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Aliases for A1BG Gene

Aliases for A1BG Gene

  • Alpha-1-B Glycoprotein 2 3 4 5
  • Epididymis Secretory Sperm Binding Protein Li 163pA 3
  • Alpha-1B-Glycoprotein 3
  • HEL-S-163pA 3
  • HYST2477 3
  • A1B 3
  • ABG 3
  • GAB 3

External Ids for A1BG Gene

Previous GeneCards Identifiers for A1BG Gene

  • GC19M059755
  • GC19M059310
  • GC19M063532
  • GC19M063548
  • GC19M058858
  • GC19M055168

Summaries for A1BG Gene

Entrez Gene Summary for A1BG Gene

  • The protein encoded by this gene is a plasma glycoprotein of unknown function. The protein shows sequence similarity to the variable regions of some immunoglobulin supergene family member proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for A1BG Gene

A1BG (Alpha-1-B Glycoprotein) is a Protein Coding gene. Diseases associated with A1BG include Middle Ear Disease. Among its related pathways are Immune System and Response to elevated platelet cytosolic Ca2+. An important paralog of this gene is IGSF1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for A1BG Gene

Genomics for A1BG Gene

Regulatory Elements for A1BG Gene

Enhancers for A1BG Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F058346 0.7 ENCODE 18.1 +6.0 5970 1.6 HDGF ATF1 CREB3L1 SIN3A ZNF2 ZEB1 GLIS2 SCRT2 ZNF143 ZNF207 A1BG ZNF324 ZNF446 RNU6-1337P A1BG-AS1 PIR61497
GH19F058330 0.9 Ensembl ENCODE 13.5 +22.7 22732 0.9 POLR2A ATF3 IKZF1 HMBOX1 A1BG MIR6806 LOC105372480
GH19F058325 0.2 ENCODE 12.2 +26.6 26629 3.6 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF134 ZNF17 ZNF549 ZNF606 ZNF773 ZNF256 ZNF417 ZNF551 ZNF548 ZNF211
GH19F058313 0.7 FANTOM5 10.2 +40.0 40048 0.3 ZNF8 ZNF446 RNU6-1337P ZBTB45 A1BG ZNF256 PIR41037 GC19P058313 LOC100887072
GH19F058361 0.2 ENCODE 9.2 -8.9 -8906 2.1 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 TRIM28 LOC105372483 ENSG00000268392 ZNF17 ZNF749 RPS5 ZNF550 A1BG ENSG00000268912 ZNF132
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around A1BG on UCSC Golden Path with GeneCards custom track

Genomic Location for A1BG Gene

Chromosome:
19
Start:
58,345,178 bp from pter
End:
58,353,499 bp from pter
Size:
8,322 bases
Orientation:
Minus strand

Genomic View for A1BG Gene

Genes around A1BG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
A1BG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for A1BG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for A1BG Gene

Proteins for A1BG Gene

  • Protein details for A1BG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04217-A1BG_HUMAN
    Recommended name:
    Alpha-1B-glycoprotein
    Protein Accession:
    P04217
    Secondary Accessions:
    • A8K052
    • Q68CK0
    • Q8IYJ6
    • Q96P39

    Protein attributes for A1BG Gene

    Size:
    495 amino acids
    Molecular mass:
    54254 Da
    Quaternary structure:
    • Interacts with CRISP3.

    Alternative splice isoforms for A1BG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for A1BG Gene

Post-translational modifications for A1BG Gene

  • Glycosylation at Asn 44, Asn 179, Asn 363, and Asn 371
  • Modification sites at PhosphoSitePlus

Other Protein References for A1BG Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for A1BG (alpha 1B-Glycoprotein)
  • Abcam antibodies for A1BG

No data available for DME Specific Peptides for A1BG Gene

Domains & Families for A1BG Gene

Gene Families for A1BG Gene

Suggested Antigen Peptide Sequences for A1BG Gene

Graphical View of Domain Structure for InterPro Entry

P04217

UniProtKB/Swiss-Prot:

A1BG_HUMAN :
  • Contains 5 Ig-like V-type (immunoglobulin-like) domains.
Domain:
  • Contains 5 Ig-like V-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with A1BG: view

Function for A1BG Gene

Molecular function for A1BG Gene

GENATLAS Biochemistry:
glycoprotein,alpha-1-B-

Gene Ontology (GO) - Molecular Function for A1BG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with A1BG: view
genes like me logo Genes that share phenotypes with A1BG: view

Animal Model Products

  • Taconic Biosciences Mouse Models for A1BG

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for A1BG Gene

Localization for A1BG Gene

Subcellular locations from UniProtKB/Swiss-Prot for A1BG Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for A1BG Gene COMPARTMENTS Subcellular localization image for A1BG gene
Compartment Confidence
extracellular 5
plasma membrane 3
endoplasmic reticulum 2
cytosol 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for A1BG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IDA 16502470
GO:0031093 platelet alpha granule lumen TAS --
GO:0070062 extracellular exosome IDA 19056867
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with A1BG: view

Pathways & Interactions for A1BG Gene

genes like me logo Genes that share pathways with A1BG: view

Gene Ontology (GO) - Biological Process for A1BG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with A1BG: view

No data available for SIGNOR curated interactions for A1BG Gene

Drugs & Compounds for A1BG Gene

(2) Drugs for A1BG Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
2'-Deoxyguanosine-5'-Monophosphate Experimental Pharma Target 0
Cysteinesulfonic Acid Experimental Pharma Target 0
genes like me logo Genes that share compounds with A1BG: view

Transcripts for A1BG Gene

Unigene Clusters for A1BG Gene

Alpha-1-B glycoprotein:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for A1BG Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8
SP1: - -
SP2:
SP3:

Relevant External Links for A1BG Gene

GeneLoc Exon Structure for
A1BG
ECgene alternative splicing isoforms for
A1BG

Expression for A1BG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for A1BG Gene

mRNA differential expression in normal tissues according to GTEx for A1BG Gene

This gene is overexpressed in Liver (x45.8).

Protein differential expression in normal tissues from HIPED for A1BG Gene

This gene is overexpressed in Plasma (14.1), Serum (10.1), Synovial fluid (9.6), and Monocytes (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for A1BG Gene



Protein tissue co-expression partners for A1BG Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of A1BG Gene:

A1BG

SOURCE GeneReport for Unigene cluster for A1BG Gene:

Hs.529161

mRNA Expression by UniProt/SwissProt for A1BG Gene:

P04217-A1BG_HUMAN
Tissue specificity: Plasma.
genes like me logo Genes that share expression patterns with A1BG: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for A1BG Gene

Orthologs for A1BG Gene

This gene was present in the common ancestor of chordates.

Orthologs for A1BG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia A1BG 34 35
  • 98.59 (n)
dog
(Canis familiaris)
Mammalia A1BG 34 35
  • 74.7 (n)
cow
(Bos Taurus)
Mammalia A1BG 34 35
  • 73.42 (n)
mouse
(Mus musculus)
Mammalia A1bg 16 35 34
  • 60.08 (n)
rat
(Rattus norvegicus)
Mammalia A1bg 34
  • 58.64 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 34 (a)
ManyToMany
-- 35
  • 27 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 14 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 21 (a)
OneToMany
Species where no ortholog for A1BG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for A1BG Gene

ENSEMBL:
Gene Tree for A1BG (if available)
TreeFam:
Gene Tree for A1BG (if available)

Paralogs for A1BG Gene

Variants for A1BG Gene

Sequence variations from dbSNP and Humsavar for A1BG Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10164322 -- 58,351,795(+) CCATT(C/T)TTTTT intron-variant, upstream-variant-2KB
rs10164334 -- 58,352,075(+) aggcg(C/T)gagcc intron-variant, nc-transcript-variant
rs10402021 -- 58,354,221(+) CTCCA(C/T)GGACA intron-variant, upstream-variant-2KB
rs1047461 -- 58,346,970(-) GGATT(C/T)TGGAC utr-variant-3-prime
rs111251782 -- 58,347,032(+) TTTCT(A/G/T)GACAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for A1BG Gene

Variant ID Type Subtype PubMed ID
nsv1058109 CNV gain 25217958
nsv515731 CNV gain+loss 19592680
nsv817878 CNV loss 17921354
nsv833887 CNV loss 17160897
nsv833888 CNV loss 17160897

Variation tolerance for A1BG Gene

Residual Variation Intolerance Score: 18.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.88; 35.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for A1BG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
A1BG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for A1BG Gene

Disorders for A1BG Gene

MalaCards: The human disease database

(1) MalaCards diseases for A1BG Gene - From: DISEASES

Disorder Aliases PubMed IDs
middle ear disease
  • disorder of middle ear
- elite association - COSMIC cancer census association via MalaCards
Search A1BG in MalaCards View complete list of genes associated with diseases

Relevant External Links for A1BG

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
A1BG
genes like me logo Genes that share disorders with A1BG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for A1BG Gene

Publications for A1BG Gene

  1. Cysteine-rich secretory protein 3 is a ligand of alpha1B-glycoprotein in human plasma. (PMID: 15461460) Udby L. … Kjeldsen L. (Biochemistry 2004) 3 4 22 64
  2. Human CRISP-3 binds serum alpha(1)B-glycoprotein across species. (PMID: 20116414) Udby L. … Borregaard N. (Biochim. Biophys. Acta 2010) 3 22 64
  3. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T. … Smith R.D. (J. Proteome Res. 2005) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for A1BG Gene

Sources for A1BG Gene

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