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A4GALT Gene

protein-coding GIFtS: 60

GC22M041412

alpha 1,4-galactosyltransferase
(Previous names: alpha 1,4-galactosyltransferase (globotriaosylceramide synthase, P blood group) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
A14GALT ^¹, ², ³
A4GALT1 ^², ³
Alpha-1,4-N-acetylglucosaminyltransferase ^³
Alpha-1,4-galactosyltransferase ^³
Alpha4Gal-T1 ^³
EC 2.4.1.228 ^³
P1 ^²
PK ^², ⁵
alpha-1,4-N-acetylglucosaminyltransferase ^²
alpha4Gal-T1 ^²

Descriptions
CD77 synthase ^², ³
Gb3 synthase ^², ³
Globotriaosylceramide synthase ^², ³
P blood group (P one antigen) ^²
P(k) antigen synthase ^²
P1/Pk synthase ^², ³
UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase ^², ³
alpha 1,4-galactosyltransferase ^²
alpha 1,4-galactosyltransferase (globotriaosylceramide synthase, P blood group) ^¹
lactosylceramide 4-alpha-galactosyltransferase ^²

External Ids
HGNC: 18149¹
Entrez Gene: 53947²
UniProtKB: Q9NPC4³
Ensembl: ENSG00000128274⁷

Search outside databases for aliases for A4GALT gene

Previous GC identifers: GC22M039690 GC22M041319

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for A4GALT:

The protein encoded by this gene catalyzes the transfer of galactose to lactosylceramide to form

globotriaosylceramide, which has been identified as the P(k) antigen of the P blood group system.

The encoded protein, which is a type II membrane protein found in the Golgi, is also required for

the synthesis of the bacterial verotoxins receptor. [provided by RefSeq]

UniProtKB/Swiss-Prot: A4GAT_HUMAN, Q9NPC4

Function: Necessary for the biosynthesis of the Pk antigen of blood histogroup P. Catalyzes the

transfer of galactose to lactosylceramide and galactosylceramide. Necessary for the synthesis of

the receptor for bacterial verotoxins

Gene Wiki entry for A4GALT

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the A4GALT gene

Entrez Gene cytogenetic band: 22q11.2-q13.2 Ensembl cytogenetic band: 22q13.2 HGNC cytogenetic band: 22q13.2

A4GALT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22M041412: (about GC identifiers)

Start:	41,418,071 bp from pter
End:	41,446,820 bp from pter
Size:	28,750 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000022.9 NT_011520.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: A4GAT_HUMAN, Q9NPC4 (See protein sequence)

Recommended Name: Lactosylceramide 4-alpha-galactosyltransferase

Size: 353 amino acids; 40499 Da

Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein (Probable)

Secondary accessions: Q9P1X5

REFSEQ proteins: NP_059132.1

ENSEMBL proteins:

ENSP00000384794 ENSP00000370678 ENSP00000370676 ENSP00000249005

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (CD77)
	Human Recombinant Proteins from Abnova (A4GALT)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/7 Gene Ontology (GO) cellular component terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	IEA	--
GO:0005624	membrane fraction	IDA	10748143
GO:0005794	Golgi apparatus	IEA	--
GO:0005795	Golgi stack	IEA	--
GO:0016020	membrane	IEA	--

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Antibodies for A4GALT:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for A4GALT
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (CD77), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (A4GALT)
	Novus Biologicals Antibody for A4GALT

Assays for A4GALT:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q9NPC4

ProtoNet protein and cluster: Q9NPC4

1 Blocks protein family: IPB007652 Alpha 1,4-glycosyltransferase conserved region

UniProtKB/Swiss-Prot: A4GAT_HUMAN, Q9NPC4

Domain: The conserved DXD motif is involved in enzyme activity (By similarity)

Similarity: Belongs to the glycosyltransferase 32 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (A4GALT)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (A4GALT)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_017436

Applied Biosystems Silencer® siRNAs for A4GALT

Sigma-Aldrich siRNA for A4GALT

Sigma-Aldrich shRNA for A4GALT

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for A4GALT
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_017436
Myc/DDK tagged cDNA clone in CMV expression vector: NM_017436
untagged cDNA clones in CMV expression vector (see all 2): BC017068

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_017436

UniProtKB/Swiss-Prot: A4GAT_HUMAN, Q9NPC4

Function: Necessary for the biosynthesis of the Pk antigen of blood histogroup P. Catalyzes the

transfer of galactose to lactosylceramide and galactosylceramide. Necessary for the synthesis of

the receptor for bacterial verotoxins

Catalytic activity: UDP-galactose + beta-D-galactosyl-(1->4)-D-glucosyl-(1<->1)-ceramide = UDP +

alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-D-glucosyl-(1<->1)-ceramide

