V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

POTED Gene

protein-coding GIFtS: 37

GC21P013910

POTE ankyrin domain family, member D
(Previous names: ankyrin repeat domain 21, ANKRD26-like family B, member 3 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: ANKRD21, A26B3)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
A26B3 ^², ³
ANKRD21 ^², ³
POTE ^¹, ², ³
POTE-21 ^¹, ²
POTE21 ^¹, ²

Descriptions
ANKRD26-like family B member 3 ^³
ANKRD26-like family B, member 3 ^¹, ²
Ankyrin repeat domain-containing protein 21 ^³
Expressed in prostate, ovary, testis, and placenta ^²
POTE ankyrin domain family, member D ^²
Prostate, ovary, testis-expressed protein ^³
Protein POTE ^³
ankyrin repeat domain 21 ^¹, ²
pote protein ^²

External Ids
HGNC: 23822¹
Entrez Gene: 317754²
UniProtKB: Q86YR6³
Ensembl: ENSG00000166351⁷

Search outside databases for aliases for POTED gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q11.2 Ensembl cytogenetic band: 21q11.2 HGNC cytogenetic band: 21q11.2

POTED Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 21 GeneLoc Exon Structure

GeneLoc location for GC21P013910: (about GC identifiers)

Start:	13,904,054 bp from pter
End:	13,935,777 bp from pter
Size:	31,724 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000021.7 NT_011512.10

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: POTED_HUMAN, Q86YR6 (See protein sequence)

Recommended Name: POTE ankyrin domain family member D

Size: 584 amino acids; 66378 Da

Subcellular location: Cell membrane; Peripheral membrane protein

REFSEQ proteins: NP_778146.2

ENSEMBL proteins:

ENSP00000299443

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (POTED)
	Human Recombinant Proteins from Abnova (A26B3)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--

About this table

Antibodies for POTED:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (POTED), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (A26B3)
	Search Novus for antibodies for POTED

Assays for POTED:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q86YR6

ProtoNet protein and cluster: Q86YR6

1 Blocks protein family: IPB002110 Ankyrin repeat signature

UniProtKB/Swiss-Prot: POTED_HUMAN, Q86YR6

Similarity: Belongs to the POTE family

Similarity: Contains 6 ANK repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_174981

Applied Biosystems Silencer® siRNAs for POTED

Sigma-Aldrich siRNA for POTED

Sigma-Aldrich shRNA for POTED

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_174981
Myc/DDK tagged cDNA clone in CMV expression vector: NM_174981
untagged cDNA clone in CMV expression vector: NM_174981

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_174981

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for POTED

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_174981

Sigma-Aldrich siRNA for POTED

Sigma-Aldrich shRNA for POTED

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_174981

REFSEQ mRNAs for POTED gene:

NM_174981.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_174981

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_174981
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_174981
                                 untagged cDNA clone in CMV expression vector: NM_174981

Additional cDNA sequence:

AY172978.1 BC146605.1

1 DOTS entry:

DT.91644757

2 AceView cDNA sequences:

NM_174981 AY172978

Unigene Cluster for POTED:

POTE ankyrin domain family, member D

Hs.442712

Unigene Representative Sequence: AY172978

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000299443

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

POTED expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for POTED

¹ / ²

1 probe-set matching POTED gene

	Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
	Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
	1553474_at²	U133Plus2	16	1.00	0.24	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTAAGACTGG

SOURCE GeneReport for Unigene cluster: Hs.442712
UniProtKB/Swiss-Prot: POTED_HUMAN, Q86YR6
Tissue specificity: Expressed in prostate, ovary, testis, placenta and prostate cancer cell lines.
Localizes to basal and terminal prostate epithelial cells

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

ENSEMBL Gene Tree for POTED

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for POTED gene

POTEF² ANKRD20A5² ENSG00000181626² ANKRD36² ENSG00000187984² ENSG00000222038² POTEH² POTEA²

ENSG00000222036² ENSG00000196834² ENSG00000213114² POTEC² POTEG² ENSG00000155319² ANKRD19² POTEE²

ACTBL3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/300 NCBI SNPs in POTED are shown (see all 300 )

