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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AACS Gene

protein-coding   GIFtS: 56
GCID: GC12P125549

acetoacetyl-CoA synthetase
 Explore 3 diseases affiliated with
AACS via
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Biological research products
for AACS    

Aliases
for AACS gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Acetoacetyl-CoA Synthetase1 2     EC 6.2.1.163 8
ACSF11 2 3     FLJ123891
SUR-51 2     Acetoacetate-CoA Ligase2
Acyl-CoA Synthetase Family Member 12 3     Homolog Of C. Elegans Supressor Of Ras 5 (Sur-5)2
Protein Sur-5 Homolog2 3     EC 6.2.18

External Ids:    HGNC: 212981   Entrez Gene: 659852   Ensembl: ENSG000000817607   OMIM: 6143645   UniProtKB: Q86V213   

Export aliases for AACS gene to outside databases

Previous GC identifers: GC12P125273 GC12P123904 GC12P123905 GC12P124074 GC12P124115 GC12P122513


Summaries
for AACS gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: AACS_HUMAN, Q86V21
Function: Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty
acid-synthesis during adipose tissue development (By similarity)




Genomic Views
for AACS gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009755.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AACS gene promoter:
         E2F-3a   E2F-4   USF1   E2F-5   FOXF2   CUTL1   E2F-2   E2F-1   E2F   USF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: AACS promoter sequence
   Search SABiosciences Chromatin IP Primers for AACS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AACS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24.31

AACS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AACS gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P125549:  view genomic region     (about GC identifiers)

Start:
 125,549,925 bp from pter      End:
 125,627,873 bp from pter
Size:
 77,949 bases      Orientation:
 plus strand

Proteins
for AACS gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: AACS_HUMAN, Q86V21 (See protein sequence)
Recommended Name: Acetoacetyl-CoA synthetase  
Size: 672 amino acids; 75144 Da
Subcellular location: Cytoplasm, cytosol (By similarity)
Sequence caution: Sequence=AAH41000.1; Type=Frameshift; Positions=201; Sequence=BAB14793.1; Type=Frameshift;
Positions=519;
Secondary accessions: Q49AB9 Q49AC3 Q658Q8 Q8IWD2 Q8NEW5 Q9BSJ9 Q9H829 Q9HA19
Alternative splicing: 3 isoforms:  Q86V21-1   Q86V21-2   Q86V21-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for AACS: NX_Q86V21

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q86V21

    • 4/20 DME Specific Peptides for AACS (Q86V21) (see all 20)
     STGSPLK  GWMMWNW  GTTGAPK  DFWAEFWK 

    AACS Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_076417.2  
    ENSEMBL proteins: 
     ENSP00000324842   ENSP00000442691   ENSP00000416461   ENSP00000439931   ENSP00000442956  
     ENSP00000392967   ENSP00000324929   ENSP00000439151   ENSP00000441686   ENSP00000441387  
     ENSP00000441331   ENSP00000442007   ENSP00000261686  

    Human Recombinant Protein Products: 
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: AACS
    OriGene Custom Protein Services for AACS 
    GenScript Custom Purified and Recombinant Proteins Services for AACS
    Novus Biologicals AACS Proteins
    Novus Biologicals AACS Lysates
    Sino Biological Recombinant Protein for AACS
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for AACS

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol IEA--


    AACS for ontologies           About GeneDecksing



    AACS Antibody Products: 
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    Uscn Antibodies for AACS
    Search ThermoFisher Antibodies for AACS

    Assay Products for AACS: 
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    Uscn ELISAs and CLIAs for AACS

    Protein Domains /
    Families
    for AACS gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    AACS for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR005914 Acac_CoA_synth
     IPR000873 AMP-dep_Synth/Lig
     IPR024597 Acyl-CoA_synth_DUF3448
     IPR020845 AMP-binding_CS

    Graphical View of Domain Structure for InterPro Entry Q86V21

    ProtoNet protein and cluster: Q86V21

    1 Blocks protein family: IPB000873 AMP-binding signature

    UniProtKB/Swiss-Prot: AACS_HUMAN, Q86V21
    Similarity: Belongs to the ATP-dependent AMP-binding enzyme family


    Function
    for AACS gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: AACS_HUMAN, Q86V21
    Function: Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty
    acid-synthesis during adipose tissue development (By similarity)
    Catalytic activity: ATP + acetoacetate + CoA = AMP + diphosphate + acetoacetyl-CoA

    Enzyme Numbers (IUBMB): EC 6.2.1.161 2 EC 6.2.12

    miRNA
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    hsa-mir-122 (MIRT003093)

    OriGene 3'-UTR Clone: AACS
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AACS
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate AACS:
    hsa-miR-544b hsa-miR-1226
    SwitchGear 3'UTR luciferase reporter plasmid: AACS 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AACS (see all 7)
    OriGene shRNA RFP: AACS
    OriGene siRNA: AACS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AACS

