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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AACS Gene

protein-coding   GIFtS: 58
GCID: GC12P125549

Acetoacetyl-CoA Synthetase

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Acetoacetyl-CoA Synthetase1 2     SUR-52
Acyl-CoA Synthetase Family Member 11 2 3     Acetoacetate-CoA Ligase2
Protein Sur-5 Homolog2 3     Homolog Of C. Elegans Supressor Of Ras 5 (Sur-5)2
ACSF12 3     EC 6.2.18
EC 6.2.1.163 8     

External Ids:    HGNC: 212981   Entrez Gene: 659852   Ensembl: ENSG000000817607   OMIM: 6143645   UniProtKB: Q86V213   

Export aliases for AACS gene to outside databases

Previous GC identifers: GC12P125273 GC12P123904 GC12P123905 GC12P124074 GC12P124115 GC12P122513


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for AACS Gene: 
AACS (acetoacetyl-CoA synthetase) is a protein-coding gene. Diseases associated with AACS include tracheal cancer, and compartment syndrome, and among its related super-pathways are Synthesis and degradation of ketone bodies. GO annotations related to this gene include acetoacetate-CoA ligase activity and butyrate-CoA ligase activity. An important paralog of this gene is ACSS3.

UniProtKB/Swiss-Prot: AACS_HUMAN, Q86V21
Function: Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty
acid-synthesis during adipose tissue development (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_009755.19  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AACS gene promoter:
         E2F-3a   E2F-4   USF1   E2F-5   FOXF2   CUTL1   E2F-2   E2F-1   E2F   USF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAACS promoter sequence
   Search SABiosciences Chromatin IP Primers for AACS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AACS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24.31

AACS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AACS gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P125549:  view genomic region     (about GC identifiers)

Start:
125,549,925 bp from pter      End:
125,627,873 bp from pter
Size:
77,949 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AACS_HUMAN, Q86V21 (See protein sequence)
Recommended Name: Acetoacetyl-CoA synthetase  
Size: 672 amino acids; 75144 Da
Subcellular location: Cytoplasm, cytosol (By similarity)
Sequence caution: Sequence=AAH41000.1; Type=Frameshift; Positions=201; Sequence=BAB14793.1; Type=Frameshift;
Positions=519;
Secondary accessions: Q49AB9 Q49AC3 Q658Q8 Q8IWD2 Q8NEW5 Q9BSJ9 Q9H829 Q9HA19
Alternative splicing: 3 isoforms:  Q86V21-1   Q86V21-2   Q86V21-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for AACS: NX_Q86V21

Explore proteomics data for AACS at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86V21

  • 4/20 DME Specific Peptides for AACS (Q86V21) (see all 20)
     STGSPLK  GWMMWNW  GTTGAPK  DFWAEFWK 

    AACS Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    AACS Protein Expression
    REFSEQ proteins: NP_076417.2  
    ENSEMBL proteins: 
     ENSP00000324842   ENSP00000442691   ENSP00000416461   ENSP00000439931   ENSP00000442956  
     ENSP00000392967   ENSP00000324929   ENSP00000439151   ENSP00000441686   ENSP00000441387  
     ENSP00000441331   ENSP00000442007   ENSP00000261686  

    Human Recombinant Protein Products for AACS: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for AACS
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    Novus Biologicals AACS Proteins
    Novus Biologicals AACS Lysates
    Sino Biological Recombinant Protein for AACS
    Sino Biological Cell Lysate for AACS 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for AACS 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol IEA--

    AACS for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ACS: Acyl-CoA synthetase family

    4 InterPro protein domains:
     IPR005914 Acac_CoA_synth
     IPR000873 AMP-dep_Synth/Lig
     IPR024597 Acyl-CoA_synth_DUF3448
     IPR020845 AMP-binding_CS

    Graphical View of Domain Structure for InterPro Entry Q86V21

    ProtoNet protein and cluster: Q86V21

    1 Blocks protein domain: IPB000873 AMP-binding signature

    UniProtKB/Swiss-Prot: AACS_HUMAN, Q86V21
    Similarity: Belongs to the ATP-dependent AMP-binding enzyme family


    AACS for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AACS_HUMAN, Q86V21
    Function: Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty
    acid-synthesis during adipose tissue development (By similarity)
    Catalytic activity: ATP + acetoacetate + CoA = AMP + diphosphate + acetoacetyl-CoA

         Enzyme Numbers (IUBMB): EC 6.2.1.161 2 EC 6.2.12

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0005524ATP binding IEA--
    GO:0030729acetoacetate-CoA ligase activity IEA--
    GO:0047760butyrate-CoA ligase activity IEA--
         
