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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

STAT1 Gene

protein-coding GIFtS: 72
GCID: GC02M191829

signal transducer and activator of transcription 1, 91kDa

(Previous names: signal transducer and activator of transcription 1, 91kD...)

Explore 147 diseases affiliated with
STAT1 via

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Signal Transducer And Activator Of Transcription 1, 91kDa¹ ²		Signal Transducer And Activator Of Transcription 1, 91kD¹
ISGF-3¹ ²		CANDF7²
STAT91¹ ²		Signal Transducer And Activator Of Transcription 1-Alpha/Beta²
Transcription Factor ISGF-3 Components P91/P84² ³		Signal Transducer And Activator Of Transcription-1²

External Ids:	HGNC: 11362¹	Entrez Gene: 6772²	Ensembl: ENSG00000115415⁷	OMIM: 600555⁵	UniProtKB: P42224³

Export aliases for STAT1 gene to outside databases

Previous GC identifers: GC02M190028 GC02M190536 GC02M191797 GC02M192036 GC02M191659 GC02M191542 GC02M183693

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for STAT1:

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors,

STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that

translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various

ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a

variety of genes, which is thought to be important for cell viability in response to different cell stimuli and

pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. (provided by

RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: STAT1_HUMAN, P42224

Function: Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs),

cytokine KITLG/SCF and other cytokines and growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to

cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to

tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a

complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element

(ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In

response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed

IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to

drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to

KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4

Gene Wiki entry for STAT1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the STAT1 gene promoter:
STAT5B Max1 AP-1 IRF-1 S8 COMP1 FOXO1a RSRFC4 c-Myc FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): STAT1 promoter sequence

Search SABiosciences Chromatin IP Primers for STAT1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STAT1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q32.2 Ensembl cytogenetic band: 2q32.2 HGNC cytogenetic band: 2q32.2-q32.3

STAT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STAT1 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M191829: view genomic region (about GC identifiers)

Start:	191,829,084 bp from pter	End:	191,885,686 bp from pter
Size:	56,603 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: STAT1_HUMAN, P42224 (See protein sequence)

Recommended Name: Signal transducer and activator of transcription 1-alpha/beta

Size: 750 amino acids; 87335 Da

Subunit: Isoform alpha homodimerizes upon IFN-gamma induced phosphorylation. Heterodimer with STAT2 upon IFN-alpha/beta

induced phosphorylation. Interacts with NMI. Interacts with Sendai virus C', C, Y1 and Y2 proteins, Nipah virus P, V

and W proteins, and rabies virus phosphoprotein preventing activation of ISRE and GAS promoter (By similarity).

Interacts with HCV core protein; the interaction results in STAT1 degradation. Interacts with PIAS1; the interaction

requires phosphorylation on Ser-727 and inhibits STAT1 activation. Interacts with IFNAR1; the interaction requires the

phosphorylation of IFNAR1 at 'Tyr-466'. Interacts with IFNAR2. Interacts with PIAS1 (dimethylated on arginine); the

interaction results in release of STAT1 from its target gene. Interacts with SRC (By similarity). Interacts with ERBB4

(phosphorylated). Interacts with PTK2/FAK1

Subcellular location: Cytoplasm. Nucleus. Note=Translocated into the nucleus upon tyrosine phosphorylation and

dimerization, in response to IFN-gamma and signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4

3 PDB 3D structures from and Proteopedia for STAT1:

1BF5 (3D)

1YVL (3D)

2KA6 (3D)

Secondary accessions: A8K989 B2RCA0 D2KFR8 D3DPI7 Q53S88 Q53XW4 Q68D00 Q9UDL5

Alternative splicing: 2 isoforms: P42224-1 P42224-2

Explore the universe of human proteins at neXtProt for STAT1: NX_P42224

Post-translational modifications:

Phosphorylated on tyrosine and serine residues in response to a variety of cytokines/growth hormones including

IFN-alpha, IFN-gamma, PDGF and EGF. Activated KIT promotes phosphorylation on tyrosine residues and subsequent

translocation to the nucleus. Tyrosine phosphorylated in response to constitutively activated FGFR1, FGFR2, FGFR3 and

FGFR4. Upon EGF stimulation, phosphorylation on Tyr-701 (lacking in beta form) by JAK1, JAK2 or TYK2 promotes

dimerization and subsequent translocation to the nucleus. Growth hormone (GH) activates STAT1 signaling only via JAK2.

PHosphorylation on Ser-727 by several kinases including MAPK14, ERK1/2 and CAMKII on IFN-gamma stimulation, regulates

STAT1 transcriptional activity. Phosphorylation on Ser-727 promotes sumoylation though increasing interaction with

PIAS. Phosphorylation on Ser-727 by PKCdelta induces apoptosis in response to DNA-damaging agents. Phosphorylated on

tyrosine residues when PTK2/FAK1 is activated; most likely this is catalyzed by a SRC family kinase¹

Sumoylated with SUMO1, SUMO2 and SUMO3. Sumoylation is enhanced by IFN-gamma-induced phosphorylation on Ser-727, and by

interaction with PIAS proteins. Enhances the transactivation activity¹

ISGylated¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P42224

STAT1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_009330.1 NP_644671.1

ENSEMBL proteins:

ENSP00000388240 ENSP00000354394 ENSP00000386244 ENSP00000388772 ENSP00000376136

ENSP00000394512 ENSP00000376137 ENSP00000402548 ENSP00000411398 ENSP00000416019

ENSP00000438703

Reactome Protein details: P42224
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant STAT1 Protein
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 2): STAT1 OriGene Protein Over-expression Lysate (see all 3): STAT1 OriGene Custom Protein Services for STAT1
	GenScript Custom Purified and Recombinant Proteins Services for STAT1
	Novus Biologicals STAT1 Proteins Novus Biologicals STAT1 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for STAT1
	Uscn Proteins for STAT1

Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000790	nuclear chromatin	IDA	18035482
GO:0005634	nucleus	IDA	--
GO:0005654	nucleoplasm	TAS	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	IDA	--

STAT1 for ontologies About GeneDecksing

STAT1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of STAT1
	R&D Systems Antibodies for STAT1
	Cell Signaling Technology (CST) Antibodies for STAT1
	OriGene Antibodies (see all 12): STAT1 OriGene Custom Antibody Services for STAT1
	GenScript Custom Superior Antibodies Services for STAT1
	Novus Biologicals STAT1 Antibodies
	Abcam antibodies for STAT1
	Uscn Antibodies for STAT1
	ThermoFisher Antibody for STAT1

Assay Products for STAT1:

	EMD Millipore Kits and Assays for the Analysis of STAT1
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for STAT1 (see all)
	GenScript Custom Assay Services for STAT1
	Cell Signaling Technology (CST) Sandwich ELISA Kits for STAT1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for STAT1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

STAT1 for domains About GeneDecksing

5/10 InterPro domains/families (see all 10):

IPR013801 STAT_TF_DNA-bd

IPR008967 p53-like_TF_DNA-bd

IPR011992 EF-hand-like_dom

IPR013800 STAT_TF_alpha

IPR022752 STAT1_TAZ2-bd_C

Graphical View of Domain Structure for InterPro Entry P42224

ProtoNet protein and cluster: P42224

1 Blocks protein family: IPB001217 STAT protein

UniProtKB/Swiss-Prot: STAT1_HUMAN, P42224

Similarity: Belongs to the transcription factor STAT family

Similarity: Contains 1 SH2 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary: