A1BG Gene
protein-coding GIFtS: 52
GCID: GC19M058858
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|
alpha-1-B glycoprotein
| |
Aliases
for A1BG gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Alpha-1-B Glycoprotein1 2 3 | | A1B2 | | ABG2 | | GAB2 | | HYST24772 | | Alpha-1B-Glycoprotein1 |
Export aliases for A1BG gene to outside databasesPrevious GC identifers: GC19M059755 GC19M059310 GC19M063532 GC19M063548 GC19M055168 |
Summaries
for A1BG gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for A1BG:
The protein encoded by this gene is a plasma glycoprotein of unknown function. The protein shows sequence similarity tothe variable regions of some immunoglobulin supergene family member proteins. (provided by RefSeq, Jul 2008)
|
Genomic Views
for A1BG gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the A1BG gene promoter:
TBP RFX1 Pbx1a Nkx5-1 Meis-1b RORalpha1 STAT3 Meis-1a Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for A1BG
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat A1BG |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.4 Ensembl cytogenetic band: 19q13.43 HGNC cytogenetic band: 19qA1BG Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M058858: view genomic region
(about GC identifiers)
Start:
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58,858,172 bp from pter |
End:
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58,864,865 bp from pter |
Size:
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6,694 bases |
Orientation:
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minus strand |
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Proteins
for A1BG gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: A1BG_HUMAN, P04217 (See
protein sequence)Recommended Name: Alpha-1B-glycoprotein precursor Size: 495 amino acids; 54254 Da
Subunit: Interacts with CRISP3
Subcellular location: Secreted
Secondary accessions: A8K052 Q68CK0 Q8IYJ6 Q96P39Alternative splicing: 2 isoforms: P04217-1 P04217-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for A1BG: NX_P04217
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P04217
A1BG Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_570602.2
ENSEMBL proteins: ENSP00000263100
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
A1BG for ontologies About GeneDecksing
A1BG Antibody Products:
Assay Products for A1BG: |
Protein
Domains /
Families
for A1BG gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
A1BG for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P04217ProtoNet protein and cluster: P04217 1 Blocks protein family: IPB003598 Immunoglobulin C-2 type
UniProtKB/Swiss-Prot: A1BG_HUMAN, P04217Similarity: Contains 5 Ig-like V-type (immunoglobulin-like) domains |
Function
for A1BG gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
Genatlas biochemistry entry for A1BG:glycoprotein,alpha-1-B-
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for A1BG (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for A1BG
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for A1BG | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat A1BG |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for A1BG |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
A1BG for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for A1BG:
|
Pathways & Interactions
for A1BG gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for A1BG
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5/12 Interacting proteins for A1BG (P042172, 3 ENSP000002631004) via UniProtKB, MINT, STRING, and/or I2D (see all 12)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
A1BG for ontologies About GeneDecksing
|
Drugs & Compounds
for A1BG gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for A1BG
Search CenterWatch for drugs/clinical trials and news about A1BG
|
Transcripts
for A1BG gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for A1BG gene: NM_130786.3 Unigene Cluster for A1BG: Alpha-1-B glycoprotein Hs.529161 [show with all ESTs]Unigene Representative Sequence: AK0562011 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000263100(uc002qsd.4 uc002qsf.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for A1BG (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for A1BG
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: A1BG (NM_130786) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for A1BG | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat A1BG |
Additional cDNA sequence: AB073611.1 AF414429.1 AK056201.1 AK289417.1 BC035719.1 BX537419.1 8 DOTS entries: DT.95230508 DT.207949 DT.100768640 DT.97823153 DT.121451092 DT.100878023 DT.100878029 DT.100878031 24/152 AceView cDNA sequences (see all 152): AL118990 CB130055 CB137745 BM722278 CB115657 CB148855 CB137690 CB130118 CB144217 AL118991 CB138248 BX282528 CB156790 BU740127 CB134894 BX410165 CB163893 CB130078 CB144216 BF196450 CB130068 CR604603 CB121414 BM153273
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for A1BG About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 |
|---|
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| SP1: | | | | | | | | | | | - | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for A1BG
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Expression
for A1BG gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| A1BG expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACAACCAAAA
About this image
See A1BG Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for A1BG
SOURCE GeneReport for Unigene cluster: Hs.529161
UniProtKB/Swiss-Prot: A1BG_HUMAN, P04217Tissue specificity: Plasma
SABiosciences Custom PCR Arrays for A1BG
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for A1BG
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat A1BG | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat A1BG | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat A1BG | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for A1BG |
Orthologs
for A1BG gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for A1BG gene from 2/7 species (see all 7) About this table
ENSEMBL Gene Tree for A1BG (if available)
TreeFam Gene Tree for A1BG (if available) |
Paralogs
for A1BG gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for A1BG gene
- KIR2DL42 LILRB42 LILRB12 LILRA62 IGSF12 LILRA52 KIR3DL12 OSCAR2
- NCR12 LILRA42 ENSG000002177922 TARM12 KIR3DX12 LILRA32 LILRB52 LILRA12
- KIR3DL32 KIR2DL12 LILRB22 KIR2DL22 LILRA22 KIR3DL22 KIR2DL32 FCAR2
- LILRB32 GP62
A1BG for paralogs About GeneDecksing
|
Genomic Variants
for A1BG gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for A1BG (58858172 - 58864865 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for A1BG
4 CNVs: 50238 50237 10572 5119 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing A1BG |
|
Disorders
/ Diseases
for A1BG gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
A1BG for disorders About GeneDecksing
OMIM gene information: 138670
OMIM disorders: --
9  diseases for A1BG: About MalaCardsotitis media pancreatic ductal adenocarcinoma otosclerosis respiratory failure
nephrotic syndrome cholesteatoma hepatoblastoma adenocarcinoma
pancreatitis
2 diseases from the University of Copenhagen DISEASES database for A1BG:Cholesteatoma Otosclerosis Export disorders for A1BG gene to outside databases
|
Publications
for A1BG gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for A1BG gene, integrated from 9 sources (see all 34):
(articles sorted by number of sources associating them with A1BG) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cysteine-rich secretory protein 3 is a ligand of alpha1B-glycoprotein in human plasma. (PubMed id 15461460)1, 2, 9 Udby L.... Kjeldsen L. (2004)
- Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
- Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (PubMed id 15221005)1, 2 Yamada S....Nakagawara A. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Screening for N-glycosylated proteins by liquid chromatography mass spectrometry. (PubMed id 14760718)1, 2 Bunkenborg J.... Wisniewski J.R. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Linkage between alpha 1B-glycoprotein (A1BG) and Lutheran (LU) red blood group system: assignment to chromosome 19: new genetic variants of A1BG. (PubMed id 2591067)1, 3 Eiberg H....Mohr J. (1989)
- Amino acid sequence of human plasma alpha 1B-glycoprotein: homology to the immunoglobulin supergene family. (PubMed id 3458201)1, 2 Ishioka N.... Putnam F.W. (1986)
- Human CRISP-3 binds serum alpha(1)B-glycoprotein acro ss species. (PubMed id 20116414)1, 9 Udby L....Borregaard N. (2010)
- Discovery and initial validation of I+ 1-B glycoprotei n fragmentation as a differential urinary biomarker in pediatric steroid-resist ant nephrotic syndrome. (PubMed id 21591266)1 Piyaphanee N....Bennett M.R. (2011)
|
External Searches for A1BG gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing A1BG gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing A1BG gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing A1BG gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for A1BG | Pharmacogenomics, SNPs, Pathways | | SHMPD | http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=alpha1B |
|
| | |
About This Section
| Patent Information for A1BG gene:
Search GeneIP for patents involving A1BG
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for A1BG gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat A1BG | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing A1BG | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat A1BG | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat A1BG | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat A1BG | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat A1BG |
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|  |  |  | | | | ThermoFisher Antibodies for A1BG |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat A1BG |
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