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POTEA Gene

protein-coding   GIFtS: 34

GC08P043268
POTE ankyrin domain family, member A
(Previous names: ANKRD26-like family A, member 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: A26A1)
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Aliases &
Descriptions
for POTEA

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
A26A1 2, 3
POTE-8 1, 2, 3
POTE8 1, 2, 3
Descriptions
ANKRD26-like family A member 1 3
ANKRD26-like family A, member 1 1, 2
POTE ankyrin domain family, member A 2
Prostate, ovary, testis-expressed protein on chromosome 8 3
protein expressed in prostate, ovary, testis, and placenta
8 2
External Ids
HGNC: 338931
Entrez Gene: 3404412
UniProtKB: Q6S8J73
Ensembl: ENSG000001888777
Search outside databases for aliases for POTEA gene

Summaries
for POTEA

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

   --

Genomic Location
for POTEA

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p11.1   Ensembl cytogenetic band:  8p11.1   HGNC cytogenetic band: 8p11.1

POTEA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P043268:     (about GC identifiers)

Start:
 43,266,742 bp from pter
End:
 43,337,485 bp from pter
Size:
 70,744 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000008.9  NT_007995.14  

Proteins
for POTEA

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: POTEA_HUMAN, Q6S8J7 (See protein sequence)
Recommended Name: POTE ankyrin domain family member A  
Size: 498 amino acids; 56166 Da
Secondary accessions: A6ND17 A6ND71 Q6S8J6
Alternative splicing: 2 isoforms:  Q6S8J7-1   Q6S8J7-2   

REFSEQ proteins (2 alternative transcripts): 
NP_001002920.1  NP_001005365.2  


ENSEMBL proteins: 
ENSP00000343031 ENSP00000346193 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


Antibodies for POTEA: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for POTEA

Assays for POTEA: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for POTEA

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro domain/family:
 IPR002110 ANK


   GeneDecks  POTEA for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q6S8J7

ProtoNet protein and cluster: Q6S8J7

1 Blocks protein family: IPB002110 Ankyrin repeat signature

UniProtKB/Swiss-Prot: POTEA_HUMAN, Q6S8J7
Similarity: Belongs to the POTE family
Similarity: Contains 5 ANK repeats

Gene Function
for POTEA

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (POTEA)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): XM_294480

              Applied Biosystems Silencer® siRNAs for POTEA

              Sigma-Aldrich siRNA for POTEA  
                     Sigma-Aldrich shRNA for POTEA  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001002920
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001002920
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001002920 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_001005365

Pathways & Interactions
for POTEA

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


  --

Drugs & Compounds
for POTEA

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for POTEA

Transcripts
for POTEA

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (POTEA)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): XM_294480

              Sigma-Aldrich siRNA for POTEA  
                     Sigma-Aldrich shRNA for POTEA  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001002920  NM_001005365  

REFSEQ mRNAs for POTEA gene (2 alternative transcripts): 

NM_001002920.1   NM_001005365.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001002920  NM_001005365  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001002920
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001002920
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001002920 

Additional cDNA sequence: 

AY462869.1 AY462870.1 

2 DOTS entries:

DT.102826485  DT.102826537 

3 AceView cDNA sequences:

AY462870 NM_001002920 AY462869 

Unigene Cluster for POTEA:

POTE ankyrin domain family, member A
Hs.531579
Unigene Representative Sequence: AY462869


GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for POTEA

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1:                                                                              
SP2:                          -                                                   

About this scheme

ECgene alternative splicing isoforms for POTEA

2 Ensembl transcripts including schematic representations:
ENST00000344403  ENST00000354247  

Expression
for POTEA

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

POTEA expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for POTEA

1Data from GNF BioGPS
    About these images

About these images

CGAP SAGE TAG: CTAAGAATAG

SOURCE GeneReport for Unigene cluster: Hs.531579

Orthologs
for POTEA

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for POTEA gene from 1 species
Organism Gene Locus Description Human
Similarity		 NCBI accessions
chimpanzee
(Pan troglodytes)		 POTEA1   -- POTE ankyrin domain family, member A 98.93(n)
97.99(a)		 472754  XM_001140309.1  XP_001140309.1 
About this table        Species with no ortholog for POTEA

ENSEMBL Gene Tree for POTEA

Paralogs
for POTEA

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for POTEA gene
POTEF2  ANKRD20A52  ENSG000001816262  ANKRD362  ENSG000001879842  ENSG000002220382  POTEH2  ENSG000001968342  
ENSG000002220362  ENSG000002131142  POTEC2  POTEG2  ENSG000001553192  ANKRD192  POTED2  POTEE2  
ACTBL32  

SNPs/Variants
for POTEA

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/379 NCBI SNPs in POTEA are shown (see all 379 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 54)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 8 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
--
rs96939471,2
A,F,H43337815(+) AAAgaC/Tggggc 2 -- ng314Minor allele frequency- T:0.01EU EA WA 400
--
rs96930221,2
A,F,H43337831(+) accatT/Ctttcc 2 -- ng314Minor allele frequency- C:0.04EU EA WA 420
--
rs96938641,2
H43337668(+) GAACAG/TGTTTA 2 -- ng313Minor allele frequency- T:0.00EU EA 296
--
rs9226321,2
A,C,F,H,O43269531(+) TTGTGA/GATGTA 2 -- int112Minor allele frequency- N:0.00EA NA EU WA 1046
--
rs14715301,2
A,C,F,H,O43274461(+) TATAGA/GGATAA 2 -- int17Minor allele frequency- G:0.16EU EA WA NA 518
rs8819071,2
A,C,F,H43336698(+) CAATGC/TTTAGA 2 -- int14Minor allele frequency- T:0.16EU EA WA 418
--
rs69987701,2
A,C,F,H43292069(+) TGGCCA/GCTGAA 2 -- int14Minor allele frequency- G:0.03EU EA WA 416
rs78134561,2
A,C,F,H43325707(+) ggaagT/Atacct 2 -- int17Minor allele frequency- A:0.03EU EA WA NA 560
--
rs19939991,2
C,F,H,O43288053(+) AAATCT/CCAGAT 2 -- int18Minor allele frequency- C:0.15EU EA WA NA 608
--
rs64744361,2
A,C,F,H43268975(+) GCATAG/AATACA 2 -- int14Minor allele frequency- A:0.15EU EA WA 392
About this table

HapMap Linkage Disequilibrium images for POTEA (up to first 250kb)

Disorders & Mutations
for POTEA

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

 OMIM: 608915

Medical News
for POTEA

(Possibly Related Articles in Doctor's Guide)
About This Section

   --

Publications
for POTEA

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

2 PubMed articles for POTEA gene:

Search for POTEA

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing POTEA

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section
Entrez Gene: 340441 HGNC: 33893 AceView: POTE8 Ensembl:ENSG00000188877 euGenes: HUgn340441
ECgene: POTEA H-InvDB: POTEA

Other Databases showing POTEA

(According to HUGE)
About This Section

   --

Specialized Databases showing POTEA

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

   --

Licensable Technologies
for POTEA

(Available from WIS Yeda, Salk, Tufts)
About This Section

  --

Services
for POTEA

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for POTEA:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for POTEA-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for POTEA Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for POTEA Browse small molecules at Sigma-Aldrich
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 Search Novus for antibodies for POTEA

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