays cellular triglyceride lipase activity in liver. Increases intracellular fatty acids derived
from hydrolysis of newly formed triglyceride stores

Gene Wiki entry for AADAC


Genomic Views
for AADAC gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AADAC gene promoter:
         MEF-2A   TBP   POU2F1   POU2F1a   FOXO4   aMEF-2   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: AADAC promoter sequence
   Search SABiosciences Chromatin IP Primers for AADAC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AADAC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q25.1   Ensembl cytogenetic band:  3q25.1   HGNC cytogenetic band: 3q25.1

AADAC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AADAC gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P151531:  view genomic region     (about GC identifiers)

Start:
 151,531,825 bp from pter      End:
 151,546,276 bp from pter
Size:
 14,452 bases      Orientation:
 plus strand

Proteins
for AADAC gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: AAAD_HUMAN, P22760 (See protein sequence)
Recommended Name: Arylacetamide deacetylase  
Size: 399 amino acids; 45734 Da
Subcellular location: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Microsome membrane;
Single-pass type II membrane protein
Sequence caution: Sequence=AAA35551.1; Type=Frameshift; Positions=53, 56;
Secondary accessions: A8K3L3 D3DNJ6 Q8N1A9

Explore the universe of human proteins at neXtProt for AADAC: NX_P22760

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P22760

    • 4 DME Specific Peptides for AADAC (P22760)
     GDSAGGNL  DPDVKIKLK  RFWSEYFTTDR  LRRGLFYIHGGGWC 

    AADAC Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001077.2  
    ENSEMBL proteins: 
     ENSP00000232892   ENSP00000419620  

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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for AADAC

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IDA19339378
    GO:0005792microsome ----
    GO:0016021integral to membrane IEA--


    AADAC for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for AADAC

    Protein Domains /
    Families
    for AADAC gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    AADAC for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR017157 Arylacetamide_deacetylase
     IPR013094 AB_hydrolase_3
     IPR002168 Lipase_GDXG_AS

    Graphical View of Domain Structure for InterPro Entry P22760

    ProtoNet protein and cluster: P22760

    2 Blocks protein families:
    IPB002168 Lipolytic enzyme
    IPB013094 Alpha/beta hydrolase fold-3


    UniProtKB/Swiss-Prot: AAAD_HUMAN, P22760
    Similarity: Belongs to the 'GDXG' lipolytic enzyme family


    Function
    for AADAC gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: AAAD_HUMAN, P22760
    Function: Arylacetamide deacetylation is an important enzyme activity in the metabolic activation of arylamine
    substrates to ultimate carcinogens. Displays major serine hydrolase activity in liver microsomes. Hydrolyzes also
    flutamide, which is an antiandrogen drug used for the treatment of prostate cancer that occasionally causes severe
    hepatotoxicity. Displays cellular triglyceride lipase activity in liver. Increases intracellular fatty acids derived
    from hydrolysis of newly formed triglyceride stores
    Catalytic activity: Triacylglycerol + H(2)O = diacylglycerol + a carboxylate
    Biophysicochemical properties: Kinetic parameters: KM=0.8 mM for flutamide; Vmax=1.1 nmol/min/mg enzyme toward
    flutamide;

         Genatlas biochemistry entry for AADAC:
    arylacetamide deacetylase,microsomal,liver

    Enzyme Numbers (IUBMB): EC 3.1.1.31 EC 3.1.12 EC 3.1.1.792

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity TAS8063807
    GO:0004091carboxylesterase activity IEA--
    GO:0004806triglyceride lipase activity ISS--
    GO:0016298lipase activity TAS11481320
    GO:0016787hydrolase activity ----


    AADAC for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for AADAC:
     Decreased viability with pacli 


    Pathways & Interactions
    for AADAC gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AADAC

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for AADAC (ENSP000002328924) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HDAC2ENSP000003813314STRING: ENSP00000381331
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008152metabolic process ----
    GO:0010898positive regulation of triglyceride catabolic process ISS--


    AADAC for ontologies           About GeneDecksing



    Drugs & Compounds
    for AADAC gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    AADAC for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for AADAC

