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Aliases for A1BG Gene

Aliases for A1BG Gene

  • Alpha-1-B Glycoprotein 2 3 4
  • Epididymis Secretory Sperm Binding Protein Li 163pA 3
  • Alpha-1B-Glycoprotein 3
  • HEL-S-163pA 3
  • HYST2477 3
  • GAB 3
  • A1B 3
  • ABG 3

External Ids for A1BG Gene

Previous GeneCards Identifiers for A1BG Gene

  • GC19M059755
  • GC19M059310
  • GC19M063532
  • GC19M063548
  • GC19M058858
  • GC19M055168

Summaries for A1BG Gene

Entrez Gene Summary for A1BG Gene

  • The protein encoded by this gene is a plasma glycoprotein of unknown function. The protein shows sequence similarity to the variable regions of some immunoglobulin supergene family member proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for A1BG Gene

A1BG (Alpha-1-B Glycoprotein) is a Protein Coding gene. Diseases associated with A1BG include pancreatic ductal adenocarcinoma. An important paralog of this gene is KIR2DL4.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for A1BG Gene

Genomics for A1BG Gene

Regulatory Elements for A1BG Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for A1BG Gene

58,345,178 bp from pter
58,353,499 bp from pter
8,322 bases
Minus strand

Genomic View for A1BG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for A1BG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for A1BG Gene

Proteins for A1BG Gene

  • Protein details for A1BG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8K052
    • Q68CK0
    • Q8IYJ6
    • Q96P39

    Protein attributes for A1BG Gene

    495 amino acids
    Molecular mass:
    54254 Da
    Quaternary structure:
    • Interacts with CRISP3.

    Alternative splice isoforms for A1BG Gene


neXtProt entry for A1BG Gene

Proteomics data for A1BG Gene at MOPED

Post-translational modifications for A1BG Gene

  • Glycosylation at Asn44, Asn179, Asn363, and Asn371
  • Modification sites at PhosphoSitePlus

Other Protein References for A1BG Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for A1BG (alpha 1B-Glycoprotein)

No data available for DME Specific Peptides for A1BG Gene

Domains for A1BG Gene

Gene Families for A1BG Gene

  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing

Protein Domains for A1BG Gene

Suggested Antigen Peptide Sequences for A1BG Gene

Graphical View of Domain Structure for InterPro Entry



  • P04217
  • Contains 5 Ig-like V-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with A1BG: view

Function for A1BG Gene

Molecular function for A1BG Gene

GENATLAS Biochemistry:

Gene Ontology (GO) - Molecular Function for A1BG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with A1BG: view

Phenotypes for A1BG Gene

genes like me logo Genes that share phenotypes with A1BG: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for A1BG

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for A1BG Gene

Localization for A1BG Gene

Subcellular locations from UniProtKB/Swiss-Prot for A1BG Gene


Subcellular locations from

Jensen Localization Image for A1BG Gene COMPARTMENTS Subcellular localization image for A1BG gene
Compartment Confidence
extracellular 5
plasma membrane 2
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for A1BG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IDA 3458201
GO:0005615 extracellular space IDA 16502470
GO:0070062 extracellular exosome IDA 19056867
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with A1BG: view

Pathways for A1BG Gene

SuperPathways for A1BG Gene

No Data Available

Gene Ontology (GO) - Biological Process for A1BG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with A1BG: view

No data available for Pathways by source for A1BG Gene

Transcripts for A1BG Gene

Unigene Clusters for A1BG Gene

Alpha-1-B glycoprotein:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for A1BG

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for A1BG Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8
SP1: - -

Relevant External Links for A1BG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for A1BG Gene

mRNA expression in normal human tissues for A1BG Gene

mRNA differential expression in normal tissues according to GTEx for A1BG Gene

This gene is overexpressed in Liver (45.8).

Protein differential expression in normal tissues for A1BG Gene

This gene is overexpressed in Plasma (14.1), Serum (10.1), Synovial fluid (9.6), and Monocytes (9.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for A1BG Gene

SOURCE GeneReport for Unigene cluster for A1BG Gene Hs.529161

mRNA Expression by UniProt/SwissProt for A1BG Gene

Tissue specificity: Plasma
genes like me logo Genes that share expressions with A1BG: view

Expression partners for A1BG Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for A1BG Gene

Orthologs for A1BG Gene

This gene was present in the common ancestor of chordates.

Orthologs for A1BG Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia A1BG 35
  • 73.42 (n)
  • 62.42 (a)
A1BG 36
  • 61 (a)
(Canis familiaris)
Mammalia A1BG 35
  • 74.7 (n)
  • 67.21 (a)
A1BG 36
  • 62 (a)
(Mus musculus)
Mammalia A1bg 35
  • 60.08 (n)
  • 46.23 (a)
A1bg 16
A1bg 36
  • 44 (a)
(Pan troglodytes)
Mammalia A1BG 35
  • 98.59 (n)
  • 97.98 (a)
A1BG 36
  • 98 (a)
(Rattus norvegicus)
Mammalia A1bg 35
  • 58.64 (n)
  • 46.15 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 14 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 34 (a)
-- 36
  • 27 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 21 (a)
Species with no ortholog for A1BG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for A1BG Gene

Gene Tree for A1BG (if available)
Gene Tree for A1BG (if available)

Paralogs for A1BG Gene

genes like me logo Genes that share paralogs with A1BG: view

Variants for A1BG Gene

Sequence variations from dbSNP and Humsavar for A1BG Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs893180 -- 58,353,725(-) GGTTC(C/T)AGGAT upstream-variant-2KB
rs893181 -- 58,353,716(-) ATCCA(A/T)CACTG upstream-variant-2KB
rs1047461 -- 58,346,970(-) GGATT(C/T)TGGAC utr-variant-3-prime
rs1265957 -- 58,347,310(+) CAAAC(A/G)TCAGC intron-variant
rs1265958 -- 58,347,686(+) aggcc(A/G)cgccc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for A1BG Gene

Variant ID Type Subtype PubMed ID
nsv833887 CNV Loss 17160897
nsv515731 CNV Gain+Loss 19592680
dgv4030n71 CNV Loss 21882294
nsv833888 CNV Loss 17160897
dgv4031n71 CNV Loss 21882294
nsv817878 CNV Loss 17921354

Relevant External Links for A1BG Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for A1BG Gene

Disorders for A1BG Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for A1BG Gene in MalaCards »

(1) Diseases for A1BG Gene including...

(2) University of Copenhagen DISEASES for A1BG Gene

genes like me logo Genes that share disorders with A1BG: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for A1BG Gene

Publications for A1BG Gene

  1. Cysteine-rich secretory protein 3 is a ligand of alpha1B-glycoprotein in human plasma. (PMID: 15461460) Udby L. … Kjeldsen L. (Biochemistry 2004) 3 4 23
  2. Human CRISP-3 binds serum alpha(1)B-glycoprotein across species. (PMID: 20116414) Udby L. … Borregaard N. (Biochim. Biophys. Acta 2010) 3 23
  3. Linkage between alpha 1B-glycoprotein (A1BG) and Lutheran (LU) red blood group system: assignment to chromosome 19: new genetic variants of A1BG. (PMID: 2591067) Eiberg H. … Mohr J. (Clin. Genet. 1989) 2 3
  4. Amino acid sequence of human plasma alpha 1B-glycoprotein: homology to the immunoglobulin supergene family. (PMID: 3458201) Ishioka N. … Putnam F.W. (Proc. Natl. Acad. Sci. U.S.A. 1986) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for A1BG Gene

Sources for A1BG Gene

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