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AADAC Gene

protein-coding   GIFtS: 59
GCID: GC03P151531

Arylacetamide Deacetylase

(Previous name: arylacetamide deacetylase (esterase))
  See AADAC-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Arylacetamide Deacetylase1 2     EC 3.1.1.33
DAC2 3 5     EC 3.1.18
Arylacetamide Deacetylase (Esterase)1 2     EC 3.1.1.798
CES5A12     

External Ids:    HGNC: 171   Entrez Gene: 132   Ensembl: ENSG000001147717   OMIM: 6003385   UniProtKB: P227603   

Export aliases for AADAC gene to outside databases

Previous GC identifers: GC03P148473 GC03P152364 GC03P152813 GC03P152852 GC03P153014 GC03P151515 GC03P148922


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AADAC Gene:
Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase,
which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens
(provided by RefSeq, Jul 2008)

GeneCards Summary for AADAC Gene:
AADAC (arylacetamide deacetylase) is a protein-coding gene. Diseases associated with AADAC include neutral lipid storage disease, and ectropion. GO annotations related to this gene include and deacetylase activity. An important paralog of this gene is AADACL4.

UniProtKB/Swiss-Prot: AAAD_HUMAN, P22760
Function: Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty
acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density
lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide
substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds
and increasing their toxicity

Gene Wiki entry for AADAC Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the AADAC gene promoter:
         MEF-2A   TBP   POU2F1   POU2F1a   FOXO4   aMEF-2   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAADAC promoter sequence
   Search Chromatin IP Primers for AADAC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AADAC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q25.1   Ensembl cytogenetic band:  3q25.1   HGNC cytogenetic band: 3q25.1

AADAC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AADAC gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P151531:  view genomic region     (about GC identifiers)

Start:
151,531,825 bp from pter      End:
151,546,276 bp from pter
Size:
14,452 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: AAAD_HUMAN, P22760 (See protein sequence)
Recommended Name: Arylacetamide deacetylase  
Size: 399 amino acids; 45734 Da
Miscellaneous: Can hydrolyze a number of clinical drugs such as flutamide, an antiandrogen drug used for the
treatment of prostate cancer; phenacetin, an analgesic antipyretic which has been withdrawn from the market due
to its links with renal failure; and rifamycins which have been used as antituberculosis drugs
Sequence caution: Sequence=AAA35551.1; Type=Frameshift; Positions=53, 56;
Secondary accessions: A8K3L3 D3DNJ6 Q8N1A9

Explore the universe of human proteins at neXtProt for AADAC: NX_P22760

Explore proteomics data for AADAC at MOPED

Post-translational modifications: 

  • Glycosylation is required for enzyme activity1
  • Glycosylation2 at Asn78, Asn282
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for AADAC (P22760)
     GDSAGGNL  DPDVKIKLK  RFWSEYFTTDR  LRRGLFYIHGGGWC 


    See AADAC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001077.2  
    ENSEMBL proteins: 
     ENSP00000232892   ENSP00000419620  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR017157 Arylacetamide_deacetylase
     IPR013094 AB_hydrolase_3
     IPR002168 Lipase_GDXG_AS

    Graphical View of Domain Structure for InterPro Entry P22760

    ProtoNet protein and cluster: P22760

    2 Blocks protein domains:
    IPB002168 Lipolytic enzyme
    IPB013094 Alpha/beta hydrolase fold-3


    UniProtKB/Swiss-Prot: AAAD_HUMAN, P22760
    Similarity: Belongs to the 'GDXG' lipolytic enzyme family


    Find genes that share domains with AADAC           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AAAD_HUMAN, P22760
    Function: Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty
    acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density
    lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide
    substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds
    and increasing their toxicity
    Catalytic activity: Triacylglycerol + H(2)O = diacylglycerol + a carboxylate
    Biophysicochemical properties: Kinetic parameters: KM=0.8 mM for flutamide (PubMed:19339378); KM=0.6 mM for
    flutamide (PubMed:22207054); KM=0.472 mM for flutamide (PubMed:22415931); KM=3.05 mM for phenacetin
    (PubMed:24125761); KM=1.8 mM for phenacetin (PubMed:22207054); KM=1.42 mM for phenacetin (PubMed:22415931);
    KM=0.2 mM for rifampicin (PubMed:22207054); KM=0.154 mM for rifampicin (PubMed:22415931); Vmax=1.1 nmol/min/mg
    enzyme toward flutamide (PubMed:19339378); Vmax=1.1 nmol/min/mg enzyme toward flutamide (PubMed:22207054);
    Vmax=0.617 nmol/min/mg enzyme toward flutamide (PubMed:22415931); Vmax=1.34 nmol/min/mg enzyme toward phenacetin
    (PubMed:24125761); Vmax=6.4 nmol/min/mg enzyme toward phenacetin (PubMed:22207054); Vmax=1.42 nmol/min/mg enzyme
    toward phenacetin (PubMed:22415931); Vmax=0.149 nmol/min/mg enzyme toward rifampicin (PubMed:22207054);
    Vmax=0.060 nmol/min/mg enzyme toward rifampicin (PubMed:22415931);
    Induction: Down-regulated following infection with hepatis C virus which results in impaired triacylglycerol
    lipolysis and impaired assembly of very low density lipoproteins. This may represent a cellular adaptation to
    infection that is aimed at limiting viral production

         Genatlas biochemistry entry for AADAC:
    arylacetamide deacetylase,microsomal,liver

         Enzyme Numbers (IUBMB): EC 3.1.1.31 EC 3.1.12 EC 3.1.1.792

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity TAS8063807
    GO:0004806triglyceride lipase activity ISS--
    GO:0016298lipase activity TAS11481320
    GO:0016787hydrolase activity ----
    GO:0017171serine hydrolase activity IDA17936933
         
    Find genes that share ontologies with AADAC           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for AADAC:
     Decreased viability with pacli 

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AAAD_HUMAN, P22760: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Microsome membrane;
    Single-pass type II membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    golgi apparatus3
    extracellular2
    cytosol1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IDA10318829
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with AADAC           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including AADAC: 
              Drug Metabolism: Phase I Enzymes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for AADAC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for AADAC (ENSP000002328924) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HDAC2ENSP000003813314STRING: ENSP00000381331
    PFDN1ENSP000002618134STRING: ENSP00000261813
    PFDN5ENSP000003341884STRING: ENSP00000334188
    SIN3AENSP000003536224STRING: ENSP00000353622
    SIN3BENSP000003691314STRING: ENSP00000369131
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008152metabolic process ----
    GO:0010898positive regulation of triglyceride catabolic process ISS--

    Find genes that share ontologies with AADAC           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AADAC (AAAD)

    3 HMDB Compounds for AADAC    About this table
    CompoundSynonyms CAS #PubMed Ids
    3-Aminosalicylic acid3-Amino Salicylate (see all 16)570-23-0--
    AnilineAminobenzene (see all 16)62-53-3--
    Ecgonine(2R,3S)-3-hydroxy-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid (see all 5)481-37-8--

    1 Novoseek inferred chemical compound relationship for AADAC gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arylamine 76.3 3 8063807 (2)



    Find genes that share compounds with AADAC           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for AADAC gene: 
    NM_001086.2  

    Unigene Cluster for AADAC:

    Arylacetamide deacetylase
    Hs.506908  [show with all ESTs]
    Unigene Representative Sequence: NM_001086
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000232892(uc003eze.3) ENST00000488869
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat AADAC

    Additional mRNA sequence: 

    AK290628.1 BC020706.1 BC032309.1 L32179.1 

    6 DOTS entries:

    DT.415010  DT.95156022  DT.101980759  DT.92460876  DT.99957497  DT.434029 

    Selected AceView cDNA sequences (see all 68):

    AV685871 BC032309 CB148233 CR624107 CB156860 AW951425 L32179 CB105350 
    AV702720 BX431750 BI760687 BC020706 AA777647 AV685841 AV705031 NM_001086 
    BG569285 CF597071 BG567565 BQ695358 BX443932 AV703616 BG542396 AA702700 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AADAC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGCATAATT
    AADAC Expression
    About this image


    AADAC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Kidney (Urinary System)    fully expand to see all 7 entries
             Presumptive Podocytes Podocyte Layer
             Metanephros
     
     Epithelial Cells
             Duct Cells Pancreatic Ducts
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Eye (Sensory Organs)
             Lens
     
     Neural Tube (Nervous System)
             Metencephalon
    AADAC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AADAC Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.506908

    UniProtKB/Swiss-Prot: AAAD_HUMAN, P22760
    Tissue specificity: Detected in liver (at protein level). Mainly expressed in liver, small intestine, colon,
    adrenal gland and bladder

        Pathway & Disease-focused RT2 Profiler PCR Array including AADAC: 
              Drug Metabolism: Phase I Enzymes in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for AADAC gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aadac1 , 5 arylacetamide deacetylase (esterase)1, 5 72.73(n)1
    69.95(a)1
      3 (29.17 cM)5
    677581  NM_023383.11  NP_075872.11 
     600317635 
    chicken
    (Gallus gallus)
    Aves AADACL21 arylacetamide deacetylase-like 2 61.49(n)
    57.89(a)
      425034  XM_422836.4  XP_422836.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    61(a)
    1 → many
    3(17851732-17873020)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia aadac1 arylacetamide deacetylase 60.15(n)
    53.63(a)
      448381  NM_001004960.1  NP_001004960.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1001489121 arylacetamide deacetylase-like 54.39(n)
    50.13(a)
      100148912  XM_001923679.4  XP_001923714.2 
    worm
    (Caenorhabditis elegans)
    Secernentea trcs-16
    F16F9.46
    (see all 4)
    Protein F16F9.4 (F16F9.4) mRNA, complete cds
    (see all 4)
    25(a)
    24(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    IV(9587098-9588834) WBGene00009186
    X(8459822-8463330) WBGene00017515


    ENSEMBL Gene Tree for AADAC (if available)
    TreeFam Gene Tree for AADAC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AADAC gene
    AADACL42  AADACL32  NCEH12  AADACL22  
    4 SIMAP similar genes for AADAC using alignment to 2 protein entries:     AAAD_HUMAN (see all proteins):
    AADACL2    NCEH1    AADACL3    AADACL4

    Find genes that share paralogs with AADAC           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for AADAC
    PGOHUM00000238233 PGOHUM00000238234


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    AAAD_HUMAN, P22760: Three alleles are known: AADAC*1, AADAC*2 and AADAC*3. The sequence shown is that of AADAC*1 which
    is found in European American, African American, Japanese and Korean populations at allelic frequencies of 39.3
    to 47.4%. The AADAC*2 allele is found in European American, African American, Korean, and Japanese populations at
    allelic frequencies of 52.6 to 63.5% whereas the AADAC*3 allele is found in European American (1.3%) and African
    American (2.0%) samples but not in Japanese or Korean samples


    Selected SNPs for AADAC (see all 461)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs622728851,2
    C,F--151529878(+) ACCCAT/CAGCAC 1 -- us2k14Minor allele frequency- C:0.04NA CSA WA 242
    rs1862160561,2
    --151529933(+) CCATTC/TGACTT 1 -- us2k10--------
    rs346387341,2
    C,F--151529999(+) GAATAC/ACTCCC 1 -- us2k19Minor allele frequency- A:0.18NA WA EA 372
    rs1915129221,2
    --151530007(+) CCCAAC/TACTCT 1 -- us2k10--------
    rs21209821,2
    C,F,O,A,H--151530121(-) TGTTGA/GTTTTT 1 -- us2k1 tfbs338Minor allele frequency- N:0.00NS EA NA WA CSA 3398
    rs1393849501,2
    --151530144(+) AAGTGC/TGAAAT 1 -- us2k10--------
    rs1833436301,2
    --151530145(+) AGTGCA/GAAATC 1 -- us2k10--------
    rs730164051,2
    C,F--151530259(+) CACCAG/ACTAAC 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1910209881,2
    --151530301(+) CTCTTC/GTCAGA 1 -- us2k10--------
    rs168339351,2
    C,F,H--151530313(+) CAATTC/TGACTC 1 -- us2k127Minor allele frequency- T:0.16NA EA NS WA CSA 2390

    HapMap Linkage Disequilibrium report for AADAC (151531825 - 151546276 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for AADAC (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2672544CNV Deletion23128226
    dgv622n27CNV Loss19166990
    dgv5276n71CNV Loss21882294
    nsv514175CNV Loss21397061
    nsv522472CNV Loss19592680
    nsv517155CNV Loss19592680
    dgv621n27CNV Loss19166990
    nsv877654CNV Loss21882294
    nsv877655CNV Loss21882294
    esv25716CNV Loss19812545

    Human Gene Mutation Database (HGMD): AADAC
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AADAC
    DNA2.0 Custom Variant and Variant Library Synthesis for AADAC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600338    OMIM disorders: --

    3 diseases for AADAC:    
    About MalaCards
    neutral lipid storage disease    ectropion    lipid storage disease

    2 diseases from the University of Copenhagen DISEASES database for AADAC:
    Neutral lipid storage disease     Ectropion

    Find genes that share disorders with AADAC           About GenesLikeMe

    Genetic Association Database (GAD): AADAC
    Human Genome Epidemiology (HuGE) Navigator: AADAC (2 documents)

    Export disorders for AADAC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AADAC gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with AADAC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human liver arylacetamide deacetylase. Molecular cloning of a novel esterase involved in the metabolic activation of arylamine carcinogens with high sequence similarity to hormone-sensitive lipase. (PubMed id 8063807)1, 2, 3, 9 Probst M.R.... Gasser R. (J. Biol. Chem. 1994)
    2. Human arylacetamide deacetylase is a principal enzyme in flutamide hydrolysis. (PubMed id 19339378)1, 2, 9 Watanabe A.... Yokoi T. (Drug Metab. Dispos. 2009)
    3. Purification and characterization of a human liver arylacetamide deacetylase. (PubMed id 2043131)1, 2, 9 Probst M.R.... Meyer U.A. (Biochem. Biophys. Res. Commun. 1991)
    4. N-Glycosylation during translation is essential for human arylacetamide deacetylase enzyme activity. (PubMed id 24125761)1, 2 Muta K.... Yokoi T. (Biochem. Pharmacol. 2014)
    5. Arylacetamide deacetylase: a novel host factor with important roles in the lipolysis of cellular triacylglycerol stores, VLDL assembly and HCV production. (PubMed id 23542347)1, 2 Nourbakhsh M.... Kneteman N.M. (J. Hepatol. 2013)
    6. A novel polymorphic allele of human arylacetamide deacetylase leads to decreased enzyme activity. (PubMed id 22415931)1, 2 Shimizu M....Yokoi T. (Drug Metab. Dispos. 2012)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    8. Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency. (PubMed id 20694011)1, 4 Ferreira R.C....HammarstrAPm L. (Nat. Genet. 2010)
    9. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1, 4 Saito A....Kamatani N. (J. Hum. Genet. 2009)
    10. Human carboxylesterases and their role in xenobiotic and endobiotic metabolism. (PubMed id 17936933)1, 2 Ross M.K. and Crow J.A. (J. Biochem. Mol. Toxicol. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 13 HGNC: 17 AceView: AADAC Ensembl:ENSG00000114771 euGenes: HUgn13
    ECgene: AADAC H-InvDB: AADAC

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for AADAC Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for AADAC Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for AADAC gene:
    Search GeneIP for patents involving AADAC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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