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POTEH Gene

protein-coding   GIFtS: 37

GC22M014640
POTE ankyrin domain family, member H
(Previous names: actin, beta-like 1, ANKRD26-like family C, member 3 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: ACTBL1, A26C3)
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Aliases &
Descriptions
for POTEH

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
A26C3 2, 3
ACTBL1 2, 3
POTE-22 3
POTE22 1, 2, 3
Descriptions
ANKRD26-like family C member 3 3
ANKRD26-like family C, member 3 1, 2
POTE ankyrin domain family, member H 2
Prostate, ovary, testis-expressed protein on chromosome 22 3
actin, beta-like 1 1, 2
protein expressed in prostate, ovary, testis, and placenta
22 2
protein expressed in prostate, ovary, testis, and placenta
POTE14 like 2
External Ids
HGNC: 1331
Entrez Gene: 237842
UniProtKB: Q6S5453
Ensembl: ENSG000001980627
Search outside databases for aliases for POTEH gene

Summaries
for POTEH

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

   --

Genomic Location
for POTEH

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.1   Ensembl cytogenetic band:  22q11.1   HGNC cytogenetic band: 22q11.1

POTEH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M014640:     (about GC identifiers)

Start:
 14,636,332 bp from pter
End:
 14,667,937 bp from pter
Size:
 31,606 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000022.9  NT_028395.3  

Proteins
for POTEH

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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 UniProtKB/Swiss-Prot: POTEH_HUMAN, Q6S545 (See protein sequence)
Recommended Name: POTE ankyrin domain family member H  
Size: 545 amino acids; 60965 Da
Secondary accessions: A2CEK4 A6NCI1 A9Z1W0

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (2 alternative transcripts): 
    NP_001004053.2  NP_001129685.1  


    ENSEMBL proteins: 
    ENSP00000348134 ENSP00000340610 ENSP00000347095 ENSP00000352595 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse Abcam for Recombinant Proteins
    Human Recombinant Proteins from Abnova (ACTBL1)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


    Antibodies for POTEH: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
    Monoclonal and Polyclonal Antibodies from Abnova (ACTBL1)
    Novus Biologicals Antibodies for POTEH

    Assays for POTEH: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for POTEH

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro domain/family:
     IPR002110 ANK


       GeneDecks  POTEH for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q6S545

    ProtoNet protein and cluster: Q6S545

    1 Blocks protein family: IPB002110 Ankyrin repeat signature

    UniProtKB/Swiss-Prot: POTEH_HUMAN, Q6S545
    Similarity: Belongs to the POTE family
    Similarity: Contains 7 ANK repeats

    Gene Function
    for POTEH

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Browse Invitrogen for RNAi
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ACTBL1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001004053

                  Applied Biosystems Silencer® siRNAs for POTEH

                  Sigma-Aldrich siRNA for POTEH  
                         Sigma-Aldrich shRNA for POTEH  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001004053
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001004053
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001004053 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001136213

    Pathways & Interactions
    for POTEH

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


      --

    Drugs & Compounds
    for POTEH

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for POTEH

    Transcripts
    for POTEH

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene)
    About This Section
    Inhib.
    RNA:    		Browse Invitrogen for RNAi
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ACTBL1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001004053

                  Sigma-Aldrich siRNA for POTEH  
                         Sigma-Aldrich shRNA for POTEH  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001136213  

    REFSEQ mRNAs for POTEH gene (2 alternative transcripts): 

    NM_001004053.2   NM_001136213.1   


                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001004053
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001004053
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001004053 

    1 DOTS entry:

    DT.120670748 

    1 AceView cDNA sequence:

    BX504356 

    Unigene Cluster for POTEH:

    POTE ankyrin domain family, member H
    Hs.581075
    Unigene Representative Sequence: NM_001136213


    GeneLoc Exon Structure

    4 Ensembl transcripts including schematic representations:
    ENST00000355872  ENST00000343518  ENST00000354997  ENST00000359587  

    Expression
    for POTEH

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    POTEH expression in normal and diseased human tissues

    1Data from GNF BioGPS
        About these images

    About these images

    CGAP SAGE TAG: AGCAAAAACA

    SOURCE GeneReport for Unigene cluster: Hs.581075

    Orthologs
    for POTEH

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for POTEH gene from 1 species
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    chimpanzee
    (Pan troglodytes)    		 POTEH1   -- POTE ankyrin domain family, member H 97.94(n)
    95.71(a)    		 746411  XM_001153699.1  XP_001153699.1 
    About this table        Species with no ortholog for POTEH

    ENSEMBL Gene Tree for POTEH

    Paralogs
    for POTEH

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for POTEH gene
    POTEF2  ANKRD20A52  ENSG000001816262  ANKRD362  ENSG000001879842  ENSG000002220382  POTEA2  ENSG000002220362  
    ENSG000001968342  ENSG000002131142  POTEC2  POTEG2  ENSG000001553192  ANKRD192  POTED2  POTEE2  
    ACTBL32  

    SNPs/Variants
    for POTEH

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/20 NCBI SNPs in POTEH are shown (see all 20 )
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 22 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    --
    rs22121211,2
    		C,F,O14645110(+) AAATAC/TTAAAG 1 -- int13Minor allele frequency- T:0.07NA 140
    --
    rs169795771,2
    		F,H14645118(+) AAGGTC/ATCAAC 1 -- int17Minor allele frequency- A:0.02NA EU EA WA 510
    --
    rs101546111,2
    		F,H14647521(+) TCATTT/CTAGAG 1 -- int14Minor allele frequency- C:0.01EU EA WA 408
    --
    rs28451991,2
    		H14647567(+) AGATGG/ACCCTT 1 -- int14Minor allele frequency- A:0.00EU EA WA 418
    --
    rs622248411,2
    		--14668594(+) ACTGCC/TGCGCG 1 -- ng310--------
    --
    rs622248401,2
    		--14668538(+) GCGTGC/TGGCGT 1 -- ng310--------
    --
    rs622248391,2
    		--14668531(+) CTGCCA/GCGCGT 1 -- ng310--------
    --
    rs712457381,2
    		--14668437(-) TGCTTG/TCACGC 1 -- ng310--------
    --
    rs677753241,2
    		--14668776(+) ACCACA/GAATGT 1 -- ng310--------
    --
    rs731547331,2
    		--14668704(+) GCGCAA/TCTCTG 1 -- ng310--------
    About this table

    HapMap Linkage Disequilibrium images for POTEH (up to first 250kb)

    Disorders & Mutations
    for POTEH

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 608913

    Medical News
    for POTEH

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for POTEH

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		4 PubMed articles for POTEH gene:

    Search for POTEH

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing POTEH

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 23784 HGNC: 133 AceView: ACTBL1.3 Ensembl:ENSG00000198062 euGenes: HUgn23784
    ECgene: POTEH H-InvDB: POTEH

    Other Databases showing POTEH

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing POTEH

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    		   --

    Licensable Technologies
    for POTEH

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for POTEH

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for POTEH:
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for POTEH-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for POTEH Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for POTEH Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
     Recombinant & Natural Proteins  

     Recombinant Proteins (ACTBL1)
     Antibodies (ACTBL1)
     Chimera RNAi (ACTBL1)
     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Search for Recombinant Proteins
     Search for Antibodies
     Search OriGene for POTEH
     Search Tocris compounds for POTEH




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for POTEH

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