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Aliases for A4GNT Gene

Aliases for A4GNT Gene

  • Alpha-1,4-N-Acetylglucosaminyltransferase 5 2 3
  • Alpha4GnT 3 4
  • EC 2.4.1.- 4

External Ids for A4GNT Gene

Previous GeneCards Identifiers for A4GNT Gene

  • GC03M139325
  • GC03M137842
  • GC03M135217

Summaries for A4GNT Gene

Entrez Gene Summary for A4GNT Gene

  • This gene encodes a protein from the glycosyltransferase 32 family. The enzyme catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans. It forms a unique glycan, GlcNAcalpha1-->4Galbeta-->R and is largely associated with the Golgi apparatus membrane. [provided by RefSeq, Jul 2008]

GeneCards Summary for A4GNT Gene

A4GNT (Alpha-1,4-N-Acetylglucosaminyltransferase) is a Protein Coding gene. Among its related pathways are O-linked glycosylation and heparan sulfate biosynthesis. GO annotations related to this gene include acetylglucosaminyltransferase activity. An important paralog of this gene is A4GALT.

UniProtKB/Swiss-Prot for A4GNT Gene

  • Necessary for the synthesis of type III mucin. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for A4GNT Gene

Genomics for A4GNT Gene

Regulatory Elements for A4GNT Gene

Genomic Location for A4GNT Gene

Chromosome:
3
Start:
138,123,718 bp from pter
End:
138,132,387 bp from pter
Size:
8,670 bases
Orientation:
Minus strand

Genomic View for A4GNT Gene

Genes around A4GNT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
A4GNT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for A4GNT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for A4GNT Gene

Proteins for A4GNT Gene

  • Protein details for A4GNT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UNA3-A4GCT_HUMAN
    Recommended name:
    Alpha-1,4-N-acetylglucosaminyltransferase
    Protein Accession:
    Q9UNA3
    Secondary Accessions:
    • Q0VDK1
    • Q0VDK2

    Protein attributes for A4GNT Gene

    Size:
    340 amino acids
    Molecular mass:
    39497 Da
    Quaternary structure:
    No Data Available

neXtProt entry for A4GNT Gene

Proteomics data for A4GNT Gene at MOPED

Post-translational modifications for A4GNT Gene

  • Glycosylation at Asn 99, Asn 138, Asn 251, and Asn 282
  • Modification sites at PhosphoSitePlus

Other Protein References for A4GNT Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for A4GNT ("Alpha-1,4-N-Acetylglucosaminyltransferase 4/A4GNT")

No data available for DME Specific Peptides for A4GNT Gene

Domains & Families for A4GNT Gene

Gene Families for A4GNT Gene

Suggested Antigen Peptide Sequences for A4GNT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UNA3

UniProtKB/Swiss-Prot:

A4GCT_HUMAN :
  • The conserved DXD motif is involved in enzyme activity.
  • Belongs to the glycosyltransferase 32 family.
Domain:
  • The conserved DXD motif is involved in enzyme activity.
Family:
  • Belongs to the glycosyltransferase 32 family.
genes like me logo Genes that share domains with A4GNT: view

Function for A4GNT Gene

Molecular function for A4GNT Gene

UniProtKB/Swiss-Prot Function:
Necessary for the synthesis of type III mucin. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans.

Enzyme Numbers (IUBMB) for A4GNT Gene

Gene Ontology (GO) - Molecular Function for A4GNT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008375 acetylglucosaminyltransferase activity IEA,TAS --
genes like me logo Genes that share ontologies with A4GNT: view
genes like me logo Genes that share phenotypes with A4GNT: view

Animal Models for A4GNT Gene

MGI Knock Outs for A4GNT:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for A4GNT Gene

Localization for A4GNT Gene

Subcellular locations from UniProtKB/Swiss-Prot for A4GNT Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for A4GNT Gene COMPARTMENTS Subcellular localization image for A4GNT gene
Compartment Confidence
golgi apparatus 5
extracellular 3
endoplasmic reticulum 1
lysosome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for A4GNT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane TAS 10430883
genes like me logo Genes that share ontologies with A4GNT: view

Pathways & Interactions for A4GNT Gene

genes like me logo Genes that share pathways with A4GNT: view

UniProtKB/Swiss-Prot Q9UNA3-A4GCT_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Interacting Proteins for A4GNT Gene

Gene Ontology (GO) - Biological Process for A4GNT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS 10430883
GO:0006493 protein O-linked glycosylation IEA,TAS 10430883
GO:0016266 O-glycan processing TAS --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with A4GNT: view

No data available for SIGNOR curated interactions for A4GNT Gene

Drugs & Compounds for A4GNT Gene

No Compound Related Data Available

Transcripts for A4GNT Gene

mRNA/cDNA for A4GNT Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for A4GNT Gene

Alpha-1,4-N-acetylglucosaminyltransferase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for A4GNT Gene

No ASD Table

Relevant External Links for A4GNT Gene

GeneLoc Exon Structure for
A4GNT
ECgene alternative splicing isoforms for
A4GNT

Expression for A4GNT Gene

mRNA expression in normal human tissues for A4GNT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for A4GNT Gene

This gene is overexpressed in Stomach (x19.3) and Pancreas (x12.2).

SOURCE GeneReport for Unigene cluster for A4GNT Gene Hs.278960

mRNA Expression by UniProt/SwissProt for A4GNT Gene

Q9UNA3-A4GCT_HUMAN
Tissue specificity: Detected in stomach and pancreas.
genes like me logo Genes that share expression patterns with A4GNT: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for A4GNT Gene

Orthologs for A4GNT Gene

This gene was present in the common ancestor of animals.

Orthologs for A4GNT Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia A4GNT 35
  • 83.82 (n)
  • 81.18 (a)
A4GNT 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia A4GNT 35
  • 83.97 (n)
  • 80.24 (a)
A4GNT 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia A4gnt 35
  • 77.25 (n)
  • 71.18 (a)
A4gnt 16
A4gnt 36
  • 71 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia A4GNT 35
  • 98.43 (n)
  • 98.53 (a)
A4GNT 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia A4gnt 35
  • 78.63 (n)
  • 73.82 (a)
oppossum
(Monodelphis domestica)
Mammalia A4GNT 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia A4GNT 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves A4GNT 35
  • 66.56 (n)
  • 62.74 (a)
A4GNT 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia A4GNT 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733902 35
  • 61.88 (n)
  • 57.45 (a)
fruit fly
(Drosophila melanogaster)
Insecta alpha4GT1 36
  • 21 (a)
ManyToMany
alpha4GT2 36
  • 18 (a)
ManyToMany
Species with no ortholog for A4GNT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for A4GNT Gene

ENSEMBL:
Gene Tree for A4GNT (if available)
TreeFam:
Gene Tree for A4GNT (if available)

Paralogs for A4GNT Gene

Paralogs for A4GNT Gene

(1) SIMAP similar genes for A4GNT Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for A4GNT Gene

genes like me logo Genes that share paralogs with A4GNT: view

Variants for A4GNT Gene

Sequence variations from dbSNP and Humsavar for A4GNT Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs2246945 - 138,124,634(-) TTCAG(A/C)CATTT reference, missense
rs1564496 -- 138,124,176(-) CTTGG(C/G/T)GGGGT utr-variant-3-prime
rs2170309 -- 138,124,264(-) AAATA(A/C/G)AGCTA reference, synonymous-codon
rs2724688 -- 138,127,575(+) TCTCA(A/C)AAAAA intron-variant
rs2724689 -- 138,128,190(+) gcagc(C/T)tctcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for A4GNT Gene

Variant ID Type Subtype PubMed ID
nsv428422 CNV Gain+Loss 18775914
dgv1511e1 CNV Complex 17122850
esv2751978 CNV Loss 17911159
dgv1512e1 CNV Complex 17122850

Variation tolerance for A4GNT Gene

Residual Variation Intolerance Score: 86.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.30; 53.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for A4GNT Gene

HapMap Linkage Disequilibrium report
A4GNT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for A4GNT Gene

Disorders for A4GNT Gene

Relevant External Links for A4GNT

Genetic Association Database (GAD)
A4GNT
Human Genome Epidemiology (HuGE) Navigator
A4GNT
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
A4GNT

No disorders were found for A4GNT Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for A4GNT Gene

Publications for A4GNT Gene

  1. Expression cloning of a human alpha1, 4-N- acetylglucosaminyltransferase that forms GlcNAcalpha1-->4Galbeta-->R, a glycan specifically expressed in the gastric gland mucous cell-type mucin. (PMID: 10430883) Nakayama J. … Fukuda M. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 3 4 23 67
  2. Immunohistochemical demonstration of alpha1,4-N-acetylglucosaminyltransferase that forms GlcNAcalpha1,4Galbeta residues in human gastrointestinal mucosa. (PMID: 11304796) Zhang M.X. … Fukuda M. (J. Histochem. Cytochem. 2001) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Essential role of gastric gland mucin in preventing gastric cancer in mice. (PMID: 22307328) Karasawa F. … Nakayama J. (J. Clin. Invest. 2012) 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3

Products for A4GNT Gene

Sources for A4GNT Gene

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