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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

A1CF Gene

protein-coding   GIFtS: 54
GCID: GC10M052566

APOBEC1 Complementation Factor

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
APOBEC1 Complementation Factor1 2     APOBEC1CF2
ACF2 3     Apo-B RNA Editing Protein2
ASP2 3     Apobec-1 Complementation Factor (ACF) (ASP)2
ACF642     APOBEC-1 Stimulating Protein2
ACF652     APOBEC1-Stimulating Protein3

External Ids:    HGNC: 240861   Entrez Gene: 299742   Ensembl: ENSG000001485847   UniProtKB: Q9NQ943   

Export aliases for A1CF gene to outside databases

Previous GC identifers: GC10M052237 GC10M046544


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for A1CF Gene:
Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component
enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene.
The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding
proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks
APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA
editing or RNA processing events. Several transcript variants encoding a few different isoforms have been found
for this gene. (provided by RefSeq, Nov 2010)

GeneCards Summary for A1CF Gene: 
A1CF (APOBEC1 complementation factor) is a protein-coding gene. Diseases associated with A1CF include anisometropia, and hydrocele, and among its related super-pathways are mRNA Editing and Processing of Capped Intron-Containing Pre-mRNA. GO annotations related to this gene include double-stranded RNA binding and RNA binding. An important paralog of this gene is SYNCRIP.

UniProtKB/Swiss-Prot: A1CF_HUMAN, Q9NQ94
Function: Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the
postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is
probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target
cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay

Gene Wiki entry for A1CF (ACF) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_030059.13  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the A1CF gene promoter:
         Arnt   RORalpha2   RORalpha1   POU2F1   POU2F1b   POU2F1a   STAT3   FOXO1a   POU2F1c   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidA1CF promoter sequence
   Search SABiosciences Chromatin IP Primers for A1CF

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat A1CF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q11.23   Ensembl cytogenetic band:  10q11.23   HGNC cytogenetic band: 10q21.1

A1CF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
A1CF gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M052566:  view genomic region     (about GC identifiers)

Start:
52,559,169 bp from pter      End:
52,645,435 bp from pter
Size:
86,267 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: A1CF_HUMAN, Q9NQ94 (See protein sequence)
Recommended Name: APOBEC1 complementation factor  
Size: 594 amino acids; 65202 Da
Subunit: Part of the apolipoprotein B mRNA editing complex with APOBEC1. Interacts with TNPO2; TNPO2 may be
responsible for transport of A1CF into the nucleus. Interacts with SYNCRIP. Interacts with CELF2/CUGBP2 (By
similarity)
Subcellular location: Nucleus. Endoplasmic reticulum (By similarity). Cytoplasm. Note=Predominantly nuclear where
it localizes to heterochromatin. Also cytoplasmic where it is found at the outer surface of the endoplasmic
reticulum (By similarity). Shuttles between the nucleus and cytoplasm. May be transported into the nucleus by the
nuclear import protein TNPO2/TRN2 or by APOBEC1
Sequence caution: Sequence=BAA91086.1; Type=Frameshift; Positions=148;
1 PDB 3D structure from and Proteopedia for A1CF:
2CPD (3D)    
Secondary accessions: A1L4F2 A8K7G7 B7ZM14 Q5SZQ0 Q9NQ93 Q9NQX8 Q9NQX9 Q9NXC9 Q9NZD3
Alternative splicing: 6 isoforms:  Q9NQ94-1   Q9NQ94-2   Q9NQ94-3   Q9NQ94-4   Q9NQ94-5   Q9NQ94-6   (Minor isoform found in 2-3% of cDNA clones)

Explore the universe of human proteins at neXtProt for A1CF: NX_Q9NQ94

Explore proteomics data for A1CF at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NQ94

  • A1CF Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    A1CF Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001185747.1  NP_001185748.1  NP_001185749.1  NP_055391.2  NP_620310.1  NP_620311.1  

    ENSEMBL proteins: 
     ENSP00000363105   ENSP00000363113   ENSP00000363109   ENSP00000363107   ENSP00000397953  
     ENSP00000282641   ENSP00000378873   ENSP00000378868  
    Reactome Protein details: Q9NQ94
    Human Recombinant Protein Products for A1CF: 
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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA--
    GO:0005783endoplasmic reticulum IEA--
    GO:0030895apolipoprotein B mRNA editing enzyme complex IDA10781591

    A1CF for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RBM: RNA binding motif (RRM) containing

    4 InterPro protein domains:
     IPR006535 HnRNP_R/Q_splicing_fac
     IPR000504 RRM_dom
     IPR014720 dsRNA-bd-like_dom
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry Q9NQ94

    ProtoNet protein and cluster: Q9NQ94

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: A1CF_HUMAN, Q9NQ94
    Domain: The RRM domains are necessary but not sufficient for binding to APOB mRNA. Additional residues in the
    pre-RRM and C-terminal regions are required for RNA-binding and for complementing APOBEC1 activity
    Similarity: Contains 3 RRM (RNA recognition motif) domains


    A1CF for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: A1CF_HUMAN, Q9NQ94
    Function: Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the
    postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is
    probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target
    cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding TAS10669759
    GO:0003725NOT double-stranded RNA binding IDA11871661
    GO:0003727single-stranded RNA binding IDA11871661
         
    A1CF for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for A1cf):
     cellular  mortality/aging 

    A1CF for phenotypes           About GeneDecksing

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidA1CF 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for A1CF About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Formation of editosomes by ADAR proteins
    mRNA Editing0.50
    mRNA Editing: C to U Conversion0.50
    Formation of the Editosome0.50
    2mRNA Splicing - Major Pathway
    mRNA Processing0.85
    3Generic Transcription Pathway
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5        Reactome Pathways for A1CF
        Formation of the Editosome
    mRNA Editing
    Gene Expression
    mRNA Editing: C to U Conversion
    mRNA Processing



    A1CF for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for A1CF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/10 Interacting proteins for A1CF (Q9NQ943 ENSP000002826414) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APOBEC1P412383, ENSP000002293044I2D: score=2 STRING: ENSP00000229304
    CELF2O953193, ENSP000003899514I2D: score=2 STRING: ENSP00000389951
    SYNCRIPO605063, ENSP000003586354I2D: score=2 STRING: ENSP00000358635
    KHSRPQ929453, ENSP000003812164I2D: score=2 STRING: ENSP00000381216
    TNPO2O147873, ENSP000003973794I2D: score=2 STRING: ENSP00000397379
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006397mRNA processing IEA--
    GO:0010467gene expression TAS--
    GO:0016554cytidine to uridine editing TAS--
    GO:0016556mRNA modification TAS--
    GO:0050821protein stabilization IDA12881431

    A1CF for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    A1CF for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for A1CF

    1 HMDB Compound for A1CF    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cytosine4-Amino-2(1H)-pyrimidinone (see all 6)71-30-7--

    4 Novoseek inferred chemical compound relationships for A1CF gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cytidine 82.4 6 12881431 (1), 16055734 (1), 10669759 (1), 15451168 (1) (see all 6)
    uridine 62.9 1 11870221 (1)
    ethanol 25.2 2 16820530 (2)
    serine 13.8 1 16820530 (1)

    Search CenterWatch for drugs/clinical trials and news about A1CF

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for A1CF gene (6 alternative transcripts): 
    NM_001198818.1  NM_001198819.1  NM_001198820.1  NM_014576.3  NM_138932.2  NM_138933.2  

    Unigene Cluster for A1CF:

    APOBEC1 complementation factor
    Hs.282795  [show with all ESTs]
    Unigene Representative Sequence: NM_001198819
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373993 ENST00000374001 ENST00000373997(uc009xov.3 uc001jji.3)
    ENST00000373995(uc010qhn.2 uc001jjh.3) ENST00000493415 ENST00000473480
    ENST00000414883(uc001jjk.1) ENST00000282641(uc001jjj.3) ENST00000395495
    ENST00000395489(uc010qho.2)
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    Additional mRNA sequence: 

