Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TMC6 Gene

protein-coding GIFtS: 55
GCID: GC17M076108

transmembrane channel-like 6

(Previous name: epidermodysplasia verruciformis 1 )
(Previous symbol: EVER1)

Explore 9 diseases affiliated with
TMC6 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Transmembrane Channel-Like 6¹ ²		Epidermodysplasia Verruciformis Protein 1² ³
EVER1¹ ² ³ ⁵		Protein LAK-4² ³
EVIN1¹ ² ³		EV1² ⁵
LAK-4P¹ ²		Expressed In Activated T/LAK Lymphocytes²
Epidermodysplasia Verruciformis 1¹ ²		Transmembrane Channel-Like Protein 6²

External Ids:	HGNC: 18021¹	Entrez Gene: 11322²	Ensembl: ENSG00000141524⁷	OMIM: 605828⁵	UniProtKB: Q7Z403³

Export aliases for TMC6 gene to outside databases

Previous GC identifers: GC17M073619 GC17M071533

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TMC6:

Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to

human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is

caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral

membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This

gene encodes a transmembrane channel-like protein with 10 transmembrane domains and 2 leucine zipper motifs. (provided

by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TMC6_HUMAN, Q7Z403

Function: Probable ion channel (By similarity)

Gene Wiki entry for TMC6

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010783.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TMC6 gene promoter:
c-Ets-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TMC6 promoter sequence

Search SABiosciences Chromatin IP Primers for TMC6

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMC6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.3 Ensembl cytogenetic band: 17q25.3 HGNC cytogenetic band: 17q25.3

TMC6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMC6 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M076108: view genomic region (about GC identifiers)

Start:	76,106,539 bp from pter	End:	76,128,488 bp from pter
Size:	21,950 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TMC6_HUMAN, Q7Z403 (See protein sequence)

Recommended Name: Transmembrane channel-like protein 6

Size: 805 amino acids; 90045 Da

Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein

Sequence caution: Sequence=AAH35648.1; Type=Erroneous initiation; Sequence=BAA24179.2; Type=Erroneous initiation;

Sequence=BAB84891.1; Type=Erroneous initiation;

Secondary accessions: O43284 Q45VJ2 Q8IU98 Q8IUI7 Q8IWU8 Q8TEQ7 Q9HAG5

Alternative splicing: 4 isoforms: Q7Z403-1 Q7Z403-2 Q7Z403-3 Q7Z403-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TMC6: NX_Q7Z403

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q7Z403

TMC6 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001120670.1 NP_009198.4

ENSEMBL proteins:

ENSP00000465261 ENSP00000376260 ENSP00000313408 ENSP00000306405 ENSP00000464853

ENSP00000465359 ENSP00000468255 ENSP00000466885 ENSP00000467016 ENSP00000466159

ENSP00000313479

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 2): TMC6 OriGene Custom Protein Services for TMC6
	GenScript Custom Purified and Recombinant Proteins Services for TMC6
	Novus Biologicals TMC6 Proteins Novus Biologicals TMC6 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TMC6

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

TMC6 for ontologies About GeneDecksing

TMC6 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies (see all 2): TMC6 OriGene Custom Antibody Services for TMC6
	GenScript Custom Superior Antibodies Services for TMC6
	Novus Biologicals TMC6 Antibodies
	Search for Antibodies for TMC6 at Abcam
	Uscn Antibodies for TMC6
	ThermoFisher Antibodies for TMC6

Assay Products for TMC6:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TMC6
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TMC6

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TMC6 for domains About GeneDecksing

1 InterPro domain/family:

IPR012496 TMC

Graphical View of Domain Structure for InterPro Entry Q7Z403

ProtoNet protein and cluster: Q7Z403

1 Blocks protein family: IPB012496 TMC

UniProtKB/Swiss-Prot: TMC6_HUMAN, Q7Z403

Similarity: Belongs to the TMC family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TMC6_HUMAN, Q7Z403

Function: Probable ion channel (By similarity)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): TMC6 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMC6
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate TMC6:
		hsa-miR-518a-5p hsa-miR-3121-3p hsa-miR-1207-5p hsa-miR-450b-5p
		SwitchGear 3'UTR luciferase reporter plasmid: TMC6 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMC6 (see all 4) OriGene shRNA RFP: TMC6 OriGene siRNA: TMC6
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMC6

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for TMC6

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMC6 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMC6 (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): TMC6 (NM_007267)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMC6
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMC6

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TMC6
		Search LifeMap BioReagents cell lines for TMC6

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMC6

Animal Models:
3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Tmc6):

hematopoietic system

homeostasis/metabolism

immune system

TMC6 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TMC6

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for TMC6 (ENSP00000313408⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBC	ENSP00000344818⁴	STRING: ENSP00000344818