    3 HMDB Compounds for AADAC    About this table
    CompoundSynonyms CAS #PubMed Ids
    3-Aminosalicylic acid3-Amino Salicylate (see all 16)570-23-0--
    AnilineAminobenzene (see all 16)62-53-3--
    Ecgonine(2R,3S)-3-hydroxy-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid (see all 5)481-37-8--
    1 Novoseek chemical compound relationship for AADAC gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arylamine 76.3 3 8063807 (2)

    Search CenterWatch for drugs/clinical trials and news about AADAC / AAAD 

    Transcripts
    for AADAC gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for AADAC gene: 
    NM_001086.2  

    Unigene Cluster for AADAC:

    Arylacetamide deacetylase
    Hs.506908  [show with all ESTs]
    Unigene Representative Sequence: NM_001086
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000232892(uc003eze.3) ENST00000488869

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    Inhib. RNA
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    Additional cDNA sequence: 

    AK290628.1 BC020706.1 BC032309.1 L32179.1 

    6 DOTS entries:

    DT.415010  DT.95156022  DT.101980759  DT.92460876  DT.99957497  DT.434029 

    24/68 AceView cDNA sequences (see all 68):

    CR624107 CB156860 BC032309 AV685871 CB148233 CB105350 AW951425 AV702720 
    BI760687 BG567565 BX431750 BG542396 N76857 AA045320 AA777647 NM_001086 
    BG569285 CF597071 BQ695358 AA045221 AV705031 AV703616 AA700863 AA702700 

    GeneLoc Exon Structure


    Expression
    for AADAC gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AADAC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAGCATAATT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    AADAC expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    7 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyLoop of HenleLoop of Henle CellsKidney
    KidneyProximal TubuleProximal Tubule CellsKidney
    KidneyEpithelial TubuleKidney
    KidneyLoop of HenleKidney
    KidneyMetanephrosKidney
    KidneyProximal TubuleKidney
    Reproductive SystemMesonephrosReproductive System
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)Endothelium
    PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)Cartilage, Neural Crest

    See AADAC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AADAC

    SOURCE GeneReport for Unigene cluster: Hs.506908

    UniProtKB/Swiss-Prot: AAAD_HUMAN, P22760
    Tissue specificity: Mainly expressed in liver, small intestine, colon and adrenal gland

        SABiosciences Expression via Pathway-Focused PCR Array including AADAC: 
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    In Situ
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    Orthologs
    for AADAC gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for AADAC gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves AADACL21 arylacetamide deacetylase-like 2 61.49(n)
    57.89(a)    		   425034  XM_422836.3  XP_422836.2 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 61(a)
    		 1 → many
    		 3(17852058-17873020)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1001489121 arylacetamide deacetylase-like 54.25(n)
    50.51(a)    		   100148912  XM_001923679.3  XP_001923714.2 
    worm
    (Caenorhabditis elegans)    		 Secernentea Y43F8A.36
    F16F9.46
    (see all 4)    		 Protein F16F9.4
    (see all 4)    		 24(a)
    23(a)
    (see all 4)    		 many ↔ many
    many ↔ many
    (see all 4)    		 V(19377415-19381002)
    X(8459769-8463277)
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria aes6
    		 acetyl esterase
    		 18(a)
    		 possible ortholog
    		 Chromosome(498238-499197)


    ENSEMBL Gene Tree for AADAC (if available)
    TreeFam Gene Tree for AADAC (if available) 

    Paralogs
    for AADAC gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AADAC gene
    AADACL42  LIPE2  AADACL32  NCEH12  AADACL22  
    4 SIMAP similar genes for AADAC using alignment to 2 protein entries:     AAAD_HUMAN (see all proteins):
    AADACL2    NCEH1    AADACL3    AADACL4

    AADAC for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for AADAC
    PGOHUM00000238233 PGOHUM00000238234


