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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

A4GNT Gene

protein-coding   GIFtS: 50
GCID: GC03M137842

alpha-1,4-N-acetylglucosaminyltransferase

 Explore 3 diseases affiliated with
A4GNT via our new
 Human Malady Compendium 
Biological research products
for A4GNT
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Alpha-1,4-N-Acetylglucosaminyltransferase1
Alpha4GnT3
Alpha4GnT3
EC 2.4.1.-3

External Ids:    HGNC: 179681   Entrez Gene: 511462   Ensembl: ENSG000001180177   UniProtKB: Q9UNA33   

Export aliases for A4GNT gene to outside databases

Previous GC identifers: GC03M139325 GC03M135217


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for A4GNT:
This gene encodes a protein from the glycosyltransferase 32 family. The enzyme catalyzes the transfer of
N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans. It forms a unique glycan, GlcNAcalpha1-->4Galbeta-->R
and is largely associated with the Golgi apparatus membrane. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: A4GCT_HUMAN, Q9UNA3
Function: Necessary for the synthesis of type III mucin. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core
2 branched O-glycans




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the A4GNT gene promoter:
         Bach1   E2F-3a   E2F-4   E2F-5   E2F-2   E2F-1   E2F   POU2F1   POU2F1a   FOXO1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidA4GNT promoter sequence
   Search SABiosciences Chromatin IP Primers for A4GNT

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat A4GNT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p14.3   Ensembl cytogenetic band:  3q22.3   HGNC cytogenetic band: 3p14.3

A4GNT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
A4GNT gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M137842:  view genomic region     (about GC identifiers)

Start:
137,842,560 bp from pter      End:
137,851,229 bp from pter
Size:
8,670 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: A4GCT_HUMAN, Q9UNA3 (See protein sequence)
Recommended Name: Alpha-1,4-N-acetylglucosaminyltransferase  
Size: 340 amino acids; 39497 Da
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein (Probable)
Secondary accessions: Q0VDK1 Q0VDK2

Explore the universe of human proteins at neXtProt for A4GNT: NX_Q9UNA3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UNA3

  • A4GNT Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_057245.1  
    ENSEMBL proteins: 
     ENSP00000236709  

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    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005624membrane fraction ----
    GO:0005795Golgi stack IEA--
    GO:0016020membrane TAS10430883
    GO:0016021integral to membrane IEA--


    A4GNT for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    A4GNT for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR007577 GlycoTrfase_DXD_sugar-bd_CS
     IPR007652 A1-4-GlycosylTfrase_dom

    Graphical View of Domain Structure for InterPro Entry Q9UNA3

    ProtoNet protein and cluster: Q9UNA3

    1 Blocks protein family: IPB007652 Alpha 1,4-glycosyltransferase conserved region

    UniProtKB/Swiss-Prot: A4GCT_HUMAN, Q9UNA3
    Domain: The conserved DXD motif is involved in enzyme activity (By similarity)
    Similarity: Belongs to the glycosyltransferase 32 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: A4GCT_HUMAN, Q9UNA3
    Function: Necessary for the synthesis of type III mucin. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core
    2 branched O-glycans

    Enzyme Number (IUBMB): EC 2.4.1.-1

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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008375acetylglucosaminyltransferase activity IDA10430883
    GO:0008378galactosyltransferase activity IEA--


    A4GNT for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for A4GNT:
     Increased viability after born 

    Animal Models:
         Mouse knock-out A4gnttm1Jnaka for A4GNT
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for A4gnt):
     cardiovascular system  cellular  digestive/alimentary  immune system  tumorigenesis 

    A4GNT for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1heparan sulfate biosynthesis
    heparan sulfate biosynthesis1.00
    heparan sulfate biosynthesis (late stages)0.78


    2 BioSystems Pathways for A4GNT 
        heparan sulfate biosynthesis (late stages)
    heparan sulfate biosynthesis


    UniProtKB/Swiss-Prot: A4GCT_HUMAN, Q9UNA3
    Pathway: Protein modification; protein glycosylation

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for A4GNT

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS10430883
    GO:0006493protein O-linked glycosylation TAS10430883
    GO:0009101glycoprotein biosynthetic process IDA10430883


    A4GNT for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for A4GNT
    Search CenterWatch for drugs/clinical trials and news about A4GNT / A4GCT 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for A4GNT gene: 
    NM_016161.2  

    Unigene Cluster for A4GNT:

    Alpha-1,4-N-acetylglucosaminyltransferase
    Hs.278960  [show with all ESTs]
    Unigene Representative Sequence: AK225668
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000236709(uc003ers.2)

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    Additional cDNA sequence: 

    AF141315.1 AK225668.1 BC119639.1 BC119640.2 

    1 DOTS entry:

    DT.91743826 

    7 AceView cDNA sequences:

    AF141315 NM_016161 BM769023 BX094798 BP343384 AI344512 AW869791 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    A4GNT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AACCAGGAGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    A4GNT expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See A4GNT Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for A4GNT

    SOURCE GeneReport for Unigene cluster: Hs.278960

    UniProtKB/Swiss-Prot: A4GCT_HUMAN, Q9UNA3
    Tissue specificity: Detected in stomach and pancreas

        SABiosciences Expression via Pathway-Focused PCR Array including A4GNT: 
              Glycosylation in human mouse rat

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for A4GNT gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia A4gnt1 , 5 alpha-1,4-N-acetylglucosaminyltransferase1, 5 77.25(n)1
    71.18(a)1
      9 (51.91 cM)5
    3334241  NM_001077424.21  NP_001070892.11 
     996125025 
    chicken
    (Gallus gallus)
    Aves A4GNT1 alpha-1,4-N-acetylglucosaminyltransferase 66.56(n)
    61.66(a)
      429136  XM_426692.2  XP_426692.2 
    lizard
    (Anolis carolinensis)
    Reptilia A4GNT6
    --
    59(a)
    1 ↔ 1
    3(33025514-33028022)
    African clawed frog
    (Xenopus laevis)
    Amphibia CF285652.12   -- 69.58(n)    CF285652.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta alpha4GT16
    alpha4GT26
    alpha4GT2
    21(a)
    20(a)
    many ↔ many
    many ↔ many
    2L(3021309-3023141)
    3R(21657971-21668287)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G199006
    AT2G381526
    (see all 6)
    alpha 1,4-glycosyltransferase-like protein
    (see all 6)
    9(a)
    20(a)
    (see all 6)
    many ↔ many
    many ↔ many
    (see all 6)
    4(10789096-10791433)
    2(15984062-15985278)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    glycosyltransferase sugar-binding region containin...
    glycosyltransferase sugar-binding region containin...
    14(a)
    12(a)
    many ↔ many
    many ↔ many
    4(26319098-26322713)
    7(22790768-22797444)


    ENSEMBL Gene Tree for A4GNT (if available)
    TreeFam Gene Tree for A4GNT (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for A4GNT gene
    A4GALT2  
    1 SIMAP similar gene for A4GNT using alignment to 1 protein entry:     A4GCT_HUMAN:
    A4GALT

    A4GNT for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for A4GNT
    PGOHUM00000237787


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/168 NCBI SNPs in A4GNT are shown (see all 168    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1396967761,2
    --137842060(+) TAGATC/GGATAT 1 -- ds50010--------
    rs26226971,2
    C,H,--137842092(-) CCAAAT/CGTAAA 1 -- ds50018Minor allele frequency- C:0.29WA NA CSA EA 366
    rs1821880201,2
    --137842140(+) AAAAGC/GAAAGT 1 -- ds50010--------
    rs1867895081,2
    --137842248(+) CAAATA/GAAAAT 1 -- ds50010--------
    rs795584211,2
    C,F,--137842361(+) AAGTTG/ACTTCT 1 -- ds50011Minor allele frequency- A:0.06EA 120
    rs1154284401,2
    --137842407(+) GAAAGA/GGGTAG 1 -- ds50011Minor allele frequency- G:0.01WA 118
    rs1916138231,2
    --137842492(+) GTGCTA/GAGGAT 1 -- ds50010--------
    rs1144635811,2
    F,--137842540(+) ATCAAT/CGTTTG 1 -- ds50011Minor allele frequency- C:0.02NA 120
    rs1144583991,2
    F,--137842622(+) TCAAGT/CCTCTT 1 -- ut311Minor allele frequency- C:0.08WA 118
    rs1442601991,2
    --137842713(+) CCTATC/GCCAGT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for A4GNT (137842560 - 137851229 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for A4GNT
         2 CNVs: 8991 3449
    Human Gene Mutation Database (HGMD): A4GNT

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing A4GNT
    DNA2.0 Custom Variant and Variant Library Synthesis for A4GNT

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    A4GNT for disorders           About GeneDecksing

    3 diseases for A4GNT:    About MalaCards
    gastric cancer    pancreatic cancer    pancreatitis

    1 disease from the University of Copenhagen DISEASES database for A4GNT:
    Gastric adenocarcinoma
    Human Genome Epidemiology (HuGE) Navigator: A4GNT (2 documents)

    Export disorders for A4GNT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for A4GNT gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with A4GNT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression cloning of a human alpha1, 4-N- acetylglucosaminyltransferase that forms GlcNAcalpha1-->4Galbeta-->R, a glycan specifically expressed in the gastric gland mucous cell-type mucin. (PubMed id 10430883)1, 2, 3, 9 Nakayama J.... Fukuda M. (1999)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Immunohistochemical demonstration of alpha1,4-N-acetylglucosaminyltransferase that forms GlcNAcalpha1,4Galbeta residues in human gastrointestinal mucosa. (PubMed id 11304796)1, 9 Zhang M.X....Fukuda M. (2001)
    4. Essential role of gastric gland mucin in preventing ga stric cancer in mice. (PubMed id 22307328)1 Karasawa F....Nakayama J. (2012)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    6. Genetic variation in a4GnT in relation to Helicobacte r pylori serology and gastric cancer risk. (PubMed id 19751437)1 Zheng Z....Ye W. (2009)
    7. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    8. Clinical utility of quantitative RT-PCR targeted to alpha1,4-N-acetylglucosaminyltransferase mRNA for detection of pancreatic cancer. (PubMed id 16441422)1 Ishizone S....Nakayama J. (2006)
    9. Usefulness of the real-time reverse transcription-polymerase chain reaction assay targeted to alpha1,4-N-acetylglucosaminyltransferase for the detection of gastric cancer. (PubMed id 12594234)1 Shimizu F....Katsuyama T. (2003)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51146 HGNC: 17968 AceView: A4GNT Ensembl:ENSG00000118017 euGenes: HUgn51146
    ECgene: A4GNT H-InvDB: A4GNT

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for A4GNT Pharmacogenomics, SNPs, Pathways
    GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_532

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for A4GNT gene:
    Search GeneIP for patents involving A4GNT

    GeneCards and IP:
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