Free for academic non-profit institutions. Other users need a Commercial license

Aliases for A1BG Gene

Aliases for A1BG Gene

  • Alpha-1-B Glycoprotein 2 3 4 5
  • Epididymis Secretory Sperm Binding Protein Li 163pA 3
  • HEL-S-163pA 3
  • HYST2477 3
  • A1B 3
  • ABG 3
  • GAB 3

External Ids for A1BG Gene

Previous GeneCards Identifiers for A1BG Gene

  • GC19M059755
  • GC19M059310
  • GC19M063532
  • GC19M063548
  • GC19M058858
  • GC19M055168

Summaries for A1BG Gene

Entrez Gene Summary for A1BG Gene

  • The protein encoded by this gene is a plasma glycoprotein of unknown function. The protein shows sequence similarity to the variable regions of some immunoglobulin supergene family member proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for A1BG Gene

A1BG (Alpha-1-B Glycoprotein) is a Protein Coding gene. Diseases associated with A1BG include Middle Ear Disease and Labyrinthine Disease. Among its related pathways are Platelet activation, signaling and aggregation. An important paralog of this gene is KIR2DL4.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for A1BG Gene

Genomics for A1BG Gene

Regulatory Elements for A1BG Gene

Enhancers for A1BG Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around A1BG on UCSC Golden Path with GeneCards custom track

Promoters for A1BG Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around A1BG on UCSC Golden Path with GeneCards custom track

Genomic Location for A1BG Gene

58,345,178 bp from pter
58,353,499 bp from pter
8,322 bases
Minus strand

Genomic View for A1BG Gene

Genes around A1BG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
A1BG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for A1BG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for A1BG Gene

Proteins for A1BG Gene

  • Protein details for A1BG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8K052
    • Q68CK0
    • Q8IYJ6
    • Q96P39

    Protein attributes for A1BG Gene

    495 amino acids
    Molecular mass:
    54254 Da
    Quaternary structure:
    • Interacts with CRISP3.

    Alternative splice isoforms for A1BG Gene


neXtProt entry for A1BG Gene

Proteomics data for A1BG Gene at MOPED

Post-translational modifications for A1BG Gene

  • Glycosylation at Asn 44, Asn 179, Asn 363, and Asn 371
  • Modification sites at PhosphoSitePlus

Other Protein References for A1BG Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for A1BG (alpha 1B-Glycoprotein)
  • Abcam antibodies for A1BG

No data available for DME Specific Peptides for A1BG Gene

Domains & Families for A1BG Gene

Gene Families for A1BG Gene

Protein Domains for A1BG Gene

Suggested Antigen Peptide Sequences for A1BG Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 5 Ig-like V-type (immunoglobulin-like) domains.
  • Contains 5 Ig-like V-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with A1BG: view

Function for A1BG Gene

Molecular function for A1BG Gene

GENATLAS Biochemistry:
genes like me logo Genes that share phenotypes with A1BG: view

Animal Model Products

  • Taconic Biosciences Mouse Models for A1BG

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for A1BG Gene

Localization for A1BG Gene

Subcellular locations from UniProtKB/Swiss-Prot for A1BG Gene


Subcellular locations from

Jensen Localization Image for A1BG Gene COMPARTMENTS Subcellular localization image for A1BG gene
Compartment Confidence
extracellular 5
plasma membrane 3
endoplasmic reticulum 2
cytosol 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for A1BG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 16502470
GO:0070062 extracellular exosome IDA 19056867
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with A1BG: view

Pathways & Interactions for A1BG Gene

genes like me logo Genes that share pathways with A1BG: view

Gene Ontology (GO) - Biological Process for A1BG Gene


No data available for SIGNOR curated interactions for A1BG Gene

Drugs & Compounds for A1BG Gene

(2) Drugs for A1BG Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
2'-Deoxyguanosine-5'-Monophosphate Experimental Pharma Target 0
Cysteinesulfonic Acid Experimental Pharma Target 0
genes like me logo Genes that share compounds with A1BG: view

Transcripts for A1BG Gene

Unigene Clusters for A1BG Gene

Alpha-1-B glycoprotein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for A1BG Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8
SP1: - -

Relevant External Links for A1BG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for A1BG Gene

mRNA expression in normal human tissues for A1BG Gene

mRNA differential expression in normal tissues according to GTEx for A1BG Gene

This gene is overexpressed in Liver (x45.8).

