Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



A1CF Gene

protein-coding   GIFtS: 53
GCID: GC10M052566

APOBEC1 Complementation Factor

  See A1CF-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
APOBEC1 Complementation Factor1 2     APOBEC1CF2
ACF2 3     Apo-B RNA Editing Protein2
ASP2 3     Apobec-1 Complementation Factor (ACF) (ASP)2
ACF642     APOBEC-1 Stimulating Protein2
ACF652     APOBEC1-Stimulating Protein3

External Ids:    HGNC: 240861   Entrez Gene: 299742   Ensembl: ENSG000001485847   UniProtKB: Q9NQ943   

Export aliases for A1CF gene to outside databases

Previous GC identifers: GC10M052237 GC10M046544


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for A1CF Gene:
Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component
enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene.
The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding
proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks
APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA
editing or RNA processing events. Several transcript variants encoding a few different isoforms have been found
for this gene. (provided by RefSeq, Nov 2010)

GeneCards Summary for A1CF Gene:
A1CF (APOBEC1 complementation factor) is a protein-coding gene. Diseases associated with A1CF include anisometropia, and amblyopia. GO annotations related to this gene include double-stranded RNA binding and RNA binding. An important paralog of this gene is SYNCRIP.

UniProtKB/Swiss-Prot: A1CF_HUMAN, Q9NQ94
Function: Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the
postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is
probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target
cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay

Gene Wiki entry for A1CF (ACF) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the A1CF gene promoter:
         Arnt   RORalpha2   RORalpha1   POU2F1   POU2F1b   POU2F1a   STAT3   FOXO1a   POU2F1c   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidA1CF promoter sequence
   Search Chromatin IP Primers for A1CF

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat A1CF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q11.23   Ensembl cytogenetic band:  10q11.23   HGNC cytogenetic band: 10q21.1

A1CF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
A1CF gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M052566:  view genomic region     (about GC identifiers)

Start:
52,559,169 bp from pter      End:
52,645,435 bp from pter
Size:
86,267 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: A1CF_HUMAN, Q9NQ94 (See protein sequence)
Recommended Name: APOBEC1 complementation factor  
Size: 594 amino acids; 65202 Da
Subunit: Part of the apolipoprotein B mRNA editing complex with APOBEC1. Interacts with TNPO2; TNPO2 may be
responsible for transport of A1CF into the nucleus. Interacts with SYNCRIP. Interacts with CELF2/CUGBP2 (By
similarity)
Sequence caution: Sequence=BAA91086.1; Type=Frameshift; Positions=148;
1 PDB 3D structure from and Proteopedia for A1CF:
2CPD (3D)    
Secondary accessions: A1L4F2 A8K7G7 B7ZM14 Q5SZQ0 Q9NQ93 Q9NQX8 Q9NQX9 Q9NXC9 Q9NZD3
Alternative splicing: 6 isoforms:  Q9NQ94-1   Q9NQ94-2   Q9NQ94-3   Q9NQ94-4   Q9NQ94-5   Q9NQ94-6   (Minor isoform found in 2-3% of cDNA clones)

Explore the universe of human proteins at neXtProt for A1CF: NX_Q9NQ94

Explore proteomics data for A1CF at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See A1CF Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001185747.1  NP_001185748.1  NP_001185749.1  NP_055391.2  NP_620310.1  NP_620311.1  

    ENSEMBL proteins: 
     ENSP00000363113   ENSP00000363105   ENSP00000363109   ENSP00000363107   ENSP00000397953  
     ENSP00000282641   ENSP00000378873   ENSP00000378868  
    Reactome Protein details: Q9NQ94

    A1CF Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for A1CF
    OriGene Protein Over-expression Lysate for A1CF
    OriGene MassSpec for A1CF
    OriGene Custom Protein Services for A1CF
    GenScript Custom Purified and Recombinant Proteins Services for A1CF
    Novus Biologicals A1CF Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for A1CF 

    A1CF Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for A1CF
    Novus Biologicals A1CF Antibodies
    Abcam antibodies for A1CF
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for A1CF
    LSBio Antibodies in human, mouse, rat for A1CF

    A1CF Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for A1CF
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for A1CF
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for A1CF 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    4 InterPro protein domains:
     IPR006535 HnRNP_R/Q_splicing_fac
     IPR000504 RRM_dom
     IPR014720 dsRNA-bd_dom
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry Q9NQ94

    ProtoNet protein and cluster: Q9NQ94

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: A1CF_HUMAN, Q9NQ94
    Domain: The RRM domains are necessary but not sufficient for binding to APOB mRNA. Additional residues in the
    pre-RRM and C-terminal regions are required for RNA-binding and for complementing APOBEC1 activity
    Similarity: Contains 3 RRM (RNA recognition motif) domains


    Find genes that share domains with A1CF           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: A1CF_HUMAN, Q9NQ94
    Function: Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the
    postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is
    probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target
    cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding TAS10669759
    GO:0003725NOT double-stranded RNA binding IDA11871661
    GO:0003727single-stranded RNA binding IDA11871661
         
    Find genes that share ontologies with A1CF           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for A1cf):
     cellular  mortality/aging 

    Find genes that share phenotypes with A1CF           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for A1CF
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for A1CF

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for A1CF
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for A1CF

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat A1CF using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate A1CF (see all 90):
    hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-15a hsa-miR-30d hsa-miR-519a hsa-miR-502-3p hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidA1CF 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for A1CF
    Predesigned siRNA for gene silencing in human, mouse, rat A1CF

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for A1CF

    Clone
    Products:
         
    OriGene clones in human, mouse for A1CF (see all 16)
    OriGene ORF clones in mouse, rat for A1CF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): A1CF (NM_138932)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for A1CF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat A1CF

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for A1CF
    Browse ESI BIO Cell Lines and PureStem Progenitors for A1CF 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for A1CF


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    A1CF_HUMAN, Q9NQ94: Nucleus. Endoplasmic reticulum (By similarity). Cytoplasm. Note=Predominantly nuclear where
    it localizes to heterochromatin. Also cytoplasmic where it is found at the outer surface of the endoplasmic
    reticulum (By similarity). Shuttles between the nucleus and cytoplasm. May be transported into the nucleus by the
    nuclear import protein TNPO2/TRN2 or by APOBEC1
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    endoplasmic reticulum2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA12881431
    GO:0005783endoplasmic reticulum IEA--

    Find genes that share ontologies with A1CF           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for A1CF About    
    See pathways by source

    SuperPathContained pathways About
    1Formation of editosomes by ADAR proteins
    mRNA Editing0.50
    mRNA Editing- C to U Conversion0.00
    Formation of the Editosome0.50
    2Gene Expression
    Gene Expression0.40


    Find genes that share SuperPaths with A1CF           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for A1CF
        Formation of the Editosome
    mRNA Editing: C to U Conversion


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for A1CF
    Interactions:

        Search GeneGlobe Interaction Network for A1CF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    Selected Interacting proteins for A1CF (Q9NQ943 ENSP000002826414) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APOBEC1P412383, ENSP000002293044I2D: score=2 STRING: ENSP00000229304
    CELF2O953193, ENSP000003899514I2D: score=2 STRING: ENSP00000389951
    SYNCRIPO605063, ENSP000003586354I2D: score=2 STRING: ENSP00000358635
    KHSRPQ929453, ENSP000003812164I2D: score=2 STRING: ENSP00000381216
    TNPO2O147873, ENSP000003973794I2D: score=2 STRING: ENSP00000397379
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006397mRNA processing IEA--
    GO:0010467gene expression TAS--
    GO:0016554cytidine to uridine editing TAS--
    GO:0016556mRNA modification TAS--
    GO:0050821protein stabilization IDA12881431

    Find genes that share ontologies with A1CF           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for A1CF

    1 HMDB Compound for A1CF    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cytosine4-Amino-2(1H)-pyrimidinone (see all 6)71-30-7--

    4 Novoseek inferred chemical compound relationships for A1CF gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cytidine 82.4 6 12881431 (1), 16055734 (1), 10669759 (1), 15451168 (1) (see all 6)
    uridine 62.9 1 11870221 (1)
    ethanol 25.2 2 16820530 (2)
    serine 13.8 1 16820530 (1)



    Find genes that share compounds with A1CF           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for A1CF gene (6 alternative transcripts): 
    NM_001198818.1  NM_001198819.1  NM_001198820.1  NM_014576.3  NM_138932.2  NM_138933.2  

    Unigene Cluster for A1CF:

    APOBEC1 complementation factor
    Hs.282795  [show with all ESTs]
    Unigene Representative Sequence: NM_001198819
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374001 ENST00000373993 ENST00000373997(uc009xov.3 uc001jji.3)
    ENST00000373995(uc010qhn.2 uc001jjh.3) ENST00000493415 ENST00000473480
    ENST00000414883(uc001jjk.1) ENST00000282641(uc001jjj.3) ENST00000395495
    ENST00000395489(uc010qho.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat A1CF using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate A1CF (see all 90):
    hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-15a hsa-miR-30d hsa-miR-519a hsa-miR-502-3p hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidA1CF 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for A1CF
    Predesigned siRNA for gene silencing in human, mouse, rat A1CF
    Clone
    Products:
         
    OriGene clones in human, mouse for A1CF (see all 16)
    OriGene ORF clones in mouse, rat for A1CF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): A1CF (NM_138932)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for A1CF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat A1CF
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for A1CF
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat A1CF
      QuantiTect SYBR Green Assays in human, mouse, rat A1CF
      QuantiFast Probe-based Assays in human, mouse, rat A1CF

    Additional mRNA sequence: 

    AF209192.1 AF271789.1 AF271790.1 AJ272078.1 AJ272079.1 AK000324.1 AK130022.1 AK291982.1 
    AK303801.1 BC022263.1 BC054873.1 BC130519.1 BC144194.1 BC144196.1 CR749831.1 

    11 DOTS entries:

    DT.101966638  DT.92425892  DT.95374373  DT.100022638  DT.86841758  DT.100765861  DT.99940798  DT.95374372 
    DT.95374374  DT.95325400  DT.92425886 

    Selected AceView cDNA sequences (see all 110):

    CK825749 CK825748 BF431668 BC054873 T39997 NM_014576 CA942681 CA942922 
    NM_138932 BG617808 T78557 AI913746 AF271789 NM_138933 AJ272079 AJ272078 
    BM479119 T78476 BG565161 N77737 AV660671 BV199907 AW610448 BG618487 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for A1CF    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14
    SP1:        -                                   -           -                       -                     
    SP2:                          -                 -           -                       -                     
    SP3:                          -                 -           -                                             
    SP4:                                                                                                      
    SP5:        -                 -                                                                           


    ECgene alternative splicing isoforms for A1CF

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    A1CF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    A1CF Expression
    About this image


    A1CF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     NULL (Uncategorized)
             Endoderm progenitor-like cells
    A1CF Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    A1CF Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.282795

    UniProtKB/Swiss-Prot: A1CF_HUMAN, Q9NQ94
    Tissue specificity: Widely expressed with highest levels in brain, liver, pancreas, colon and spleen

        Custom PCR Arrays for A1CF
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for A1CF
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat A1CF
    QuantiTect SYBR Green Assays in human, mouse, rat A1CF
    QuantiFast Probe-based Assays in human, mouse, rat A1CF
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for A1CF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for A1CF gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia A1cf1 , 5 APOBEC1 complementation factor1, 5 88.4(n)1
    93.69(a)1
      19 (26.58 cM)5
    698651  NM_001081074.11  NP_001074543.11 
     318687615 
    chicken
    (Gallus gallus)
    Aves A1CF1 APOBEC1 complementation factor 79.37(n)
    88.79(a)
      423680  XM_421561.4  XP_421561.3 
    lizard
    (Anolis carolinensis)
    Reptilia A1CF6
    APOBEC1 complementation factor
    82(a)
    1 ↔ 1
    GL343246.1(1350881-1396063)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia a1cf1 APOBEC1 complementation factor 76.82(n)
    84.08(a)
      100493284  XM_002935424.2  XP_002935470.2 
    zebrafish
    (Danio rerio)
    Actinopterygii a1cf1 apobec1 complementation factor 74.2(n)
    82.07(a)
      562916  XM_680086.5  XP_685178.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG178386
    --
    26(a)
    1 → many
    3R(16582451-16631963)
    worm
    (Caenorhabditis elegans)
    Secernentea hrp-26
    Protein HRP-2, isoform a (hrp-2) mRNA, complete cd...
    27(a)
    1 → many
    I(12060276-12064897) WBGene00002000


    ENSEMBL Gene Tree for A1CF (if available)
    TreeFam Gene Tree for A1CF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for A1CF gene
    SYNCRIP2  RBM472  DND12  RBM462  HNRNPR2  
    13 SIMAP similar genes for A1CF using alignment to 4 protein entries:     A1CF_HUMAN (see all proteins):
    RBM47    RBM46    HNRPR    DKFZp686A13234    SYNCRIP    HNRNPR
    DKFZp686C17209    DKFZp781C0423    DKFZp781I1140    DND1    RBM39    RBMY1A1
    CELF1

    Find genes that share paralogs with A1CF           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for A1CF (see all 1641)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1433158651,2
    C,Funtested152973088(+) TATAGG/AATTTT 12 /I syn12Minor allele frequency- A:0.00NA EU 5857
    rs1455739521,2
    C--46559818(+) TTTTT-/TCAGAC 6 -- int10--------
    rs560604921,2
    C--52564075(+) AATGAT/-TTTTT 6 -- ut311Minor allele frequency- -:0.00NA 2
    rs109946251,2
    --52586240(+) TTCAAC/TATTCT 6 -- int10--------
    rs122607771,2
    C,F--52587692(+) taagcG/Acaata 6 -- int11Minor allele frequency- A:0.50CSA 2
    rs1138630791,2
    F--52591142(+) TCCCAG/AATATA 6 -- int11Minor allele frequency- A:0.50CSA 2
    rs1135885181,2
    C,F--52591211(+) AGGCCG/AGGCGT 6 -- int11Minor allele frequency- A:0.50WA 2
    rs1124177711,2
    C,F--52591348(+) CCAGGC/TGTGGT 6 -- int11Minor allele frequency- T:0.50CSA 2
    rs733267761,2
    C,F--52599612(+) CAAGCG/AATTCT 6 -- int12Minor allele frequency- A:0.33WA CSA 3
    rs2021614911,2
    C--52600036(+) TTTTT-/TATCAT 6 -- int10--------

    HapMap Linkage Disequilibrium report for A1CF (52559169 - 52645435 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for A1CF:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2658700CNV Deletion23128226

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing A1CF
    DNA2.0 Custom Variant and Variant Library Synthesis for A1CF

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    2 diseases for A1CF:    
    About MalaCards
    anisometropia    amblyopia

    2 diseases from the University of Copenhagen DISEASES database for A1CF:
    Amblyopia     Anisometropia

