V3 here soon-try beta now
Gene Search (GeneCards Home) | GeneCards Guide | User Feedback | Terms of Use | Notice about third-party sites
 

POTEE Gene

protein-coding   GIFtS: 31

GC02P131695
POTE ankyrin domain family, member E
(Previous names: ANKRD26-like family C, member 1A )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: A26C1A)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
A26C1 1, 2
A26C1A 2, 3
POTE-2 1, 2, 3
POTE2 1, 2, 3
Descriptions
ANKRD26-like family C member 1A 3
ANKRD26-like family C, member 1A 1, 2
POTE ankyrin domain family, member E 2
Prostate, ovary, testis-expressed protein on chromosome 2 3
protein expressed in prostate, ovary, testis, and placenta
2 2
External Ids
HGNC: 338951
Entrez Gene: 4455822
UniProtKB: Q6S8J33
Ensembl: ENSG000001882197
Search outside databases for aliases for POTEE gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q21.1   Ensembl cytogenetic band:  2q21.1   HGNC cytogenetic band: 2q21.1

POTEE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P131695:     (about GC identifiers)

Start:
131,692,394 bp from pter
End:
131,739,435 bp from pter
Size:
47,042 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000002.10  NT_022135.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: POTEE_HUMAN, Q6S8J3 (See protein sequence)
Recommended Name: POTE ankyrin domain family member E  
Size: 1075 amino acids; 121363 Da
Secondary accessions: Q6S8J4 Q6S8J5 Q6S8J8
Alternative splicing: 3 isoforms:  Q6S8J3-1   Q6S8J3-2   Q6S8J3-3   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_001077007.1  

    ENSEMBL proteins: 
    ENSP00000349391 ENSP00000350797 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Sigma-Aldrich AQUA Peptides for POTEE  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse Abcam for Recombinant Proteins
    Browse Abnova for Human Recombinant Proteins
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


    Antibodies for POTEE: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for POTEE

    Assays for POTEE: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    3 InterPro domains/families:
     IPR004001 Actin_CS
     IPR004000 Actin-like
     IPR002110 ANK


       GeneDecks  POTEE for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q6S8J3

    ProtoNet protein and cluster: Q6S8J3

    1 Blocks protein family: IPB002110 Ankyrin repeat signature

    UniProtKB/Swiss-Prot: POTEE_HUMAN, Q6S8J3
    Similarity: In the N-terminal section; belongs to the POTE family
    Similarity: In the C-terminal section; belongs to the actin family
    Similarity: Contains 5 ANK repeats

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Browse Invitrogen for RNAi
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_001004054

                  Applied Biosystems Silencer® siRNAs for POTEE

                  Sigma-Aldrich siRNA for POTEE  
                         Sigma-Aldrich shRNA for POTEE  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_001083538
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_001083538
                                     untagged cDNA clones in CMV expression vector (see all 4): NM_001004054 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001083538

    2 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515 protein binding IEA--
    GO:0005524 ATP binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


      --
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for POTEE

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Browse Invitrogen for RNAi
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_001004054

                  Sigma-Aldrich siRNA for POTEE  
                         Sigma-Aldrich shRNA for POTEE  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001083538  

    REFSEQ mRNAs for POTEE gene: 

    NM_001083538.1   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001083538  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_001083538
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_001083538
                                     untagged cDNA clones in CMV expression vector (see all 4): NM_001004054 

    Additional cDNA sequence: AY462871.1 

    5 DOTS entries:

    DT.102839155  DT.100750951  DT.100848643  DT.92010774  DT.99980275 

    Unigene Cluster for POTEE:

    POTE ankyrin domain family, member E
    Hs.686146  [show with all ESTs]
    Unigene Representative Sequence: NM_001083538


    GeneLoc Exon Structure

    2 Ensembl transcripts including schematic representations:
    ENST00000356920  ENST00000358087  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    POTEE expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for POTEE

