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Aliases for A3GALT2 Gene

Aliases for A3GALT2 Gene

  • Alpha 1,3-Galactosyltransferase 2 2 3
  • Alpha 1,3-Galactosyltransferase 2, Pseudogene 2 3
  • Isoglobotriaosylceramide Synthase 2 3
  • IGb3 Synthase 2 3
  • A3GALT2P 3
  • IGBS3S 3

External Ids for A3GALT2 Gene

Previous Symbols for A3GALT2 Gene

  • A3GALT2P

Summaries for A3GALT2 Gene

GeneCards Summary for A3GALT2 Gene

A3GALT2 (Alpha 1,3-Galactosyltransferase 2) is a Protein Coding gene. Among its related pathways are Glycosphingolipid biosynthesis - ganglio series. An important paralog of this gene is GLT6D1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for A3GALT2 Gene

Genomics for A3GALT2 Gene

Genomic Location for A3GALT2 Gene

Start:
33,306,766 bp from pter
End:
33,321,098 bp from pter
Size:
14,333 bases
Orientation:
Minus strand

Genomic View for A3GALT2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for A3GALT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for A3GALT2 Gene

Regulatory Elements for A3GALT2 Gene

Proteins for A3GALT2 Gene

  • Protein details for A3GALT2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    U3KPV4-U3KPV4
    Recommended name:
    Protein A3GALT2
    Protein Accession:
    U3KPV4
    Secondary Accessions:

    Protein attributes for A3GALT2 Gene

    Size:
    340 amino acids
    Molecular mass:
    38754 Da
    Quaternary structure:
    No Data Available

neXtProt entry for A3GALT2 Gene

Proteomics data for A3GALT2 Gene at MOPED

Post-translational modifications for A3GALT2 Gene

No Post-translational modifications

Other Protein References for A3GALT2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for A3GALT2 Gene

Domains for A3GALT2 Gene

Gene Families for A3GALT2 Gene

HGNC:
  • GLT6 :Glycosyltransferase family 6 domain containing

Protein Domains for A3GALT2 Gene

genes like me logo Genes that share domains with A3GALT2: view

No data available for UniProtKB/Swiss-Prot for A3GALT2 Gene

Function for A3GALT2 Gene

Gene Ontology (GO) - Molecular Function for A3GALT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001962 alpha-1,3-galactosyltransferase activity --
GO:0016757 transferase activity, transferring glycosyl groups --
GO:0016758 transferase activity, transferring hexosyl groups --
genes like me logo Genes that share ontologies with A3GALT2: view

Phenotypes for A3GALT2 Gene

genes like me logo Genes that share phenotypes with A3GALT2: view

Animal Models for A3GALT2 Gene

MGI Knock Outs for A3GALT2:

No data available for Molecular function , Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for A3GALT2 Gene

Localization for A3GALT2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for A3GALT2 Gene COMPARTMENTS Subcellular localization image for A3GALT2 gene
Compartment Confidence
golgi apparatus 3
extracellular 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for A3GALT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus --
GO:0016020 membrane --
GO:0031982 vesicle --
genes like me logo Genes that share ontologies with A3GALT2: view

Pathways for A3GALT2 Gene

genes like me logo Genes that share pathways with A3GALT2: view

Pathways by source for A3GALT2 Gene

1 BioSystems pathway for A3GALT2 Gene

Interacting Proteins for A3GALT2 Gene

Gene Ontology (GO) - Biological Process for A3GALT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process --
GO:0006688 glycosphingolipid biosynthetic process --
GO:0030259 lipid glycosylation --
genes like me logo Genes that share ontologies with A3GALT2: view

Transcripts for A3GALT2 Gene

mRNA/cDNA for A3GALT2 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for A3GALT2 Gene

No ASD Table

Relevant External Links for A3GALT2 Gene

GeneLoc Exon Structure for
A3GALT2
ECgene alternative splicing isoforms for
A3GALT2

Expression for A3GALT2 Gene

mRNA expression in normal human tissues for A3GALT2 Gene

mRNA differential expression in normal tissues according to GTEx for A3GALT2 Gene

This gene is overexpressed in Whole Blood (8.3) and Testis (4.5).
genes like me logo Genes that share expressions with A3GALT2: view

Orthologs for A3GALT2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for A3GALT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ABO 37
  • 37 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia A3GALT2 36
  • 86.96 (n)
  • 80.29 (a)
A3GALT2 37
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia A3GALT2 36
  • 89.41 (n)
  • 82.35 (a)
A3GALT2 37
  • 58 (a)
OneToOne
mouse
(Mus musculus)
Mammalia A3galt2 36
  • 77.38 (n)
  • 69.07 (a)
A3galt2 16
A3galt2 37
  • 64 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 41 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 40 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia A3galt2 36
  • 77.68 (n)
  • 69.62 (a)
Species with no ortholog for A3GALT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for A3GALT2 Gene

ENSEMBL:
Gene Tree for A3GALT2 (if available)
TreeFam:
Gene Tree for A3GALT2 (if available)

Paralogs for A3GALT2 Gene

Paralogs for A3GALT2 Gene

Selected SIMAP similar genes for A3GALT2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with A3GALT2: view

Variants for A3GALT2 Gene

Sequence variations from dbSNP and Humsavar for A3GALT2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs4073404 -- 33,308,252(-) TTCTT(A/C)TATGG intron-variant
rs4074333 -- 33,307,278(+) CACGT(A/C)TTGCC reference, missense
rs4233197 -- 33,318,147(+) GCCGC(A/G)TTCTT intron-variant
rs4652839 -- 33,319,328(+) TACCT(C/G)AGGGC intron-variant
rs4653006 -- 33,308,490(+) AACCT(C/T)TGCCT intron-variant

Relevant External Links for A3GALT2 Gene

HapMap Linkage Disequilibrium report
A3GALT2

No data available for Structural Variations from Database of Genomic Variants (DGV) for A3GALT2 Gene

Disorders for A3GALT2 Gene

No disorders were found for A3GALT2 Gene.

No data available for UniProtKB/Swiss-Prot for A3GALT2 Gene

Publications for A3GALT2 Gene

  1. Humans lack iGb3 due to the absence of functional iGb3-synthase: implications for NKT cell development and transplantation. (PMID: 18630988) Christiansen D. … Sandrin M.S. (PLoS Biol. 2008) 2 3
  2. Lack of iGb3 and Isoglobo-Series Glycosphingolipids in Pig Organs Used for Xenotransplantation: Implications for Natural Killer T-Cell Biology. (PMID: 23378701) Tahiri F. … Zhou D. (J Carbohydr Chem 2013) 3
  3. Expression cloning of a new member of the ABO blood group glycosyltransferases, iGb3 synthase, that directs the synthesis of isoglobo-glycosphingolipids. (PMID: 10854427) Keusch J.J. … Baenziger J.U. (J. Biol. Chem. 2000) 2
  4. Carbohydrate residues downstream of the terminal Galalpha(1,3)Gal epitope modulate the specificity of xenoreactive antibodies. (PMID: 17724458) Milland J. … Sandrin M.S. (Immunol. Cell Biol. 2007) 23
  5. Sensitive detection of isoglobo and globo series tetraglycosylceramides in human thymus by ion trap mass spectrometry. (PMID: 18056651) Li Y. … Zhou D. (Glycobiology 2008) 23

Products for A3GALT2 Gene

Sources for A3GALT2 Gene

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