Enzyme Number (IUBMB): EC 2.4.1.228

2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for A4galt):

homeostasis/metabolism

life span-post-weaning/aging

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008378	galactosyltransferase activity	IDA	10747952
GO:0016757	transferase activity, transferring glycosyl groups	IEA	--
GO:0050512	lactosylceramide 4-alpha-galactosyltransferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for A4GALT (Your Favorite Gene powered by Ingenuity)

Glycosphingolipid Biosynthesis - Globoseries

GeneDecks A4GALT for the pathways selected above

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UniProtKB/Swiss-Prot: A4GAT_HUMAN, Q9NPC4

Pathway: Protein modification; protein glycosylation

5/14 Interacting proteins for A4GALT (Q9NPC4² ENSP00000370678³) via UniProtKB, MINT, and/or STRING (see all 14 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
B3GALNT1	ENSP00000323479³	STRING (score=.987)
STX1A	ENSP00000222812³	STRING (score=.936)
HEXA	ENSP00000268097³	STRING (score=.899)
STX2	ENSP00000342554³	STRING (score=.89)
B4GALT6	ENSP00000306459³	STRING (score=.873)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006688	glycosphingolipid biosynthetic process	NAS	10748143
GO:0007009	plasma membrane organization	IDA	10747952
GO:0008610	lipid biosynthetic process	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for A4GALT
6 Novoseek chemical compound relationships for A4GALT gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
lactosylceramide	87.08	5	9988695 (1), 12232838 (1), 16100442 (1), 15633106 (1) (see all 5)
shiga toxin	82.54	3	15633106 (1)
verotoxins	79.24	3	8039905 (1)
glucosylceramide	70.47	2	9988695 (1), 15633106 (1)
ceramide	62.35	3	9988695 (1), 12232838 (1), 16100442 (1)
glycosphingolipid	58.20	1	10854428 (1)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (A4GALT)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (A4GALT)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_017436

Sigma-Aldrich siRNA for A4GALT

Sigma-Aldrich shRNA for A4GALT

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_017436

REFSEQ mRNAs for A4GALT gene:

NM_017436.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_017436

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_017436
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_017436
                                 untagged cDNA clones in CMV expression vector (see all 2): BC017068

Additional cDNA sequence:

AB037883.1 AJ245581.1 AK074388.1 AK130208.1 AK312927.1 BC017068.2 BC055286.1 CR604491.1

13 DOTS entries:

DT.442686 DT.100699121 DT.120628638 DT.100821222 DT.95272953 DT.95272956 DT.101959088 DT.120628635

DT.120628647 DT.92424195 DT.99988912 DT.100821221 DT.120628618

24/105 AceView cDNA sequences (see all 105 ):

BU944582 BF939428 AB037883 AJ245581 BU944049 AI401691 BE646115 NM_017436

BU956377 BQ059688 CR604491 BQ061875 BF915976 BC017068 BI754786 AI970069

BF914923 BE019172 CB152865 CF132207 BP352881 CK823292 AW575194 BM966881

highest scoring ESTs for A4GALT:

AB037883 BC017068 BE890045 BG721380 BI084280 BM924907 BQ706071 BQ707951 BQ709200 BQ712615

Unigene Cluster for A4GALT:

Alpha 1,4-galactosyltransferase

Hs.105956 [show with all ESTs]

Unigene Representative Sequence: BC055286

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for A4GALT

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	·	4c	·	4d
SP1:			-		-		-
SP2:					-		-
SP3:					-		-
SP4:							-
SP5:

About this scheme

ECgene alternative splicing isoforms for A4GALT

4 Ensembl transcripts including schematic representations:

ENST00000401850 ENST00000381278 ENST00000381276 ENST00000249005

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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A4GALT expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for A4GALT

¹ / ² / ³

3 probe-sets matching A4GALT gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
56837_at²^{, 3}	U95-B	2	1.00	0.97	1.00	1.00	AA769110	0.60	1.00	0.82	1
219488_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_017436	0.60	1.00	0.82	1
219488_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks A4GALT for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AAAATGTACT

SOURCE GeneReport for Unigene cluster: Hs.105956
UniProtKB/Swiss-Prot: A4GAT_HUMAN, Q9NPC4
Tissue specificity: Ubiquitous. Highly expressed in kidney, heart, spleen, liver, testis and
placenta

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for A4GALT gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	A4GALT¹	--	alpha 1,4-galactosyltransferase	87.82(n) 86.4(a)	481222 XM_538343.2 XP_538343.2
chimpanzee (Pan troglodytes)	A4GALT¹	--	alpha 1,4-galactosyltransferase	99.43(n) 99.43(a)	470230 NM_001009123.1 NP_001009123.1
rat (Rattus norvegicus)	A4galt¹	--	alpha 1,4-galactosyltransferase	80.42(n) 81.09(a)	63888 NM_022240.2 NP_071576.1
mouse (Mus musculus)	A4galt^{1, 5}	15⁵	alpha 1,4-galactosyltransferase^{1, 5}	80.65(n)¹ 78.45(a)¹	239559¹ NM_001004150.1¹ NP_001004150.1¹ AK139833⁵ AK149186⁵ (see all 12)
chicken (Gallus gallus)	A4GALT¹	--	alpha 1,4-galactosyltransferase (globotriaosylceramide more	66.57(n) 66.29(a)	418223 XM_416448.2 XP_416448.2

About this table Species with no ortholog for A4GALT

ENSEMBL Gene Tree for A4GALT

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for A4GALT gene

A4GNT²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

UniProtKB/Swiss-Prot: A4GAT_HUMAN, Q9NPC4

Polymorphism: Different combinations or absence of the P blood group system antigens define 5

different phenotypes: P1, P2, P1(k), P2(k), and p. Genetic variation in A4GALT determines the p

phenotype, which is rare and does not express any antigens. It is also known as null phenotype; p

individuals have antibodies against P, P1 and Pk antigens in their sera. These antibodies are

clinically important because they can cause severe transfusion reactions and miscarriage

10/416 NCBI SNPs in A4GALT are shown (see all 416 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 147)

AB	SNP ID	Valid	Chr 22 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs135106^1,2	A,C,F,H	41418379(+)	`CAAAGC/TATCCT`	1	--	ut3¹		10	EA NA MN NS EU WA	904
--	rs5751351^1,2	A,C,F,H	41447542(+)	`cagctG/Catgac`	1	--	ng3¹		6	EU EA WA NS	444
	rs5758898^1,2	A,C,F,H	41447407(+)	`TCTCTT/GTGGAA`	1	--	ng3¹		6	EU EA WA NS	450
	rs1053026^1,2	A,C,F,H	41418205(-)	`GCTCTG/ACCCCT`	1	--	ut3¹		7	EA MN NS WA	2064
	rs11541159^1,2	C,F,H	41419793(-)	`CCATCA/GTGATC`	1	M/V	mis¹		6	EU EA WA NS	512
--	rs9607929^1,2	A,C,F	41446981(+)	`GGCGGG/CTGCGG`	1	--	ng3¹		2	NS	74
	rs8142445^1,2	A,C,F	41417588(+)	`GTCTCG/ACCCTG`	1	--	ng5¹		2	NS	94
	rs3747194^1,2	A,C,F	41418493(+)	`AGCACC/TGGCCT`	1	--	ut3¹ ese³		3	EA NS	1580
--	rs5751350^1,2	A,C,F	41447539(+)	`actcaG/Actgat`	1	--	ng3¹		2	NS	32
--	rs5845556^1,2	C,F	41447319(+)	`TCACAG/-CATAT`	1	--	ng3¹		2	NS	32

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HapMap Linkage Disequilibrium images for A4GALT (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 607922 disorders: 111400

1 Novoseek disease relationship for A4GALT gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	0.00	1	11745412 (1)

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Blood Group Antigen Gene Mutation Database (BGMUT) Pk blood group system

Human Gene Mutation Database: A4GALT

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/33 PubMed articles for A4GALT gene (see all 33 ):

Cloning and expression of the histo-blood group Pk UDP- galactose:Galbeta1-4Glcbeta1-Cer alpha1,4-galactosyltransferase. Molecular genetic basis of the p phenotype. (PubMed id 10747952)^{1, 3, 4} Steffensen R.... Clausen H. (2000)
Three-base deletion and one-base insertion of the alpha(1,4)galactosyltransferase gene responsible for the P phenotype. (PubMed id 11896312)^{1, 3, 4} Koda Y.... Kimura H. (2002)
Cloning of Gb3 synthase, the key enzyme in globo-series glycosphingolipid synthesis, predicts a family of alpha 1, 4-glycosyltransferases conserved in plants, insects, and mammals. (PubMed id 10854428)^{1, 2, 3} Keusch J.J....Baenziger J.U. (2000)
Molecular basis for the p phenotype. Identification of distinct and multiple mutations in the alpha 1,4-galactosyltransferase gene in Swedish and Japanese individuals. (PubMed id 10993874)^{1, 3, 4} Furukawa K.... Furukawa K. (2000)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Molecular cloning of globotriaosylceramide/CD77 synthase, a glycosyltransferase that initiates the synthesis of globo series glycosphingolipids. (PubMed id 10748143)^{3, 4} Kojima Y.... Furukawa K. (2000)
The DNA sequence of human chromosome 22. (PubMed id 10591208)^{3, 4} Dunham I....O'Brien K.P. (1999)
Two previously proposed P1/P2-differentiating and nine novel polymorphisms at the A4GALT (Pk) locus do not correlate with the presence of the P1 blood group antigen. (PubMed id 16212661)^{1, 3} Hellberg A....Olsson M.L. (2005)
Expression of a novel missense mutation found in the A4GALT gene of Amish individuals with the p phenotype. (PubMed id 18067504)^{1, 3} Hellberg A....Olsson M.L. (2008)
Genetic heterogeneity at the glycosyltransferase loci underlying the GLOB blood group system and collection. (PubMed id 15142124)^{1, 3} Hellberg A....Olsson M.L. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 53947	HGNC: 18149	AceView: A4GALT	Ensembl:ENSG00000128274	euGenes: HUgn53947
ECgene: A4GALT	H-InvDB: A4GALT

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
GGDB	http://riodb.ibase.aist.go.jp/rcmg/ggdb/
SeattleSNPs	http://pga.gs.washington.edu/data/a4galt/
Functional Glycomics Gateway - GTase	http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_428

Licensable Technologies for A4GALT
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for A4GALT:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for A4GALT-related products

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	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for A4GALT		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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A4GALT Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for A4GALT

Summaries
for A4GALT

Genomic Location
for A4GALT

Proteins
for A4GALT

Protein Domains/
Families
for A4GALT

Gene Function
for A4GALT

Pathways & Interactions
for A4GALT

Drugs & Compounds
for A4GALT

Transcripts
for A4GALT

Expression
for A4GALT

Orthologs
for A4GALT

Paralogs
for A4GALT

SNPs/Variants
for A4GALT

Disorders & Mutations
for A4GALT

Medical News
for A4GALT

Publications
for A4GALT

Search for A4GALT

Genome Databases showing A4GALT

Other Databases showing A4GALT

Specialized Databases showing A4GALT

Licensable Technologies
for A4GALT

Services
for A4GALT

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

A4GALT (Gene Symbol)
A14GALT
A4GALT1
Alpha-1,4-N-acetylglucosaminyltransferase
Alpha-1,4-galactosyltransferase
Alpha4Gal-T1
EC 2.4.1.228
P1
PK
alpha-1,4-N-acetylglucosaminyltransferase
alpha4Gal-T1
CD77 synthase
Gb3 synthase
Globotriaosylceramide synthase
P blood group (P one antigen)
P(k) antigen synthase
P1/Pk synthase
UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase
alpha 1,4-galactosyltransferase
alpha 1,4-galactosyltransferase (globotriaosylceramide synthase, P blood group)
lactosylceramide 4-alpha-galactosyltransferase

A4GALT Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor A4GALT

Summariesfor A4GALT

Genomic Locationfor A4GALT

Proteinsfor A4GALT

Protein Domains/Familiesfor A4GALT

Gene Functionfor A4GALT

Pathways & Interactionsfor A4GALT

Drugs & Compoundsfor A4GALT

Transcriptsfor A4GALT

Expression for A4GALT

Orthologsfor A4GALT

Paralogsfor A4GALT

SNPs/Variantsfor A4GALT

Disorders & Mutationsfor A4GALT

Medical Newsfor A4GALT

Publicationsfor A4GALT

Search for A4GALT

Genome Databases showing A4GALT

Other Databases showing A4GALT

Specialized Databases showing A4GALT

Licensable Technologiesfor A4GALT

Servicesfor A4GALT

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for A4GALT

Summaries
for A4GALT

Genomic Location
for A4GALT

Proteins
for A4GALT

Protein Domains/
Families
for A4GALT

Gene Function
for A4GALT

Pathways & Interactions
for A4GALT

Drugs & Compounds
for A4GALT

Transcripts
for A4GALT

Expression
for A4GALT

Orthologs
for A4GALT

Paralogs
for A4GALT

SNPs/Variants
for A4GALT

Disorders & Mutations
for A4GALT

Medical News
for A4GALT

Publications
for A4GALT

Licensable Technologies
for A4GALT

Services
for A4GALT