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POTEF Gene

protein-coding   GIFtS: 28

GC02M130558
POTE ankyrin domain family, member F
(Previous names: ANKRD26-like family C, member 1B )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: A26C1B)
Services    

Aliases &
Descriptions
for POTEF

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
A26C1B 2, 3
POTEACTIN 1, 2
Descriptions
ANKRD26-like family C member 1B 3
ANKRD26-like family C, member 1B 1, 2
Chimeric POTE-actin protein 3
POTE ankyrin domain family, member F 2
POTE-2 alpha-actin 2
prostate, ovary, testis expressed protein on chromosome 2 2
External Ids
HGNC: 339051
Entrez Gene: 7283782
UniProtKB: A5A3E03
Ensembl: ENSG000001966047
Search outside databases for aliases for POTEF gene

Summaries
for POTEF

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

   --

Genomic Location
for POTEF

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q21.1   Ensembl cytogenetic band:  2q21.1   HGNC cytogenetic band: 2q21.1

POTEF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M130558:     (about GC identifiers)

Start:
 130,547,578 bp from pter
End:
 130,603,265 bp from pter
Size:
 55,688 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000002.10  NT_022135.15  

Proteins
for POTEF

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: POTEF_HUMAN, A5A3E0 (See protein sequence)
Recommended Name: POTE ankyrin domain family member F  
Size: 1075 amino acids; 121445 Da
Subcellular location: Cytoplasm, cell cortex. Note=Colocalizes with actin filaments
Miscellaneous: Results from the insertion of a beta-actin fragment at the C-terminus in the POTEE
paralog gene leading to the formation of a new functional chimeric protein. This insertion occured
before the divergence of the Old World monkeys and apes
Secondary accessions: A6NC34

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_001093241.1  

    ENSEMBL proteins: 
    ENSP00000386786 ENSP00000350052 ENSP00000355012 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
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    Browse Abcam for Recombinant Proteins
    Browse Abnova for Human Recombinant Proteins
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm IEA--
    About this table

    Antibodies for POTEF: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for POTEF

    Assays for POTEF: 
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    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for POTEF

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro domains/families:
     IPR004001 Actin_CS
     IPR004000 Actin-like
     IPR002110 ANK


       GeneDecks  POTEF for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry A5A3E0

    ProtoNet protein and cluster: A5A3E0

    UniProtKB/Swiss-Prot: POTEF_HUMAN, A5A3E0
    Similarity: In the N-terminal section; belongs to the POTE family
    Similarity: In the C-terminal section; belongs to the actin family
    Similarity: Contains 5 ANK repeats

    Gene Function
    for POTEF

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Browse Invitrogen for RNAi
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                    Browse Origene for 29mer shRNA kit in GFP-retroviral vector

                  Applied Biosystems Silencer® siRNAs for POTEF

                  Browse siRNA at Sigma-Aldrich  
                         Browse shRNA at Sigma-Aldrich  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_001099771
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_001099771
                                     untagged cDNA clone in CMV expression vector: NM_001099771 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001099771

    2 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515 protein binding IEA--
    GO:0005524 ATP binding IEA--
    About this table

    Pathways & Interactions
    for POTEF

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


      --

    Drugs & Compounds
    for POTEF

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for POTEF

    Transcripts
    for POTEF

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Browse Invitrogen for RNAi
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                    Browse Origene for 29mer shRNA kit in GFP-retroviral vector

                  Browse siRNA at Sigma-Aldrich  
                         Browse shRNA at Sigma-Aldrich  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001099771  

    REFSEQ mRNAs for POTEF gene: 

    NM_001099771.1   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001099771  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_001099771
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_001099771
                                     untagged cDNA clone in CMV expression vector: NM_001099771 

    Additional cDNA sequence: EF523384.1 

    3 DOTS entries:

    DT.92010774  DT.97779283  DT.99980275 

    Unigene Cluster for POTEF:

    POTE ankyrin domain family, member F
    Hs.580547  [show with all ESTs]
    Unigene Representative Sequence: NM_001099771


    GeneLoc Exon Structure

    3 Ensembl transcripts including schematic representations:
    ENST00000409914  ENST00000357462  ENST00000361163  

    Expression
    for POTEF

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    POTEF expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for POTEF

    1Data from GNF BioGPS
        About these images

    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.580547

    UniProtKB/Swiss-Prot: POTEF_HUMAN, A5A3E0
    Tissue specificity: Expressed in breast cancer cell lines (at protein level)

    Orthologs
    for POTEF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for POTEF gene from 4 species
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    chimpanzee
    (Pan troglodytes)    		 A26C1A1   -- ANKRD26-like family C, member 1A 98.54(n)
    97.86(a)    		 739395  XM_001147448.1  XP_001147448.1 
    fruit fly
    (Drosophila melanogaster)    		 Act79B1   -- Actin 79B 83.65(n)
    87.13(a)    		 40444  NM_079486.3  NP_524210.1 
    African malaria mosquito
    (Anopheles gambiae)    		 ENSANGG000000125501   -- ENSANGP00000015039 80.52(n)
    89.28(a)    		 1275175  XM_314406.2  XP_314406.2 
    rice
    (Oryza sativa)    		 Os05g04388001   -- hypothetical protein 71.67(n)
    80.97(a)    		 4338914  NM_001062196.1  NP_001055661.1 
    About this table        Species with no ortholog for POTEF

    ENSEMBL Gene Tree for POTEF

    Paralogs
    for POTEF

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for POTEF gene
    POTEE1 2  ANKRD20A52  ENSG000001816262  ANKRD362  ENSG000001879842  ENSG000002220382  POTEH2  POTEA2  
    ENSG000002220362  ENSG000001968342  ENSG000002131142  POTEC2  POTEG2  ENSG000001553192  ANKRD192  POTED2  
    ACTBL32  

    SNPs/Variants
    for POTEF

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/100 NCBI SNPs in POTEF are shown (see all 100 )
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 2 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    --
    rs109289541,2
    		A,C130594667(+) AGAAAA/TGTCAA 1 -- ng31 trp30--------
    --
    rs39905671,2
    		A,C,F,H130576781(+) ctattT/Cgcaag 1 -- int14Minor allele frequency- C:0.35EU EA WA 416
    --
    rs108036131,2
    		A,C130587033(+) TGAACA/GGCAGT 1 -- int10--------
    --
    rs24436931,2
    		F,H130583096(+) TTCAGC/GTCAAA 1 -- int14Minor allele frequency- G:0.01EU EA WA 402
    --
    rs108036141,2
    		A,C130587067(+) AAGGTA/CTTATT 1 -- int10--------
    --
    rs22189021,2
    		A,C130576695(+) tcccaC/Gagcaa 1 -- int10--------
    --
    rs18171001,2
    		C,F130581097(+) CCTCAT/CACAGT 1 -- int13Minor allele frequency- C:0.15NA 130
    --
    rs67319131,2
    		A,C130593400(+) gagacA/Ggggtt 1 -- int10--------
    --
    rs18398411,2
    		A,C130577102(+) TGTTTC/TCCTCC 1 -- int10--------
    --
    rs22596921,2
    		A,C130576486(+) TAGAAA/GCATCT 1 -- int10--------
    About this table

    HapMap Linkage Disequilibrium images for POTEF (up to first 250kb)

    Disorders & Mutations
    for POTEF

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		   --

    Medical News
    for POTEF

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for POTEF

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		3 PubMed articles for POTEF gene:

    Search for POTEF

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing POTEF

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 728378 HGNC: 33905 Ensembl:ENSG00000196604 euGenes: HUgn728378 ECgene: POTEF
    H-InvDB: POTEF

    Other Databases showing POTEF

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing POTEF

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    		   --

    Licensable Technologies
    for POTEF

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for POTEF

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for POTEF:
     TaqMan ® Gene Expression Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for POTEF-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Browse siRNAs at Sigma-Aldrich Browse antibodies at Sigma-Aldrich
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     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Search Novus for antibodies for POTEF

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