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for AACS

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AACS (see all 3)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AACS 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for AACS
    Search LifeMap BioReagents cell lines for AACS

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AACS

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0005524ATP binding IEA--
    GO:0030729acetoacetate-CoA ligase activity IEA--
    GO:0047760butyrate-CoA ligase activity IEA--


    AACS for ontologies           About GeneDecksing



    Pathways & Interactions
    for AACS gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Ketone body metabolism
    		Butanoate metabolism0.17

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for AACS):
        Butanoate metabolism


    AACS for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AACS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/12 Interacting proteins for AACS (ENSP000003248424) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACAT1ENSP000002658384STRING: ENSP00000265838
    ACAT2ENSP000003560154STRING: ENSP00000356015
    BDH1ENSP000003509144STRING: ENSP00000350914
    BDH2ENSP000002964244STRING: ENSP00000296424
    EHHADHENSP000002318874STRING: ENSP00000231887
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001889liver development IEA--
    GO:0006631fatty acid metabolic process IEA--
    GO:0007584response to nutrient IEA--
    GO:0010243response to organic nitrogen ----
    GO:0014070response to organic cyclic compound ----


    AACS for ontologies           About GeneDecksing



    Drugs & Compounds
    for AACS gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AACS

    7 HMDB Compounds for AACS    About this table
    CompoundSynonyms CAS #PubMed Ids
    Acetoacetic acid3-Ketobutyrate (see all 9)541-50-4--
    Acetoacetyl-CoA3-acetoacetyl-CoA (see all 9)1420-36-6--
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Coenzyme AAcetoacetyl coenzyme A sodium salt (see all 21)85-61-0--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
    Search CenterWatch for drugs/clinical trials and news about AACS 

    Transcripts
    for AACS gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for AACS gene: 
    NM_023928.3  

    Unigene Cluster for AACS:

    Acetoacetyl-CoA synthetase
    Hs.656073  [show with all ESTs]
    Unigene Representative Sequence: BC036694
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000316519(uc001uhc.3 uc001uhd.3 uc009zyh.3) ENST00000536752
    ENST00000418937(uc009zyg.2) ENST00000537477 ENST00000537564 ENST00000441247
    ENST00000316543(uc009zyi.3) ENST00000539251 ENST00000538851 ENST00000545511
    ENST00000536118 ENST00000543665 ENST00000398953 ENST00000261686

    miRNA
    Products:             		 OriGene 3'-UTR Clone: AACS
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AACS
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate AACS:
    hsa-miR-544b hsa-miR-1226
    SwitchGear 3'UTR luciferase reporter plasmid: AACS 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AACS (see all 7)
    OriGene shRNA RFP: AACS
    OriGene siRNA: AACS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AACS
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AACS (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AACS
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: AACS (NM_023928)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AACS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AACS 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AACS
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AACS
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AACS

    Additional cDNA sequence: 

    AB054121.1 AK022451.1 AK024760.1 AK123245.1 AK304176.1 AK308779.1 AL833047.1 AY091468.1 
    BC004997.1 BC036694.1 BC040490.1 BC040574.1 BC041000.1 BC051862.1 

    15 DOTS entries:

    DT.444953  DT.101982814  DT.100816242  DT.95247372  DT.97775423  DT.101982816  DT.100816246  DT.99967357 
    DT.95084150  DT.121138180  DT.92435351  DT.95084155  DT.100843153  DT.121643665  DT.99971630 

    24/203 AceView cDNA sequences (see all 203):

    CR613420 AI783692 BE208094 CD723748 BQ888370 BU543521 BQ653038 BQ055505 
    BI856890 AU131024 BC051862 BF108425 BQ438135 AB054121 BC040574 CA308247 
    BC040490 BQ056788 BC004997 CB154636 CB123545 BI861200 BQ447105 AK123245 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for AACS (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b · 19c ·
    SP1:                                -                       -                       -                             -                       -                     
    SP2:                                -                       -                       -     -     -     -     -     -     -                                       
    SP3:                                                                                                              -                       -                     
    SP4:                                                                                                              -                                             
    SP5:                                                                    -     -     -     -     -     -     -     -     -                                       

    ExUns: 19d · 19e
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for AACS

    Expression
    for AACS gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AACS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTGAAAAAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    AACS expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeRetinaEye
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See AACS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AACS

    SOURCE GeneReport for Unigene cluster: Hs.656073

    UniProtKB/Swiss-Prot: AACS_HUMAN, Q86V21
    Tissue specificity: Highly expressed in kidney, heart and brain, but low in liver

        SABiosciences Custom PCR Arrays for AACS
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AACS

    Orthologs
    for AACS gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for AACS gene from 7/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves AACS1 acetoacetyl-CoA synthetase 77.09(n)
    86.1(a)    		   416811  NM_001006184.1  NP_001006184.1 
    lizard
    (Anolis carolinensis)    		 Reptilia AACS6
    		 --
    		 83(a)
    		 1 ↔ 1
    		 LGb(1270684-1298519)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.189082 Transcribed sequence with weak similarity to protein more 76.95(n)    AL898753.2 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc561052 similar to acetoacetyl-CoA synthetase 76.51(n)   393984  BC050501.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea sur-51 Protein SUR-5 49.35(n)
    40.69(a)    		   180992  NM_076828.4  NP_509229.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AAE186
    AAE176
    		 acyl-activating enzyme 17
    		 15(a)
    15(a)
    		 1 ↔ many
    1 ↔ many
    		 1(20633360-20636892)
    5(7731269-7735439)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 AMP-binding enzyme, putative, expressed
    		 14(a)
    14(a)
    		 1 ↔ many
    1 ↔ many
    		 9(12816152-12820683)
    3(33624793-33629717)


    ENSEMBL Gene Tree for AACS (if available)
    TreeFam Gene Tree for AACS (if available) 

    Paralogs
    for AACS gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AACS gene
    1 SIMAP similar gene for AACS using alignment to 13 protein entries:     AACS_HUMAN (see all proteins):
    ACSS3

    AACS for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for AACS
    PGOHUM00000260034 PGOHUM00000260035 PGOHUM00000260036


    Genomic Variants
    for AACS gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1618 NCBI SNPs in AACS are shown (see all 1618)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1808335121,2
    		--125548063(+) CACCAC/GCTTGG 1 -- us2k10--------
    rs734218461,2
    		C,--125548102(+) CTGCAG/ACGTGT 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs800836031,2
    		C,--125548103(+) TGCAGC/TGTGTT 1 -- us2k13Minor allele frequency- T:0.09WA CSA 121
    rs71336461,2
    		C,A,--125548232(+) GCCCCT/CACTCA 1 -- us2k18Minor allele frequency- C:0.07NA WA CSA 15
    rs128206491,2
    		C,F,--125548246(+) TGGAGC/TTGCTC 1 -- us2k13Minor allele frequency- T:0.50NA 6
    rs619439301,2
    		C,--125548507(+) GCAAAG/TAAAAG 1 -- us2k15Minor allele frequency- T:0.05WA CSA NA EA 361
    rs1855759381,2
    		--125548634(+) CGAGGC/TGGGTG 1 -- us2k10--------
    rs1900389911,2
    		--125548806(+) CAGCCC/TGACCA 1 -- us2k10--------
    rs796404381,2
    		C--125548824(+) AAAACA/CCTGTC 1 -- us2k10--------
    rs1142159981,2
    		F,--125548938(+) GTTGCC/TGTGTG 1 -- us2k11Minor allele frequency- T:0.03WA 118

    HapMap Linkage Disequilibrium report for AACS (125549925 - 125627873 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for AACS
         1 Indel: 41679

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    Disorders / Diseases
    for AACS gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    AACS for disorders           About GeneDecksing

    OMIM gene information: 614364    OMIM disorders: --

    3 diseases for AACS:    About MalaCards
    compartment syndrome    tracheal cancer    cholesterol

    1 disease from the University of Copenhagen DISEASES database for AACS:
    Tracheal cancer
    Human Genome Epidemiology (HuGE) Navigator: AACS (1 document)

    Export disorders for AACS gene to outside databases

    Publications
    for AACS gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AACS gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with AACS)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of acetoacetyl-CoA synthetase, a novel cytosolic ketone body-utilizing enzyme, in human brain. (PubMed id 12623130)1, 2, 3, 9 Ohgami M.... Fukui T. (2003)
    2. Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. (PubMed id 17762044)1, 2, 3 Watkins P.A.... Pevsner J. (2007)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Caenorhabditis elegans SUR-5, a novel but conserved protein, negatively regulates LET-60 Ras activity during vulval induction. (PubMed id 9671465)1, 2 Gu T.... Han M. (1998)
    5. Transcriptional regulation of the human acetoacetyl-C oA synthetase gene by PPARgamma. (PubMed id 20102333)1, 9 AguilA^ F....Haro D. (2010)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)1 Lu Y....Boer J.M. (2008)
    10. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)

    External Searches for AACS gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing AACS gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 65985 HGNC: 21298 AceView: AACS Ensembl:ENSG00000081760 euGenes: HUgn65985
    ECgene: AACS Kegg: 65985 H-InvDB: AACS

    Other Databases showing AACS gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing AACS gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AACS Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for AACS gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for AACS gene:
    Search GeneIP for patents involving AACS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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     Regulatory tfbs in AACS promoter
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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