Aliases for XPA Gene
External Ids for XPA Gene
Previous GeneCards Identifiers for XPA Gene
This gene encodes a zinc finger protein involved in DNA excision repair. The encoded protein is part of the NER (nucleotide excision repair) complext which is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens. Mutations in this gene are associated with xeroderma pigmentosum complementation group A. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]
GeneCards Summary for XPA Gene
XPA (Xeroderma Pigmentosum, Complementation Group A) is a Protein Coding gene. Diseases associated with XPA include Xeroderma Pigmentosum, Group A and Xpa-Related Xeroderma Pigmentosum. Among its related pathways are Transcription-Coupled Nucleotide Excision Repair (TC-NER) and Chks in Checkpoint Regulation. GO annotations related to this gene include protein homodimerization activity and damaged DNA binding.
UniProtKB/Swiss-Prot for XPA Gene
Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation.