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Aliases for A1CF Gene

Aliases for A1CF Gene

  • APOBEC1 Complementation Factor 2 3
  • ASP 3 4
  • ACF 3 4
  • Apobec-1 Complementation Factor (ACF) (ASP) 3
  • APOBEC-1 Stimulating Protein 3
  • APOBEC1-Stimulating Protein 4
  • Apo-B RNA Editing Protein 3
  • APOBEC1CF 3
  • ACF64 3
  • ACF65 3

External Ids for A1CF Gene

Previous GeneCards Identifiers for A1CF Gene

  • GC10M052237
  • GC10M052566
  • GC10M046544

Summaries for A1CF Gene

Entrez Gene Summary for A1CF Gene

  • Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for A1CF Gene

A1CF (APOBEC1 Complementation Factor) is a Protein Coding gene. Among its related pathways are Gene Expression and C6 deamination of adenosine. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is RBM46.

UniProtKB/Swiss-Prot for A1CF Gene

  • Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay.

Gene Wiki entry for A1CF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for A1CF Gene

Genomics for A1CF Gene

Regulatory Elements for A1CF Gene

Genomic Location for A1CF Gene

Chromosome:
10
Start:
50,799,409 bp from pter
End:
50,885,675 bp from pter
Size:
86,267 bases
Orientation:
Minus strand

Genomic View for A1CF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for A1CF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for A1CF Gene

Proteins for A1CF Gene

  • Protein details for A1CF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQ94-A1CF_HUMAN
    Recommended name:
    APOBEC1 complementation factor
    Protein Accession:
    Q9NQ94
    Secondary Accessions:
    • A1L4F2
    • A8K7G7
    • B7ZM14
    • Q5SZQ0
    • Q9NQ93
    • Q9NQX8
    • Q9NQX9
    • Q9NXC9
    • Q9NZD3

    Protein attributes for A1CF Gene

    Size:
    594 amino acids
    Molecular mass:
    65202 Da
    Quaternary structure:
    • Part of the apolipoprotein B mRNA editing complex with APOBEC1. Interacts with TNPO2; TNPO2 may be responsible for transport of A1CF into the nucleus. Interacts with SYNCRIP. Interacts with CELF2/CUGBP2 (By similarity).
    SequenceCaution:
    • Sequence=BAA91086.1; Type=Frameshift; Positions=148; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for A1CF Gene

    Alternative splice isoforms for A1CF Gene

neXtProt entry for A1CF Gene

Proteomics data for A1CF Gene at MOPED

Post-translational modifications for A1CF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for A1CF Gene

Domains & Families for A1CF Gene

Gene Families for A1CF Gene

Suggested Antigen Peptide Sequences for A1CF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NQ94

UniProtKB/Swiss-Prot:

A1CF_HUMAN :
  • The RRM domains are necessary but not sufficient for binding to APOB mRNA. Additional residues in the pre-RRM and C-terminal regions are required for RNA-binding and for complementing APOBEC1 activity.
Domain:
  • The RRM domains are necessary but not sufficient for binding to APOB mRNA. Additional residues in the pre-RRM and C-terminal regions are required for RNA-binding and for complementing APOBEC1 activity.
  • Contains 3 RRM (RNA recognition motif) domains.
genes like me logo Genes that share domains with A1CF: view

Function for A1CF Gene

Molecular function for A1CF Gene

UniProtKB/Swiss-Prot Function:
Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay.

Gene Ontology (GO) - Molecular Function for A1CF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding TAS 10669759
GO:0003725 NOT double-stranded RNA binding IDA 11871661
GO:0003727 single-stranded RNA binding IDA 11871661
genes like me logo Genes that share ontologies with A1CF: view

Phenotypes for A1CF Gene

genes like me logo Genes that share phenotypes with A1CF: view

Animal Model Products

CRISPR Products

miRNA for A1CF Gene

miRTarBase miRNAs that target A1CF

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for A1CF

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for A1CF Gene

Localization for A1CF Gene

Subcellular locations from UniProtKB/Swiss-Prot for A1CF Gene

Nucleus. Endoplasmic reticulum. Cytoplasm. Note=Predominantly nuclear where it localizes to heterochromatin. Also cytoplasmic where it is found at the outer surface of the endoplasmic reticulum (By similarity). Shuttles between the nucleus and cytoplasm. May be transported into the nucleus by the nuclear import protein TNPO2/TRN2 or by APOBEC1. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for A1CF Gene COMPARTMENTS Subcellular localization image for A1CF gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 3

Gene Ontology (GO) - Cellular Components for A1CF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005720 nuclear heterochromatin --
GO:0005737 cytoplasm IDA 12881431
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with A1CF: view

Pathways & Interactions for A1CF Gene

genes like me logo Genes that share pathways with A1CF: view

Pathways by source for A1CF Gene

Gene Ontology (GO) - Biological Process for A1CF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
GO:0010467 gene expression TAS --
GO:0010609 mRNA localization resulting in posttranscriptional regulation of gene expression --
GO:0016554 cytidine to uridine editing TAS --
GO:0016556 mRNA modification TAS --
genes like me logo Genes that share ontologies with A1CF: view

No data available for SIGNOR curated interactions for A1CF Gene

Drugs & Compounds for A1CF Gene

(4) Drugs for A1CF Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ethanol Approved Pharma 1708
Cytidine Experimental Pharma 0
Uridine Experimental Pharma 0
serine Nutra 420

