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Aliases for A1BG Gene

Aliases for A1BG Gene

  • Alpha-1-B Glycoprotein 2 3 4
  • Epididymis Secretory Sperm Binding Protein Li 163pA 3
  • Alpha-1B-Glycoprotein 3
  • HEL-S-163pA 3
  • HYST2477 3
  • GAB 3
  • A1B 3
  • ABG 3

External Ids for A1BG Gene

Summaries for A1BG Gene

Entrez Gene Summary for A1BG Gene

  • The protein encoded by this gene is a plasma glycoprotein of unknown function. The protein shows sequence similarity to the variable regions of some immunoglobulin supergene family member proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for A1BG Gene

A1BG (Alpha-1-B Glycoprotein) is a Protein Coding gene. Diseases associated with A1BG include pancreatic ductal adenocarcinoma. An important paralog of this gene is KIR2DL4.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for A1BG Gene

Genomics for A1BG Gene

Genomic Location for A1BG Gene

Start:
58,345,178 bp from pter
End:
58,353,499 bp from pter
Size:
8,322 bases
Orientation:
Minus strand

Genomic View for A1BG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for A1BG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for A1BG Gene

Regulatory Elements for A1BG Gene

Proteins for A1BG Gene

  • Protein details for A1BG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04217-A1BG_HUMAN
    Recommended name:
    Alpha-1B-glycoprotein
    Protein Accession:
    P04217
    Secondary Accessions:
    • A8K052
    • Q68CK0
    • Q8IYJ6
    • Q96P39

    Protein attributes for A1BG Gene

    Size:
    495 amino acids
    Molecular mass:
    54254 Da
    Quaternary structure:
    • Interacts with CRISP3.

    Alternative splice isoforms for A1BG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for A1BG Gene

Proteomics data for A1BG Gene at MOPED

Post-translational modifications for A1BG Gene

  • Glycosylation at Asn44, Asn179, Asn363, and Asn371

Other Protein References for A1BG Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for A1BG Gene

Domains for A1BG Gene

Gene Families for A1BG Gene

HGNC:
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing

Protein Domains for A1BG Gene

UniProtKB/Swiss-Prot:

A1BG_HUMAN
Domain:
  • Contains 5 Ig-like V-type (immunoglobulin-like) domains.:
    • P04217
genes like me logo Genes that share domains with A1BG: view

Function for A1BG Gene

Molecular function for A1BG Gene

GENATLAS Biochemistry: glycoprotein,alpha-1-B-

Gene Ontology (GO) - Molecular Function for A1BG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with A1BG: view

Phenotypes for A1BG Gene

genes like me logo Genes that share phenotypes with A1BG: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for A1BG Gene

Localization for A1BG Gene

Subcellular locations from UniProtKB/Swiss-Prot for A1BG Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for A1BG Gene COMPARTMENTS Subcellular localization image for A1BG gene
Compartment Confidence
extracellular 5
plasma membrane 2
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for A1BG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IDA 3458201
GO:0005615 extracellular space IDA 16502470
GO:0070062 extracellular exosome IDA 19056867
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with A1BG: view

Pathways for A1BG Gene

SuperPathways for A1BG Gene

No Data Available

Gene Ontology (GO) - Biological Process for A1BG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with A1BG: view

No data available for Pathways by source for A1BG Gene

Transcripts for A1BG Gene

Unigene Clusters for A1BG Gene

Alpha-1-B glycoprotein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for A1BG Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8
SP1: - -
SP2:
SP3:

Relevant External Links for A1BG Gene

GeneLoc Exon Structure for
A1BG
ECgene alternative splicing isoforms for
A1BG

Expression for A1BG Gene

mRNA expression in normal human tissues for A1BG Gene

mRNA differential expression in normal tissues according to GTEx for A1BG Gene

This gene is overexpressed in Liver (45.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for A1BG Gene

SOURCE GeneReport for Unigene cluster for A1BG Gene Hs.529161

mRNA Expression by UniProt/SwissProt for A1BG Gene

P04217-A1BG_HUMAN
Tissue specificity: Plasma
genes like me logo Genes that share expressions with A1BG: view

Orthologs for A1BG Gene

This gene was present in the common ancestor of chordates.

Orthologs for A1BG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia A1BG 36
  • 98.59 (n)
  • 97.98 (a)
A1BG 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia A1BG 36
  • 73.42 (n)
  • 62.42 (a)
A1BG 37
  • 61 (a)
OneToOne
dog
(Canis familiaris)
Mammalia A1BG 36
  • 74.7 (n)
  • 67.21 (a)
A1BG 37
  • 62 (a)
OneToOne
mouse
(Mus musculus)
Mammalia A1bg 36
  • 60.08 (n)
  • 46.23 (a)
A1bg 16
A1bg 37
  • 44 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 14 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 34 (a)
ManyToMany
-- 37
  • 27 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia A1bg 36
  • 58.64 (n)
  • 46.15 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 21 (a)
OneToMany
Species with no ortholog for A1BG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for A1BG Gene

ENSEMBL:
Gene Tree for A1BG (if available)
TreeFam:
Gene Tree for A1BG (if available)

Paralogs for A1BG Gene

genes like me logo Genes that share paralogs with A1BG: view

Variants for A1BG Gene

Sequence variations from dbSNP and Humsavar for A1BG Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs77832535 -- 58,349,015(+) AAAGA(A/T)TAAAC intron-variant
rs79902891 -- 58,349,337(+) CATCA(A/G)TTGTG intron-variant
rs111251782 -- 58,347,032(+) TTTCT(A/G/T)GACAA intron-variant
rs111266697 -- 58,349,117(+) GGGTT(A/C)AAGCA intron-variant
rs111942548 -- 58,349,148(+) CAAGT(A/G)GCTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for A1BG Gene

Variant ID Type Subtype PubMed ID
nsv833887 CNV Loss 17160897
nsv515731 CNV Gain+Loss 19592680
dgv4030n71 CNV Loss 21882294
nsv833888 CNV Loss 17160897
dgv4031n71 CNV Loss 21882294
nsv817878 CNV Loss 17921354

Relevant External Links for A1BG Gene

HapMap Linkage Disequilibrium report
A1BG

Disorders for A1BG Gene

(2) University of Copenhagen DISEASES for A1BG Gene

genes like me logo Genes that share disorders with A1BG: view

No data available for UniProtKB/Swiss-Prot for A1BG Gene

Publications for A1BG Gene

  1. Cysteine-rich secretory protein 3 is a ligand of alpha1B-glycoprotein in human plasma. (PMID: 15461460) Udby L. … Kjeldsen L. (Biochemistry 2004) 3 4 23
  2. Human CRISP-3 binds serum alpha(1)B-glycoprotein across species. (PMID: 20116414) Udby L. … Borregaard N. (Biochim. Biophys. Acta 2010) 3 23
  3. Linkage between alpha 1B-glycoprotein (A1BG) and Lutheran (LU) red blood group system: assignment to chromosome 19: new genetic variants of A1BG. (PMID: 2591067) Eiberg H. … Mohr J. (Clin. Genet. 1989) 2 3
  4. Amino acid sequence of human plasma alpha 1B-glycoprotein: homology to the immunoglobulin supergene family. (PMID: 3458201) Ishioka N. … Putnam F.W. (Proc. Natl. Acad. Sci. U.S.A. 1986) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for A1BG Gene

Sources for A1BG Gene

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