AB	SNP ID	Valid	Chr 21 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs6517870^1,2	A,C,H	13904823(+)	`ACCACG/ATCCGT`	1	V/I	mis¹ ese³		4		EU EA WA	418
--	rs4818445^1,2	A,C,H	13903204(+)	`AGTGTC/ACTGTT`	1	--	ng5¹		4		EU EA WA	418
--	rs4818444^1,2	A,C	13903077(+)	`GCAGCC/TTGGAG`	1	--	ng5¹		0	--	--	--	--
--	rs4818442^1,2	A,C	13902778(+)	`TGTCGC/TCCAGG`	1	--	ng5¹		0	--	--	--	--
--	rs2187117^1,2	A	13902738(+)	`tctctC/Gcctct`	1	--	ng5¹ trp³		0	--	--	--	--
--	rs9980318^1,2	C	13902486(+)	`caccaA/Gttctt`	1	--	ng5¹		0	--	--	--	--
--	rs9977518^1,2	C	13903990(+)	`TGTAAC/TGGGTG`	1	--	ng5¹		0	--	--	--	--
--	rs9985065^1,2	C	13902457(+)	`tagccC/Tggtaa`	1	--	ng5¹ tfbs³		0	--	--	--	--
--	rs6517869^1,2	C	13904757(+)	`GGAGCA/GGCAAG`	1	G/S	mis¹ ese³		0	--	--	--	--
--	rs9977514^1,2	C	13903985(+)	`TTACCA/TGTAAT`	1	--	ng5¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for POTED (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 607549

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

7 PubMed articles for POTED gene:

Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths. (PubMed id 15276201)^{2, 3, 4} Bera T.K....Pastan I. (2004)
POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer. (PubMed id 12475935)^{2, 3, 4} Bera T.K.... Pastan I. (2002)
Duplication and extensive remodeling shaped POTE family genes encoding proteins containing ankyrin repeat and coiled coil domains. (PubMed id 16364570)^{1, 2, 3} Hahn Y....Lee B. (2006)
The DNA sequence of human chromosome 21. (PubMed id 10830953)^{3, 4} Hattori M....Yaspo M.L. (2000)
Expression of POTE protein in human testis detected by novel monoclonal antibodies. (PubMed id 17996727)³ Ise T....Pastan I. (2008)
Palmitoylation of POTE family proteins for plasma membrane targeting. (PubMed id 17904529)¹ Das S....Pastan I. (2007)
Identification of the putrescine recognition site on polyamine transport protein PotE. (PubMed id 10964926)¹ Kashiwagi K....Igarashi K. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 317754	HGNC: 23822	AceView: ANKRD21	Ensembl:ENSG00000166351	euGenes: HUgn317754
ECgene: POTED	H-InvDB: POTED

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for POTED
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for POTED:

TaqMan ® Gene Expression Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for POTED-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for POTED		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for POTED		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (A26B3)
	Antibodies (A26B3)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (POTED)
	Antibodies (POTED)

Search OriGene for POTED

Search Tocris compounds for POTED

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for POTED

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
POTED Gene at Home site.
Version 2.41.1
server5.xennexinc.com

POTED Gene

protein-coding GIFtS: 37

Aliases &
Descriptions
for POTED

Summaries
for POTED

Genomic Location
for POTED

Proteins
for POTED

Protein Domains/
Families
for POTED

Gene Function
for POTED

Pathways & Interactions
for POTED

Drugs & Compounds
for POTED

Transcripts
for POTED

Expression
for POTED

Orthologs
for POTED

Paralogs
for POTED

SNPs/Variants
for POTED

Disorders & Mutations
for POTED

Medical News
for POTED

Publications
for POTED

Search for POTED

Genome Databases showing POTED

Other Databases showing POTED

Specialized Databases showing POTED

Licensable Technologies
for POTED

Services
for POTED

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

POTED Gene

protein-coding GIFtS: 37

Aliases & Descriptionsfor POTED

Summariesfor POTED

Genomic Locationfor POTED

Proteinsfor POTED

Protein Domains/Familiesfor POTED

Gene Functionfor POTED

Pathways & Interactionsfor POTED

Drugs & Compoundsfor POTED

Transcriptsfor POTED

Expression for POTED

Orthologsfor POTED

Paralogsfor POTED

SNPs/Variantsfor POTED

Disorders & Mutationsfor POTED

Medical Newsfor POTED

Publicationsfor POTED

Search for POTED

Genome Databases showing POTED

Other Databases showing POTED

Specialized Databases showing POTED

Licensable Technologiesfor POTED

Servicesfor POTED

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for POTED

Summaries
for POTED

Genomic Location
for POTED

Proteins
for POTED

Protein Domains/
Families
for POTED

Gene Function
for POTED

Pathways & Interactions
for POTED

Drugs & Compounds
for POTED

Transcripts
for POTED

Expression
for POTED

Orthologs
for POTED

Paralogs
for POTED

SNPs/Variants
for POTED

Disorders & Mutations
for POTED

Medical News
for POTED

Publications
for POTED

Licensable Technologies
for POTED

Services
for POTED