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TMC6
Search CenterWatch for drugs/clinical trials and news about TMC6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TMC6 gene (2 alternative transcripts):

NM_001127198.1 NM_007267.6

Unigene Cluster for TMC6:

Transmembrane channel-like 6

Hs.632227 [show with all ESTs]

Unigene Representative Sequence: AK074065

18/25 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):

ENST00000590602 ENST00000592076 ENST00000392467(uc010dhf.1 uc002juk.2 uc002jun.4 uc002juo.2)

ENST00000322914(uc002juj.1 uc002jul.1 uc002jum.4) ENST00000590494

ENST00000306591(uc010dhg.1 uc010wtp.1 uc010wtq.1) ENST00000593044

ENST00000591436 ENST00000589933 ENST00000590934 ENST00000591756 ENST00000588087

ENST00000589553 ENST00000585849 ENST00000586271 ENST00000589271 ENST00000591594

ENST00000592063

miRNA Products:		OriGene 3'-UTR Clone (see all 2): TMC6 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMC6
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate TMC6:
		hsa-miR-518a-5p hsa-miR-3121-3p hsa-miR-1207-5p hsa-miR-450b-5p
		SwitchGear 3'UTR luciferase reporter plasmid: TMC6 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMC6 (see all 4) OriGene shRNA RFP: TMC6 OriGene siRNA: TMC6
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMC6

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMC6 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMC6 (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): TMC6 (NM_007267)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMC6
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMC6

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMC6 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TMC6
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMC6
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMC6

Additional cDNA sequence:

AB002405.2 AK021738.1 AK074065.1 AK096076.1 AK303165.1 AK303584.1 AK310734.1 AY057379.1

AY099356.1 AY099357.1 AY236496.1 BC007766.1 BC018346.1 BC023597.2 BC035648.1 BC105697.1

DQ104440.1

24/29 DOTS entries (see all 29):

DT.100038896 DT.212556 DT.100038901 DT.86856226 DT.100787279 DT.92432484 DT.100692092 DT.121009547

DT.100038899 DT.100787285 DT.100038898 DT.95198569 DT.91650003 DT.100038897 DT.91805707 DT.95245867

DT.95340056 DT.100035410 DT.91754331 DT.100787282 DT.100812189 DT.121009548 DT.121009571 DT.121009596

24/244 AceView cDNA sequences (see all 244):

BG744104 BM854639 CA308911 BQ705911 BU146412 BQ711012 BQ682678 BQ957570

BM756205 AW291188 BE048247 BU146939 CR596410 BU689228 CB529021 AK096076

BX376133 AB002405 BM822951 BM563964 BE746094 BQ710978 BC023597 NM_007267

GeneLoc Exon Structure

5/19 Alternative Splicing Database (ASD) splice patterns (SP) for TMC6 (see all 19) About this scheme

ExUns:	1	^	2	^	3a	·	3b	·	3c	·	3d	·	3e	·	3f	·	3g	^	4a	·	4b	·	4c	·	4d	^	5	^	6a	·	6b	·	6c	·	6d	·	6e	^	7	^	8a	·	8b	·	8c	^	9	^	10a	·	10b	^
SP1:			-		-		-		-		-		-		-		-		-		-										-		-		-		-								-
SP2:																			-		-										-		-		-		-								-
SP3:																															-		-		-		-								-
SP4:																															-		-		-		-								-
SP5:

ExUns:	11a	·	11b	·	11c	^	12a	·	12b	^	13	^	14	^	15	^	16a	·	16b	^	17	^	18a	·	18b	^	19	^	20a	·	20b	^	21
SP1:	-								-								-						-
SP2:	-								-								-						-
SP3:	-								-								-						-
SP4:	-								-		-		-		-		-		-		-		-		-		-		-		-
SP5:									-						-		-						-

ECgene alternative splicing isoforms for TMC6

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TMC6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACGAGGCCG

About this image

TMC6 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TMC6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMC6

SOURCE GeneReport for Unigene cluster: Hs.632227

UniProtKB/Swiss-Prot: TMC6_HUMAN, Q7Z403

Tissue specificity: Expressed in placenta, prostate, testis, activated T-lymphocytes and lymphokine-activated killer

(LAK) lymphocytes

SABiosciences Custom PCR Arrays for TMC6

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMC6 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TMC6
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMC6
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMC6

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMC6

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TMC6 gene from 5/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LOC100859142¹	transmembrane channel-like protein 6-like	66.16(n) 59.37(a)		100859142 XM_003642364.1 XP_003642412.1
lizard (Anolis carolinensis)	Reptilia	TMC6⁶	--	59(a)	1 ↔ 1	2(102357259-102376620)
African clawed frog (Xenopus laevis)	Amphibia	Xl.6120²	Xenopus laevis transcribed sequence with weak similarity more	70.95(n)		BJ620886.1
zebrafish (Danio rerio)	Actinopterygii	tmc6b¹	transmembrane channel-like 6b	59.26(n) 52.44(a)		436978 NM_001002705.1 NP_001002705.1
mosquito (Anopheles gambiae)	Insecta	AgaP_AGAP000578¹	AGAP000578-PA	48.08(n) 30.41(a)		1271642 XM_310494.3 XP_310494.3

