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Aliases for A1CF Gene

Aliases for A1CF Gene

  • APOBEC1 Complementation Factor 2 3 5
  • ACF 3 4
  • ASP 3 4
  • Apobec-1 Complementation Factor (ACF) (ASP) 3
  • APOBEC-1 Stimulating Protein 3
  • APOBEC1-Stimulating Protein 4
  • Apo-B RNA Editing Protein 3
  • APOBEC1CF 3
  • ACF64 3
  • ACF65 3

External Ids for A1CF Gene

Previous GeneCards Identifiers for A1CF Gene

  • GC10M052237
  • GC10M052566
  • GC10M046544

Summaries for A1CF Gene

Entrez Gene Summary for A1CF Gene

  • Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for A1CF Gene

A1CF (APOBEC1 Complementation Factor) is a Protein Coding gene. Among its related pathways are C6 deamination of adenosine and Gene Expression. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is HNRNPR.

UniProtKB/Swiss-Prot for A1CF Gene

  • Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay.

Gene Wiki entry for A1CF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for A1CF Gene

Genomics for A1CF Gene

Regulatory Elements for A1CF Gene

Promoters for A1CF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around A1CF on UCSC Golden Path with GeneCards custom track

Genomic Location for A1CF Gene

Chromosome:
10
Start:
50,799,409 bp from pter
End:
50,885,675 bp from pter
Size:
86,267 bases
Orientation:
Minus strand

Genomic View for A1CF Gene

Genes around A1CF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
A1CF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for A1CF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for A1CF Gene

Proteins for A1CF Gene

  • Protein details for A1CF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQ94-A1CF_HUMAN
    Recommended name:
    APOBEC1 complementation factor
    Protein Accession:
    Q9NQ94
    Secondary Accessions:
    • A1L4F2
    • A8K7G7
    • B7ZM14
    • Q5SZQ0
    • Q9NQ93
    • Q9NQX8
    • Q9NQX9
    • Q9NXC9
    • Q9NZD3

    Protein attributes for A1CF Gene

    Size:
    594 amino acids
    Molecular mass:
    65202 Da
    Quaternary structure:
    • Part of the apolipoprotein B mRNA editing complex with APOBEC1. Interacts with TNPO2; TNPO2 may be responsible for transport of A1CF into the nucleus. Interacts with SYNCRIP. Interacts with CELF2/CUGBP2 (By similarity).
    SequenceCaution:
    • Sequence=BAA91086.1; Type=Frameshift; Positions=148; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for A1CF Gene

    Alternative splice isoforms for A1CF Gene

neXtProt entry for A1CF Gene

Proteomics data for A1CF Gene at MOPED

Post-translational modifications for A1CF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for A1CF Gene

Domains & Families for A1CF Gene

Gene Families for A1CF Gene

Suggested Antigen Peptide Sequences for A1CF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NQ94

UniProtKB/Swiss-Prot:

A1CF_HUMAN :
  • The RRM domains are necessary but not sufficient for binding to APOB mRNA. Additional residues in the pre-RRM and C-terminal regions are required for RNA-binding and for complementing APOBEC1 activity.
Domain:
  • The RRM domains are necessary but not sufficient for binding to APOB mRNA. Additional residues in the pre-RRM and C-terminal regions are required for RNA-binding and for complementing APOBEC1 activity.
  • Contains 3 RRM (RNA recognition motif) domains.
genes like me logo Genes that share domains with A1CF: view

Function for A1CF Gene

Molecular function for A1CF Gene

UniProtKB/Swiss-Prot Function:
Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay.

Gene Ontology (GO) - Molecular Function for A1CF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005515 protein binding IPI 10669759
genes like me logo Genes that share ontologies with A1CF: view
genes like me logo Genes that share phenotypes with A1CF: view

Animal Models for A1CF Gene

MGI Knock Outs for A1CF:

Animal Model Products

CRISPR Products

miRNA for A1CF Gene

miRTarBase miRNAs that target A1CF

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for A1CF Gene

Localization for A1CF Gene

Subcellular locations from UniProtKB/Swiss-Prot for A1CF Gene

Nucleus. Endoplasmic reticulum. Cytoplasm. Note=Predominantly nuclear where it localizes to heterochromatin. Also cytoplasmic where it is found at the outer surface of the endoplasmic reticulum (By similarity). Shuttles between the nucleus and cytoplasm. May be transported into the nucleus by the nuclear import protein TNPO2/TRN2 or by APOBEC1. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for A1CF Gene COMPARTMENTS Subcellular localization image for A1CF gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 3
cytosol 1

Gene Ontology (GO) - Cellular Components for A1CF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with A1CF: view

Pathways & Interactions for A1CF Gene

genes like me logo Genes that share pathways with A1CF: view

Pathways by source for A1CF Gene

Gene Ontology (GO) - Biological Process for A1CF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with A1CF: view

No data available for SIGNOR curated interactions for A1CF Gene

Drugs & Compounds for A1CF Gene

(4) Drugs for A1CF Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for A1CF Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Cytosine
  • 4-Amino-2(1H)-pyrimidinone
  • 4-Amino-2-hydroxypyrimidine
  • 4-Amino-2-oxo-1,2-dihydropyrimidine
  • 4-Aminouracil
  • Cytosine
71-30-7
genes like me logo Genes that share compounds with A1CF: view

Transcripts for A1CF Gene

Unigene Clusters for A1CF Gene

APOBEC1 complementation factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for A1CF Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4:
SP5: - -

Relevant External Links for A1CF Gene

GeneLoc Exon Structure for
A1CF
ECgene alternative splicing isoforms for
A1CF

Expression for A1CF Gene

mRNA expression in normal human tissues for A1CF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for A1CF Gene

This gene is overexpressed in Liver (x36.4), Colon - Transverse (x4.6), and Pancreas (x4.3).

Protein differential expression in normal tissues from HIPED for A1CF Gene

This gene is overexpressed in Fetal Liver (22.7), Liver (21.7), Pancreas (12.2), and Gallbladder (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for A1CF Gene



SOURCE GeneReport for Unigene cluster for A1CF Gene Hs.282795

mRNA Expression by UniProt/SwissProt for A1CF Gene

Q9NQ94-A1CF_HUMAN
Tissue specificity: Widely expressed with highest levels in brain, liver, pancreas, colon and spleen.
genes like me logo Genes that share expression patterns with A1CF: view

Protein tissue co-expression partners for A1CF Gene

Primer Products

In Situ Assay Products

Orthologs for A1CF Gene

This gene was present in the common ancestor of animals.

Orthologs for A1CF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia A1CF 35
  • 99.6 (n)
  • 99.6 (a)
A1CF 36
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia A1CF 36
  • 90 (a)
OneToOne
A1CF 35
  • 90.96 (n)
  • 95.9 (a)
dog
(Canis familiaris)
Mammalia A1CF 35
  • 89.29 (n)
  • 95.19 (a)
A1CF 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia A1cf 16
A1cf 35
  • 88.4 (n)
  • 93.69 (a)
A1cf 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia A1CF 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia A1CF 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia A1cf 35
  • 88.66 (n)
  • 94.19 (a)
chicken
(Gallus gallus)
Aves A1CF 35
  • 79.37 (n)
  • 88.79 (a)
A1CF 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia A1CF 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia a1cf 35
  • 76.82 (n)
  • 84.08 (a)
zebrafish
(Danio rerio)
Actinopterygii a1cf 36
  • 78 (a)
OneToOne
a1cf 35
  • 74.2 (n)
  • 82.07 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17838 36
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hrp-2 36
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
OneToOne
Species with no ortholog for A1CF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for A1CF Gene

ENSEMBL:
Gene Tree for A1CF (if available)
TreeFam:
Gene Tree for A1CF (if available)

Paralogs for A1CF Gene

Paralogs for A1CF Gene

genes like me logo Genes that share paralogs with A1CF: view

Variants for A1CF Gene

Sequence variations from dbSNP and Humsavar for A1CF Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs9073 - 50,806,851(+) AGACA(C/T)GGGTG reference, missense
rs11817448 - 50,806,842(+) CTGGG(A/C)TGCAG reference, missense
rs4145577 -- 50,853,275(+) CTGCA(C/T)TGTAT intron-variant
rs3808918 -- 50,886,603(-) TTTCT(A/G)TAGAC upstream-variant-2KB
rs4245012 -- 50,881,804(+) AACTG(C/T)GCAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for A1CF Gene

Variant ID Type Subtype PubMed ID
esv2658700 CNV Deletion 23128226

Variation tolerance for A1CF Gene

Residual Variation Intolerance Score: 11.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.77; 58.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for A1CF Gene

HapMap Linkage Disequilibrium report
A1CF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for A1CF Gene

Disorders for A1CF Gene

Relevant External Links for A1CF

Genetic Association Database (GAD)
A1CF
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
A1CF

No disorders were found for A1CF Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for A1CF Gene

Publications for A1CF Gene

  1. A novel nuclear localization signal in the auxiliary domain of apobec-1 complementation factor regulates nucleocytoplasmic import and shuttling. (PMID: 12896982) Blanc V. … Davidson N.O. (J. Biol. Chem. 2003) 3 4 23 67
  2. Two proteins essential for apolipoprotein B mRNA editing are expressed from a single gene through alternative splicing. (PMID: 11815617) Dance G.S. … Smith H.C. (J. Biol. Chem. 2002) 2 3 23
  3. Targeted deletion of the murine apobec-1 complementation factor (acf) gene results in embryonic lethality. (PMID: 16055734) Blanc V. … Davidson N.O. (Mol. Cell. Biol. 2005) 3 23
  4. The apolipoprotein B mRNA editing complex performs a multifunctional cycle and suppresses nonsense-mediated decay. (PMID: 12881431) Chester A. … Navaratnam N. (EMBO J. 2003) 3 23
  5. Identification of domains in apobec-1 complementation factor required for RNA binding and apolipoprotein-B mRNA editing. (PMID: 11871661) Mehta A. … Driscoll D.M. (RNA 2002) 3 23

Products for A1CF Gene

Sources for A1CF Gene

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