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Aliases for AACS Gene

Aliases for AACS Gene

  • Acetoacetyl-CoA Synthetase 2 3
  • Acyl-CoA Synthetase Family Member 1 2 3 4
  • ACSF1 3 4 6
  • Protein Sur-5 Homolog 3 4
  • EC 4 63
  • Homolog Of C. Elegans Supressor Of Ras 5 (Sur-5) 3
  • Acetoacetate-CoA Ligase 3
  • EC 6.2.1 63
  • SUR-5 3

External Ids for AACS Gene

Previous GeneCards Identifiers for AACS Gene

  • GC12P125273
  • GC12P123904
  • GC12P123905
  • GC12P124074
  • GC12P124115
  • GC12P125549
  • GC12P122513

Summaries for AACS Gene

GeneCards Summary for AACS Gene

AACS (Acetoacetyl-CoA Synthetase) is a Protein Coding gene. Diseases associated with AACS include tracheal cancer. Among its related pathways are Butanoate metabolism. GO annotations related to this gene include butyrate-CoA ligase activity and acetoacetate-CoA ligase activity. An important paralog of this gene is ACSS3.

UniProtKB/Swiss-Prot for AACS Gene

  • Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AACS Gene

Genomics for AACS Gene

Regulatory Elements for AACS Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for AACS Gene

125,065,379 bp from pter
125,143,333 bp from pter
77,955 bases
Plus strand

Genomic View for AACS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AACS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AACS Gene

Proteins for AACS Gene

  • Protein details for AACS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Acetoacetyl-CoA synthetase
    Protein Accession:
    Secondary Accessions:
    • Q49AB9
    • Q49AC3
    • Q658Q8
    • Q8IWD2
    • Q8NEW5
    • Q9BSJ9
    • Q9H829
    • Q9HA19

    Protein attributes for AACS Gene

    672 amino acids
    Molecular mass:
    75144 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH41000.1; Type=Frameshift; Positions=201; Evidence={ECO:0000305}; Sequence=BAB14793.1; Type=Frameshift; Positions=519; Evidence={ECO:0000305};

    Alternative splice isoforms for AACS Gene


neXtProt entry for AACS Gene

Proteomics data for AACS Gene at MOPED

Post-translational modifications for AACS Gene

  • Ubiquitination at Lys95
  • Modification sites at PhosphoSitePlus

Other Protein References for AACS Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for AACS Gene

Gene Families for AACS Gene

  • ACS :Acyl-CoA synthetase family

Protein Domains for AACS Gene

Suggested Antigen Peptide Sequences for AACS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q86V21
  • Belongs to the ATP-dependent AMP-binding enzyme family.
genes like me logo Genes that share domains with AACS: view

Function for AACS Gene

Molecular function for AACS Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + acetoacetate + CoA = AMP + diphosphate + acetoacetyl-CoA
UniProtKB/Swiss-Prot Function: Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development (By similarity).

Enzyme Numbers (IUBMB) for AACS Gene

Gene Ontology (GO) - Molecular Function for AACS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IEA --
GO:0030729 acetoacetate-CoA ligase activity IEA --
GO:0047760 butyrate-CoA ligase activity IEA --
genes like me logo Genes that share ontologies with AACS: view

Animal Model Products

CRISPR Products

miRNA for AACS Gene

miRTarBase miRNAs that target AACS

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AACS

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for AACS Gene

Localization for AACS Gene

Subcellular locations from UniProtKB/Swiss-Prot for AACS Gene

Cytoplasm, cytosol.

Subcellular locations from

Jensen Localization Image for AACS Gene COMPARTMENTS Subcellular localization image for AACS gene
Compartment Confidence
cytosol 2
mitochondrion 2
nucleus 2
peroxisome 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for AACS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with AACS: view

Pathways for AACS Gene

SuperPathways for AACS Gene

Superpath Contained pathways
1 Butanoate metabolism
genes like me logo Genes that share pathways with AACS: view

Pathways by source for AACS Gene

1 KEGG pathway for AACS Gene

Gene Ontology (GO) - Biological Process for AACS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001889 liver development IEA --
GO:0006629 lipid metabolic process --
GO:0006631 fatty acid metabolic process IEA --
GO:0007584 response to nutrient IEA --
GO:0008152 metabolic process --
genes like me logo Genes that share ontologies with AACS: view

Compounds for AACS Gene

(7) HMDB Compounds for AACS Gene

Compound Synonyms Cas Number PubMed IDs
Acetoacetic acid
  • 3-Ketobutyrate
  • 3-acetoacetyl-CoA
Adenosine monophosphate
  • 5'-AMP
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
Coenzyme A
  • Acetoacetyl coenzyme A sodium salt
genes like me logo Genes that share compounds with AACS: view

Transcripts for AACS Gene

Unigene Clusters for AACS Gene

Acetoacetyl-CoA synthetase:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AACS

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AACS Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b · 19c ·
SP1: - - - - -
SP2: - - - - - - - - -
SP3: - -
SP4: -
SP5: - - - - - - - - -
SP7: - -
SP8: -

ExUns: 19d · 19e

Relevant External Links for AACS Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AACS Gene

mRNA expression in normal human tissues for AACS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AACS Gene

SOURCE GeneReport for Unigene cluster for AACS Gene Hs.656073

mRNA Expression by UniProt/SwissProt for AACS Gene

Tissue specificity: Highly expressed in kidney, heart and brain, but low in liver.
genes like me logo Genes that share expressions with AACS: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for AACS Gene

Orthologs for AACS Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AACS Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia AACS 35
  • 99.22 (n)
  • 99.06 (a)
  • 100 (a)
(Bos Taurus)
Mammalia AACS 35
  • 86.81 (n)
  • 91.67 (a)
  • 92 (a)
(Canis familiaris)
Mammalia AACS 35
  • 85.98 (n)
  • 87.46 (a)
(Mus musculus)
Mammalia Aacs 35
  • 84.67 (n)
  • 89.88 (a)
Aacs 16
Aacs 36
  • 90 (a)
(Monodelphis domestica)
Mammalia AACS 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 78 (a)
-- 36
  • 63 (a)
(Rattus norvegicus)
Mammalia Aacs 35
  • 84.52 (n)
  • 89.29 (a)
(Gallus gallus)
Aves AACS 35
  • 77.09 (n)
  • 86.1 (a)
  • 81 (a)
(Anolis carolinensis)
Reptilia AACS 36
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia aacs 35
  • 72.15 (n)
  • 78.13 (a)
Str.18908 35
(Danio rerio)
Actinopterygii aacs 35
  • 72.59 (n)
  • 77.81 (a)
aacs 36
  • 78 (a)
zgc56105 35
(Caenorhabditis elegans)
Secernentea sur-5 35
  • 49.35 (n)
  • 40.55 (a)
sur-5 36
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ACS2 36
  • 20 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00446 35
  • 51.14 (n)
  • 44.1 (a)
Species with no ortholog for AACS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AACS Gene

Gene Tree for AACS (if available)
Gene Tree for AACS (if available)

Paralogs for AACS Gene

Paralogs for AACS Gene Pseudogenes for AACS Gene

genes like me logo Genes that share paralogs with AACS: view

Variants for AACS Gene

Sequence variations from dbSNP and Humsavar for AACS Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs728906 -- 125,069,974(+) TTCAG(A/G)GTTCC intron-variant
rs751807 -- 125,128,612(-) TTCAA(C/T)GACCA intron-variant
rs877405 -- 125,089,254(-) TCCAA(C/G)GGGCA intron-variant
rs879993 -- 125,070,916(+) TCACT(A/G)TGTGG intron-variant
rs900410 -- 125,097,845(+) TTTCA(C/T)TCCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AACS Gene

Variant ID Type Subtype PubMed ID
nsv899596 CNV Loss 21882294
esv2746555 CNV Deletion 23290073
esv2746556 CNV Deletion 23290073
esv2746557 CNV Deletion 23290073
esv2784 CNV Deletion 18987735
esv2746558 CNV Deletion 23290073
esv2746559 CNV Deletion 23290073
esv2746560 CNV Deletion 23290073
esv2746561 CNV Deletion 23290073
esv2746562 CNV Deletion 23290073

Relevant External Links for AACS Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AACS Gene

Disorders for AACS Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for AACS Gene including...

Search for AACS Gene in MalaCards »

(1) University of Copenhagen DISEASES for AACS Gene

Relevant External Links for AACS

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with AACS: view

No data available for UniProtKB/Swiss-Prot for AACS Gene

Publications for AACS Gene

  1. Expression of acetoacetyl-CoA synthetase, a novel cytosolic ketone body-utilizing enzyme, in human brain. (PMID: 12623130) Ohgami M. … Fukui T. (Biochem. Pharmacol. 2003) 2 3 4 23
  2. Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. (PMID: 17762044) Watkins P.A. … Pevsner J. (J. Lipid Res. 2007) 2 3 4
  3. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PMID: 18660489) Lu Y. … Boer J.M. (J. Lipid Res. 2008) 3 48
  4. Transcriptional regulation of the human acetoacetyl-CoA synthetase gene by PPARgamma. (PMID: 20102333) AguilA^ F. … Haro D. (Biochem. J. 2010) 3 23
  5. Caenorhabditis elegans SUR-5, a novel but conserved protein, negatively regulates LET-60 Ras activity during vulval induction. (PMID: 9671465) Gu T. … Han M. (Mol. Cell. Biol. 1998) 3 4

Products for AACS Gene

Sources for AACS Gene

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