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Aliases for A4GNT Gene

Aliases for A4GNT Gene

  • Alpha-1,4-N-Acetylglucosaminyltransferase 2 3 3 5
  • Alpha4GnT 3 4
  • EC 2.4.1.- 4

External Ids for A4GNT Gene

Previous GeneCards Identifiers for A4GNT Gene

  • GC03M139325
  • GC03M137842
  • GC03M135217

Summaries for A4GNT Gene

Entrez Gene Summary for A4GNT Gene

  • This gene encodes a protein from the glycosyltransferase 32 family. The enzyme catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans. It forms a unique glycan, GlcNAcalpha1-->4Galbeta-->R and is largely associated with the Golgi apparatus membrane. [provided by RefSeq, Jul 2008]

GeneCards Summary for A4GNT Gene

A4GNT (Alpha-1,4-N-Acetylglucosaminyltransferase) is a Protein Coding gene. Among its related pathways are heparan sulfate biosynthesis and Metabolism of proteins. GO annotations related to this gene include acetylglucosaminyltransferase activity. An important paralog of this gene is A4GALT.

UniProtKB/Swiss-Prot for A4GNT Gene

  • Necessary for the synthesis of type III mucin. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for A4GNT Gene

Genomics for A4GNT Gene

Regulatory Elements for A4GNT Gene

Enhancers for A4GNT Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F138173 1 ENCODE 38.4 -42.2 -42180 1.9 ATF1 CREB3L1 ARID4B SIN3A DMAP1 ZNF48 BRCA1 ZNF2 YY1 GLIS2 A4GNT DBR1
GH03F138124 0.8 Ensembl ENCODE 40.2 +6.9 6866 2.2 ZFHX2 MAZ JUND KLF17 FOS WT1 A4GNT DZIP1L
GH03F138118 1 Ensembl ENCODE 29.1 +13.3 13287 1.0 CTCF ZNF654 STAT1 SUZ12 TRIM22 ZBTB8A REST RAD21 ZNF518A RFX5 A4GNT MRAS DZIP1L
GH03F138112 0.9 ENCODE 27.2 +18.1 18114 4.4 ZNF76 KLF17 SIN3A DMAP1 ZNF2 RAD21 GLIS2 ZNF366 EGR2 ZNF263 A4GNT PIR46402 KRT8P36
GH03F138134 0.4 Ensembl 50.9 -3.7 -3715 3.4 CEBPB REST A4GNT DBR1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around A4GNT on UCSC Golden Path with GeneCards custom track

Genomic Location for A4GNT Gene

Chromosome:
3
Start:
138,123,718 bp from pter
End:
138,132,387 bp from pter
Size:
8,670 bases
Orientation:
Minus strand

Genomic View for A4GNT Gene

Genes around A4GNT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
A4GNT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for A4GNT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for A4GNT Gene

Proteins for A4GNT Gene

  • Protein details for A4GNT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UNA3-A4GCT_HUMAN
    Recommended name:
    Alpha-1,4-N-acetylglucosaminyltransferase
    Protein Accession:
    Q9UNA3
    Secondary Accessions:
    • Q0VDK1
    • Q0VDK2

    Protein attributes for A4GNT Gene

    Size:
    340 amino acids
    Molecular mass:
    39497 Da
    Quaternary structure:
    No Data Available

neXtProt entry for A4GNT Gene

Post-translational modifications for A4GNT Gene

  • Glycosylation at Asn 99, Asn 138, Asn 251, and Asn 282
  • Modification sites at PhosphoSitePlus

Other Protein References for A4GNT Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for A4GNT Gene

Domains & Families for A4GNT Gene

Gene Families for A4GNT Gene

Suggested Antigen Peptide Sequences for A4GNT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UNA3

UniProtKB/Swiss-Prot:

A4GCT_HUMAN :
  • The conserved DXD motif is involved in enzyme activity.
  • Belongs to the glycosyltransferase 32 family.
Domain:
  • The conserved DXD motif is involved in enzyme activity.
Family:
  • Belongs to the glycosyltransferase 32 family.
genes like me logo Genes that share domains with A4GNT: view

Function for A4GNT Gene

Molecular function for A4GNT Gene

UniProtKB/Swiss-Prot Function:
Necessary for the synthesis of type III mucin. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans.

Enzyme Numbers (IUBMB) for A4GNT Gene

Gene Ontology (GO) - Molecular Function for A4GNT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008375 acetylglucosaminyltransferase activity IDA,TAS --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with A4GNT: view
genes like me logo Genes that share phenotypes with A4GNT: view

Animal Models for A4GNT Gene

MGI Knock Outs for A4GNT:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for A4GNT Gene

Localization for A4GNT Gene

Subcellular locations from UniProtKB/Swiss-Prot for A4GNT Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for A4GNT gene
Compartment Confidence
golgi apparatus 5
extracellular 3
plasma membrane 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for A4GNT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane TAS 10430883
GO:0016021 integral component of membrane IEA,TAS --
genes like me logo Genes that share ontologies with A4GNT: view

Pathways & Interactions for A4GNT Gene

genes like me logo Genes that share pathways with A4GNT: view

UniProtKB/Swiss-Prot Q9UNA3-A4GCT_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Interacting Proteins for A4GNT Gene

