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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

AACS Gene

protein-coding GIFtS: 56
GCID: GC12P125549

acetoacetyl-CoA synthetase

Explore 3 diseases affiliated with
AACS via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Acetoacetyl-CoA Synthetase¹ ²		EC 6.2.1.16³ ⁸
ACSF1¹ ² ³		FLJ12389¹
SUR-5¹ ²		Acetoacetate-CoA Ligase²
Acyl-CoA Synthetase Family Member 1² ³		Homolog Of C. Elegans Supressor Of Ras 5 (Sur-5)²
Protein Sur-5 Homolog² ³		EC 6.2.1⁸

External Ids:	HGNC: 21298¹	Entrez Gene: 65985²	Ensembl: ENSG00000081760⁷	OMIM: 614364⁵	UniProtKB: Q86V21³

Export aliases for AACS gene to outside databases

Previous GC identifers: GC12P125273 GC12P123904 GC12P123905 GC12P124074 GC12P124115 GC12P122513

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: AACS_HUMAN, Q86V21

Function: Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty

acid-synthesis during adipose tissue development (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_009755.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the AACS gene promoter:
E2F-3a E2F-4 USF1 E2F-5 FOXF2 CUTL1 E2F-2 E2F-1 E2F USF-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: AACS promoter sequence

Search SABiosciences Chromatin IP Primers for AACS

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AACS

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31 Ensembl cytogenetic band: 12q24.31 HGNC cytogenetic band: 12q24.31

AACS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AACS gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P125549: view genomic region (about GC identifiers)

Start:	125,549,925 bp from pter	End:	125,627,873 bp from pter
Size:	77,949 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: AACS_HUMAN, Q86V21 (See protein sequence)

Recommended Name: Acetoacetyl-CoA synthetase

Size: 672 amino acids; 75144 Da

Subcellular location: Cytoplasm, cytosol (By similarity)

Sequence caution: Sequence=AAH41000.1; Type=Frameshift; Positions=201; Sequence=BAB14793.1; Type=Frameshift;

Positions=519;

Secondary accessions: Q49AB9 Q49AC3 Q658Q8 Q8IWD2 Q8NEW5 Q9BSJ9 Q9H829 Q9HA19

Alternative splicing: 3 isoforms: Q86V21-1 Q86V21-2 Q86V21-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for AACS: NX_Q86V21

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q86V21

4/20 DME Specific Peptides for AACS (Q86V21) (see all 20)

STGSPLK

GWMMWNW

GTTGAPK

DFWAEFWK

AACS Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_076417.2

ENSEMBL proteins:

ENSP00000324842 ENSP00000442691 ENSP00000416461 ENSP00000439931 ENSP00000442956

ENSP00000392967 ENSP00000324929 ENSP00000439151 ENSP00000441686 ENSP00000441387

ENSP00000441331 ENSP00000442007 ENSP00000261686

Human Recombinant Protein Products for AACS:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	GenScript Custom Purified and Recombinant Proteins Services for AACS
	Novus Biologicals AACS Proteins Novus Biologicals AACS Lysates
	Sino Biological Recombinant Protein for AACS
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for AACS

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	IEA	--

AACS for ontologies About GeneDecksing

AACS Antibody Products:

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Assay Products for AACS:

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	Uscn ELISAs and CLIAs for AACS

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

AACS for domains About GeneDecksing

4 InterPro domains/families:

IPR005914 Acac_CoA_synth

IPR000873 AMP-dep_Synth/Lig

IPR024597 Acyl-CoA_synth_DUF3448

IPR020845 AMP-binding_CS

Graphical View of Domain Structure for InterPro Entry Q86V21

ProtoNet protein and cluster: Q86V21

1 Blocks protein family: IPB000873 AMP-binding signature

UniProtKB/Swiss-Prot: AACS_HUMAN, Q86V21

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: AACS_HUMAN, Q86V21

Function: Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty

acid-synthesis during adipose tissue development (By similarity)

Catalytic activity: ATP + acetoacetate + CoA = AMP + diphosphate + acetoacetyl-CoA

Enzyme Numbers (IUBMB): EC 6.2.1.16¹ ² EC 6.2.1²

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003824	catalytic activity	--	--
GO:0005524	ATP binding	IEA	--
GO:0030729	acetoacetate-CoA ligase activity	IEA	--
GO:0047760	butyrate-CoA ligase activity	IEA	--

AACS for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for AACS

miRNA Products:		miRTarBase miRNAs that target AACS: hsa-mir-122 (MIRT003093)

		OriGene 3'-UTR Clone: AACS Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AACS
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate AACS:
		hsa-miR-544b hsa-miR-1226
		SwitchGear 3'UTR luciferase reporter plasmid: AACS 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AACS (see all 7) OriGene shRNA RFP: AACS OriGene siRNA: AACS
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		Sirion Biotech Custom design and validation of potent shRNA sequences against AACS

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		GenScript: all cDNA clones in your preferred vector: AACS (NM_023928)
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AACS

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Ketone body metabolism

Butanoate metabolism

0.17

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Kegg Pathway (Kegg details for AACS):

Butanoate metabolism

AACS for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for AACS

STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

5/12 Interacting proteins for AACS (ENSP00000324842⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 12)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ACAT1	ENSP00000265838⁴	STRING: ENSP00000265838
ACAT2	ENSP00000356015⁴	STRING: ENSP00000356015
BDH1	ENSP00000350914⁴	STRING: ENSP00000350914
BDH2	ENSP00000296424⁴	STRING: ENSP00000296424
EHHADH	ENSP00000231887⁴	STRING: ENSP00000231887

About this table

Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001889	liver development	IEA	--
GO:0006631	fatty acid metabolic process	IEA	--
GO:0007584	response to nutrient	IEA	--
GO:0010243	response to organic nitrogen	--	--
GO:0014070	response to organic cyclic compound	--	--

AACS for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for AACS

7 HMDB Compounds for AACS About this table

Compound	Synonyms	CAS #	PubMed Ids
Acetoacetic acid	3-Ketobutyrate (see all 9)	541-50-4	--
Acetoacetyl-CoA	3-acetoacetyl-CoA (see all 9)	1420-36-6	--
Adenosine monophosphate	5'-AMP (see all 28)	61-19-8	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
Coenzyme A	Acetoacetyl coenzyme A sodium salt (see all 21)	85-61-0	--
Phosphoric acid	acide phosphorique (FRENCH) (see all 20)	7664-38-2	--
Pyrophosphate	(4-)Diphosphoric acid ion (see all 10)	14000-31-8	--

Search CenterWatch for drugs/clinical trials and news about AACS

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for AACS gene:

NM_023928.3

Unigene Cluster for AACS:

Acetoacetyl-CoA synthetase

Hs.656073 [show with all ESTs]

Unigene Representative Sequence: BC036694

14 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000316519(uc001uhc.3 uc001uhd.3 uc009zyh.3) ENST00000536752

ENST00000418937(uc009zyg.2) ENST00000537477 ENST00000537564 ENST00000441247

ENST00000316543(uc009zyi.3) ENST00000539251 ENST00000538851 ENST00000545511

ENST00000536118 ENST00000543665 ENST00000398953 ENST00000261686

miRNA Products:		OriGene 3'-UTR Clone: AACS Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AACS
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate AACS:
		hsa-miR-544b hsa-miR-1226
		SwitchGear 3'UTR luciferase reporter plasmid: AACS 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		Sirion Biotech Custom design and validation of potent shRNA sequences against AACS

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		GenScript: all cDNA clones in your preferred vector: AACS (NM_023928)
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AACS
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AACS

Additional cDNA sequence:

AB054121.1 AK022451.1 AK024760.1 AK123245.1 AK304176.1 AK308779.1 AL833047.1 AY091468.1

BC004997.1 BC036694.1 BC040490.1 BC040574.1 BC041000.1 BC051862.1

15 DOTS entries:

DT.444953 DT.101982814 DT.100816242 DT.95247372 DT.97775423 DT.101982816 DT.100816246 DT.99967357

DT.95084150 DT.121138180 DT.92435351 DT.95084155 DT.100843153 DT.121643665 DT.99971630

24/203 AceView cDNA sequences (see all 203):

CR613420 AI783692 BE208094 CD723748 BQ888370 BU543521 BQ653038 BQ055505

BI856890 AU131024 BC051862 BF108425 BQ438135 AB054121 BC040574 CA308247

BC040490 BQ056788 BC004997 CB154636 CB123545 BI861200 BQ447105 AK123245

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for AACS (see all 8) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10a	·	10b	^	11a	·	11b	^	12a	·	12b	^	13	^	14a	·	14b	^	15a	·	15b	^	16	^	17	^	18	^	19a	·	19b	·	19c	·
SP1:											-								-								-										-								-
SP2:											-								-								-		-		-		-		-		-		-
SP3:																																					-								-
SP4:																																					-
SP5:																							-		-		-		-		-		-		-		-		-

ExUns:	19d	·	19e
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for AACS

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

AACS expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGAAAAAAA

About this image

AACS expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Retina

Eye

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See AACS Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AACS

SOURCE GeneReport for Unigene cluster: Hs.656073

UniProtKB/Swiss-Prot: AACS_HUMAN, Q86V21

Tissue specificity: Highly expressed in kidney, heart and brain, but low in liver