    1Data from GNF BioGPS
        About these images

    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.686146
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for POTEE gene from 4 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    chimpanzee
    (Pan troglodytes)
    A26C1A1   -- ANKRD26-like family C, member 1A 98.76(n)
    98.14(a)
    739395  XM_001147448.1  XP_001147448.1 
    fruit fly
    (Drosophila melanogaster)
    Act79B1   -- Actin 79B 84.05(n)
    87.43(a)
    40444  NM_079486.3  NP_524210.1 
    African malaria mosquito
    (Anopheles gambiae)
    ENSANGG000000125501   -- ENSANGP00000015039 80.93(n)
    89.57(a)
    1275175  XM_314406.2  XP_314406.2 
    rice
    (Oryza sativa)
    Os05g04388001   -- hypothetical protein 71.75(n)
    81.02(a)
    4338914  NM_001062196.1  NP_001055661.1 
    About this table        Species with no ortholog for POTEE

    ENSEMBL Gene Tree for POTEE
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for POTEE gene
    POTEF1 2  ANKRD20A52  ENSG000001816262  ANKRD362  ENSG000001879842  ENSG000002220382  POTEH2  POTEA2  
    ENSG000002220362  ENSG000001968342  ENSG000002131142  POTEC2  POTEG2  ENSG000001553192  ANKRD192  POTED2  
    ACTBL32  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/35 NCBI SNPs in POTEE are shown (see all 35 )
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 2 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    --
    rs74254101,2
    C131738017(+) CGTGCC/TGTCCC 1 P/L mis10--------
    --
    rs20734071,2
    C131702320(-) CTTGCC/TGATCC 1 S/S syn10--------
    --
    rs101794221,2
    A,C131693783(+) tcaaaA/Gaaaaa 1 -- int1 trp30--------
    --
    rs76094321,2
    A,C131709728(+) ttctcC/Tggaga 1 -- int10--------
    --
    rs48502701,2
    A,C131704739(+) ATGTAC/TTCATA 1 -- int10--------
    --
    rs124712791,2
    A131703301(+) GGGTTC/TAAATA 1 -- int10--------
    --
    rs118874971,2
    --131692337(+) TTGACA/TTTTCT 1 -- ng510--------
    --
    rs74240291,2
    --131738099(+) TATGAG/TGGGAA 1 E/D mis10--------
    --
    rs115469361,2
    --131737945(+) CAACCA/GCGAGA 1 R/H mis10--------
    --
    rs621775151,2
    --131692742(+) ATGGGC/GAAGTG 1 G/G syn10--------
    About this table

    HapMap Linkage Disequilibrium images for POTEE (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 608914

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    7 PubMed articles for POTEE gene:
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 445582 HGNC: 33895 Ensembl:ENSG00000188219 euGenes: HUgn445582 ECgene: POTEE
    H-InvDB: POTEE
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for POTEE:
     TaqMan ® Gene Expression Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for POTEE-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for POTEE Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Proteins for POTEE
     Lentivirus-delivered shRNAs for POTEE Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
     Antibodies   Primer Pairs  
     Cell Culture Products   ELISAs  
     Flow Cytometry Kits   Protease Activity Assays & Reagents  
     Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
     Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
     Recombinant & Natural Proteins  

     Search for Recombinant Proteins
     Search for Antibodies
     Search for Chimera RNAi
     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Search for Recombinant Proteins
     Search for Antibodies
     Search OriGene for POTEE
     Search Tocris compounds for POTEE




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Search Novus for antibodies for POTEE

    GeneCards Homepage    -    Last full update: 2 Jul 2009        Incremental update: 13 Oct 2009

    Random Gene From GIFtS : about GIFtS

    Gene Index:   3   5   A   B   C   D   E   F   G   H   I   J   K   L   M   N   O   P   Q   R   S   T   U   V   W   X   Y   Z

    Developed at the Crown Human Genome Center & Weizmann Institute of Science



    The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
    POTEE Gene at Home site.
    Version 2.41.1
    server5.xennexinc.com