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A2BP1 Gene

protein-coding GIFtS: 41

GC16P006009

ataxin 2-binding protein 1
symbol from the EntrezGene Database
NOT approved by the HUGO Gene Nomenclature Committee (HGNC).

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
FOX1 ^², ⁵
HRNBP1 ^², ⁵

Descriptions
ataxin 2-binding protein 1 ^²
hexaribonucleotide binding protein 1 ^²

External Ids
Entrez Gene: 54715²
UniProtKB: B7ZLH9⁴

Search outside databases for aliases for A2BP1 gene

Previous GC identifers: GC16P006921 GC16P006101 GC16P005290 GC16P006069

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for A2BP1:

Ataxin-2 binding protein 1 has an RNP motif that is highly conserved among RNA-binding proteins.

This protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of

spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the gene product of the SCA2 gene which causes

familial neurodegenerative diseases. Ataxin-2 binding protein 1 and ataxin-2 are both localized in

the trans-Golgi network. Several alternatively spliced transcript variants encoding different

isoforms have been found for this gene. Additional transcript variants have been found but their

full length nature has not been determined. [provided by RefSeq]

Gene Wiki entry for A2BP1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3

A2BP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P006009: (about GC identifiers)

Start:	6,009,133 bp from pter
End:	7,702,500 bp from pter
Size:	1,693,368 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000016.8 NT_037887.4

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/TrEMBL: B7ZLH9 (See protein sequence)

Recommended Name: A2BP1 protein

Size: 370 amino acids; 39656 Da

REFSEQ proteins (6 alternative transcripts):

NP_001135805.1 NP_001135806.1 NP_061193.2 NP_665898.1 NP_665899.1 NP_665900.1

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (A2BP1 / Fox1)
	Browse Abnova for Human Recombinant Proteins

OriGene Purified Recombinant Human Protein: A2BP1

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IDA	10814712
GO:0005802	trans-Golgi network	IDA	10814712

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Antibodies for A2BP1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (A2BP1 / Fox1), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for A2BP1

Assays for A2BP1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry B7ZLH9

ProtoNet protein and cluster: B7ZLH9

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (A2BP1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (A2BP1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 6): NM_018723

Applied Biosystems Silencer® siRNAs for A2BP1

Sigma-Aldrich siRNA for A2BP1

Sigma-Aldrich shRNA for A2BP1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 6): NM_001142333
Myc/DDK tagged cDNA clones in CMV expression vector (see all 6): NM_001142333
untagged cDNA clones in CMV expression vector (see all 6): NM_001142333

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_145891

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003723	RNA binding	NAS	10814712
GO:0008022	protein C-terminus binding	IPI	10814712

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(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006397	mRNA processing	IEA	--
GO:0008380	RNA splicing	IEA	--
GO:0050658	RNA transport	NAS	10814712

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for A2BP1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (A2BP1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (A2BP1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 6): NM_018723

Sigma-Aldrich siRNA for A2BP1

Sigma-Aldrich shRNA for A2BP1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001142333 NM_001142334 NM_018723 NM_145891 NM_145892 NM_145893

REFSEQ mRNAs for A2BP1 gene (6 alternative transcripts):

NM_001142333.1 NM_001142334.1 NM_018723.3 NM_145891.2 NM_145892.2 NM_145893.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001142333 NM_001142334 NM_018723 NM_145891 NM_145892 NM_145893

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 6): NM_001142333
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 6): NM_001142333
                                 untagged cDNA clones in CMV expression vector (see all 6): NM_001142333

Additional cDNA sequence:

AB208826.1 AF094849.1 AF107203.1 AF109106.1 AF229057.1 AF448859.1 AK001027.1 AK293951.1

AK299664.1 AL713700.1 BC026312.1 BC033885.1 BC113691.1 BC143816.1 CR621423.1

10 DOTS entries:

DT.97818089 DT.75102802 DT.110299 DT.95271436 DT.92420142 DT.101982518 DT.75102801 DT.95271435

DT.101954710 DT.120674134

13 AceView cDNA sequences:

BI913836 BI912943 BI916407 BI914778 BI548624 BM543647 BI918754 NM_018723

BI918511 AF448859 AF107203 BM011737 AL713700

highest scoring ESTs for A2BP1:

AI497900 AI802453 AA193138 AA193168 AA424255 AA436955 AA773715 AF094849 AF109106 AF229057

Unigene Cluster for A2BP1:

Ataxin 2-binding protein 1

Hs.459842 [show with all ESTs]

Unigene Representative Sequence: NM_018723

GeneLoc Exon Structure

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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A2BP1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for A2BP1

¹ / ² / ³

8 probe-sets matching A2BP1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
64249_at²^{, 3}	U95-C	2	1.00	0.72	0.96	1.45	AI497900	1.00	1.00	1.00	1
62465_at²^{, 3}	U95-C	2	1.00	0.50	0.90	0.76	AI885361	0.80	1.00	0.91	1
55419_at²^{, 3}	U95-C	2	1.00	0.50	0.99	0.83	AI802453	1.00	1.00	1.00	1
235070_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AL133898	0.80	1.00	0.91	1
221217_s_at²^{, 3}	U133-A	2	1.00	0.50	--	--	NM_018723	0.60	1.00	0.82	1
235070_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1553422_s_at²	U133Plus2	2	1.00	0.50	--	--	--	--	--	--	--
221217_s_at²	U133Plus2	2	1.00	0.50	--	--	--	--	--	--	--

GeneDecks A2BP1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
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About these images

CGAP SAGE TAG: CAGTAGTACA

SOURCE GeneReport for Unigene cluster: Hs.459842

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for A2BP1 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LOC609116¹	--	similar to ataxin 2-binding protein 1 isoform 2	95.14(n) 98.8(a)	609116 XM_846368.1 XP_851461.1
rat (Rattus norvegicus)	A2bp1¹	--	ataxin 2 binding protein 1	89.82(n) 95.67(a)	302920 XM_220155.4 XP_220155.3
mouse (Mus musculus)	A2bp1^{1, 5}	16 (7.20 cM)⁵	ataxin 2 binding protein 1^{1, 5}	91.29(n)¹ 97.12(a)¹	268859¹ NM_183188.1¹ NP_899011.1¹ AB041596⁵ AF107204⁵ (see all 20)
chicken (Gallus gallus)	A2BP1¹	--	ataxin 2-binding protein 1	86.41(n) 92.56(a)	416645 XM_414942.2 XP_414942.2
zebrafish (Danio rerio)	Dr.11261²	--	Transcribed sequence with moderate similarity to protein more	87.47(n)	CK018173.1

About this table Species with no ortholog for A2BP1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/15880 NCBI SNPs in A2BP1 are shown (see all 15880 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 6122)

AB	SNP ID	Valid	Chr 16 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs7190299^1,2	A,C,F,H	7322359(+)	`AAATAC/TAAGCT`	4	--	ng5¹ int¹		7		EU EA NA	512
	rs881562^1,2	A,C,F,H	7700885(-)	`AATGTC/AAtttt`	4	--	ng3¹ ut3¹		5		MN EU EA WA	600
	rs9302854^1,2	C,F,H	7701530(+)	`TATCAT/CTGCTG`	3	--	ut3¹		7		EU EA WA NA	554
	rs17671597^1,2	C,F,H	7321107(+)	`TCTGCC/GAAACC`	4	--	int¹ ng5¹		12		NA EU EA WA	1054
	rs1424124^1,2	C,F,H	6007593(-)	`TTTGGG/CTTGAT`	1	--	ng5¹		6		EA WA NA	390
	rs6501012^1,2	C,F,H	7702047(+)	`AAGTAG/CATCCA`	3	--	ut3¹		4		EU EA WA	408
	rs8061981^1,2	C,F,H	7701176(+)	`TTTTGT/CGAAAG`	4	--	ng3¹ ut3¹		4		EU EA WA	404
--	rs7193053^1,2	A,C	6009485(+)	`CCCCTC/TCGCCC`	1	--	ut5¹		0	--	--	--	--
	rs11865831^1,2	C,H	7700961(+)	`GGTTCC/TGTAGT`	4	--	ng3¹ ut3¹		6		EU EA WA NA	600
	rs17739067^1,2	F,H	7321300(+)	`TATCAA/GGTGTC`	4	--	int¹ ng5¹		7		NA EU EA WA	542

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HapMap Linkage Disequilibrium images for A2BP1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 605104

1 Novoseek disease relationship for A2BP1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
spinocerebellar ataxia type 2	91.83	1	15148587 (1)

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Human Gene Mutation Database: A2BP1
Human Genome Epidemiology Navigator: A2BP1 (4 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/22 PubMed articles for A2BP1 gene (see all 22 ):

Identification and expression of a mouse ortholog of A2BP1. (PubMed id 11471052)^{1, 3} Kiehl T.R....Pulst S.M. (2001)
A novel protein with RNA-binding motifs interacts with ataxin-2. (PubMed id 10814712)^{1, 3} Shibata H.... Pulst S.-M. (2000)
Cytogenetic and molecular characterization of A2BP1/FOX1 as a candidate gene for autism. (PubMed id 17503474)^{1, 3} Martin C.L....Geschwind D.H. (2007)
Role for Fox-1/Fox-2 in mediating the neuronal pathway of calcitonin/calcitonin gene-related peptide alternative RNA processing. (PubMed id 17101796)^{1, 3} Zhou H.L....Lou H. (2007)
Defining the regulatory network of the tissue-specific splicing factors Fox-1 and Fox-2. (PubMed id 18794351)^{1, 3} Zhang C....Zhang M.Q. (2008)
Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort. (PubMed id 19308021)³ Ollila H.M....Paunio T. (2009)
Genome-wide analysis of survival in early-stage non-small-cell lung cancer. (PubMed id 19414679)³ Huang Y.T....Christiani D.C. (2009)
Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PubMed id 18519826)³ Uhl G.R....Lerman C. (2008)
Repression of prespliceosome complex formation at two distinct steps by Fox-1/Fox-2 proteins. (PubMed id 18573872)³ Zhou H.L. and Lou H. (2008)
Expression of 24,426 human alternative splicing events and predicted cis regulation in 48 tissues and cell lines. (PubMed id 18978788)³ Castle J.C....Johnson J.M. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 54715

AceView: A2BP1.2

euGenes: HUgn54715

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for A2BP1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for A2BP1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for A2BP1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for A2BP1		Browse antibodies at Sigma-Aldrich
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A2BP1 Gene

protein-coding GIFtS: 41

Aliases &
Descriptions
for A2BP1

Summaries
for A2BP1

Genomic Location
for A2BP1

Proteins
for A2BP1

Protein Domains/
Families
for A2BP1

Gene Function
for A2BP1

Pathways & Interactions
for A2BP1

Drugs & Compounds
for A2BP1

Transcripts
for A2BP1

Expression
for A2BP1

Orthologs
for A2BP1

Paralogs
for A2BP1

SNPs/Variants
for A2BP1

Disorders & Mutations
for A2BP1

Medical News
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Publications
for A2BP1

Search for A2BP1

Genome Databases showing A2BP1

Other Databases showing A2BP1

Specialized Databases showing A2BP1

Licensable Technologies
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Services
for A2BP1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

A2BP1 Gene

protein-coding GIFtS: 41

Aliases & Descriptionsfor A2BP1

Summariesfor A2BP1

Genomic Locationfor A2BP1

Proteinsfor A2BP1

Protein Domains/Familiesfor A2BP1

Gene Functionfor A2BP1

Pathways & Interactionsfor A2BP1

Drugs & Compoundsfor A2BP1

Transcriptsfor A2BP1

Expression for A2BP1

Orthologsfor A2BP1

Paralogsfor A2BP1

SNPs/Variantsfor A2BP1

Disorders & Mutationsfor A2BP1

Medical Newsfor A2BP1

Publicationsfor A2BP1

Search for A2BP1

Genome Databases showing A2BP1

Other Databases showing A2BP1

Specialized Databases showing A2BP1

Licensable Technologiesfor A2BP1

Servicesfor A2BP1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for A2BP1

Summaries
for A2BP1

Genomic Location
for A2BP1

Proteins
for A2BP1

Protein Domains/
Families
for A2BP1

Gene Function
for A2BP1

Pathways & Interactions
for A2BP1

Drugs & Compounds
for A2BP1

Transcripts
for A2BP1

Expression
for A2BP1

Orthologs
for A2BP1

Paralogs
for A2BP1

SNPs/Variants
for A2BP1

Disorders & Mutations
for A2BP1

Medical News
for A2BP1

Publications
for A2BP1

Licensable Technologies
for A2BP1

Services
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