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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

A1CF Gene

protein-coding GIFtS: 52
GCID: GC10M052566

APOBEC1 complementation factor

Explore 6 diseases affiliated with
A1CF via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
APOBEC1 Complementation Factor¹ ²		APOBEC1CF¹ ²
ACF¹ ² ³		Apo-B RNA Editing Protein²
ASP¹ ² ³		Apobec-1 Complementation Factor (ACF) (ASP)²
ACF64¹ ²		APOBEC-1 Stimulating Protein²
ACF65¹ ²		APOBEC1-Stimulating Protein³

External Ids:	HGNC: 24086¹	Entrez Gene: 29974²	Ensembl: ENSG00000148584⁷	UniProtKB: Q9NQ94³

Export aliases for A1CF gene to outside databases

Previous GC identifers: GC10M052237 GC10M046544

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for A1CF:

Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component

enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The

gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins.

It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to

deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA

processing events. Several transcript variants encoding a few different isoforms have been found for this gene.

(provided by RefSeq, Nov 2010)

UniProtKB/Swiss-Prot: A1CF_HUMAN, Q9NQ94

Function: Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the

postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is

probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target

cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay

Gene Wiki entry for A1CF (ACF)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_030059.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the A1CF gene promoter:
Arnt RORalpha2 RORalpha1 POU2F1 POU2F1b POU2F1a STAT3 FOXO1a POU2F1c FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: A1CF promoter sequence

Search SABiosciences Chromatin IP Primers for A1CF

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat A1CF

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q11.23 Ensembl cytogenetic band: 10q11.23 HGNC cytogenetic band: 10q21.1

A1CF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
A1CF gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M052566: view genomic region (about GC identifiers)

Start:	52,566,322 bp from pter	End:	52,645,435 bp from pter
Size:	79,114 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: A1CF_HUMAN, Q9NQ94 (See protein sequence)

Recommended Name: APOBEC1 complementation factor

Size: 594 amino acids; 65202 Da

Subunit: Part of the apolipoprotein B mRNA editing complex with APOBEC1. Interacts with TNPO2; TNPO2 may be responsible

for transport of A1CF into the nucleus. Interacts with SYNCRIP. Interacts with CELF2/CUGBP2 (By similarity)

Subcellular location: Nucleus. Endoplasmic reticulum (By similarity). Cytoplasm. Note=Predominantly nuclear where it

localizes to heterochromatin. Also cytoplasmic where it is found at the outer surface of the endoplasmic reticulum (By

similarity). Shuttles between the nucleus and cytoplasm. May be transported into the nucleus by the nuclear import

protein TNPO2/TRN2 or by APOBEC1

Sequence caution: Sequence=BAA91086.1; Type=Frameshift; Positions=148;

1 PDB 3D structure from and Proteopedia for A1CF:

2CPD (3D)

Secondary accessions: A1L4F2 A8K7G7 B7ZM14 Q5SZQ0 Q9NQ93 Q9NQX8 Q9NQX9 Q9NXC9 Q9NZD3

Alternative splicing: 6 isoforms: Q9NQ94-1 Q9NQ94-2 Q9NQ94-3 Q9NQ94-4 Q9NQ94-5 Q9NQ94-6 (Minor isoform found in 2-3% of cDNA clones)

Explore the universe of human proteins at neXtProt for A1CF: NX_Q9NQ94

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9NQ94

A1CF Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (6 alternative transcripts):

NP_001185747.1 NP_001185748.1 NP_001185749.1 NP_055391.2 NP_620310.1 NP_620311.1

ENSEMBL proteins:

ENSP00000363113 ENSP00000363105 ENSP00000363109 ENSP00000363107 ENSP00000397953

ENSP00000282641 ENSP00000378873 ENSP00000378868

Reactome Protein details: Q9NQ94
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	Uscn Proteins for A1CF

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005654	nucleoplasm	TAS	--
GO:0005720	nuclear heterochromatin	--	--
GO:0005737	cytoplasm	IDA	--
GO:0005783	endoplasmic reticulum	IEA	--

A1CF for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

A1CF for domains About GeneDecksing

4 InterPro domains/families:

IPR006535 HnRNP_R/Q_splicing_fac

IPR000504 RRM_dom

IPR014720 dsRNA-bd-like_dom

IPR012677 Nucleotide-bd_a/b_plait

Graphical View of Domain Structure for InterPro Entry Q9NQ94

ProtoNet protein and cluster: Q9NQ94

1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

UniProtKB/Swiss-Prot: A1CF_HUMAN, Q9NQ94

Domain: The RRM domains are necessary but not sufficient for binding to APOB mRNA. Additional residues in the pre-RRM

and C-terminal regions are required for RNA-binding and for complementing APOBEC1 activity

Similarity: Contains 3 RRM (RNA recognition motif) domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: A1CF_HUMAN, Q9NQ94

Function: Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the

postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is

probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target

cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for A1CF

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003723	RNA binding	TAS	10669759
GO:0003725	NOT double-stranded RNA binding	IDA	11871661
GO:0003727	single-stranded RNA binding	IDA	11871661
GO:0003729	mRNA binding	--	--

A1CF for ontologies About GeneDecksing

Animal Models:
2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for A1cf):

cellular

mortality/aging

A1CF for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Formation of editosomes by ADAR proteins

	mRNA Editing	0.50			Formation of the Editosome	0.00
	mRNA Editing: C to U Conversion	0.00

mRNA Splicing - Major Pathway

mRNA Processing

0.82

Generic Transcription Pathway

Gene Expression

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

5 Reactome Pathways for A1CF

	Formation of the Editosome
	mRNA Editing
	Gene Expression
	mRNA Editing: C to U Conversion
	mRNA Processing

A1CF for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for A1CF

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

5/10 Interacting proteins for A1CF (Q9NQ94³ ENSP00000282641⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 10)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
APOBEC1	P41238³, ENSP00000229304⁴	I2D: score=2 STRING: ENSP00000229304
CELF2	O95319³, ENSP00000389951⁴	I2D: score=2 STRING: ENSP00000389951
SYNCRIP	O60506³, ENSP00000358635⁴	I2D: score=2 STRING: ENSP00000358635
KHSRP	Q92945³, ENSP00000381216⁴	I2D: score=2 STRING: ENSP00000381216
TNPO2	O14787³, ENSP00000397379⁴	I2D: score=2 STRING: ENSP00000397379

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006397	mRNA processing	IEA	--
GO:0010467	gene expression	TAS	--
GO:0016554	cytidine to uridine editing	TAS	--
GO:0016556	mRNA modification	TAS	--
GO:0050821	protein stabilization	IDA	12881431

A1CF for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

A1CF for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for A1CF

1 HMDB Compound for A1CF About this table

Compound	Synonyms	CAS #	PubMed Ids
Cytosine	4-Amino-2(1H)-pyrimidinone (see all 6)	71-30-7	--

4 Novoseek chemical compound relationships for A1CF gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cytidine	82.4	6	12881431 (1), 16055734 (1), 10669759 (1), 15451168 (1) (see all 6)
uridine	62.9	1	11870221 (1)
ethanol	25.2	2	16820530 (2)
serine	13.8	1	16820530 (1)

Search CenterWatch for drugs/clinical trials and news about A1CF

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for A1CF gene (6 alternative transcripts):

NM_001198818.1 NM_001198819.1 NM_001198820.1 NM_014576.3 NM_138932.2 NM_138933.2

Unigene Cluster for A1CF:

APOBEC1 complementation factor

Hs.282795 [show with all ESTs]

Unigene Representative Sequence: NM_001198819

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000374001 ENST00000373993 ENST00000373997(uc009xov.3 uc001jji.3)

ENST00000373995(uc010qhn.2 uc001jjh.3) ENST00000493415 ENST00000473480

ENST00000414883(uc001jjk.1) ENST00000282641(uc001jjj.3) ENST00000395495

ENST00000395489(uc010qho.2)

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Additional cDNA sequence:

AF209192.1 AF271789.1 AF271790.1 AJ272078.1 AJ272079.1 AK000324.1 AK130022.1 AK291982.1

AK303801.1 BC022263.1 BC054873.1 BC130519.1 BC144194.1 BC144196.1 CR749831.1

11 DOTS entries:

DT.101966638 DT.92425892 DT.95374373 DT.100022638 DT.86841758 DT.100765861 DT.99940798 DT.95374372

DT.95374374 DT.95325400 DT.92425886

24/110 AceView cDNA sequences (see all 110):

CK825749 BF431668 CK825748 T39997 BC054873 NM_014576 CA942922 NM_138932

BG617808 T78557 CA942681 AJ272078 BM479119 AJ272079 AI913746 AF271789

NM_138933 T78476 BX101891 AV684607 AV660671 N77737 AW610448 BG618487

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for A1CF About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11	^	12a	·	12b	^	13	^	14
SP1:			-												-				-								-
SP2:									-						-				-								-
SP3:									-						-				-
SP4:
SP5:			-						-

ECgene alternative splicing isoforms for A1CF

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

A1CF expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

A1CF expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Endoderm progenitor-like cells (Generation and expan...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See A1CF Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for A1CF

SOURCE GeneReport for Unigene cluster: Hs.282795

UniProtKB/Swiss-Prot: A1CF_HUMAN, Q9NQ94

Tissue specificity: Widely expressed with highest levels in brain, liver, pancreas, colon and spleen

SABiosciences Custom PCR Arrays for A1CF

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for A1CF gene from 6/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	A1CF¹	APOBEC1 complementation factor	79.31(n) 88.97(a)		423680 XM_003641458.1 XP_003641506.1
lizard (Anolis carolinensis)	Reptilia	A1CF⁶	--	80(a)	1 ↔ 1	GL343246.1(1350881-1383168)
zebrafish (Danio rerio)	Actinopterygii	a1cf¹	apobec1 complementation factor	74.31(n) 82.07(a)		562916 XM_680086.4 XP_685178.1
honey bee (Apis mellifera)	Insecta	--	--	35(a)	1 → many	Group2.12(581162-583785)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT4G00830⁶ AT3G52660⁶ (see all 4)	RNA recognition motif-containing protein (see all 4)	22(a) 21(a) (see all 4)	many ↔ many many ↔ many (see all 4)	4(352016-355233) 3(19521660-19524953)
rice (Oryza sativa)	Liliopsida	-- -- (see all 8)	RNA recognition motif containing protein, expresse... APOBEC1 complementation factor, putative, expresse... (see all 8)	25(a) 24(a) (see all 8)	many ↔ many many ↔ many (see all 8)	10(3112799-3117851) 11(8096480-8101158)

