CYBB Gene
protein-coding GIFtS: 63
GCID: GC0XP037639
|
|
cytochrome b-245, beta polypeptide(Previous name: chronic granulomatous disease )
(Previous symbol: CGD)
| |
Aliases
for CYBB gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cytochrome B-245, Beta Polypeptide1 2 | | P22 Phagocyte B-Cytochrome2 3 | | NOX21 2 3 | | Chronic Granulomatous Disease1 | | CGD1 2 5 | | AMCBX22 | | GP91-PHOX1 2 | | GP91-12 | | Cytochrome B(558) Subunit Beta2 3 | | GP91PHOX2 | | Cytochrome B558 Subunit Beta2 3 | | Cytochrome B-245 Heavy Chain2 | | Heme-Binding Membrane Glycoprotein Gp91phox2 3 | | P91-PHOX1 | | Neutrophil Cytochrome B 91 KDa Polypeptide2 3 | | EC 1.-.-.-3 | | Superoxide-Generating NADPH Oxidase Heavy Chain Subunit2 3 | | Gp91-11 | | CGD91-Phox1 | | Gp91-Phox1 | | NADPH Oxidase 22 3 | | EC 1.6.38 |
Export aliases for CYBB gene to outside databasesPrevious GC identifers: GC0XP035744 GC0XP035926 GC0XP036483 GC0XP036670 GC0XP037395 GC0XP037524 GC0XP035383 |
Summaries
for CYBB gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CYBB:
Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primarycomponent of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemicaldefects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity ofphagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles.The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliveractivated oxygen into the phagocytic vacuole. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: CY24B_HUMAN, P04839Function: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminalcomponent of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane tomolecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents ofresting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc
Gene Wiki entry for CYBB
|
Genomic Views
for CYBB gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_079573.4
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CYBB gene promoter:
PPAR-gamma1 AP-1 ATF-2 STAT3 c-Jun PPAR-gamma2 CUTL1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CYBB
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYBB |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp21.1 Ensembl cytogenetic band: Xp11.4 HGNC cytogenetic band: Xp21.1CYBB Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP037639: view genomic region
(about GC identifiers)
Start:
|
37,639,264 bp from pter |
End:
|
37,672,714 bp from pter |
Size:
|
33,451 bases |
Orientation:
|
plus strand |
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Proteins
for CYBB gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CY24B_HUMAN, P04839 (See
protein sequence)Recommended Name: Cytochrome b-245 heavy chain Size: 570 amino acids; 65336 Da
Cofactor: FAD (Probable)
Subunit: Composed of a heavy chain (beta) and a light chain (alpha). Interacts with calprotectin (S100A8/9)
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence caution: Sequence=CAA27635.1; Type=Erroneous initiation; Sequence=CAA29327.1; Type=Erroneous gene modelprediction;
1 PDB 3D structure from  and Proteopedia  for CYBB:3A1F (3D)
Secondary accessions: A8K138 Q2PP16Explore the universe of human proteins at neXtProt for CYBB: NX_P04839
Post-translational modifications:
Glycosylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P04839
4 DME Specific Peptides for CYBB (P04839)
CYBB Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_000388.2
ENSEMBL proteins: ENSP00000367851 ENSP00000441896 ENSP00000441958 Reactome Protein details: P04839
Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
CYBB for ontologies About GeneDecksing
CYBB Antibody Products:
Assay Products for CYBB: |
Protein
Domains /
Families
for CYBB gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CYBB for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry P04839ProtoNet protein and cluster: P04839 2 Blocks protein families: IPB000778 Cytochrome B-245 heavy chain signature IPB013130 Ferric reductase-like transmembrane component
UniProtKB/Swiss-Prot: CY24B_HUMAN, P04839Similarity: Contains 1 FAD-binding FR-type domainSimilarity: Contains 1 ferric oxidoreductase domain |
Function
for CYBB gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CY24B_HUMAN, P04839Function: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminalcomponent of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane tomolecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents ofresting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc Genatlas biochemistry entry for CYBB:cytochrome b-558,beta polypeptide,(91kDa,membrane bound component of the NADPH oxidasesystem,cypb245),gp91-phox,expressed in neutrophils,oxygen dependent mechanism of phagocytosis