Protein differential expression in normal tissues from HIPED for A1BG Gene

This gene is overexpressed in Plasma (14.1), Serum (10.1), Synovial fluid (9.6), and Monocytes (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for A1BG Gene

SOURCE GeneReport for Unigene cluster for A1BG Gene Hs.529161

mRNA Expression by UniProt/SwissProt for A1BG Gene

Tissue specificity: Plasma.
genes like me logo Genes that share expression patterns with A1BG: view

Protein tissue co-expression partners for A1BG Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for A1BG Gene

Orthologs for A1BG Gene

This gene was present in the common ancestor of chordates.

Orthologs for A1BG Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia A1BG 35
  • 73.42 (n)
  • 62.42 (a)
A1BG 36
  • 61 (a)
(Canis familiaris)
Mammalia A1BG 35
  • 74.7 (n)
  • 67.21 (a)
A1BG 36
  • 62 (a)
(Mus musculus)
Mammalia A1bg 35
  • 60.08 (n)
  • 46.23 (a)
A1bg 16
A1bg 36
  • 44 (a)
(Pan troglodytes)
Mammalia A1BG 35
  • 98.59 (n)
  • 97.98 (a)
A1BG 36
  • 98 (a)
(Rattus norvegicus)
Mammalia A1bg 35
  • 58.64 (n)
  • 46.15 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 14 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 34 (a)
-- 36
  • 27 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 21 (a)
Species with no ortholog for A1BG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for A1BG Gene

Gene Tree for A1BG (if available)
Gene Tree for A1BG (if available)

Paralogs for A1BG Gene

genes like me logo Genes that share paralogs with A1BG: view

Variants for A1BG Gene

Sequence variations from dbSNP and Humsavar for A1BG Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_018369 -
VAR_018370 -
rs12978513 -- 58,347,569(+) GCAGC(G/T)CAGGA reference, missense
rs12980208 -- 58,349,446(+) aggag(G/T)tcaag intron-variant
rs67397428 -- 58,347,697(-) GGCGT(-/GGCCTGGGCGC)GGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for A1BG Gene

Variant ID Type Subtype PubMed ID
nsv833887 CNV Loss 17160897
nsv515731 CNV Gain+Loss 19592680
dgv4030n71 CNV Loss 21882294
nsv833888 CNV Loss 17160897
dgv4031n71 CNV Loss 21882294
nsv817878 CNV Loss 17921354

Variation tolerance for A1BG Gene

Residual Variation Intolerance Score: 18.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.88; 35.17% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for A1BG Gene

Disorders for A1BG Gene

MalaCards: The human disease database

(3) MalaCards diseases for A1BG Gene - From: DISEASES

Disorder Aliases PubMed IDs
middle ear disease
  • disorder of middle ear
labyrinthine disease
  • labyrinthine dysfunction
granulomatous angiitis
  • vasculitis, central nervous system
- elite association - COSMIC cancer census association via MalaCards
Search A1BG in MalaCards View complete list of genes associated with diseases

Relevant External Links for A1BG

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with A1BG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for A1BG Gene

Publications for A1BG Gene

  1. Cysteine-rich secretory protein 3 is a ligand of alpha1B-glycoprotein in human plasma. (PMID: 15461460) Udby L. … Kjeldsen L. (Biochemistry 2004) 3 4 23 67
  2. Human CRISP-3 binds serum alpha(1)B-glycoprotein across species. (PMID: 20116414) Udby L. … Borregaard N. (Biochim. Biophys. Acta 2010) 3 23
  3. Linkage between alpha 1B-glycoprotein (A1BG) and Lutheran (LU) red blood group system: assignment to chromosome 19: new genetic variants of A1BG. (PMID: 2591067) Eiberg H. … Mohr J. (Clin. Genet. 1989) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Whole genome RNAi screens reveal a critical role of REV3 in coping with replication stress. (PMID: 25113059) Kotov I.N. … Marti T.M. (Mol Oncol 2014) 3

Products for A1BG Gene

Sources for A1BG Gene