ENSEMBL Gene Tree for A1CF (if available)
TreeFam Gene Tree for A1CF (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for A1CF gene

RBM47² SYNCRIP² DND1² RBM46² HNRNPR²

13 SIMAP similar genes for A1CF using alignment to 4 protein entries: A1CF_HUMAN (see all proteins):

RBM47 RBM46 HNRPR DKFZp686A13234 SYNCRIP HNRNPR

DKFZp686C17209 DKFZp781C0423 DKFZp781I1140 DND1 RBM39 RBMY1A1

CELF1

A1CF for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs12262967^1,2	C,F,H,	--	46537314(+)	`TTTTAA/GCTCAA`	6	--	ds500¹		13		NS EA NA WA	1394
rs74968037^1,2	C,F,	--	46537346(+)	`CTGGAT/CTTGGT`	6	--	ds500¹		1		WA	118
rs112429040^1,2	C	--	46537709(+)	`TATAAA/C/TGGCAC`	12	--	ut3¹		1		CSA	1
rs61856570^1,2		--	46537807(+)	`TGCCCG/ATTATG`	6	--	ut3¹		1		NA	2
rs10994518^1,2	F,	--	46538910(+)	`TCTCTG/AAAGAA`	6	--	ut3¹		1		WA	118
rs10994521^1,2	C,F,H,	--	46539174(+)	`GAAGGA/TAAAAA`	6	--	ut3¹		6		NS EA WA	540
rs12259425^1,2	C,F,	--	46539671(+)	`TGGGGT/AGTGTG`	6	--	ut3¹		2		WA	4
rs75842905^1,2		--	46540140(+)	`AGAGTA/CCAAGG`	6	--	ut3¹		1		WA	118
rs59030524^1,2	F,	--	46540159(+)	`TAGCTT/CTCCTA`	6	--	ut3¹		1		WA	118
rs200309842^1,2	C	--	46540959(+)	`CTTAGA/TGNNNN`	6	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for A1CF (52566322 - 52645435 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for A1CF: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

A1CF for disorders About GeneDecksing

6 diseases for A1CF: About MalaCards

anisometropia hydrocele amblyopia cholera

hepatocellular carcinoma carcinoma

2 diseases from the University of Copenhagen DISEASES database for A1CF:

Amblyopia Anisometropia

Export disorders for A1CF gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for A1CF gene, integrated from 9 sources (see all 30):
(articles sorted by number of sources associating them with A1CF)

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world of online information

A novel nuclear localization signal in the auxiliary domain of apobec-1 complementation factor regulates nucleocytoplasmic import and shuttling. (PubMed id 12896982)^{1, 2, 9} Blanc V.... Davidson N.O. (2003)
Molecular cloning of APOBEC-1 complementation factor, a novel RNA- binding protein involved in the editing of apolipoprotein B mRNA. (PubMed id 10669759)^{1, 2, 9} Mehta A.... Driscoll D.M. (2000)
Two proteins essential for apolipoprotein B mRNA editing are expressed from a single gene through alternative splicing. (PubMed id 11815617)^{1, 3, 9} Dance G.S....Smith H.C. (2002)
Isolation, characterization and developmental regulation of the human apobec-1 complementation factor (ACF) gene. (PubMed id 11718896)^{1, 2, 9} Henderson J.O.... Davidson N.O. (2001)
Identification of domains in apobec-1 complementation factor required for RNA binding and apolipoprotein-B mRNA editing. (PubMed id 11871661)^{1, 2, 9} Mehta A. and Driscoll D.M. (2002)
The apolipoprotein B mRNA editing complex performs a multifunctional cycle and suppresses nonsense-mediated decay. (PubMed id 12881431)^{1, 2, 9} Chester A.... Navaratnam N. (2003)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{1, 2} Deloukas P.... Rogers J. (2004)
Identification of GRY-RBP as an apolipoprotein B RNA-binding protein that interacts with both apobec-1 and apobec-1 complementation factor to modulate C to U editing. (PubMed id 11134005)^{1, 2} Blanc V.... Davidson N.O. (2001)
Purification and molecular cloning of a novel essential component of the apolipoprotein B mRNA editing enzyme-complex. (PubMed id 10781591)^{1, 2} Lellek H.... Greeve J. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 29974	HGNC: 24086	AceView: ACF	Ensembl:ENSG00000148584	euGenes: HUgn29974
ECgene: A1CF	H-InvDB: A1CF

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for A1CF	Pharmacogenomics, SNPs, Pathways

Intellectual Property for A1CF gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for A1CF gene:
Search GeneIP for patents involving A1CF

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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