Enzyme Numbers (IUBMB): EC 1.6.32 EC 1.-.-.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYBB (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYBB
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CYBB (NM_000397) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CYBB | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYBB |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYBB |
Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9): About this table
CYBB for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for CYBB:
Animal Models:
Mouse knock-out Cybbtm1Din for CYBB
11 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Cybb):
CYBB for phenotypes About GeneDecksing
|
Pathways & Interactions
for CYBB gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/16 super-pathways (see all 16) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | G-protein signaling_RAC1 in cellular process | | | 2 | Immune response _CCR3 signaling in eosinophils | | | 3 | Immune System | | | 4 | Insulin receptor recycling | | | 5 | G-protein signaling Regulation of RAC1 activity | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 EMD Millipore Pathways for CYBB
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CYBB
4  GeneGo (Thomson Reuters) Pathways for CYBB
2  BioSystems Pathways for CYBB
5/8 
Reactome Pathways for CYBB (see all 8)
3 
Kegg Pathways (Kegg details for CYBB):
CYBB for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CYBB
STRING Interaction
Network Preview (showing 5 interactants - click image to see 22)
5/26 Interacting proteins for CYBB (P048393 ENSP000003678514) via UniProtKB, MINT, STRING, and/or I2D (see all 26)About this table
Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I |
TAS | -- | | GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent |
TAS | -- | | GO:0006801 | superoxide metabolic process |
TAS | 12716910 | | GO:0006954 | inflammatory response |
TAS | 7719350 | | GO:0022900 | electron transport chain |
IEA | -- |
CYBB for ontologies About GeneDecksing
|
Drugs & Compounds
for CYBB gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CYBB for compounds About GeneDecksing
 Browse Tocris compounds for CYBB
3 HMDB Compounds for CYBB About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| FAD | 1H-Purin-6-amine flavin dinucleotide (see all 21) | 146-14-5 | -- | | Heme | (protoporphyrinato)iron (see all 19) | 14875-96-8 | -- | | NADPH | 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23) | 53-57-6 | -- |
10/38 Novoseek chemical compound relationships for CYBB gene (see all 38) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| nadph |
93 |
236 |
16895900 (5), 9794432 (5), 10187835 (5), 8400270 (3) (see all 99) |
| superoxide |
81.3 |
58 |
10092521 (3), 11435314 (2), 16472678 (2), 10673720 (2) (see all 43) |
| apocynin |
78.1 |
5 |
20188821 (2), 20171179 (1) |
| diphenyleneiodonium |
76.7 |
1 |
12480817 (1) |
| iodonitrotetrazolium |
61 |
3 |
15684431 (1), 10498623 (1) |
| oxygen |
60.8 |
19 |
18783311 (3), 11122248 (1), 16895900 (1), 17259440 (1) (see all 16) |
| dihydrorhodamine 123 |
59.7 |
11 |
17543165 (1), 19131770 (1), 12589359 (1), 14697745 (1) |
| nitroblue tetrazolium |
49.3 |
2 |
9737693 (1) |
| succinylacetone |
46.2 |
1 |
9933639 (1) |
| phorbol-12-myristate |
45.7 |
2 |
19028840 (1), 10187835 (1) |
Search CenterWatch for drugs/clinical trials and news about CYBB / CY24B
|
Transcripts
for CYBB gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CYBB gene: NM_000397.3 Unigene Cluster for CYBB: Cytochrome b-245, beta polypeptide Hs.292356 [show with all ESTs]Unigene Representative Sequence: NM_0003974 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000378588(uc011mke.1 uc004ddr.2 uc011mkf.1 uc011mkg.1)
ENST00000492288 ENST00000545017 ENST00000536160
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYBB (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYBB
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CYBB (NM_000397) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CYBB | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYBB |
Additional cDNA sequence: AK289753.1 AK301476.1 AK301491.1 AK304033.1 AK312929.1 BC032720.1 S67289.1 X04011.1 9 DOTS entries: DT.452942 DT.100023570 DT.86667935 DT.95243651 DT.40118023 DT.40118024 DT.95231650 DT.91747707 DT.97815018 24/142 AceView cDNA sequences (see all 142): AI284069 BC032720 AL541407 AW503342 AA259056 BX118931 AA904971 BI030731 BE502434 AA213406 CF136693 AI189931 CD370536 BX338252 CB154356 AA463492 BF902005 AW504422 CR622452 BE830747 H72222 BI910418 CR601230 AA286677
GeneLoc Exon Structure
|
Expression
for CYBB gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CYBB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTCTGGCTC
About this image
See CYBB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CYBB
SOURCE GeneReport for Unigene cluster: Hs.292356
SABiosciences Expression via Pathway-Focused PCR Arrays including CYBB:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CYBB
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CYBB | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYBB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYBB | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYBB |
Orthologs
for CYBB gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CYBB gene from 6/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
CYBB1 |
cytochrome b-245, beta polypeptide |
77.89(n)
84.74(a) |
|
418581 NM_001100286.1 NP_001093756.1 |
lizard
(Anolis carolinensis) |
Reptilia |
CYBB6 |
-- |
80(a) |
1 ↔ 1 |
3(132174675-132215448) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.199432 |
Xenopus laevis transcribed sequence with moderate similarity more |
77.9(n) |
|
CF342089.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc641442 |
hypothetical protein MGC64144 |
74.74(n) |
|
393386 BC054624.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT1G192301 |
riboflavin synthase-like protein |
48.84(n)
39.32(a) |
|
838506 NM_101781.2 NP_173357.1 |
rice
(Oryza sativa) |
Liliopsida |
Os08g04537001 |
hypothetical protein |
50.57(n)
39.31(a) |
|
4345742 NM_001068491.1 NP_001061956.1 |
ENSEMBL Gene Tree for CYBB (if available)
TreeFam Gene Tree for CYBB (if available) |
Paralogs
for CYBB gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CYBB gene
- NOX12 NOX32 NOX42 DUOX22 NOX52 DUOX12
3 SIMAP similar genes for CYBB using alignment to 4 protein entries: CY24B_HUMAN (see all proteins):NOX3 NOX1 NOX4
CYBB for paralogs About GeneDecksing
|
Genomic Variants
for CYBB gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CYBB (37639264 - 37672714 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CYBB: --
Human Gene Mutation Database (HGMD): CYBB
Locus Specific Mutation Databases (LSDB): CYBB
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CYBB |
|
Disorders
/ Diseases
for CYBB gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CYBB for disorders About GeneDecksing
OMIM gene information: 300481
OMIM disorders: 306400
UniProtKB/Swiss-Prot: CY24B_HUMAN, P04839
Defects in CYBB are a cause of granulomatous disease,chronic, X-linked (CGD) [MIM:306400]. A disordercharacterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients sufferfrom life-threatening bacterial/fungal infections Defects in CYBB are a cause of mycobacteriosis atypical X-linked type 2 (AMCBX2) [MIM:300645]. A rarecondition characterized by predisposition to illness caused by moderately virulent mycobacterial species, such asBacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulentMycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals withsusceptibility to mycobacterial infections
20/34  diseases for CYBB (see all 34): About MalaCardschronic granulomatous disease chronic granulomatous disease, x-linked diastolic heart failure ehrlichiosis
retinitis pigmentosa mycobacterial infection ectodermal dysplasia myeloid leukemia
hepatopulmonary syndrome sarcoidosis anoxia teratoma
mediastinitis hypercholesterolemia retinitis aldosteronism
liver disease atherosclerosis pulmonary disease leukemia
1 disease from the University of Copenhagen DISEASES database for CYBB:Chronic granulomatous disease 10/17 Novoseek disease relationships for CYBB gene (see all 17) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| granulomatous disease chronic |
95.8 |
87 |
10452961 (2), 12804147 (2), 15308575 (2), 8611697 (2) (see all 72) |
| single gene defects |
40.1 |
1 |
12201957 (1) |
| myeloid leukemia |
37.4 |
5 |
7759529 (1), 8234321 (1), 9083071 (1), 10187835 (1) |
| human granulocytic ehrlichiosis |
35.6 |
2 |
10754283 (1), 15618156 (1) |
| immunodeficiency |
35 |
2 |
18278805 (1), 18625437 (1) |
| genetic disorder |
23.6 |
1 |
17101097 (1) |
| vascular diseases |
22.3 |
1 |
14678249 (1) |