ENSEMBL Gene Tree for TMC6 (if available)
TreeFam Gene Tree for TMC6 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TMC6 gene

TMC7² TMC3² TMC2² TMC8² TMC5² TMC1² TMC4²

1 SIMAP similar gene for TMC6 using alignment to 7 protein entries: TMC6_HUMAN (see all proteins):

TMC5

TMC6 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for TMC6
PGOHUM00000243986

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs72022987^1,2	C,	--	71549471(+)	`GGCAG-/CGCCCC CCCCC`	1	--	us2k¹		0	--	--	--	--
rs55952362^1,2	C	--	71549472(+)	`GCAGCG/CCCCCC`	1	--	us2k¹		1		WA	2
rs77036372^1,2	F,	--	71549801(+)	`CAGCCA/CAAGCA`	1	--	us2k¹		1		WA	118
rs11870628^1,2	C,H,	--	71550099(+)	`CTGGCA/GTGGAG`	1	--	us2k¹		1		NA	6
rs73375756^1,2	C,	--	71550456(+)	`GCCCAG/AGGACA`	1	--	us2k¹		1		WA	2
rs76900826^1,2	F,	--	71550685(+)	`AGGGTG/CAGGCC`	1	--	us2k¹		1		WA	118
rs74660316^1,2	F,	--	71550817(+)	`GGCCTC/GAGCTG`	1	--	us2k¹		2		WA NA	238
rs743048^1,2	C,	--	71552501(+)	`CCAATC/GGGCCC`	1	--	int¹		2		WA	120
rs11869028^1,2	C,H	--	71552941(+)	`AGAGCA/GTGGCG`	1	--	int¹		1		NA	2
rs112167286^1,2	C,	--	71554080(+)	`TACCCC/TGACTC`	1	--	int¹		2		CSA WA	120

HapMap Linkage Disequilibrium report for TMC6 (76106539 - 76128488 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for TMC6
2 CNVs: 30027 49933
Human Gene Mutation Database (HGMD): TMC6

Locus Specific Mutation Databases (LSDB): TMC6

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMC6

DNA2.0 Custom Variant and Variant Library Synthesis for TMC6

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TMC6 for disorders           About GeneDecksing

OMIM gene information: 605828
OMIM disorders: 226400
UniProtKB/Swiss-Prot: TMC6_HUMAN, Q7Z403

Defects in TMC6 are a cause of epidermodysplasia verruciformis (EV) [MIM:226400]. It is a rare autosomal

recessive genodermatosis associated with a high risk of skin carcinoma that results from an abnormal susceptibility to

infection by specific human papillomaviruses. Infection leads to persistent wart-like or macular lesions

9 diseases for TMC6: About MalaCards

epidermodysplasia verruciformis squamous cell carcinoma pityriasis versicolor carcinoma

hearing loss skin carcinoma skin cancer psoriasis

prostatitis

3 diseases from the University of Copenhagen DISEASES database for TMC6:

Epidermodysplasia verruciformis Pityriasis versicolor Skin cancer

2 Novoseek disease relationships for TMC6 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
epidermodysplasia verruciformis	95.5	5	19706093 (2), 17008061 (1), 12906855 (1), 17139267 (1)
skin carcinoma	77.1	1	12812529 (1)

Human Genome Epidemiology (HuGE) Navigator: TMC6 (2 documents)

Export disorders for TMC6 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TMC6 gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with TMC6)

Utopia: connect your pdf to the dynamic
world of online information

Mutations in two adjacent novel genes are associated with epidermodysplasia verruciformis. (PubMed id 12426567)^{1, 2, 3, 9} Ramoz N.... Favre M. (2002)
Novel mutations of EVER1/TMC6 gene in a Japanese patient with epidermodysplasia verruciformis. (PubMed id 15042430)^{1, 2, 9} Tate G.... Mitsuya T. (2004)
Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis. (PubMed id 12906855)^{1, 2, 9} Kurima K.... Griffith A.J. (2003)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Identification of a novel mutation and a genetic polymorphism of EVER1 gene in two families with epidermodysplasia verruciformis. (PubMed id 17008061)^{1, 9} Zuo Y.G....Wang B. (2006)
Autosomal dominant epidermodysplasia verruciformis la cking a known EVER1 or EVER2 mutation. (PubMed id 19706093)^{1, 9} McDermott D.F....Hwang S.T. (2009)
TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins. (PubMed id 12812529)^{1, 9} Keresztes G.... Heller S. (2003)
Regulation of cellular zinc balance as a potential mechanism of EVER-mediated protection against pathogenesis by cutaneous oncogenic human papillomaviruses. (PubMed id 18158319)^{1, 9} Lazarczyk M....Favre M. (2008)
Contribution of TMC6 and TMC8 (EVER1 and EVER2) varian ts to cervical cancer susceptibility. (PubMed id 21387292)¹ Castro F.A....Pawlita M. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 11322	HGNC: 18021	AceView: EVER1	Ensembl:ENSG00000141524	euGenes: HUgn11322
ECgene: TMC6	H-InvDB: TMC6

