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A1BG Gene

protein-coding GIFtS: 51

GC19M063548

alpha-1-B glycoprotein
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
A1B ^²
ABG ^²
DKFZp686F0970 ^²
GAB ^²
HYST2477 ^²

Descriptions
alpha 1B-glycoprotein ^²
alpha-1-B glycoprotein ^², ³

External Ids
HGNC: 5¹
Entrez Gene: 1²
UniProtKB: P04217³
Ensembl: ENSG00000121410⁷

Search outside databases for aliases for A1BG gene

Previous GC identifers: GC19M059755 GC19M059310 GC19M063532

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for A1BG:

The protein encoded by this gene is a plasma glycoprotein of unknown function. The protein shows

sequence similarity to the variable regions of some immunoglobulin supergene family member

proteins. [provided by RefSeq]

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4 Ensembl cytogenetic band: 19q13.43 HGNC cytogenetic band: 19q

A1BG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M063548: (about GC identifiers)

Start:	63,548,356 bp from pter
End:	63,556,669 bp from pter
Size:	8,314 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000019.8 NT_011109.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: A1BG_HUMAN, P04217 (See protein sequence)

Recommended Name: Alpha-1B-glycoprotein precursor

Size: 495 amino acids; 54273 Da

Subcellular location: Secreted

Secondary accessions: Q68CK0 Q8IYJ6 Q96P39

REFSEQ proteins: NP_570602.2

ENSEMBL proteins:

ENSP00000263100

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
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	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (A1BG)
	Human Recombinant Proteins from Abnova (A1BG)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IDA	3458201

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Antibodies for A1BG:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for A1BG
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (A1BG), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (A1BG)
	Novus Biologicals Antibodies for A1BG

Assays for A1BG:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P04217

ProtoNet protein and cluster: P04217

1 Blocks protein family: IPB003598 Immunoglobulin C-2 type

UniProtKB/Swiss-Prot: A1BG_HUMAN, P04217

Similarity: Contains 5 Ig-like V-type (immunoglobulin-like) domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (A1BG)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (A1BG)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_130786

Applied Biosystems Silencer® siRNAs for A1BG

Sigma-Aldrich siRNA and siRNA Panels for A1BG

Sigma-Aldrich shRNA for A1BG

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_130786
Myc/DDK tagged cDNA clone in CMV expression vector: NM_130786
untagged cDNA clones in CMV expression vector (see all 2): NM_130786

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_130786

Genatlas biochemistry entry for A1BG:

glycoprotein,alpha-1-B-

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/34 Interacting proteins for A1BG (ENSP00000263100³) via UniProtKB, MINT, and/or STRING (see all 34 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GABPB1	ENSP00000370259³	STRING (score=.976)
GABPA	ENSP00000346886³	STRING (score=.951)
UTRN	ENSP00000356515³	STRING (score=.946)
COX4I1	ENSP00000253452³	STRING (score=.935)
ANK1	ENSP00000265709³	STRING (score=.93)

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1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008150	biological_process	ND	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for A1BG

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (A1BG)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (A1BG)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_130786

Sigma-Aldrich siRNA and siRNA Panels for A1BG

Sigma-Aldrich shRNA for A1BG

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_130786

REFSEQ mRNAs for A1BG gene:

NM_130786.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_130786

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_130786
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_130786
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_130786

Additional cDNA sequence:

AB073611.1 AF414429.1 AK055885.1 AK056201.1 AK289417.1 BC035719.1 BX537419.1 CR603363.1

CR604603.1 CR609084.1 CR612720.1 CR614062.1

8 DOTS entries:

DT.95230508 DT.207949 DT.100768640 DT.97823153 DT.121451092 DT.100878023 DT.100878029 DT.100878031

24/152 AceView cDNA sequences (see all 152 ):

CB163551 CB162205 CB135246 AB073611 CB130088 CR614062 CB138231 CB141199

CR612720 CR603363 CR609084 AW470952 CB148792 BM153273 CB121414 CR604603

CB130068 BF196450 CB144216 CB130078 CB163893 BX410165 CB134894 BU740127

highest scoring ESTs for A1BG:

