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Aliases & Descriptions for AACS
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| ACSF1 1, 2, 3 | | EC 6.2.1.16 3 | | FLJ12389 1, 2 | | FLJ41251 2 | | SUR-5 1, 2 |
| | | Descriptions |
|---|
| Acyl-CoA synthetase family member 1 2, 3 | | Protein sur-5 homolog 3 | | acetoacetate-CoA ligase 2 | | acetoacetyl-CoA synthetase 2 | | homolog of C. elegans supressor of ras 5 (sur-5) 2 |
|
| | Search outside databases for aliases for AACS genePrevious GC identifers: GC12P125273 GC12P123904 GC12P123905 |
Summaries for AACS(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: AACS_HUMAN, Q86V21Function: Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development (By similarity) |
Genomic Location for AACS
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the AACS gene 
Entrez Gene cytogenetic band: 12q24.31 Ensembl cytogenetic band: 12q24.31 HGNC cytogenetic band: 12q24.31AACS Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P124074:
(about GC identifiers)
Start:
|
124,115,878 bp from pter |
End:
|
124,193,824 bp from pter |
Size:
|
77,947 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000012.10 NT_009755.18
| Proteins for AACS
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: AACS_HUMAN, Q86V21 (See
protein sequence)Recommended Name: Acetoacetyl-CoA synthetase Size: 672 amino acids; 75144 Da
Subcellular location: Cytoplasm, cytosol (By similarity)
Sequence caution: Sequence=AAH41000.1; Type=Frameshift; Positions=201; Sequence=BAB14793.1; Type=Frameshift; Positions=519;
Secondary accessions: Q49AB9 Q49AC3 Q658Q8 Q8IWD2 Q8NEW5 Q9BSJ9 Q9H829 Q9HA19Alternative splicing: 3 isoforms: Q86V21-1 Q86V21-2 Q86V21-3 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_076417.2
ENSEMBL proteins: ENSP00000324842 ENSP00000261686 ENSP00000324929 ENSP00000331825
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- | About this table
Antibodies for AACS: Assays for AACS: | Protein
Domains/ Families for AACS(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q86V21
ProtoNet protein and cluster: Q86V21 1 Blocks protein family: IPB000873 AMP-binding signature
UniProtKB/Swiss-Prot: AACS_HUMAN, Q86V21Similarity: Belongs to the ATP-dependent AMP-binding enzyme family | Gene Function for AACS
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_023928
Applied Biosystems Silencer® siRNAs for AACS
Sigma-Aldrich siRNA for AACS  Sigma-Aldrich shRNA for AACS  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_023928                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_023928                                  untagged cDNA clone in CMV expression vector: NM_023928 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_023928
UniProtKB/Swiss-Prot: AACS_HUMAN, Q86V21Function: Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development (By similarity)Catalytic activity: ATP + acetoacetate + CoA = AMP + diphosphate + acetoacetyl-CoAEnzyme Number (IUBMB): EC 6.2.1.16 2 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016874 | ligase activity |
IEA | -- | | GO:0030729 | acetoacetate-CoA ligase activity |
IEA | -- | About this table | Pathways & Interactions for AACS
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 1 Sigma-Aldrich "Your Favorite Gene" Pathway for AACS (Your Favorite Gene powered by Ingenuity) 
5/13 Interacting proteins for AACS (ENSP000003248423) via UniProtKB, MINT, and/or STRING (see all 13
)About this table
3 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006629 | lipid metabolic process |
IEA | -- | | GO:0006631 | fatty acid metabolic process |
IEA | -- | | GO:0008152 | metabolic process |
IEA | -- | About this table
|
Drugs & Compounds for AACS(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for AACS
|
Transcripts for AACS(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_023928