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TMC6	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TMC6	Genetics and Cytogenetics in Oncology and Haematology
TMC6base	http://bioinf.uta.fi/TMC6base/

Intellectual Property for TMC6 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TMC6 gene:
Search GeneIP for patents involving TMC6

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for TMC6		OriGene shRNA RFP for TMC6
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMC6		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMC6
	OriGene Protein Over-expression Lysate for TMC6		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for TMC6		OriGene 3'-UTR Clone for TMC6
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMC6		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMC6
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for TMC6		OriGene Custom Protein Services for TMC6
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMC6
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMC6
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMC6
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMC6
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMC6
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMC6

	GenScript Custom Purified and Recombinant Proteins Services for TMC6		GenScript cDNA clones with any tag delivered in your preferred vector for TMC6
	GenScript Custom Assay Services for TMC6		GenScript Custom Superior Antibodies Services for TMC6
	GenScript Custom overexpressing Cell Line Services for TMC6		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in TMC6 promoter
	Search Chromatin IP Primers for TMC6
	RT² qPCR Primer Assay in human, mouse, rat TMC6
	Search GNC Networks for TMC6
	SABiosciences Custom PCR Arrays for TMC6

Search Tocris compounds for TMC6

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	TMC6 antibodies
	TMC6 proteins
	TMC6 lysates

	Search for Antibodies for TMC6 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for TMC6
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

TMC6 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for TMC6

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMC6

	SwitchGear 3'UTR luciferase reporter plasmids for TMC6
	SwitchGear Promoter luciferase reporter plasmids for TMC6

ThermoFisher Antibodies for TMC6

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMC6

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes TMC6 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

TMC6 Gene

transmembrane channel-like 6

Aliases
for TMC6 gene

Summaries
for TMC6 gene

Genomic Views
for TMC6 gene

Proteins
for TMC6 gene

Protein Domains /
Families
for TMC6 gene

Function
for TMC6 gene

Pathways & Interactions
for TMC6 gene

Drugs & Compounds
for TMC6 gene

Transcripts
for TMC6 gene

Expression
for TMC6 gene

Orthologs
for TMC6 gene

Paralogs
for TMC6 gene

Genomic Variants
for TMC6 gene

Disorders / Diseases
for TMC6 gene

Publications
for TMC6 gene

External Searches for TMC6 gene

Genome Databases showing TMC6 gene

Other Databases showing TMC6 gene

Specialized Databases showing TMC6 gene

Intellectual Property
for TMC6 gene

Products
for TMC6 gene

View Random Gene

Advanced Search

Export list of displayed genes

TMC6 Gene

transmembrane channel-like 6

Aliasesfor TMC6 gene

Summariesfor TMC6 gene

Genomic Viewsfor TMC6 gene

Proteinsfor TMC6 gene

Protein Domains /Familiesfor TMC6 gene

Functionfor TMC6 gene

Pathways & Interactionsfor TMC6 gene

Drugs & Compoundsfor TMC6 gene

Transcriptsfor TMC6 gene

Expression for TMC6 gene

Orthologsfor TMC6 gene

Paralogsfor TMC6 gene

Genomic Variantsfor TMC6 gene

Disorders / Diseasesfor TMC6 gene

Publicationsfor TMC6 gene

External Searches for TMC6 gene

Genome Databases showing TMC6 gene

Other Databases showing TMC6 gene

Specialized Databases showing TMC6 gene

Intellectual Propertyfor TMC6 gene

Productsfor TMC6 gene

View Random Gene

Aliases
for TMC6 gene

Summaries
for TMC6 gene

Genomic Views
for TMC6 gene

Proteins
for TMC6 gene

Protein Domains /
Families
for TMC6 gene

Function
for TMC6 gene

Pathways & Interactions
for TMC6 gene

Drugs & Compounds
for TMC6 gene

Transcripts
for TMC6 gene

Expression
for TMC6 gene

Orthologs
for TMC6 gene

Paralogs
for TMC6 gene

Genomic Variants
for TMC6 gene

Disorders / Diseases
for TMC6 gene

Publications
for TMC6 gene

Intellectual Property
for TMC6 gene

Products
for TMC6 gene