Aliases for AADAC Gene
External Ids for AADAC Gene
Previous GeneCards Identifiers for AADAC Gene
Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens [provided by RefSeq, Jul 2008]
GeneCards Summary for AADAC Gene
AADAC (Arylacetamide Deacetylase) is a Protein Coding gene. Diseases associated with AADAC include Neutral Lipid Storage Disease. Among its related pathways are Phase II conjugation and cytochrome P450. GO annotations related to this gene include hydrolase activity and triglyceride lipase activity. An important paralog of this gene is AADACL3.
UniProtKB/Swiss-Prot for AADAC Gene
Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity.