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A1CF Gene

protein-coding   GIFtS: 49

GC10M052237
APOBEC1 complementation factor
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    

Aliases &
Descriptions
for A1CF

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
ACF 1, 2, 3
ACF64 1, 2
ACF65 1, 2
APOBEC1CF 1, 2
ASP 1, 2, 3
MGC163391 2
OTTHUMP00000019611 2
OTTHUMP00000019612 2
OTTHUMP00000019614 2
OTTHUMP00000019615 2
OTTHUMP00000061209 2
RP11-564C4.2 2
Descriptions
APOBEC-1 stimulating protein 2
APOBEC1 complementation factor 2
APOBEC1-stimulating protein 3
apo-B RNA editing protein 2
apobec-1 complementation factor 2
apobec-1 complementation factor (ACF) (ASP) 2
External Ids
HGNC: 240861
Entrez Gene: 299742
UniProtKB: Q9NQ943
Ensembl: ENSG000001485847
Search outside databases for aliases for A1CF gene

Summaries
for A1CF

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for A1CF:
Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a
multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a
complementation factor encoded by this gene. The gene product has three non-identical RNA
recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed
that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to
deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other
RNA editing or RNA processing events. Alternative splicing occurs at this locus and three
full-length transcript variants, encoding three distinct isoforms, have been described. Additional
splicing has been observed but the full-length nature of these variants has not been determined.
[provided by RefSeq]

UniProtKB/Swiss-Prot: A1CF_HUMAN, Q9NQ94
Function: Essential component of the apolipoprotein B mRNA editing enzyme complex which is
responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in
APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit,
APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the
edited APOB mRNA from nonsense-mediated decay

Gene Wiki entry for A1CF (ACF)

Genomic Location
for A1CF

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q11.23   Ensembl cytogenetic band:  10q11.23   HGNC cytogenetic band: 10q21.1

A1CF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M052237:     (about GC identifiers)

Start:
 52,236,328 bp from pter
End:
 52,315,441 bp from pter
Size:
 79,114 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000010.9  NT_008583.16  

Proteins
for A1CF

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: A1CF_HUMAN, Q9NQ94 (See protein sequence)
Recommended Name: APOBEC1 complementation factor  
Size: 594 amino acids; 65202 Da
Subunit: Part of the apolipoprotein B mRNA editing complex with APOBEC1. Found in a complex with
APOBEC1 and CUGBP2. Interacts with KHSRP/KRSP which is not required for APOBEC1 activity but which
may confer stability on the editing complex. Also interacts with the nuclear import protein
TNPO2/TRN2 which may be responsible for its transport into the nucleus
Subcellular location: Nucleus. Endoplasmic reticulum (By similarity). Cytoplasm. Note=Predominantly
nuclear where it localizes to heterochromatin. Also cytoplasmic where it is found at the outer
surface of the endoplasmic reticulum (By similarity). Shuttles between the nucleus and cytoplasm.
May be transported into the nucleus by the nuclear import protein TNPO2/TRN2 or by APOBEC1
Sequence caution: Sequence=BAA91086.1; Type=Frameshift; Positions=148;
PDB structures from and Proteopedia :
2CPD (3D)    
Secondary accessions: Q5SZQ0 Q9NQ93 Q9NQX8 Q9NQX9 Q9NXC9 Q9NZD3
Alternative splicing: 6 isoforms:  Q9NQ94-1   Q9NQ94-2   Q9NQ94-3   Q9NQ94-4   Q9NQ94-5   Q9NQ94-6   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (3 alternative transcripts): 
    NP_055391.2  NP_620310.1  NP_620311.1  


    ENSEMBL proteins: 
    ENSP00000378867 ENSP00000378873 ENSP00000363107 ENSP00000378868 ENSP00000363105 ENSP00000363113 
    ENSP00000282641 ENSP00000363109 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (A1CF)
    Human Recombinant Proteins from Abnova (ACF)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    4 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    GO:0005737 cytoplasm IDA12881431
    GO:0005783 endoplasmic reticulum IEA--
    GO:0030895 apolipoprotein B mRNA editing enzyme complex IDA10781591
    About this table

    Antibodies for A1CF: 
    Invitrogen Antibodies for A1CF
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for A1CF
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (A1CF), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (ACF)
    Novus Biologicals Antibody for A1CF

    Assays for A1CF: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for A1CF

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro domains/families:
     IPR006535 HnRNP_R_Q
     IPR000504 RRM_RNP1
     IPR012677 a_b_plait_nuc_bd