    AACS for ontologies           About GeneDecksing


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    miRNA
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    miRTarBase miRNAs that target AACS:
    hsa-mir-122 (MIRT003093)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AACS
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate AACS:
    hsa-miR-544b hsa-miR-1226
    SwitchGear 3'UTR luciferase reporter plasmidAACS 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AACS


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for AACS About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Ketone body metabolism
    Butanoate metabolism0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1         Kegg Pathway  (Kegg details for AACS):
        Butanoate metabolism


    AACS for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AACS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/12 Interacting proteins for AACS (ENSP000003248424) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACAT1ENSP000002658384STRING: ENSP00000265838
    ACAT2ENSP000003560154STRING: ENSP00000356015
    BDH1ENSP000003509144STRING: ENSP00000350914
    BDH2ENSP000002964244STRING: ENSP00000296424
    EHHADHENSP000002318874STRING: ENSP00000231887
    About this table

    Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001889liver development IEA--
    GO:0006629lipid metabolic process ----
    GO:0006631fatty acid metabolic process IEA--
    GO:0007584response to nutrient IEA--
    GO:0008152metabolic process ----

    AACS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AACS

    7 HMDB Compounds for AACS    About this table
    CompoundSynonyms CAS #PubMed Ids
    Acetoacetic acid3-Ketobutyrate (see all 9)541-50-4--
    Acetoacetyl-CoA3-acetoacetyl-CoA (see all 9)1420-36-6--
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Coenzyme AAcetoacetyl coenzyme A sodium salt (see all 21)85-61-0--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    Search CenterWatch for drugs/clinical trials and news about AACS

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for AACS gene: 
    NM_023928.3  

    Unigene Cluster for AACS:

    Acetoacetyl-CoA synthetase
    Hs.656073  [show with all ESTs]
    Unigene Representative Sequence: BC036694
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000316519(uc001uhc.3 uc001uhd.3 uc009zyh.3) ENST00000536752
    ENST00000418937(uc009zyg.2) ENST00000537477 ENST00000537564 ENST00000441247
    ENST00000316543(uc009zyi.3) ENST00000539251 ENST00000538851 ENST00000545511
    ENST00000536118 ENST00000543665 ENST00000398953 ENST00000261686
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AACS
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate AACS:
    hsa-miR-544b hsa-miR-1226
    SwitchGear 3'UTR luciferase reporter plasmidAACS 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: AACS (NM_023928)
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AACS

    Additional mRNA sequence: 

    AB054121.1 AK022451.1 AK024760.1 AK123245.1 AK304176.1 AK308779.1 AL833047.1 AY091468.1 
    BC004997.1 BC036694.1 BC040490.1 BC040574.1 BC041000.1 BC051862.1 

    15 DOTS entries:

    DT.444953  DT.101982814  DT.100816242  DT.95247372  DT.97775423  DT.101982816  DT.100816246  DT.99967357 
    DT.95084150  DT.121138180  DT.92435351  DT.95084155  DT.100843153  DT.121643665  DT.99971630 

    24/203 AceView cDNA sequences (see all 203):

    BM806257 AA889907 BQ069619 CD723748 CR603159 AL833047 CB123545 BQ447105 
    BM975973 BF773032 AI783692 BQ928873 CR613420 AK123245 BC040490 BE208094 
    CB154636 BQ056788 CB143273 BI856890 BC051862 BQ055505 BC040574 AU131024 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for AACS (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b · 19c ·
    SP1:                                -                       -                       -                             -                       -                     
    SP2:                                -                       -                       -     -     -     -     -     -     -                                       
    SP3:                                                                                                              -                       -                     
    SP4:                                                                                                              -                                             
    SP5:                                                                    -     -     -     -     -     -     -     -     -                                       

    ExUns: 19d · 19e
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for AACS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AACS expression in normal human tissues (normalized intensities)      AACS embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGAAAAAAA
    AACS Expression
    About this image


    AACS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 12 entries
             Thalamus
             ganglion/cranial/facial VII   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Eye (Sensory Organs)
             Retina
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Spinal Cord (Nervous System)
             spinal/ganglion/dorsal root ganglion   

    See AACS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AACS

    SOURCE GeneReport for Unigene cluster: Hs.656073

    UniProtKB/Swiss-Prot: AACS_HUMAN, Q86V21
    Tissue specificity: Highly expressed in kidney, heart and brain, but low in liver

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AACS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for AACS gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aacs1 , 5 acetoacetyl-CoA synthetase1, 5 84.67(n)1
    89.88(a)1
      5 (64.24 cM)5
    788941  NM_030210.11  NP_084486.11 
     1254758145 
    chicken
    (Gallus gallus)
    Aves AACS1 acetoacetyl-CoA synthetase 77.09(n)
    86.1(a)
      416811  NM_001006184.1  NP_001006184.1 
    lizard
    (Anolis carolinensis)
    Reptilia AACS6
    Uncharacterized protein
    84(a)
    1 ↔ 1
    LGb(1270638-1298603)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.189082 Transcribed sequence with weak similarity to protein more 76.95(n)    AL898753.2 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc561052 similar to acetoacetyl-CoA synthetase 76.51(n)   393984  BC050501.1 
    worm
    (Caenorhabditis elegans)
    Secernentea sur-51 Protein SUR-5 49.35(n)
    40.69(a)
      180992  NM_076828.4  NP_509229.1 


    ENSEMBL Gene Tree for AACS (if available)
    TreeFam Gene Tree for AACS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AACS gene
    ACSS32  
    1 SIMAP similar gene for AACS using alignment to 13 protein entries:     AACS_HUMAN (see all proteins):
    ACSS3

    AACS for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for AACS
    PGOHUM00000260034 PGOHUM00000260035 PGOHUM00000260036


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1949 SNPs in AACS are shown (see all 1949)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0383034
    ----see VAR_0383032 I V mis40--------
    rs1808335121,2
    --125548063(+) CACCAC/GCTTGG 1 -- us2k10--------
    rs734218461,2
    C,F--125548102(+) CTGCAG/ACGTGT 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs800836031,2
    C,F--125548103(+) TGCAGC/TGTGTT 1 -- us2k13Minor allele frequency- T:0.09WA CSA 121
    rs71336461,2
    C,A--125548232(+) gccccT/Cactca 1 -- us2k18Minor allele frequency- C:0.07NA WA CSA 15
    rs128206491,2
    C,F--125548246(+) tggagC/Ttgctc 1 -- us2k13Minor allele frequency- T:0.50NA 6
    rs619439301,2
    C,F--125548507(+) GCAAAG/TAAAAG 1 -- us2k15Minor allele frequency- T:0.05WA CSA NA EA 361
    rs1855759381,2
    --125548634(+) CGAGGC/TGGGTG 1 -- us2k10--------
    rs1900389911,2
    --125548806(+) CAGCCC/TGACCA 1 -- us2k10--------
    rs796404381,2
    C--125548824(+) AAAACA/CCTGTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for AACS (125549925 - 125627873 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for AACS:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2746560CNV Deletion23290073
    esv2746559CNV Deletion23290073
    esv2746561CNV Deletion23290073
    esv2746556CNV Deletion23290073
    esv2746557CNV Deletion23290073
    esv2784CNV Deletion18987735
    esv2746562CNV Deletion23290073
    esv2746555CNV Deletion23290073
    esv2746558CNV Deletion23290073
    nsv899596CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 614364    OMIM disorders: --

    2 diseases for AACS:    About MalaCards
    tracheal cancer    compartment syndrome

    1 disease from the University of Copenhagen DISEASES database for AACS:
    Tracheal cancer

    AACS for disorders           About GeneDecksing

    Genetic Association Database (GAD): AACS
    Human Genome Epidemiology (HuGE) Navigator: AACS (1 document)

    Export disorders for AACS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AACS gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with AACS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of acetoacetyl-CoA synthetase, a novel cytosolic ketone body-utilizing enzyme, in human brain. (PubMed id 12623130)1, 2, 3, 9 Ohgami M.... Fukui T. (2003)
    2. Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. (PubMed id 17762044)1, 2, 3 Watkins P.A.... Pevsner J. (2007)
    3. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)1, 4 Lu Y....Boer J.M. (2008)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Caenorhabditis elegans SUR-5, a novel but conserved protein, negatively regulates LET-60 Ras activity during vulval induction. (PubMed id 9671465)1, 2 Gu T.... Han M. (1998)
    6. Transcriptional regulation of the human acetoacetyl-C oA synthetase gene by PPARgamma. (PubMed id 20102333)1, 9 AguilA^ F....Haro D. (2010)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 65985 HGNC: 21298 AceView: AACS Ensembl:ENSG00000081760 euGenes: HUgn65985
    ECgene: AACS Kegg: 65985 H-InvDB: AACS

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AACS Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for AACS gene:
    Search GeneIP for patents involving AACS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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     Regulatory tfbs in AACS promoter
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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