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Aliases for A3GALT2 Gene

Aliases for A3GALT2 Gene

  • Alpha 1,3-Galactosyltransferase 2 2 3 5
  • Alpha 1,3-Galactosyltransferase 2, Pseudogene 2 3
  • Isoglobotriaosylceramide Synthase 2 3
  • IGb3 Synthase 2 3
  • A3GALT2P 3
  • IGBS3S 3
  • IGB3S 3

External Ids for A3GALT2 Gene

Previous HGNC Symbols for A3GALT2 Gene

  • A3GALT2P

Previous GeneCards Identifiers for A3GALT2 Gene

  • GC01M033442
  • GC01M033544
  • GC01M033772

Summaries for A3GALT2 Gene

GeneCards Summary for A3GALT2 Gene

A3GALT2 (Alpha 1,3-Galactosyltransferase 2) is a Protein Coding gene. Among its related pathways are Glycosphingolipid biosynthesis - ganglio series. GO annotations related to this gene include transferase activity, transferring glycosyl groups and alpha-1,3-galactosyltransferase activity. An important paralog of this gene is GLT6D1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for A3GALT2 Gene

Genomics for A3GALT2 Gene

Regulatory Elements for A3GALT2 Gene

Genomic Location for A3GALT2 Gene

Chromosome:
1
Start:
33,306,766 bp from pter
End:
33,321,098 bp from pter
Size:
14,333 bases
Orientation:
Minus strand

Genomic View for A3GALT2 Gene

Genes around A3GALT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
A3GALT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for A3GALT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for A3GALT2 Gene

Proteins for A3GALT2 Gene

  • Protein details for A3GALT2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    U3KPV4
    Recommended name:
    Protein A3GALT2
    Protein Accession:
    U3KPV4

    Protein attributes for A3GALT2 Gene

    Size:
    340 amino acids
    Molecular mass:
    38754 Da
    Quaternary structure:
    No Data Available

neXtProt entry for A3GALT2 Gene

Proteomics data for A3GALT2 Gene at MOPED

Post-translational modifications for A3GALT2 Gene

No Post-translational modifications

Other Protein References for A3GALT2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for A3GALT2 Gene

Domains & Families for A3GALT2 Gene

Gene Families for A3GALT2 Gene

Protein Domains for A3GALT2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with A3GALT2: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for A3GALT2 Gene

Function for A3GALT2 Gene

Phenotypes for A3GALT2 Gene

GenomeRNAi human phenotypes for A3GALT2:
MGI mutant phenotypes for A3GALT2:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with A3GALT2: view

Animal Models for A3GALT2 Gene

MGI Knock Outs for A3GALT2:

Animal Model Products

  • Taconic Biosciences Mouse Models for A3GALT2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for A3GALT2 Gene

Localization for A3GALT2 Gene

Gene Ontology (GO) - Cellular Components for A3GALT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0031982 vesicle IEA --
genes like me logo Genes that share ontologies with A3GALT2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for A3GALT2 Gene

Pathways & Interactions for A3GALT2 Gene

genes like me logo Genes that share pathways with A3GALT2: view

Pathways by source for A3GALT2 Gene

1 BioSystems pathway for A3GALT2 Gene

Interacting Proteins for A3GALT2 Gene

Gene Ontology (GO) - Biological Process for A3GALT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
genes like me logo Genes that share ontologies with A3GALT2: view

No data available for SIGNOR curated interactions for A3GALT2 Gene

Drugs & Compounds for A3GALT2 Gene

No Compound Related Data Available

Transcripts for A3GALT2 Gene

mRNA/cDNA for A3GALT2 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for A3GALT2 Gene

No ASD Table

Relevant External Links for A3GALT2 Gene

GeneLoc Exon Structure for
A3GALT2
ECgene alternative splicing isoforms for
A3GALT2

Expression for A3GALT2 Gene

mRNA expression in normal human tissues for A3GALT2 Gene

mRNA differential expression in normal tissues according to GTEx for A3GALT2 Gene

This gene is overexpressed in Whole Blood (x8.3) and Testis (x4.5).
genes like me logo Genes that share expression patterns with A3GALT2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for A3GALT2 Gene

Orthologs for A3GALT2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for A3GALT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ABO 36
  • 37 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia A3GALT2 36
  • 84 (a)
OneToOne
A3GALT2 35
  • 86.96 (n)
  • 80.29 (a)
dog
(Canis familiaris)
Mammalia A3GALT2 35
  • 89.41 (n)
  • 82.35 (a)
A3GALT2 36
  • 58 (a)
OneToOne
mouse
(Mus musculus)
Mammalia A3galt2 36
  • 64 (a)
OneToOne
A3galt2 16
A3galt2 35
  • 77.38 (n)
  • 69.07 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 41 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 40 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia A3galt2 35
  • 77.68 (n)
  • 69.62 (a)
Species with no ortholog for A3GALT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for A3GALT2 Gene

ENSEMBL:
Gene Tree for A3GALT2 (if available)
TreeFam:
Gene Tree for A3GALT2 (if available)

Paralogs for A3GALT2 Gene

Paralogs for A3GALT2 Gene

(4) SIMAP similar genes for A3GALT2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with A3GALT2: view

Variants for A3GALT2 Gene

Sequence variations from dbSNP and Humsavar for A3GALT2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs4074333 -- 33,307,278(+) CACGT(A/C/T)TTGCC reference, missense
rs4653017 -- 33,311,127(+) AATGC(C/T)TCTTT intron-variant
rs6682438 -- 33,318,545(+) CTATC(C/T)GTGCC intron-variant
rs6664593 -- 33,312,990(+) CCAGC(C/T)GGTTC intron-variant
rs6687559 -- 33,317,699(+) GAACT(G/T)GATCA intron-variant

Variation tolerance for A3GALT2 Gene

Gene Damage Index Score: 3.54; 55.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for A3GALT2 Gene

HapMap Linkage Disequilibrium report
A3GALT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for A3GALT2 Gene

Disorders for A3GALT2 Gene

Relevant External Links for A3GALT2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
A3GALT2

No disorders were found for A3GALT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for A3GALT2 Gene

Publications for A3GALT2 Gene

  1. Humans lack iGb3 due to the absence of functional iGb3-synthase: implications for NKT cell development and transplantation. (PMID: 18630988) Christiansen D. … Sandrin M.S. (PLoS Biol. 2008) 2 3 67
  2. Lack of iGb3 and Isoglobo-Series Glycosphingolipids in Pig Organs Used for Xenotransplantation: Implications for Natural Killer T-Cell Biology. (PMID: 23378701) Tahiri F. … Zhou D. (J Carbohydr Chem 2013) 3
  3. Structural basis of UDP-galactose binding by alpha-1,3-galactosyltransferase (alpha3GT): role of negative charge on aspartic acid 316 in structure and activity. (PMID: 18651752) Tumbale P. … Acharya K.R. (Biochemistry 2008) 23
  4. Sensitive detection of isoglobo and globo series tetraglycosylceramides in human thymus by ion trap mass spectrometry. (PMID: 18056651) Li Y. … Zhou D. (Glycobiology 2008) 23
  5. Carbohydrate residues downstream of the terminal Galalpha(1,3)Gal epitope modulate the specificity of xenoreactive antibodies. (PMID: 17724458) Milland J. … Sandrin M.S. (Immunol. Cell Biol. 2007) 23

Products for A3GALT2 Gene

Sources for A3GALT2 Gene

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