| atherosclerosis |
20.2 |
1 |
11914250 (1) |
| inflammation |
15.5 |
1 |
15820617 (1) |
| necrosis |
15.1 |
6 |
19714290 (1), 1714908 (1), 14769150 (1), 14967724 (1) (see all 6) |
Genatlas disease: CYBB chronic granulomatous disease,X linked
Human Genome Epidemiology (HuGE) Navigator: CYBB (11 documents)
Export disorders for CYBB gene to outside databases
|
Publications
for CYBB gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CYBB gene, integrated from 9 sources (see all 439):
(articles sorted by number of sources associating them with CYBB) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- An in-frame triplet deletion within the gp91-phox gene in an adult X- linked chronic granulomatous disease patient with residual NADPH- oxidase activity. (PubMed id 9111587)1, 2, 9 Jendrossek V.... Gahr M. (1997)
- Molecular analysis of chronic granulomatous disease caused by defects in gp91-phox. (PubMed id 9888386)1, 2, 9 Patino P.J.... Garcia de Olarte D. (1999)
- CYBB mutation analysis in X-linked chronic granulomatous disease. (PubMed id 12139950)1, 2, 9 Jirapongsananuruk O.... Fleisher T.A. (2002)
- Evidence that the product of the human X-linked CGD gene, gp91-phox, is a voltage-gated H(+) pathway. (PubMed id 10578014)1, 2, 9 Henderson L.M. and Meech R.W. (1999)
- Characterization of 11 novel mutations in the X-linked chronic granulomatous disease (CYBB gene). (PubMed id 11462241)1, 2, 9 Gerard B.... Chollet-Martin S. (2001)
- Nonhomologous recombination between the cytochrome b558 heavy chain gene (CYBB) and LINE-1 causes an X-linked chronic granulomatous disease. (PubMed id 9790760)1, 2, 9 Kumatori A....Nakamura M. (1998)
- Statistical and mutational analysis of chronic granulomatous disease in Japan with special reference to gp91-phox and p22-phox deficiency. (PubMed id 10914676)1, 2, 9 Ishibashi F.... Kanegasaki S. (2000)
- X-linked chronic granulomatous disease: mutations in the CYBB gene encoding the gp91-phox component of respiratory-burst oxidase. (PubMed id 9585602)1, 2, 9 Rae J.... Curnutte J.T. (1998)
- Genetic analysis of 13 families with X-linked chronic granulomatous disease reveals a low proportion of sporadic patients and a high proportion of sporadic carriers. (PubMed id 9667376)1, 2, 9 Ariga T.... Sakiyama Y. (1998)
- A point mutation in gp91-phox of cytochrome b558 of the human NADPH oxidase leading to defective translocation of the cytosolic proteins p47-phox and p67-phox. (PubMed id 8182143)1, 2, 9 Leusen J.H.W.... Verhoeven A.J. (1994)
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External Searches for CYBB gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing CYBB gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing CYBB gene
(According to HUGE)
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Specialized Databases showing CYBB gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for CYBB | Pharmacogenomics, SNPs, Pathways | | CYBBbase | http://bioinf.uta.fi/CYBBbase/ | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/CYBB |
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About This Section
| Patent Information for CYBB gene:
Search GeneIP for patents involving CYBB
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for CYBB gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for CYBB | | OriGene shRNA RFP for CYBB | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CYBB | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CYBB | | | OriGene Protein Over-expression Lysate for CYBB | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CYBB | | OriGene 3'-UTR Clone for CYBB | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYBB | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYBB | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CYBB | | OriGene Custom Protein Services for CYBB | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CYBB | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CYBB | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYBB | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CYBB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYBB | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYBB |
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| | | | Search Tocris compounds for CYBB |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYBB |
|  |  |  | | | | ThermoFisher Antibodies for CYBB |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYBB |
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