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A2ML1 Gene

protein-coding   GIFtS: 48
GCID: GC12P008975

Alpha-2-Macroglobulin-Like 1

(Previous names: C3 and PZP-like, alpha-2-macroglobulin domain containing...)
(Previous symbol: CPAMD9)
  See A2ML1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Alpha-2-Macroglobulin-Like 11 2
CPAMD91 2 3
C3 And PZP-Like, Alpha-2-Macroglobulin Domain Containing 91 2
Alpha-2-Macroglobulin-Like Protein 12
C3 And PZP-Like Alpha-2-Macroglobulin Domain-Containing Protein 93

External Ids:    HGNC: 233361   Entrez Gene: 1445682   Ensembl: ENSG000001665357   OMIM: 6106275   UniProtKB: A8K2U03   

Export aliases for A2ML1 gene to outside databases

Previous GC identifers: GC12P008867 GC12P008757


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for A2ML1 Gene:
This gene encodes a member of the alpha-macroglobulin superfamily. The encoded protein acts as an inhibitor for
several proteases, and has been reported as the p170 antigen recognized by autoantibodies in the autoimmune
disease paraneoplastic pemphigus (PNP; PMID: 20805888). Alternative splicing results in multiple transcript
variants. (provided by RefSeq, Feb 2012)

GeneCards Summary for A2ML1 Gene:
A2ML1 (alpha-2-macroglobulin-like 1) is a protein-coding gene. Diseases associated with A2ML1 include paraneoplastic pemphigus. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and peptidase inhibitor activity. An important paralog of this gene is A2M.

UniProtKB/Swiss-Prot: A2ML1_HUMAN, A8K2U0
Function: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a
peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When
a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the
proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high
molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is
hydrolyzed and mediates the covalent binding of the protein to the proteinase (By similarity). Displays
inhibitory activity against chymotrypsin, papain, thermolysin, subtilisin A and, to a lesser extent, elastase but
not trypsin. May play an important role during desquamation by inhibiting extracellular proteases




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_009714.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the A2ML1 gene promoter:
         SRF   HOXA3   AP-1   SRF (504 AA)   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   PPAR-alpha   Pax-3   SRY   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidA2ML1 promoter sequence
   Search Chromatin IP Primers for A2ML1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat A2ML1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.31   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13

A2ML1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
A2ML1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P008975:  view genomic region     (about GC identifiers)

Start:
8,975,068 bp from pter      End:
9,039,597 bp from pter
Size:
64,530 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: A2ML1_HUMAN, A8K2U0 (See protein sequence)
Recommended Name: Alpha-2-macroglobulin-like protein 1 precursor  
Size: 1454 amino acids; 161107 Da
Subunit: Monomer
Developmental stage: Up-regulated during keratinocyte differentiation
Sequence caution: Sequence=BAB71612.1; Type=Erroneous initiation; Sequence=BAC04793.1; Type=Erroneous initiation;
Sequence=BAC85653.1; Type=Erroneous initiation; Sequence=BAC85654.1; Type=Erroneous initiation;
Secondary accessions: B5MDD1 Q2M224 Q6ZW52 Q6ZW53 Q8N1M4 Q96LQ8

Explore the universe of human proteins at neXtProt for A2ML1: NX_A8K2U0

Explore proteomics data for A2ML1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn120, Asn281, Asn409, Asn857, Asn1020

  • See A2ML1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001269353.1  NP_653271.2  

    ENSEMBL proteins: 
     ENSP00000299698   ENSP00000443174   ENSP00000440662   ENSP00000438292   ENSP00000440057  
     ENSP00000445674  

    A2ML1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 9):
     IPR014756 Ig_E-set
     IPR019742 MacrogloblnA2_CS
     IPR001599 Macroglobln_a2
     IPR011626 A2M_comp
     IPR002890 A2M_N

    Graphical View of Domain Structure for InterPro Entry A8K2U0

    ProtoNet protein and cluster: A8K2U0

    UniProtKB/Swiss-Prot: A2ML1_HUMAN, A8K2U0
    Similarity: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family