Selected Interacting proteins: Q9UNA3-A4GCT_HUMAN for A4GNT Gene via IID

Gene Ontology (GO) - Biological Process for A4GNT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS 10430883
GO:0006486 protein glycosylation IEA --
GO:0006493 protein O-linked glycosylation TAS 10430883
GO:0009101 glycoprotein biosynthetic process IDA 10430883
GO:0016266 O-glycan processing TAS --
genes like me logo Genes that share ontologies with A4GNT: view

No data available for SIGNOR curated interactions for A4GNT Gene

Transcripts for A4GNT Gene

mRNA/cDNA for A4GNT Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for A4GNT Gene

Alpha-1,4-N-acetylglucosaminyltransferase:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for A4GNT Gene

No ASD Table

Relevant External Links for A4GNT Gene

GeneLoc Exon Structure for
A4GNT
ECgene alternative splicing isoforms for
A4GNT

Expression for A4GNT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for A4GNT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for A4GNT Gene

This gene is overexpressed in Stomach (x19.3) and Pancreas (x12.2).

NURSA nuclear receptor signaling pathways regulating expression of A4GNT Gene:

A4GNT

SOURCE GeneReport for Unigene cluster for A4GNT Gene:

Hs.278960

mRNA Expression by UniProt/SwissProt for A4GNT Gene:

Q9UNA3-A4GCT_HUMAN
Tissue specificity: Detected in stomach and pancreas.
genes like me logo Genes that share expression patterns with A4GNT: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for A4GNT Gene

Orthologs for A4GNT Gene

This gene was present in the common ancestor of animals.

Orthologs for A4GNT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia A4GNT 34 35
  • 98.43 (n)
dog
(Canis familiaris)
Mammalia A4GNT 34 35
  • 83.97 (n)
cow
(Bos Taurus)
Mammalia A4GNT 34 35
  • 83.82 (n)
rat
(Rattus norvegicus)
Mammalia A4gnt 34
  • 78.63 (n)
mouse
(Mus musculus)
Mammalia A4gnt 34 16 35
  • 77.25 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia A4GNT 35
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia A4GNT 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves A4GNT 34 35
  • 66.56 (n)
lizard
(Anolis carolinensis)
Reptilia A4GNT 35
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733902 34
  • 61.88 (n)
fruit fly
(Drosophila melanogaster)
Insecta alpha4GT1 35
  • 21 (a)
ManyToMany
alpha4GT2 35
  • 18 (a)
ManyToMany
Species where no ortholog for A4GNT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for A4GNT Gene

ENSEMBL:
Gene Tree for A4GNT (if available)
TreeFam:
Gene Tree for A4GNT (if available)

Paralogs for A4GNT Gene

Paralogs for A4GNT Gene

(1) SIMAP similar genes for A4GNT Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for A4GNT Gene

genes like me logo Genes that share paralogs with A4GNT: view

Variants for A4GNT Gene

Sequence variations from dbSNP and Humsavar for A4GNT Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10716379 -- 138,133,992(+) CCTTG(-/T)TTTTT upstream-variant-2KB
rs111375930 -- 138,133,465(+) TCTGT(C/G)GGAGT upstream-variant-2KB
rs111515489 -- 138,124,805(+) CACCG(C/T)ATTTC reference, missense
rs111596177 -- 138,132,956(+) GCCAG(C/G)TTTGT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs111599813 -- 138,127,350(+) GTGGG(C/T)GGATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for A4GNT Gene

Variant ID Type Subtype PubMed ID
esv2751978 CNV loss 17911159
esv2759180 CNV loss 17122850
esv2762347 CNV gain 21179565
esv3442853 CNV insertion 20981092
esv3597911 CNV gain 21293372
nsv1007857 CNV gain 25217958
nsv428422 CNV gain+loss 18775914
nsv998106 CNV gain 25217958

Variation tolerance for A4GNT Gene

Residual Variation Intolerance Score: 86.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.30; 53.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for A4GNT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
A4GNT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for A4GNT Gene

Disorders for A4GNT Gene

Relevant External Links for A4GNT

Genetic Association Database (GAD)
A4GNT
Human Genome Epidemiology (HuGE) Navigator
A4GNT
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
A4GNT

No disorders were found for A4GNT Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for A4GNT Gene

Publications for A4GNT Gene

  1. Expression cloning of a human alpha1, 4-N- acetylglucosaminyltransferase that forms GlcNAcalpha1-->4Galbeta-->R, a glycan specifically expressed in the gastric gland mucous cell-type mucin. (PMID: 10430883) Nakayama J. … Fukuda M. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 3 4 22 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Genetic variation in a4GnT in relation to Helicobacter pylori serology and gastric cancer risk. (PMID: 19751437) Zheng Z. … Ye W. (Helicobacter 2009) 3 46 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Immunohistochemical demonstration of alpha1,4-N-acetylglucosaminyltransferase that forms GlcNAcalpha1,4Galbeta residues in human gastrointestinal mucosa. (PMID: 11304796) Zhang M.X. … Fukuda M. (J. Histochem. Cytochem. 2001) 3 22 64

Products for A4GNT Gene

Sources for A4GNT Gene

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