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POTEG Gene

protein-coding GIFtS: 31

GC14P018628

POTE ankyrin domain family, member G
(Previous names: ANKRD26-like family C, member 2 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: A26C2)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
A26C2 ^², ³
ACTBL1 ^²
POTE-14 ^¹, ², ³
POTE14 ^¹, ², ³
POTE22 ^²

Descriptions
ANKRD26-like family C member 2 ^³
ANKRD26-like family C, member 2 ^¹, ²
POTE ankyrin domain family, member G ^²
Prostate, ovary, testis-expressed protein on chromosome 14 ^³
protein expressed in prostate, ovary, testis, and placenta 14 ^²

External Ids
HGNC: 33896¹
Entrez Gene: 404785²
UniProtKB: Q6S5H5³
Ensembl: ENSG00000187537⁷

Search outside databases for aliases for POTEG gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.1 Ensembl cytogenetic band: 14q11.1 HGNC cytogenetic band: 14q11.1

POTEG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P018628: (about GC identifiers)

Start:	18,623,365 bp from pter
End:	18,654,942 bp from pter
Size:	31,578 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000014.7 NT_026437.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: POTEG_HUMAN, Q6S5H5 (See protein sequence)

Recommended Name: POTE ankyrin domain family member G

Size: 594 amino acids; 67077 Da

Secondary accessions: A1L153 A6NMI9 Q6S5H6 Q6S8J2

Alternative splicing: 3 isoforms: Q6S5H5-1 Q6S5H5-2 Q6S5H5-3

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001005356.1

ENSEMBL proteins:

ENSP00000340144 ENSP00000354232

Human Recombinant Proteins

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	Browse Purified and Recombinant Proteins at Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for POTEG:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for POTEG

Assays for POTEG:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q6S5H5

ProtoNet protein and cluster: Q6S5H5

1 Blocks protein family: IPB002110 Ankyrin repeat signature

UniProtKB/Swiss-Prot: POTEG_HUMAN, Q6S5H5

Similarity: Belongs to the POTE family

Similarity: Contains 5 ANK repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_207513

Applied Biosystems Silencer® siRNAs for POTEG

Sigma-Aldrich siRNA for POTEG

Sigma-Aldrich shRNA for POTEG

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001005356
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001005356
untagged cDNA clones in CMV expression vector (see all 3): NM_001005356

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001005356

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for POTEG

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene)
About This Section

Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_207513

Sigma-Aldrich siRNA for POTEG

Sigma-Aldrich shRNA for POTEG

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001005356

REFSEQ mRNAs for POTEG gene:

NM_001005356.2

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001005356
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001005356
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001005356

Additional cDNA sequence:

AY462874.1 AY465171.1 AY465172.1 AY466021.1 BC127623.1

5 DOTS entries:

DT.91846532 DT.102838331 DT.120670748 DT.100015986 DT.120764792

24/25 AceView cDNA sequences (see all 25 ):

BU584133 AY465172 BC063888 AY338952 BF477666 BU160076 BU584404 BU584403

CD358418 CD557737 AA588848 BU584020 AY462874 CD243602 AA884098 BU584045

BU584597 BU584009 NM_001004053 AY466021 BF511332 AI659600 AA578971 AW294458

Unigene Cluster for POTEG:

POTE ankyrin domain family, member G

Hs.711826 [show with all ESTs]

Unigene Representative Sequence: AY466021

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000344684 ENST00000360967

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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POTEG expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for POTEG

¹ Data from GNF BioGPS
About these images

About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.711826

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for POTEG gene from 2 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
rat (Rattus norvegicus)	LOC364620¹	--	similar to RIKEN cDNA 4921537P18	54.66(n) 40.44(a)	364620 NM_001014238.1 NP_001014260.1
mouse (Mus musculus)	4921537P18Rik¹	--	RIKEN cDNA 4921537P18 gene	55.42(n) 41.56(a)	70952 NM_026256.2 NP_080532.1

About this table Species with no ortholog for POTEG

ENSEMBL Gene Tree for POTEG

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for POTEG gene

POTEF² ANKRD20A5² ENSG00000181626² ANKRD36² ENSG00000187984² ENSG00000222038² POTEH² POTEA²

ENSG00000222036² ENSG00000196834² ENSG00000213114² POTEC² ENSG00000155319² ANKRD19² POTED² POTEE²

ACTBL3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/29 NCBI SNPs in POTEG are shown (see all 29 )

AB	SNP ID	Valid	Chr 14 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs28636425^1,2	--	18622771(+)	`ACGCGC/TGGCAG`	1	--	ng5¹		0	--	--	--	--
--	rs28573254^1,2	--	18622796(+)	`TGTAAC/GGGCTT`	1	--	ng5¹		0	--	--	--	--
--	rs61971014^1,2	--	18622617(+)	`TACTGA/CCACCA`	1	--	ng5¹		0	--	--	--	--
--	rs28464537^1,2	--	18622734(+)	`GCGCAC/TGCCGC`	1	--	ng5¹		0	--	--	--	--
--	rs28626356^1,2	--	18622825(+)	`CGCACA/GCCGGA`	1	--	ng5¹		0	--	--	--	--
--	rs61971013^1,2	--	18622569(+)	`CCAAGA/GCTTAT`	1	--	ng5¹		0	--	--	--	--
--	rs28627150^1,2	--	18622730(+)	`GCACGC/TGCACG`	1	--	ng5¹		0	--	--	--	--
--	rs28451379^1,2	--	18632781(+)	`ACTGGG/TTTTAA`	1	--	int¹		0	--	--	--	--
--	rs61971027^1,2	--	18625336(+)	`ATATAA/TATACA`	1	--	int¹		0	--	--	--	--
--	rs61971028^1,2	--	18625340(+)	`ATATAA/CAAAAT`	1	--	int¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for POTEG (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 608916

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

6 PubMed articles for POTEG gene:

Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths. (PubMed id 15276201)^{3, 4} Bera T.K....Pastan I. (2004)
Identification of a novel actin isoform in hepatocellular carcinoma. (PubMed id 16824795)³ Chang K.-W.... Yeh C.-T. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)
The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)⁴ Heilig R.... Weissenbach J. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)³ Dias Neto E....Simpson A.J.G. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 404785	HGNC: 33896	AceView: POTE14.1	Ensembl:ENSG00000187537	euGenes: HUgn404785
ECgene: POTEG	H-InvDB: POTEG

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for POTEG
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for POTEG:

TaqMan ® Gene Expression Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for POTEG-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for POTEG		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for POTEG		Browse small molecules at Sigma-Aldrich
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	Recombinant & Natural Proteins

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Search Novus for antibodies for POTEG

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POTEG Gene

protein-coding GIFtS: 31

Aliases &
Descriptions
for POTEG

Summaries
for POTEG

Genomic Location
for POTEG

Proteins
for POTEG

Protein Domains/
Families
for POTEG

Gene Function
for POTEG

Pathways & Interactions
for POTEG

Drugs & Compounds
for POTEG

Transcripts
for POTEG

Expression
for POTEG

Orthologs
for POTEG

Paralogs
for POTEG

SNPs/Variants
for POTEG

Disorders & Mutations
for POTEG

Medical News
for POTEG

Publications
for POTEG

Search for POTEG

Genome Databases showing POTEG

Other Databases showing POTEG

Specialized Databases showing POTEG

Licensable Technologies
for POTEG

Services
for POTEG

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

POTEG Gene

protein-coding GIFtS: 31

Aliases & Descriptionsfor POTEG

Summariesfor POTEG

Genomic Locationfor POTEG

Proteinsfor POTEG

Protein Domains/Familiesfor POTEG

Gene Functionfor POTEG

Pathways & Interactionsfor POTEG

Drugs & Compoundsfor POTEG

Transcriptsfor POTEG

Expression for POTEG

Orthologsfor POTEG

Paralogsfor POTEG

SNPs/Variantsfor POTEG

Disorders & Mutationsfor POTEG

Medical Newsfor POTEG

Publicationsfor POTEG

Search for POTEG

Genome Databases showing POTEG

Other Databases showing POTEG

Specialized Databases showing POTEG

Licensable Technologiesfor POTEG

Servicesfor POTEG

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for POTEG

Summaries
for POTEG

Genomic Location
for POTEG

Proteins
for POTEG

Protein Domains/
Families
for POTEG

Gene Function
for POTEG

Pathways & Interactions
for POTEG

Drugs & Compounds
for POTEG

Transcripts
for POTEG

Expression
for POTEG

Orthologs
for POTEG

Paralogs
for POTEG

SNPs/Variants
for POTEG

Disorders & Mutations
for POTEG

Medical News
for POTEG

Publications
for POTEG

Licensable Technologies
for POTEG

Services
for POTEG