(1) Additional Compounds for A1CF Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Cytosine
  • 4-Amino-2(1H)-pyrimidinone
  • 4-Amino-2-hydroxypyrimidine
  • 4-Amino-2-oxo-1,2-dihydropyrimidine
  • 4-Aminouracil
  • Cytosine
71-30-7
genes like me logo Genes that share compounds with A1CF: view

Transcripts for A1CF Gene

Unigene Clusters for A1CF Gene

APOBEC1 complementation factor:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for A1CF

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for A1CF Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4:
SP5: - -

Relevant External Links for A1CF Gene

GeneLoc Exon Structure for
A1CF
ECgene alternative splicing isoforms for
A1CF

Expression for A1CF Gene

mRNA expression in normal human tissues for A1CF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for A1CF Gene

This gene is overexpressed in Liver (x36.4), Colon - Transverse (x4.6), and Pancreas (x4.3).

Protein differential expression in normal tissues from HIPED for A1CF Gene

This gene is overexpressed in Fetal Liver (22.7), Liver (21.7), Pancreas (12.2), and Gallbladder (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for A1CF Gene



SOURCE GeneReport for Unigene cluster for A1CF Gene Hs.282795

mRNA Expression by UniProt/SwissProt for A1CF Gene

Q9NQ94-A1CF_HUMAN
Tissue specificity: Widely expressed with highest levels in brain, liver, pancreas, colon and spleen.
genes like me logo Genes that share expression patterns with A1CF: view

Protein tissue co-expression partners for A1CF Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

Orthologs for A1CF Gene

This gene was present in the common ancestor of animals.

Orthologs for A1CF Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia A1CF 35
  • 90.96 (n)
  • 95.9 (a)
A1CF 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia A1CF 35
  • 89.29 (n)
  • 95.19 (a)
A1CF 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia A1cf 35
  • 88.4 (n)
  • 93.69 (a)
A1cf 16
A1cf 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia A1CF 35
  • 99.6 (n)
  • 99.6 (a)
A1CF 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia A1cf 35
  • 88.66 (n)
  • 94.19 (a)
oppossum
(Monodelphis domestica)
Mammalia A1CF 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia A1CF 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves A1CF 35
  • 79.37 (n)
  • 88.79 (a)
A1CF 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia A1CF 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia a1cf 35
  • 76.82 (n)
  • 84.08 (a)
zebrafish
(Danio rerio)
Actinopterygii a1cf 35
  • 74.2 (n)
  • 82.07 (a)
a1cf 36
  • 78 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG17838 36
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hrp-2 36
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
OneToOne
Species with no ortholog for A1CF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for A1CF Gene

ENSEMBL:
Gene Tree for A1CF (if available)
TreeFam:
Gene Tree for A1CF (if available)

Paralogs for A1CF Gene

Paralogs for A1CF Gene

genes like me logo Genes that share paralogs with A1CF: view

Variants for A1CF Gene

Sequence variations from dbSNP and Humsavar for A1CF Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs112071365 -- 50,809,846(+) GGTTT(C/T)CCAAA intron-variant
rs112096275 -- 50,877,848(+) CCGGG(C/T)GCCGT intron-variant
rs112215925 -- 50,864,690(+) CTCAG(C/T)TCACC intron-variant
rs112224889 -- 50,843,765(+) ACAGT(C/T)ATTAG intron-variant
rs112254992 -- 50,828,735(+) AATCT(A/G)TGTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for A1CF Gene

Variant ID Type Subtype PubMed ID
esv2658700 CNV Deletion 23128226

Variation tolerance for A1CF Gene

Residual Variation Intolerance Score: 11.53% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.77; 58.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for A1CF Gene

HapMap Linkage Disequilibrium report
A1CF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for A1CF Gene

Disorders for A1CF Gene

Relevant External Links for A1CF

Genetic Association Database (GAD)
A1CF
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
A1CF
genes like me logo Genes that share disorders with A1CF: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for A1CF Gene

Publications for A1CF Gene

  1. Two proteins essential for apolipoprotein B mRNA editing are expressed from a single gene through alternative splicing. (PMID: 11815617) Dance G.S. … Smith H.C. (J. Biol. Chem. 2002) 2 23 67
  2. ApoB mRNA editing is mediated by a coordinated modulation of multiple apoB mRNA editing enzyme components. (PMID: 16920700) Chen Z. … Patterson A.P. (Am. J. Physiol. Gastrointest. Liver Physiol. 2007) 23 67
  3. Metabolic regulation of apoB mRNA editing is associated with phosphorylation of APOBEC-1 complementation factor. (PMID: 16820530) Lehmann D.M. … Smith H.C. (Nucleic Acids Res. 2006) 23 67
  4. Targeted deletion of the murine apobec-1 complementation factor (acf) gene results in embryonic lethality. (PMID: 16055734) Blanc V. … Davidson N.O. (Mol. Cell. Biol. 2005) 23 67
  5. Isolation of an mRNA-binding protein involved in C-to-U editing. (PMID: 15103077) Gerber C.A. … Driscoll D.M. (Methods Mol. Biol. 2004) 23 67

Products for A1CF Gene

Sources for A1CF Gene

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