       GeneDecks  A1CF for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q9NQ94

    ProtoNet protein and cluster: Q9NQ94

    1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: A1CF_HUMAN, Q9NQ94
    Domain: The RRM domains are necessary but not sufficient for binding to APOB mRNA. Additional
    residues in the pre-RRM and C-terminal regions are required for RNA-binding and for complementing
    APOBEC1 activity
    Similarity: Contains 3 RRM (RNA recognition motif) domains

    Gene Function
    for A1CF

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (A1CF)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ACF)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_014576

                  Applied Biosystems Silencer® siRNAs for A1CF

                  Sigma-Aldrich siRNA for A1CF  
                         Sigma-Aldrich shRNA for A1CF  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_014576
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_014576
                                     untagged cDNA clones in CMV expression vector (see all 3): NM_014576 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_138932

    UniProtKB/Swiss-Prot: A1CF_HUMAN, Q9NQ94
    Function: Essential component of the apolipoprotein B mRNA editing enzyme complex which is
    responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in
    APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit,
    APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the
    edited APOB mRNA from nonsense-mediated decay

    2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for A1cf):

    cellularlethality-prenatal/perinatal

    4 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0003725NOT double-stranded RNA binding IDA11871661
    GO:0003727 single-stranded RNA binding IDA11871661
    GO:0005515 protein binding IPI10669759 12896982
    About this table

    Pathways & Interactions
    for A1CF

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Sigma-Aldrich "Your Favorite Gene" Pathway for  A1CF  (Your Favorite Gene powered by Ingenuity) 
     Pyrimidine Metabolism

       GeneDecks  A1CF for the pathways selected above  
    About GeneDecksing


    5/24 Interacting proteins for A1CF (ENSP000003631053) via UniProtKB, MINT, and/or STRING (see all 24 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APOBEC1ENSP000002293043STRING (score=.998)
    CDAENSP000003642123STRING (score=.936)
    APOBEC3GENSP000002632473STRING (score=.924)
    APOBEC2ENSP000002446693STRING (score=.883)
    SYNCRIPENSP000003586353STRING (score=.882)
    About this table

    2 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006397 mRNA processing IEA--
    GO:0050821 protein stabilization IDA12881431
    About this table

    Drugs & Compounds
    for A1CF

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for A1CF
    3 Novoseek chemical compound relationships for A1CF gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    cytidine 82.93 6 12881431 (1), 16055734 (1), 10669759 (1), 15451168 (1) (see all 6)
    uridine 63.37 1 11870221 (1)
    ethanol 26.26 2 16820530 (2)
    About this table


    Transcripts
    for A1CF

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (A1CF)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ACF)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_014576

                  Sigma-Aldrich siRNA for A1CF  
                         Sigma-Aldrich shRNA for A1CF  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_014576  NM_138932  NM_138933  

    REFSEQ mRNAs for A1CF gene (3 alternative transcripts): 

    NM_014576.2   NM_138932.1   NM_138933.1   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_014576  NM_138932  NM_138933  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_014576
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_014576
                                     untagged cDNA clones in CMV expression vector (see all 3): NM_014576 

    Additional cDNA sequence: 

    AF209192.1 AF271789.1 AF271790.1 AJ272078.1 AJ272079.1 AK000324.1 AK291982.1 AK303801.1 
    BC022263.1 BC054873.1 BC130519.1 BC144194.1 BC144196.1 

    9 DOTS entries:

    DT.92425892  DT.95374373  DT.100022638  DT.86841758  DT.100765861  DT.95374374  DT.99940798  DT.92425886 
    DT.95374372 

    24/110 AceView cDNA sequences (see all 110 ):

    BM479119 AJ272078 AJ272079 CA942681 CA942922 T39997 NM_014576 BC054873 
    BG617808 T78557 AF271789 NM_138933 AI913746 CK825749 BF431668 CK825748 
    NM_138932 AW450191 AV684607 BQ269447 BV199907 AI672811 BU580671 AI760643 

    Unigene Cluster for A1CF:

    APOBEC1 complementation factor
    Hs.499643  [show with all ESTs]
    Unigene Representative Sequence: AK303801


    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for A1CF

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14
    SP1:        -                                   -           -                       -                     
    SP2:                          -                 -           -                       -                     
    SP3:                          -                 -           -                                             
    SP4:                                                                                                      
    SP5:        -                 -                                                                           

    About this scheme

    ECgene alternative splicing isoforms for A1CF

    8 Ensembl transcripts including schematic representations:
    ENST00000395488  ENST00000395495  ENST00000373995  ENST00000395489  ENST00000373993  ENST00000374001  
    ENST00000282641  ENST00000373997  

