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Aliases for A2M Gene

Aliases for A2M Gene

  • Alpha-2-Macroglobulin 2 3 5
  • C3 And PZP-Like Alpha-2-Macroglobulin Domain-Containing Protein 5 3 4
  • Alpha-2-M 3 4
  • CPAMD5 3 4
  • FWP007 3
  • S863-7 3
  • A2MD 3

External Ids for A2M Gene

Previous GeneCards Identifiers for A2M Gene

  • GC12M008928
  • GC12M009368
  • GC12M009120
  • GC12M009111
  • GC12M009103
  • GC12M009220
  • GC12M009001

Summaries for A2M Gene

Entrez Gene Summary for A2M Gene

  • Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008]

GeneCards Summary for A2M Gene

A2M (Alpha-2-Macroglobulin) is a Protein Coding gene. Diseases associated with A2M include alzheimer disease and alpha-2-macroglobulin deficiency. Among its related pathways are Platelet activation, signaling and aggregation and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include receptor binding and serine-type endopeptidase inhibitor activity. An important paralog of this gene is CD109.

UniProtKB/Swiss-Prot for A2M Gene

  • Is able to inhibit all four classes of proteinases by a unique trapping mechanism. This protein has a peptide stretch, called the bait region which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for A2M Gene

Genomics for A2M Gene

Regulatory Elements for A2M Gene

Promoters for A2M Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around A2M on UCSC Golden Path with GeneCards custom track

Genomic Location for A2M Gene

Chromosome:
12
Start:
9,067,664 bp from pter
End:
9,116,229 bp from pter
Size:
48,566 bases
Orientation:
Minus strand

Genomic View for A2M Gene

Genes around A2M on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
A2M Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for A2M Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for A2M Gene

Proteins for A2M Gene

  • Protein details for A2M Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01023-A2MG_HUMAN
    Recommended name:
    Alpha-2-macroglobulin
    Protein Accession:
    P01023
    Secondary Accessions:
    • Q13677
    • Q59F47
    • Q5QTS0
    • Q68DN2
    • Q6PIY3
    • Q6PN97

    Protein attributes for A2M Gene

    Size:
    1474 amino acids
    Molecular mass:
    163291 Da
    Quaternary structure:
    • Homotetramer; disulfide-linked.
    SequenceCaution:
    • Sequence=AAT02228.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAD92851.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for A2M Gene

neXtProt entry for A2M Gene

Proteomics data for A2M Gene at MOPED

Post-translational modifications for A2M Gene

  • Glycosylation at Asn 55, Asn 70, Asn 247, Asn 396, Asn 410, Asn 869, Asn 991, and Asn 1424
  • Modification sites at PhosphoSitePlus

Other Protein References for A2M Gene

Antibody Products

  • R&D Systems Antibodies for A2M (alpha 2-Macroglobulin)

Protein Products

No data available for DME Specific Peptides for A2M Gene

Domains & Families for A2M Gene

Suggested Antigen Peptide Sequences for A2M Gene

Graphical View of Domain Structure for InterPro Entry

P01023

UniProtKB/Swiss-Prot:

A2MG_HUMAN :
  • Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
Family:
  • Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
genes like me logo Genes that share domains with A2M: view

Function for A2M Gene

Molecular function for A2M Gene

GENATLAS Biochemistry:
macroglobulin,alpha-2- (protease inhibitor),may be implicated in susceptibility to Alzheimer disease (AD5)
UniProtKB/Swiss-Prot Function:
Is able to inhibit all four classes of proteinases by a unique trapping mechanism. This protein has a peptide stretch, called the bait region which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.

Gene Ontology (GO) - Molecular Function for A2M Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IMP 15226301
GO:0019838 growth factor binding IDA 9398211
GO:0019899 enzyme binding IPI 11435418
GO:0019959 interleukin-8 binding IPI 10880251
GO:0048306 calcium-dependent protein binding IPI 15226301
genes like me logo Genes that share ontologies with A2M: view
genes like me logo Genes that share phenotypes with A2M: view

Human Phenotype Ontology for A2M Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for A2M Gene

MGI Knock Outs for A2M:

Animal Model Products

miRNA for A2M Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for A2M Gene

Localization for A2M Gene

Subcellular locations from UniProtKB/Swiss-Prot for A2M Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for A2M Gene COMPARTMENTS Subcellular localization image for A2M gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 3
endosome 2
lysosome 2
plasma membrane 2
vacuole 2
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for A2M Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with A2M: view

Pathways & Interactions for A2M Gene

genes like me logo Genes that share pathways with A2M: view

Gene Ontology (GO) - Biological Process for A2M Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001869 negative regulation of complement activation, lectin pathway IDA 12538697
GO:0007596 blood coagulation TAS --
GO:0007597 blood coagulation, intrinsic pathway TAS --
GO:0010951 negative regulation of endopeptidase activity IEA --
GO:0022617 extracellular matrix disassembly TAS --
genes like me logo Genes that share ontologies with A2M: view

No data available for SIGNOR curated interactions for A2M Gene

Drugs & Compounds for A2M Gene

(11) Drugs for A2M Gene - From: Novoseek, DrugBank, PharmGKB, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bacitracin Approved Pharma Target, inhibitor 33
Becaplermin Approved, Investigational Pharma Target 0
Ocriplasmin Approved Pharma Target, ligand 0
Enzymes Pharma 0

(3) Additional Compounds for A2M Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with A2M: view

Transcripts for A2M Gene

Unigene Clusters for A2M Gene

Alpha-2-macroglobulin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for A2M Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a ·
SP1: - - - - - - - - - - - - - - - - - - -
SP2:
SP3:
SP4:
SP5:
SP6: - -
SP7: - - - - -
SP8:
SP9: - - - - - - - - - - - - - - - - -
SP10:
SP11:
SP12: -
SP13:
SP14:

ExUns: 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20a · 20b · 20c ^ 21a · 21b ^ 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27a · 27b ^ 28a · 28b ^ 29 ^ 30 ^
SP1: - - - - - - - - - - - - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: - - - - - - - - - - - - - - - - - - - - -
SP10:
SP11:
SP12:
SP13:
SP14:

ExUns: 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for A2M Gene

GeneLoc Exon Structure for
A2M
ECgene alternative splicing isoforms for
A2M

Expression for A2M Gene

mRNA expression in normal human tissues for A2M Gene

mRNA differential expression in normal tissues according to GTEx for A2M Gene

This gene is overexpressed in Lung (x7.4) and Liver (x4.6).

Protein differential expression in normal tissues from HIPED for A2M Gene

This gene is overexpressed in Synovial fluid (27.9) and Plasma (17.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for A2M Gene



SOURCE GeneReport for Unigene cluster for A2M Gene Hs.212838

mRNA Expression by UniProt/SwissProt for A2M Gene

P01023-A2MG_HUMAN
Tissue specificity: Secreted in plasma.
genes like me logo Genes that share expression patterns with A2M: view

Protein tissue co-expression partners for A2M Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for A2M Gene

Orthologs for A2M Gene

This gene was present in the common ancestor of animals.

Orthologs for A2M Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia A2M 35
  • 83.51 (n)
  • 79.35 (a)
A2M 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia A2M 35
  • 84.75 (n)
  • 80.63 (a)
A2M 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia A2m 35
  • 78.19 (n)
  • 73.39 (a)
A2m 16
A2m 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia A2M 35
  • 99.32 (n)
  • 99.19 (a)
A2M 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100911545 35
  • 78.36 (n)
  • 74.77 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 60 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 42 (a)
ManyToMany
-- 36
  • 57 (a)
ManyToMany
-- 36
  • 60 (a)
ManyToMany
chicken
(Gallus gallus)
Aves A2M 35
  • 64.21 (n)
  • 59.71 (a)
-- 36
  • 58 (a)
ManyToMany
-- 36
  • 56 (a)
ManyToMany
-- 36
  • 65 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 53 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia a2m 35
  • 57.27 (n)
  • 52.21 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100006925 35
  • 53.89 (n)
  • 44.6 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10981 35
fruit fly
(Drosophila melanogaster)
Insecta TepII 37
  • 29 (a)
Species with no ortholog for A2M:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for A2M Gene

ENSEMBL:
Gene Tree for A2M (if available)
TreeFam:
Gene Tree for A2M (if available)

Paralogs for A2M Gene

Paralogs for A2M Gene

(5) SIMAP similar genes for A2M Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with A2M: view

Variants for A2M Gene

Sequence variations from dbSNP and Humsavar for A2M Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1800434 - 9,094,987(-) TCTAC(A/G)TGTAG reference, missense
rs1800433 - 9,079,755(-) TGGCT(A/G)TGGAG reference, missense
rs669 - 9,079,672(-) CAGAG(A/G)TCAAG reference, missense
rs226405 - 9,095,637(-) AGGAC(A/G)ATGAA reference, missense
rs3180392 - 9,091,226(-) GGTCC(A/T)AAACT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for A2M Gene

Variant ID Type Subtype PubMed ID
nsv832327 CNV Loss 17160897
nsv898738 CNV Loss 21882294
nsv527404 CNV Gain 19592680

Variation tolerance for A2M Gene

Residual Variation Intolerance Score: 31.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.07; 84.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for A2M Gene

HapMap Linkage Disequilibrium report
A2M
Human Gene Mutation Database (HGMD)
A2M

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for A2M Gene

Disorders for A2M Gene

MalaCards: The human disease database

(9) MalaCards diseases for A2M Gene - From: OMIM, GeneTests, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
alzheimer disease
  • alzheimer disease, late-onset
alpha-2-macroglobulin deficiency
  • alpha-2-macroglobulin
allergic urticaria
subendocardial myocardial infarction
mastitis
  • breast inflammation
- elite association - COSMIC cancer census association via MalaCards
Search A2M in MalaCards View complete list of genes associated with diseases

Genatlas disease for A2M Gene

emphysema with lung destruction II (macroglobulin,alpha-2- deficiency)

Relevant External Links for A2M

Genetic Association Database (GAD)
A2M
Human Genome Epidemiology (HuGE) Navigator
A2M
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
A2M
genes like me logo Genes that share disorders with A2M: view

No data available for UniProtKB/Swiss-Prot for A2M Gene

Publications for A2M Gene

  1. Alpha-2 macroglobulin is genetically associated with Alzheimer disease. (PMID: 9697696) Blacker D. … Tanzi R.E. (Nat. Genet. 1998) 2 3 48 67
  2. Is alpha2-macroglobulin important in female stress urinary incontinence? (PMID: 18077315) Wen Y. … Chen B.H. (Hum. Reprod. 2008) 3 23
  3. Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulin. (PMID: 18485748) Luan Y. … Liu C.-J. (Osteoarthritis Cartilage 2008) 3 23
  4. Alpha 2-macroglobulin binds CpG oligodeoxynucleotides and enhances their immunostimulatory properties by a receptor-dependent mechanism. (PMID: 17967834) Anderson R.B. … Pizzo S.V. (J. Leukoc. Biol. 2008) 3 23
  5. Interaction of mannan binding lectin with alpha2 macroglobulin via exposed oligomannose glycans: a conserved feature of the thiol ester protein family? (PMID: 16407218) Arnold J.N. … Sim R.B. (J. Biol. Chem. 2006) 3 23

Products for A2M Gene

Sources for A2M Gene

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