    Genomic Variants
    for AADAC gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/410 NCBI SNPs in AADAC are shown (see all 410)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs622728851,2
    		F,--151529878(+) ACCCAT/CAGCAC 1 -- us2k14Minor allele frequency- C:0.04NA CSA WA 242
    rs1862160561,2
    		--151529933(+) CCATTC/TGACTT 1 -- us2k10--------
    rs346387341,2
    		C,F,--151529999(+) GAATAC/ACTCCC 1 -- us2k19Minor allele frequency- A:0.18NA WA EA 372
    rs1915129221,2
    		--151530007(+) CCCAAC/TACTCT 1 -- us2k10--------
    rs21209821,2
    		C,F,O,A,H,--151530121(-) TGTTGA/GTTTTT 1 -- us2k1 tfbs338Minor allele frequency- N:0.00NS EA NA WA CSA 3398
    rs1393849501,2
    		--151530144(+) AAGTGC/TGAAAT 1 -- us2k10--------
    rs1833436301,2
    		--151530145(+) AGTGCA/GAAATC 1 -- us2k10--------
    rs730164051,2
    		C,--151530259(+) CACCAG/ACTAAC 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1910209881,2
    		--151530301(+) CTCTTC/GTCAGA 1 -- us2k10--------
    rs168339351,2
    		C,F,H,--151530313(+) CAATTC/TGACTC 1 -- us2k127Minor allele frequency- T:0.16NA EA NS WA CSA 2390

    HapMap Linkage Disequilibrium report for AADAC (151531825 - 151546276 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 6 variations for AADAC
         6 CNVs: 53229 2479 53907 3457 63622 50962
    Human Gene Mutation Database (HGMD): AADAC

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AADAC
    DNA2.0 Custom Variant and Variant Library Synthesis for AADAC

    Disorders / Diseases
    for AADAC gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    AADAC for disorders           About GeneDecksing

    OMIM gene information: 600338    OMIM disorders: --

    8 diseases for AADAC:    About MalaCards
    ectropion    hermaphroditism    infertility    prostate cancer
    prostatitis    tuberculosis    hepatitis    mycobacterium tuberculosis

    2 diseases from the University of Copenhagen DISEASES database for AADAC:
    Neutral lipid storage disease     Ectropion
    Human Genome Epidemiology (HuGE) Navigator: AADAC (2 documents)

    Export disorders for AADAC gene to outside databases

    Publications
    for AADAC gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AADAC gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with AADAC)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human liver arylacetamide deacetylase. Molecular cloning of a novel esterase involved in the metabolic activation of arylamine carcinogens with high sequence similarity to hormone-sensitive lipase. (PubMed id 8063807)1, 2, 3, 9 Probst M.R.... Gasser R. (1994)
    2. Human arylacetamide deacetylase is a principal enzyme in flutamide hydrolysis. (PubMed id 19339378)1, 2, 9 Watanabe A.... Yokoi T. (2009)
    3. Purification and characterization of a human liver arylacetamide deacetylase. (PubMed id 2043131)1, 2, 9 Probst M.R.... Meyer U.A. (1991)
    4. Human carboxylesterases and their role in xenobiotic and endobiotic metabolism. (PubMed id 17936933)1, 2 Ross M.K. and Crow J.A. (2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Catalog of 680 variations among eight cytochrome p450 (CYP) genes, nine esterase genes, and two other genes in the Japanese population. (PubMed id 12721789)1, 2 Saito S....Nakamura Y. (2003)
    7. Radiation hybrid mapping of human arylacetamide deacetylase (AADAC) locus to chromosome 3. (PubMed id 9299245)1, 9 Yamazaki K....Tanaka I. (1997)
    8. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
    9. Human arylacetamide deacetylase is responsible for de acetylation of rifamycins: rifampicin, rifabutin, and rifapentine. (PubMed id 21856291)1 Nakajima A....Yokoi T. (2011)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)

    External Searches for AADAC gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing AADAC gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 13 HGNC: 17 AceView: AADAC Ensembl:ENSG00000114771 euGenes: HUgn13
    ECgene: AADAC H-InvDB: AADAC

    Other Databases showing AADAC gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing AADAC gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AADAC Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for AADAC Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for AADAC gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for AADAC gene:
    Search GeneIP for patents involving AADAC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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