Sigma-Aldrich siRNA for AACS  Sigma-Aldrich shRNA for AACS  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_023928 REFSEQ mRNAs for AACS gene: NM_023928.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_023928               OriGene GFP tagged cDNA clone in CMV expression vector: NM_023928                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_023928                                  untagged cDNA clone in CMV expression vector: NM_023928  Additional cDNA sequence: AB054121.1 AK022451.1 AK024760.1 AK123245.1 AK304176.1 AK308779.1 AL833047.1 AY091468.1 BC004997.1 BC036694.1 BC040490.1 BC040574.1 BC041000.1 BC051862.1 CR603159.1 CR613420.1 15 DOTS entries: DT.444953 DT.101982814 DT.100816242 DT.95247372 DT.97775423 DT.101982816 DT.100816246 DT.99967357 DT.95084150 DT.121138180 DT.92435351 DT.95084155 DT.99971630 DT.100843153 DT.121643665 24/203 AceView cDNA sequences (see all 203
):BM806257 BM665889 AB054121 BM677346 NM_023928 BU619739 BQ056788 BU507305 BQ278873 AI969149 BC040574 BQ056494 CB143273 BC051862 BQ055505 BE208094 BC040490 CB154636 BG676436 BQ653038 BQ069619 BF773032 CB129945 BQ005245
highest scoring ESTs for AACS:AA640793 AI798645 W19606 AA132979 AA349693 AA360038 AA860167 AA889907 AB054121 AI076309 Unigene Cluster for AACS: Acetoacetyl-CoA synthetase Hs.656073 [show with all ESTs]Unigene Representative Sequence: BC036694
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for AACS (see all 8
)
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19a | · | 19b | · | 19c | · | |
| SP1: | |   | |   | |   | |   | |   | - |   | |   | |   | |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | - |   | |   | |   | |   | - |   | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   |
| ExUns: | 19d | · | 19e | |
| SP1: | |   | |   | |
| SP2: | |   | |   | |
| SP3: | |   | |   | |
| SP4: | |   | |   | |
| SP5: | |   | |   |
About this scheme
ECgene alternative splicing isoforms for AACS
4 Ensembl transcripts including schematic representations: ENST00000316519
ENST00000261686
ENST00000316543
ENST00000331699
|
Expression for AACS
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| AACS expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for AACS
1 / 2 / 3 6 probe-sets matching AACS gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CTGAAAAAAA
SOURCE GeneReport for Unigene cluster: Hs.656073 UniProtKB/Swiss-Prot: AACS_HUMAN, Q86V21Tissue specificity: Highly expressed in kidney, heart and brain, but low in liver |
Orthologs for AACS
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for AACS gene from 5/11 species (see all 11
)
About this table Species with no ortholog for AACS
ENSEMBL Gene Tree for AACS | Paralogs for AACS(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for AACS(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for AACS (up to first 250kb)
|
Disorders & Mutations for AACS
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
| Human Genome Epidemiology Navigator: AACS (1 document)
|
Medical News for AACS(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for AACS (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 9 PubMed articles for AACS gene:- Expression of acetoacetyl-CoA synthetase, a novel cytosolic ketone body-utilizing enzyme, in human brain. (PubMed id 12623130)1, 2, 3, 4 Ohgami M.... Fukui T. (2003)
- Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. (PubMed id 17762044)2, 3, 4 Watkins P.A....Pevsner J. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- Caenorhabditis elegans SUR-5, a novel but conserved protein, negatively regulates LET-60 Ras activity during vulval induction. (PubMed id 9671465)3, 4 Gu T.... Han M. (1998)
- Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)3 Lu Y....Boer J.M. (2008)
- The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005)4 Bechtel S....Schupp I. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)4 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- A radiochemical assay for acetoacetyl-CoA synthetase. (PubMed id 4073493)3 Bergstrom J.D. and Edmond J. (1985)
|
Search for AACS
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing AACS
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing AACS
(According to HUGE)
About This Section
| -- |
Specialized Databases showing AACS(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for AACS(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for AACS:

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GeneCards Homepage - Last full update: 1 Jul 2009
Incremental update: 13 Oct 2009
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