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POTEB Gene

protein-coding   GIFtS: 32

GC15M019307
POTE ankyrin domain family, member B
(Previous names: ANKRD26-like family B, member 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: A26B1)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
A26B1 2, 3
MGC119371 2
MGC119373 2
POTE-15 1, 2, 3
POTE15 1, 2, 3
Descriptions
ANKRD26-like family B member 1 3
ANKRD26-like family B, member 1 1, 2
POTE ankyrin domain family, member B 2
Prostate, ovary, testis-expressed protein on chromosome 15 3
protein expressed in prostate, ovary, testis, and placenta
15 2
External Ids
HGNC: 337341
Entrez Gene: 3390102
UniProtKB: Q6S5H43
Ensembl: ENSG000001832067
Search outside databases for aliases for POTEB gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q11.2   Ensembl cytogenetic band:  15q11.2   HGNC cytogenetic band: 15q11.2

POTEB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M019307:     (about GC identifiers)

Start:
19,305,253 bp from pter
End:
19,336,667 bp from pter
Size:
31,415 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000015.8  NT_037852.5  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: POTEB_HUMAN, Q6S5H4 (See protein sequence)
Recommended Name: POTE ankyrin domain family member B  
Size: 581 amino acids; 65710 Da
Secondary accessions: Q6NXN7 Q6S5H7
Alternative splicing: 3 isoforms:  Q6S5H4-1   Q6S5H4-2   Q6S5H4-3   

REFSEQ proteins: NP_997238.2  

ENSEMBL proteins: 
ENSP00000374541 ENSP00000344792 ENSP00000329990 ENSP00000351856 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
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Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


Antibodies for POTEB: 
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Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for POTEB

Assays for POTEB: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro domain/family:
 IPR002110 ANK


   GeneDecks  POTEB for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q6S5H4

ProtoNet protein and cluster: Q6S5H4

1 Blocks protein family: IPB002110 Ankyrin repeat signature

UniProtKB/Swiss-Prot: POTEB_HUMAN, Q6S5H4
Similarity: Belongs to the POTE family
Similarity: Contains 7 ANK repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Browse Invitrogen for RNAi
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_290225

              Applied Biosystems Silencer® siRNAs for POTEB

              Sigma-Aldrich siRNA for POTEB  
                     Sigma-Aldrich shRNA for POTEB  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for POTEB
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_207355
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_207355
                                 untagged cDNA clone in CMV expression vector: NM_207355 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_207355

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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  --
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for POTEB

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Browse Invitrogen for RNAi
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_290225

              Sigma-Aldrich siRNA for POTEB  
                     Sigma-Aldrich shRNA for POTEB  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_207355  

REFSEQ mRNAs for POTEB gene: 

NM_207355.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_207355  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_207355
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_207355
                                 untagged cDNA clone in CMV expression vector: NM_207355 

Additional cDNA sequence: 

AY465170.1 AY465173.1 BC066981.1 BC101005.1 BC101006.1 BC101007.1 BC127123.1 

3 DOTS entries:

DT.102821697  DT.102821695  DT.121065142 

7 AceView cDNA sequences:

AY465173 AY465170 BC066981 BG720647 NM_207355 AL703938 BX492731 

Unigene Cluster for POTEB:

POTE ankyrin domain family, member B
Hs.558766  [show with all ESTs]
Unigene Representative Sequence: NM_207355


GeneLoc Exon Structure

4 Ensembl transcripts including schematic representations:
ENST00000389891  ENST00000339248  ENST00000327822  ENST00000358970  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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POTEB expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for POTEB

1 / 2

1 probe-set matching POTEB gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

1553474_at2 U133Plus2 16 0.91 0.19 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.558766
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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ENSEMBL Gene Tree for POTEB
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for POTEB gene
POTEC1  POTEF2  ANKRD20A52  ENSG000001816262  ANKRD362  ENSG000001879842  ENSG000002220382  POTEH2  
POTEA2  ENSG000002220362  ENSG000001968342  ENSG000002131142  POTEG2  ENSG000001553192  ANKRD192  POTED2  
POTEE2  ACTBL32  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/569 NCBI SNPs in POTEB are shown (see all 569 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 1)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 15 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
--
rs26649971,2
A,C,F,H19336725(+) CGAAGC/TGTACC 1 -- ng311Minor allele frequency- T:0.19WA 118
--
rs19492821,2
A,C,F,H19307169(-) ATTCTG/AAGGTA 1 E/K mis1 ese312Minor allele frequency- A:0.02NS EU EA WA NA 628
--
rs18288691,2
A,C,F19305414(-) TGCCAT/AGCTAA 1 K/M mis14Minor allele frequency- A:0.50EU EA WA 420
--
rs24588621,2
A,C,H19336039(-) ATGACA/GACTCC 1 N/D mis1 ese34Minor allele frequency- G:0.00EU EA WA 400
--
rs26723901,2
A,C19338215(-) gaatgA/CaaTGG 1 -- ng310--------
--
rs18497931,2
A,C19305202(+) CCTAGC/TTGTGT 1 -- ng510--------
--
rs26650121,2
A,C19338599(+) tgagaA/Cgttct 1 -- ng310--------
--
rs24456031,2
A,C19328089(-) AACAGC/GAAGTG 1 Q/E mis10--------
--
rs65997431,2
A,C19336099(+) GAAGCA/GGTGGT 1 C/R mis1 ese30--------
--
rs44292511,2
A,C19336071(-) CGGCAA/CGAGCA 1 T/K mis1 ese30--------
About this table

HapMap Linkage Disequilibrium images for POTEB (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 608912

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

4 PubMed articles for POTEB gene:
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 339010 HGNC: 33734 AceView: POTE15 Ensembl:ENSG00000183206 euGenes: HUgn339010
ECgene: POTEB H-InvDB: POTEB
(According to HUGE)
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  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for POTEB:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for POTEB-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for POTEB Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for POTEB Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Search Novus for antibodies for POTEB

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