    Expression
    for A1CF

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    A1CF expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for A1CF

    1 / 2

    3 probe-sets matching A1CF gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    47095_at2 U95-B 3 1.00 0.96 1.00 1.00 -- -- -- -- --

    		220951_s_at2 U133-A 1 1.00 1.00 -- -- -- -- -- -- --

    		220951_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  A1CF for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.499643

    UniProtKB/Swiss-Prot: A1CF_HUMAN, Q9NQ94
    Tissue specificity: Widely expressed with highest levels in brain, liver, pancreas, colon and
    spleen

    Orthologs
    for A1CF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for A1CF gene from 5/7 species (see all 7 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 A1CF1   -- APOBEC1 complementation factor 89.89(n)
    96.27(a)    		 477581  XM_534776.2  XP_534776.2 
    chimpanzee
    (Pan troglodytes)    		 A1CF1   -- APOBEC1 complementation factor 99.6(n)
    99.66(a)    		 466076  XM_001162517.1  XP_001162517.1 
    cow
    (Bos taurus)    		 A1CF1   -- APOBEC1 complementation factor 92.39(n)
    97.34(a)    		 613704  XM_864746.2  XP_869839.2 
    rat
    (Rattus norvegicus)    		 A1cf1   -- APOBEC1 complementation factor 88.66(n)
    94.19(a)    		 170912  NM_133400.1  NP_596891.1 
    mouse
    (Mus musculus)    		 A1cf1, 5 195
    		 APOBEC1 complementation factor1, 5 88.5(n)1
    93.77(a)1    		 698651  NM_001081074.11  NP_001074543.11 
     AK0079705  AY5668625  (see all 9)
    About this table        Species with no ortholog for A1CF

    ENSEMBL Gene Tree for A1CF

    Paralogs
    for A1CF

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for A1CF gene
    RBM472  RBM462  

    SNPs/Variants
    for A1CF

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/302 NCBI SNPs in A1CF are shown (see all 302 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 186)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 10 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs108218461,2
    		A,C,F,H52236063(+) TTGTGA/GCTTTG 3 -- ng5111Minor allele frequency- G:0.35NA EU EA WA 974
    rs38089191,2
    		A,C,F,H52316350(-) TCTCTC/TAATAG 3 -- ng31 tfbs312Minor allele frequency- T:0.44EA NA EU WA 1056
    rs109948601,2
    		C,F,H52315430(+) CTAATC/TGTCAT 3 -- ut51 ese39Minor allele frequency- T:0.18NA EU EA WA 740
    rs108219051,2
    		C,F,H52316099(+) ATAGAG/AAAATG 3 -- ng317Minor allele frequency- A:0.18NA EU EA WA 560
    rs40781601,2
    		C,F,H52235946(-) TGTGGG/TTTCAA 3 -- ng519Minor allele frequency- T:0.23EU EA WA NA 742
    rs90731,2
    		C,F52236617(+) AGACAC/TGGGTG 3 V/M mis1 ese36Minor allele frequency- T:0.02MN NA EU EA WA 670
    rs46190971,2
    		F,H52236055(+) TTTCCT/CCTTTG 3 -- ng514Minor allele frequency- C:0.03EU EA WA 408
    rs122505831,2
    		F,H52316004(+) AGAAGC/GACAAT 3 -- ng314Minor allele frequency- G:0.01EU EA WA 418
    --
    rs70776331,2
    		A,C52317253(+) gagttC/Tgcagt 3 -- ng310--------
    rs38089181,2
    		F,H52316369(-) TTTCTA/GTAGAC 3 -- ng314Minor allele frequency- G:0.02EU EA WA 418
    About this table

    HapMap Linkage Disequilibrium images for A1CF (up to first 250kb)

    Disorders & Mutations
    for A1CF

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		   --

    Medical News
    for A1CF

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for A1CF

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/27 PubMed articles for A1CF gene (see all 27 ):

    Search for A1CF

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing A1CF

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 29974 HGNC: 24086 AceView: ACF Ensembl:ENSG00000148584 euGenes: HUgn29974
    ECgene: A1CF H-InvDB: A1CF

    Other Databases showing A1CF

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing A1CF

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    		   --

    Licensable Technologies
    for A1CF

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for A1CF

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for A1CF:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for A1CF-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for A1CF Antibodies for A1CF
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for A1CF Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
     Antibodies   Primer Pairs  
     Cell Culture Products   ELISAs  
     Flow Cytometry Kits   Protease Activity Assays & Reagents  
     Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
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     Recombinant & Natural Proteins  

     Recombinant Proteins (ACF)
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