    Find genes that share domains with A2ML1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: A2ML1_HUMAN, A8K2U0
    Function: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a
    peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When
    a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the
    proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high
    molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is
    hydrolyzed and mediates the covalent binding of the protein to the proteinase (By similarity). Displays
    inhibitory activity against chymotrypsin, papain, thermolysin, subtilisin A and, to a lesser extent, elastase but
    not trypsin. May play an important role during desquamation by inhibiting extracellular proteases

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004866endopeptidase inhibitor activity ----
    GO:0004867serine-type endopeptidase inhibitor activity IEA--
    GO:0030414peptidase inhibitor activity IDA16298998
         
    Find genes that share ontologies with A2ML1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for A2ML1:
     Synthetic lethal with Ras 

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidA2ML1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    A2ML1_HUMAN, A8K2U0: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane2
    cytoskeleton1
    cytosol1
    endoplasmic reticulum1
    golgi apparatus1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IDA16298998
    GO:0070062extracellular vesicular exosome IDA19199708

    Find genes that share ontologies with A2ML1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for A2ML1
    Interactions:

        Search GeneGlobe Interaction Network for A2ML1

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0052548regulation of endopeptidase activity IDA16298998

    Find genes that share ontologies with A2ML1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for A2ML1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for A2ML1 gene (2 alternative transcripts): 
    NM_001282424.1  NM_144670.4  

    Unigene Cluster for A2ML1:

    Alpha-2-macroglobulin-like 1
    Hs.620532  [show with all ESTs]
    Unigene Representative Sequence: AL832139
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000299698(uc001quz.4 uc010sgm.2) ENST00000537546 ENST00000541459(uc001qva.1)
    ENST00000536789 ENST00000539547 ENST00000545692 ENST00000540049 ENST00000545850
    ENST00000537475(uc001qvb.1)
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate A2ML1:
    hsa-miR-539 hsa-miR-3919 hsa-miR-770-5p
    SwitchGear 3'UTR luciferase reporter plasmidA2ML1 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat A2ML1
      QuantiFast Probe-based Assays in human, mouse, rat A2ML1

    Additional mRNA sequence: 

    AK057908.1 AK096448.1 AK123591.1 AK123592.1 AK123601.1 AK290355.1 AK302555.1 AL832139.1 
    AL832750.1 AL833479.1 BC093840.1 BC112131.1 BX647674.1 BX648231.1 NR_046256.1 

    6 DOTS entries:

    DT.421412  DT.97822102  DT.95220277  DT.101981889  DT.121190124  DT.91979364 

    Selected AceView cDNA sequences (see all 46):

    AK057908 NM_144670 AK123601 AK096448 AK123592 BU101570 BE151370 AL700698 
    AA316097 AK122624 BX647674 AW860672 BU101571 AW862460 BX504185 AL832750 
    AL833479 AK123591 BX648231 AL832139 BX504184 AW860613 BF334660 BG680886 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for A2ML1 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
    SP1:                                                                                      -                                                                     
    SP2:                                                                                      -                                                                     
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40
    SP1:                                                                                      -         
    SP2:                                                                                                
    SP3:                                                                                      -         
    SP4:                                                                                                
    SP5:                                                                                                


    ECgene alternative splicing isoforms for A2ML1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    A2ML1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTAAAACCCG
    A2ML1 Expression
    About this image


    A2ML1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Pre-Granulosa Cells Primordial Follicle
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Esophagus (Gastrointestinal Tract)
    A2ML1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    A2ML1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.620532

    UniProtKB/Swiss-Prot: A2ML1_HUMAN, A8K2U0
    Tissue specificity: In the epidermis, expressed predominantly in the granular layer at the apical edge of
    keratinocytes (at protein level). Also detected in placenta, testis and thymus but not in epithelia of kidney,
    lung, small intestine or colon

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for A2ML1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for A2ML1 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gm72985 predicted gene 7298   --   6 (57.52 cM) 121734495 
    chicken
    (Gallus gallus)
    Aves A2ML41 alpha-2-macroglobulin-like 4 53.88(n)
    45.21(a)
      100858010  XM_003642785.2  XP_003642833.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    39(a)
    38(a)
    1 ↔ many
    1 ↔ many
    2(81152127-81252023)
    2(80967859-81091650)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mug11 mug1 protein 54.42(n)
    46.7(a)
      619594  XM_004919642.1  XP_004919699.1 