    Find genes that share disorders with A1CF           About GenesLikeMe

    Genetic Association Database (GAD): A1CF

    Export disorders for A1CF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for A1CF gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with A1CF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel nuclear localization signal in the auxiliary domain of apobec-1 complementation factor regulates nucleocytoplasmic import and shuttling. (PubMed id 12896982)1, 2, 9 Blanc V.... Davidson N.O. (J. Biol. Chem. 2003)
    2. Molecular cloning of APOBEC-1 complementation factor, a novel RNA- binding protein involved in the editing of apolipoprotein B mRNA. (PubMed id 10669759)1, 2, 9 Mehta A.... Driscoll D.M. (Mol. Cell. Biol. 2000)
    3. Two proteins essential for apolipoprotein B mRNA editing are expressed from a single gene through alternative splicing. (PubMed id 11815617)1, 3, 9 Dance G.S....Smith H.C. (J. Biol. Chem. 2002)
    4. Isolation, characterization and developmental regulation of the human apobec-1 complementation factor (ACF) gene. (PubMed id 11718896)1, 2, 9 Henderson J.O.... Davidson N.O. (Biochim. Biophys. Acta 2001)
    5. Identification of domains in apobec-1 complementation factor required for RNA binding and apolipoprotein-B mRNA editing. (PubMed id 11871661)1, 2, 9 Mehta A. and Driscoll D.M. (RNA 2002)
    6. The apolipoprotein B mRNA editing complex performs a multifunctional cycle and suppresses nonsense-mediated decay. (PubMed id 12881431)1, 2, 9 Chester A.... Navaratnam N. (EMBO J. 2003)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    9. Identification of GRY-RBP as an apolipoprotein B RNA-binding protein that interacts with both apobec-1 and apobec-1 complementation factor to modulate C to U editing. (PubMed id 11134005)1, 2 Blanc V.... Davidson N.O. (J. Biol. Chem. 2001)
    10. Purification and molecular cloning of a novel essential component of the apolipoprotein B mRNA editing enzyme-complex. (PubMed id 10781591)1, 2 Lellek H.... Greeve J. (J. Biol. Chem. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 29974 HGNC: 24086 AceView: ACF Ensembl:ENSG00000148584 euGenes: HUgn29974
    ECgene: A1CF H-InvDB: A1CF

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for A1CF Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for A1CF gene:
    Search GeneIP for patents involving A1CF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for A1CF  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for A1CF  
     OriGene MassSpec something-or-other for A1CF   OriGene clones in human, mouse for A1CF  
     OriGene qSTAR qPCR primer pairs in human, mouse for A1CF   OriGene Purified Protein for A1CF  
     OriGene ORF clones in mouse, rat for A1CF   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for A1CF   OriGene Custom Protein Services for A1CF  

     
     
     Block miRNA regulation of human, mouse, rat A1CF using miScript Target Protectors SeqTarget long-range PCR primers for resequencing A1CF
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat A1CF Predesigned siRNA for gene silencing in human, mouse, rat A1CF
     QuantiFast Probe-based Assays in human, mouse, rat A1CF QuantiTect SYBR Green Assays in human, mouse, rat A1CF
     Custom PCR Arrays for A1CF Search Chromatin IP Primers for A1CF
     Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat A1CF Search GeneGlobe Interaction Network for A1CF
     Regulatory tfbs in A1CF promoter
     GenScript Custom Purified and Recombinant Proteins Services for A1CF GenScript cDNA clones with any tag delivered in your preferred vector for A1CF
     GenScript Custom Assay Services for A1CF GenScript Custom overexpressing Cell Line Services for A1CF
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for A1CF
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     A1CF antibodies
     A1CF lysates
     Antibodies for A1CF
     See all of Abcam's Antibodies, Kits and Proteins for A1CF
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for A1CF
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for A1CF
     SwitchGear 3'UTR luciferase reporter plasmids for A1CF
     SwitchGear Promoter luciferase reporter plasmids for A1CF
     ThermoFisher Antibody for A1CF
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat A1CF
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for A1CF
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for A1CF
     LSBio Antibodies in human, mouse, rat for A1CF
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for A1CF
      Search eBioscience for proteins for A1CF
      Search eBioscience for elisas for A1CF
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      A1CF gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4