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for AACS gene from 7/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	AACS¹	acetoacetyl-CoA synthetase	77.09(n) 86.1(a)		416811 NM_001006184.1 NP_001006184.1
lizard (Anolis carolinensis)	Reptilia	AACS⁶	--	83(a)	1 ↔ 1	LGb(1270684-1298519)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.18908²	Transcribed sequence with weak similarity to protein refNP_061147.1 (H.sapiens) acetyl-CoA synthetase, isoform a; cytoplasmic acetyl-coenzyme A synthetase; acetate-CoA ligase; acyl-activating enzyme; acetate thiokinase [Homo sapiens] less	76.95(n)		AL898753.2
zebrafish (Danio rerio)	Actinopterygii	zgc56105²	similar to acetoacetyl-CoA synthetase	76.51(n)		393984 BC050501.1
worm (Caenorhabditis elegans)	Secernentea	sur-5¹	Protein SUR-5	49.35(n) 40.69(a)		180992 NM_076828.4 NP_509229.1
thale cress (Arabidopsis thaliana)	eudicotyledons	AAE18⁶ AAE17⁶	acyl-activating enzyme 17	15(a) 15(a)	1 ↔ many 1 ↔ many	1(20633360-20636892) 5(7731269-7735439)
rice (Oryza sativa)	Liliopsida	-- --	AMP-binding enzyme, putative, expressed	14(a) 14(a)	1 ↔ many 1 ↔ many	9(12816152-12820683) 3(33624793-33629717)

ENSEMBL Gene Tree for AACS (if available)
TreeFam Gene Tree for AACS (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for AACS gene

1 SIMAP similar gene for AACS using alignment to 13 protein entries: AACS_HUMAN (see all proteins):

ACSS3

AACS for paralogs About GeneDecksing

3 Pseudogenes.org Pseudogenes for AACS
PGOHUM00000260034 PGOHUM00000260035 PGOHUM00000260036

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs180833512^1,2		--	125548063(+)	`CACCAC/GCTTGG`	1	--	us2k¹		0	--	--	--	--
rs73421846^1,2	C	--	125548102(+)	`CTGCAG/ACGTGT`	1	--	us2k¹		1		WA	2
rs80083603^1,2	C	--	125548103(+)	`TGCAGC/TGTGTT`	1	--	us2k¹		3		WA CSA	121
rs7133646^1,2	C,A	--	125548232(+)	`GCCCCT/CACTCA`	1	--	us2k¹		8		NA WA CSA	15
rs12820649^1,2	C,F	--	125548246(+)	`TGGAGC/TTGCTC`	1	--	us2k¹		3		NA	6
rs61943930^1,2	C	--	125548507(+)	`GCAAAG/TAAAAG`	1	--	us2k¹		5		WA CSA NA EA	361
rs185575938^1,2		--	125548634(+)	`CGAGGC/TGGGTG`	1	--	us2k¹		0	--	--	--	--
rs190038991^1,2		--	125548806(+)	`CAGCCC/TGACCA`	1	--	us2k¹		0	--	--	--	--
rs79640438^1,2	C	--	125548824(+)	`AAAACA/CCTGTC`	1	--	us2k¹		0	--	--	--	--
rs114215998^1,2	F	--	125548938(+)	`GTTGCC/TGTGTG`	1	--	us2k¹		1		WA	118

HapMap Linkage Disequilibrium report for AACS (125549925 - 125627873 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for AACS
1 Indel: 41679

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AACS

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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AACS for disorders           About GeneDecksing

OMIM gene information: 614364    OMIM disorders: --

3 diseases for AACS:    About MalaCards

compartment syndrome tracheal cancer cholesterol

1 disease from the University of Copenhagen DISEASES database for AACS:

Tracheal cancer

Human Genome Epidemiology (HuGE) Navigator: AACS (1 document)

Export disorders for AACS gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for AACS gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with AACS)

Utopia: connect your pdf to the dynamic
world of online information

Expression of acetoacetyl-CoA synthetase, a novel cytosolic ketone body-utilizing enzyme, in human brain. (PubMed id 12623130)^{1, 2, 3, 9} Ohgami M.... Fukui T. (2003)
Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. (PubMed id 17762044)^{1, 2, 3} Watkins P.A.... Pevsner J. (2007)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Caenorhabditis elegans SUR-5, a novel but conserved protein, negatively regulates LET-60 Ras activity during vulval induction. (PubMed id 9671465)^{1, 2} Gu T.... Han M. (1998)
Transcriptional regulation of the human acetoacetyl-C oA synthetase gene by PPARgamma. (PubMed id 20102333)^{1, 9} AguilA^ F....Haro D. (2010)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)¹ Lu Y....Boer J.M. (2008)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 65985	HGNC: 21298	AceView: AACS	Ensembl:ENSG00000081760	euGenes: HUgn65985
ECgene: AACS	Kegg: 65985	H-InvDB: AACS

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for AACS	Pharmacogenomics, SNPs, Pathways

Intellectual Property for AACS gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for AACS gene:
Search GeneIP for patents involving AACS

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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