AF414429 AI022193 AK055885 AL531425 BC035719 BM545070 BX325176 BX346032 BX422371 BX427184

Unigene Cluster for A1BG:

Alpha-1-B glycoprotein

Hs.529161 [show with all ESTs]

Unigene Representative Sequence: AK055885

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for A1BG

ExUns:	1	^	2a	·	2b	^	3a	·	3b	^	4a	·	4b	^	5	^	6a	·	6b	^	7	^	8
SP1:											-		-
SP2:
SP3:

About this scheme

ECgene alternative splicing isoforms for A1BG

1 Ensembl transcript including schematic representation:

ENST00000263100

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

A1BG expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for A1BG

¹ / ² / ³

3 probe-sets matching A1BG gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
51020_at²^{, 3}	U95-B	1	0.94	1.00	1.00	1.00	AI022193	0.80	0.88	0.84	1
229819_at²^{, 3}	U133-B	1	0.91	1.00	--	--	AI022193	0.80	0.88	0.84	1
229819_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ACAACCAAAA

SOURCE GeneReport for Unigene cluster: Hs.529161
UniProtKB/Swiss-Prot: A1BG_HUMAN, P04217
Tissue specificity: Plasma

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for A1BG gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	A1BG¹	--	alpha-1-B glycoprotein	74.71(n) 67.14(a)	484230 XM_541346.2 XP_541346.2
chimpanzee (Pan troglodytes)	A1BG¹	--	alpha-1-B glycoprotein	98.58(n) 97.97(a)	742390 XM_001146598.1 XP_001146598.1
cow (Bos taurus)	A1BG¹	--	alpha-1-B glycoprotein	72.79(n) 61.82(a)	518955 NM_001046243.1 NP_001039708.1
rat (Rattus norvegicus)	A1bg¹	--	alpha-1-B glycoprotein	58.64(n) 46.15(a)	140656 NM_022258.2 NP_071594.2
mouse (Mus musculus)	A1bg^{1, 5}	15⁵	alpha-1-B glycoprotein^{1, 5}	60.08(n)¹ 46.23(a)¹	117586¹ NM_001081067.1¹ NP_001074536.1¹ AA250460⁵ AI504986⁵ (see all 9)

About this table Species with no ortholog for A1BG

ENSEMBL Gene Tree for A1BG

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for A1BG gene

OSCAR² NCR1² IGSF1² FCAR² GP6²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/61 NCBI SNPs in A1BG are shown (see all 61 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 32)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1265956^1,2	A,C,F,H,O	63548943(+)	`CATCAC/TAGACT`	1	--	ut3¹		12		MN EU EA WA NA	1156
	rs893184^1,2	A,C,F,H	63556291(-)	`GGCCCG/ACCTGG`	1	R/H	mis¹ ese³		5		MN EU EA WA	594
	rs893182^1,2	A,C,F,H	63556880(-)	`TGAGGG/ATGAGG`	1	--	ng3¹		6		NA EU EA WA	580
	rs893181^1,2	C,F,H	63556894(-)	`ATCCAA/TCACTG`	1	--	ng3¹		4		MN EU EA	484
	rs2241788^1,2	C,F,H	63553556(-)	`GCTGCA/GCGTGG`	1	H/R	mis¹ ese³		9		EA EU WA	2334
	rs893180^1,2	A,C,F	63556903(-)	`GGTTCC/TAGGAT`	1	--	ng3¹		1		MN	184
	rs893183^1,2	C,H	63556866(-)	`TTTTAG/ACATCA`	1	--	ng3¹ tfbs³		7		NA MN EU EA WA	716
	rs2375470^1,2	C	63556679(+)	`GCCCCA/GAGGGA`	1	--	ng3¹		0	--	--	--	--
--	rs1265955^1,2	C	63548624(+)	`atcacC/Ttgagc`	1	--	ut3¹ ese³		0	--	--	--	--
	rs1265957^1,2	A,C,F,H	63550488(+)	`CAAACG/ATCAGC`	1	--	int¹		4		EU EA WA	416

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HapMap Linkage Disequilibrium images for A1BG (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 138670

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/28 PubMed articles for A1BG gene (see all 28 ):

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{3, 4} Liu T.... Smith R.D. (2005)
Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (PubMed id 15221005)^{3, 4} Yamada S....Nakagawara A. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Screening for N-glycosylated proteins by liquid chromatography mass spectrometry. (PubMed id 14760718)^{3, 4} Bunkenborg J.... Wisniewski J.R. (2004)
Linkage between alpha 1B-glycoprotein (A1BG) and Lutheran (LU) red blood group system: assignment to chromosome 19: new genetic variants of A1BG. (PubMed id 2591067)^{2, 3} Eiberg H....Mohr J. (1989)
Amino acid sequence of human plasma alpha 1B-glycoprotein: homology to the immunoglobulin supergene family. (PubMed id 3458201)^{3, 4} Ishioka N.... Putnam F.W. (1986)
Cysteine-rich secretory protein 3 is a ligand of alpha1B-glycoprotein in human plasma. (PubMed id 15461460)^{1, 3} Udby L....Kjeldsen L. (2004)
Proteomic analysis identifies MMP-9, DJ-1 and A1BG as overexpressed proteins in pancreatic juice from pancreatic ductal adenocarcinoma patients. (PubMed id 18706098)³ Tian M....Han J.X. (2008)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)³ Ota T....Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 1	HGNC: 5	AceView: A1BGandZNF497	Ensembl:ENSG00000121410	euGenes: HUgn1
ECgene: A1BG	H-InvDB: A1BG

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
SHMPD	http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=alpha1B

Licensable Technologies for A1BG
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for A1BG:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for A1BG-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for A1BG		Antibodies for A1BG
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for A1BG		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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A1BG Gene

protein-coding GIFtS: 51

Aliases &
Descriptions
for A1BG

Summaries
for A1BG

Genomic Location
for A1BG

Proteins
for A1BG

Protein Domains/
Families
for A1BG

Gene Function
for A1BG

Pathways & Interactions
for A1BG

Drugs & Compounds
for A1BG

Transcripts
for A1BG

Expression
for A1BG

Orthologs
for A1BG

Paralogs
for A1BG

SNPs/Variants
for A1BG

Disorders & Mutations
for A1BG

Medical News
for A1BG

Publications
for A1BG

Search for A1BG

Genome Databases showing A1BG

Other Databases showing A1BG

Specialized Databases showing A1BG

Licensable Technologies
for A1BG

Services
for A1BG

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

A1BG Gene

protein-coding GIFtS: 51

Aliases & Descriptionsfor A1BG

Summariesfor A1BG

Genomic Locationfor A1BG

Proteinsfor A1BG

Protein Domains/Familiesfor A1BG

Gene Functionfor A1BG

Pathways & Interactionsfor A1BG

Drugs & Compoundsfor A1BG

Transcriptsfor A1BG

Expression for A1BG

Orthologsfor A1BG

Paralogsfor A1BG

SNPs/Variantsfor A1BG

Disorders & Mutationsfor A1BG

Medical Newsfor A1BG

Publicationsfor A1BG

Search for A1BG

Genome Databases showing A1BG

Other Databases showing A1BG

Specialized Databases showing A1BG

Licensable Technologiesfor A1BG

Servicesfor A1BG

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for A1BG

Summaries
for A1BG

Genomic Location
for A1BG

Proteins
for A1BG

Protein Domains/
Families
for A1BG

Gene Function
for A1BG

Pathways & Interactions
for A1BG

Drugs & Compounds
for A1BG

Transcripts
for A1BG

Expression
for A1BG

Orthologs
for A1BG

Paralogs
for A1BG

SNPs/Variants
for A1BG

Disorders & Mutations
for A1BG

Medical News
for A1BG

Publications
for A1BG

Licensable Technologies
for A1BG

Services
for A1BG