    ENSEMBL Gene Tree for A2ML1 (if available)
    TreeFam Gene Tree for A2ML1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for A2ML1 gene
    A2M2  C52  C32  C4B2  C4A2  PZP2  CPAMD82  CD1092  
    4 SIMAP similar genes for A2ML1 using alignment to 7 protein entries:     A2ML1_HUMAN (see all proteins):
    A2M    DKFZp686C0338    PZP    OVOS2

    Find genes that share paralogs with A2ML1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for A2ML1
    PGOHUM00000258659


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for A2ML1 (see all 1598)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs45346351,2
    C,F--8973175(+) ggtggC/Tgggcg 1 -- us2k11Minor allele frequency- T:0.00NA 2
    rs45424611,2
    C,F--8973268(+) cgccaT/Ctgcac 1 -- us2k14Minor allele frequency- C:0.25NA 8
    rs23775911,2
    C,A--8973275(+) GCACTC/TCAGCC 1 -- us2k16Minor allele frequency- T:0.09NA CSA 11
    rs1842111761,2
    --8973383(+) AATTGC/TTCCTG 1 -- us2k10--------
    rs1121054781,2
    F--8973394(+) GGGATG/AACATC 1 -- us2k12Minor allele frequency- A:0.50CSA 4
    rs1459762531,2
    --8973406(+) CTGCTA/GTAAAA 1 -- us2k10--------
    rs1888196821,2
    --8973418(+) CTAAGA/CTCAGT 1 -- us2k10--------
    rs1930153351,2
    --8973607(+) GCCCCG/TACCTG 1 -- us2k10--------
    rs1835228881,2
    --8973630(+) TAAAAA/TCTCTG 1 -- us2k10--------
    rs1398421221,2
    --8973672(+) TAAAAC/TTCCAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for A2ML1 (8975068 - 9039597 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for A2ML1 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2603013CNV Deletion19546169
    esv2745509CNV Deletion23290073
    esv2661025CNV Deletion23128226
    esv1448345CNV Deletion17803354
    dgv28e180CNV Deletion20482838
    esv2745510CNV Deletion23290073
    esv29462CNV Loss19812545
    nsv512254CNV Loss21212237
    nsv516260CNV Loss19592680
    nsv521922CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 610627    OMIM disorders: --

    1 disease for A2ML1:    
    About MalaCards
    paraneoplastic pemphigus


    Find genes that share disorders with A2ML1           About GenesLikeMe

    Genetic Association Database (GAD): A2ML1
    Human Genome Epidemiology (HuGE) Navigator: A2ML1 (1 document)

    Export disorders for A2ML1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for A2ML1 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with A2ML1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel protease inhibitor of the alpha2-macroglobulin family expressed in the human epidermis. (PubMed id 16298998)1, 2, 3 Galliano M.-F.... Guerrin M. (J. Biol. Chem. 2006)
    2. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PubMed id 19204726)1, 4 Chapuis J....Lambert J.C. (Mol. Psychiatry 2009)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Anti-I+-2-macroglobulin-like-1 autoantibodies are detected frequently and may be pathogenic in paraneoplastic pemphigus. (PubMed id 23407400)1 Numata S....Hashimoto T. (J. Invest. Dermatol. 2013)
    5. The protease inhibitor alpha-2-macroglobulin-like-1 is the p170 antigen recognized by paraneoplastic pemphigus autoantibodies in human. (PubMed id 20805888)1 Schepens I....Borradori L. (PLoS ONE 2010)
    6. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). (PubMed id 19199708)1 Gonzalez-Begne M....Yates J.R. (J. Proteome Res. 2009)
    7. Binding of alpha2ML1 to the low density lipoprotein receptor-related protein 1 (LRP1) reveals a new role for LRP1 in the human epidermis. (PubMed id 18648652)1 Galliano M.F....Guerrin M. (PLoS ONE 2008)
    8. Large-scale identification of human genes implicated in epidermal barrier function. (PubMed id 17562024)1 Toulza E.... Guerrin M. (Genome Biol. 2007)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 144568 HGNC: 23336 AceView: FLJ25179 Ensembl:ENSG00000166535 euGenes: HUgn144568
    ECgene: A2ML1 H-InvDB: A2ML1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for A2ML1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for A2ML1 gene:
    Search GeneIP for patents involving A2ML1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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