    AF209192.1 AF271789.1 AF271790.1 AJ272078.1 AJ272079.1 AK000324.1 AK130022.1 AK291982.1 
    AK303801.1 BC022263.1 BC054873.1 BC130519.1 BC144194.1 BC144196.1 CR749831.1 

    11 DOTS entries:

    DT.101966638  DT.92425892  DT.95374373  DT.100022638  DT.86841758  DT.100765861  DT.99940798  DT.95374372 
    DT.95374374  DT.95325400  DT.92425886 

    24/110 AceView cDNA sequences (see all 110):

    BC054873 T39997 NM_014576 CA942681 CA942922 NM_138932 BG617808 T78557 
    AI913746 AF271789 NM_138933 AJ272079 AJ272078 BM479119 CK825749 CK825748 
    BF431668 T78476 BV199907 AW610448 BG618487 BX481172 BM351836 BG188382 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for A1CF    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14
    SP1:        -                                   -           -                       -                     
    SP2:                          -                 -           -                       -                     
    SP3:                          -                 -           -                                             
    SP4:                                                                                                      
    SP5:        -                 -                                                                           


    ECgene alternative splicing isoforms for A1CF

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    A1CF expression in normal human tissues (normalized intensities)      A1CF embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    A1CF Expression
    About this image


    A1CF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Liver (Hepatobiliary System)
             Human Hepatocyte (HH)   
     
     Intestine (Gastrointestinal Tract)
             small intestine   
     
     Colon (Gastrointestinal Tract)
             colonic mucosal (ibs)   
     
     Gut Tube (Gastrointestinal Tract)
             Endoderm progenitor-like cells ( Generation and expansion of endodermal progenitor...

    See A1CF Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for A1CF

    SOURCE GeneReport for Unigene cluster: Hs.282795

    UniProtKB/Swiss-Prot: A1CF_HUMAN, Q9NQ94
    Tissue specificity: Widely expressed with highest levels in brain, liver, pancreas, colon and spleen

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for A1CF gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia A1cf1 , 5 APOBEC1 complementation factor1, 5 88.4(n)1
    93.69(a)1
      19 (26.58 cM)5
    698651  NM_001081074.11  NP_001074543.11 
     318687615 
    chicken
    (Gallus gallus)
    Aves A1CF1 APOBEC1 complementation factor 79.31(n)
    88.97(a)
      423680  XM_003641458.1  XP_003641506.1 
    lizard
    (Anolis carolinensis)
    Reptilia A1CF6
    Uncharacterized protein
    81(a)
    1 ↔ 1
    GL343246.1(1350881-1396063)
    zebrafish
    (Danio rerio)
    Actinopterygii a1cf1 apobec1 complementation factor 74.31(n)
    82.07(a)
      562916  XM_680086.4  XP_685178.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG178386
    --
    24(a)
    1 → many
    3R(16582451-16631963)
    worm
    (Caenorhabditis elegans)
    Secernentea hrp-26
    Protein HRP-2, isoform a
    25(a)
    1 → many
    I(12060276-12064899)


    ENSEMBL Gene Tree for A1CF (if available)
    TreeFam Gene Tree for A1CF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for A1CF gene
    SYNCRIP2  RBM472  DND12  RBM462  HNRNPR2  
    13 SIMAP similar genes for A1CF using alignment to 4 protein entries:     A1CF_HUMAN (see all proteins):
    RBM47    RBM46    HNRPR    DKFZp686A13234    HNRNPR    SYNCRIP
    DKFZp686C17209    DKFZp781C0423    DKFZp781I1140    DND1    RBM39    RBMY1A1
    CELF1

    A1CF for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1641 SNPs in A1CF are shown (see all 1641)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1433158651,2
    C,Funtested152973088(+) TATAGG/AATTTT 12 /I syn12Minor allele frequency- A:0.00NA EU 5857
    rs1455739521,2
    C--46559818(+) TTTTT-/TCAGAC 6 -- int10--------
    rs560604921,2
    C--52564075(+) AATGAT/-TTTTT 6 -- ut311Minor allele frequency- -:0.00NA 2
    rs109946251,2
    --52586240(+) TTCAAC/TATTCT 6 -- int10--------
    rs122607771,2
    C,F--52587692(+) taagcG/Acaata 6 -- int11Minor allele frequency- A:0.50CSA 2
    rs1138630791,2
    F--52591142(+) TCCCAG/AATATA 6 -- int11Minor allele frequency- A:0.50CSA 2
    rs1135885181,2
    C,F--52591211(+) AGGCCG/AGGCGT 6 -- int11Minor allele frequency- A:0.50WA 2
    rs1124177711,2
    C,F--52591348(+) CCAGGC/TGTGGT 6 -- int11Minor allele frequency- T:0.50CSA 2
    rs733267761,2
    C,F--52599612(+) CAAGCG/AATTCT 6 -- int12Minor allele frequency- A:0.33WA CSA 3
    rs2021614911,2
    C--52600036(+) TTTTT-/TATCAT 6 -- int10--------

    HapMap Linkage Disequilibrium report for A1CF (52559169 - 52645435 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for A1CF:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2658700CNV Deletion23128226

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing A1CF
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    5 diseases for A1CF:    About MalaCards
    anisometropia    hydrocele    amblyopia    cholera
    hepatocellular carcinoma

    2 diseases from the University of Copenhagen DISEASES database for A1CF:
    Amblyopia     Anisometropia

    A1CF for disorders           About GeneDecksing

    Genetic Association Database (GAD): A1CF

    Export disorders for A1CF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for A1CF gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with A1CF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel nuclear localization signal in the auxiliary domain of apobec-1 complementation factor regulates nucleocytoplasmic import and shuttling. (PubMed id 12896982)1, 2, 9 Blanc V.... Davidson N.O. (2003)
    2. Molecular cloning of APOBEC-1 complementation factor, a novel RNA- binding protein involved in the editing of apolipoprotein B mRNA. (PubMed id 10669759)1, 2, 9 Mehta A.... Driscoll D.M. (2000)
    3. Two proteins essential for apolipoprotein B mRNA editing are expressed from a single gene through alternative splicing. (PubMed id 11815617)1, 3, 9 Dance G.S....Smith H.C. (2002)
    4. Isolation, characterization and developmental regulation of the human apobec-1 complementation factor (ACF) gene. (PubMed id 11718896)1, 2, 9 Henderson J.O.... Davidson N.O. (2001)
    5. Identification of domains in apobec-1 complementation factor required for RNA binding and apolipoprotein-B mRNA editing. (PubMed id 11871661)1, 2, 9 Mehta A. and Driscoll D.M. (2002)
    6. The apolipoprotein B mRNA editing complex performs a multifunctional cycle and suppresses nonsense-mediated decay. (PubMed id 12881431)1, 2, 9 Chester A.... Navaratnam N. (2003)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    9. Identification of GRY-RBP as an apolipoprotein B RNA-binding protein that interacts with both apobec-1 and apobec-1 complementation factor to modulate C to U editing. (PubMed id 11134005)1, 2 Blanc V.... Davidson N.O. (2001)
    10. Purification and molecular cloning of a novel essential component of the apolipoprotein B mRNA editing enzyme-complex. (PubMed id 10781591)1, 2 Lellek H.... Greeve J. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 29974 HGNC: 24086 AceView: ACF Ensembl:ENSG00000148584 euGenes: HUgn29974
    ECgene: A1CF H-InvDB: A1CF

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for A1CF Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for A1CF gene:
    Search GeneIP for patents involving A1CF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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