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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UGT1A9 Gene

protein-coding   GIFtS: 56
GCID: GC02P234580

UDP glucuronosyltransferase 1 family, polypeptide A9

(Previous names: UDP glycosyltransferase 1 family, polypeptide A9 )
 Explore 22 diseases affiliated with
UGT1A9 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for UGT1A9    

Aliases
for UGT1A9 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
UDP Glucuronosyltransferase 1 Family, Polypeptide A91 2     UDP-Glucuronosyltransferase 1A92 3
HLUGP41 2     UDPGT 1-92 3
LUGP41 2     EC 2.4.1.173 8
UGT1AI1 2     UDPGT2
UDP Glycosyltransferase 1 Family, Polypeptide A91 2     UGT1-92
UGT-1I2 3     UDP-Glucuronosyltransferase 1-92
UGT1-092 3     GNT13
UGT1.92 3     UGT13
UGT1I2 3     UGT1*93
UDP-Glucuronosyltransferase 1-I2 3     LugP41

External Ids:    HGNC: 125411   Entrez Gene: 546002   Ensembl: ENSG000002411197   OMIM: 6064345   UniProtKB: O606563   

Export aliases for UGT1A9 gene to outside databases

Previous GC identifers: GC02U990251 GC02P234822 GC02P234885 GC02P234369 GC02P234370 GC02P234200 GC02P234210 GC02P234220 GC02P234245 GC02P226380


Summaries
for UGT1A9 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for UGT1A9:
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small
lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites.
This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen
unique alternate first exons followed by four common exons. Four of the alternate first exons are considered
pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins
with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated
by its own promoter. The enzyme encoded by this gene is active on phenols. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: UD19_HUMAN, O60656
Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics
and endogenous compounds. This isoform has specificity for phenols

Gene Wiki entry for UGT1A9


Genomic Views
for UGT1A9 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
 Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UGT1A9 gene promoter:
         COUP-TF1   ATF-2   COUP   HNF-4alpha2   HNF-4alpha1   COUP-TF   c-Jun   PPAR-gamma2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for UGT1A9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UGT1A9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37   Ensembl cytogenetic band:  2q37.1   HGNC cytogenetic band: 2q37

UGT1A9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UGT1A9 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P234580:  view genomic region     (about GC identifiers)

Start:
 234,580,499 bp from pter      End:
 234,681,951 bp from pter
Size:
 101,453 bases      Orientation:
 plus strand

Proteins
for UGT1A9 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: UD19_HUMAN, O60656 (See protein sequence)
Recommended Name: UDP-glucuronosyltransferase 1-9 precursor  
Size: 530 amino acids; 59941 Da
Subcellular location: Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein (Potential)
Sequence caution: Sequence=AAB19791.2; Type=Frameshift; Positions=59, 82;
Secondary accessions: P36509 Q9HAX0
Alternative splicing: 1 isoform:  O60656-1   

Explore the universe of human proteins at neXtProt for UGT1A9: NX_O60656

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O60656

    • 4/24 DME Specific Peptides for UGT1A9 (O60656) (see all 24)
     PEVSWQL  FWVEFVM  WLLRTDF  QYHSLDV 

    UGT1A9 Protein expression data from MOPED and PaxDb:    About this image 
    UGT1A9 Protein Expression
    REFSEQ proteins: NP_066307.1  
    ENSEMBL proteins: 
     ENSP00000346768  
    Reactome Protein details: O60656
    Human Recombinant Protein Products for UGT1A9: 
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    Novus Biologicals UGT1A9 Proteins
    Novus Biologicals UGT1A9 Lysates
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    Uscn Proteins for UGT1A9

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0005792microsome ----
    GO:0016021integral to membrane IEA--
    GO:0043231intracellular membrane-bounded organelle NAS--

    UGT1A9 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for UGT1A9

    Protein Domains /
    Families
    for UGT1A9 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    UGT1A9 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR002213 UDP_glucos_trans

    Graphical View of Domain Structure for InterPro Entry O60656

    ProtoNet protein and cluster: O60656

    1 Blocks protein family: IPB002213 UDP-glucoronosyl/UDP-glucosyl transferase

    UniProtKB/Swiss-Prot: UD19_HUMAN, O60656
    Similarity: Belongs to the UDP-glycosyltransferase family


    Function
    for UGT1A9 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UD19_HUMAN, O60656
    Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics
    and endogenous compounds. This isoform has specificity for phenols
    Catalytic activity: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

         Enzyme Number (IUBMB): EC 2.4.1.171 2

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001972retinoic acid binding IDA--
    GO:0004857enzyme inhibitor activity IDA--
    GO:0015020glucuronosyltransferase activity IDA--
    GO:0019899enzyme binding IDA--
    GO:0042803protein homodimerization activity IPI--
         
    UGT1A9 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for UGT1A9:
     Increased HPV18 LCR reporter a 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for UGT1A9 

    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate UGT1A9:
    hsa-miR-1260b hsa-miR-616* hsa-miR-371-5p hsa-miR-1260 hsa-miR-373*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UGT1A9 (see all 7)
    OriGene shRNA RFP: UGT1A9
    OriGene siRNA: UGT1A9
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    Sirion Biotech Custom design and validation of potent shRNA sequences against UGT1A9 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for UGT1A9
    Sirion Biotech Customized adenovirus for overexpression of UGT1A9 
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UGT1A9 (see all 3)
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    Cell Line
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UGT1A9


    Pathways & Interactions
    for UGT1A9 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/19 super-pathways (see all 19) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Glucuronidation
    		Glucuronidation1.00
    		Porphyrin and chlorophyll metabolism0.38
    		Glucuronidation0.67
    		Other types of O-glycan biosynthesis0.36
    		Starch and sucrose metabolism0.42
    		Drug metabolism - other enzymes0.32
    2Irinotecan Pathway, Pharmacokinetics
    		Irinotecan Pathway, Pharmacokinetics1.00
    		Irinotecan Pathway, Pharmacodynamics0.50
    		Irinotecan Pathway0.73
    		Mycophenolic acid Pathway, Pharmacokinetics0.50
    3Acetaminophen Pathway, Pharmacokinetics
    		Pathway_PA165986194 -need delete1.00
    		Acetaminophen metabolism0.43
    		Acetaminophen Pathway, Pharmacokinetics1.00
    		Acetaminophen metabolism0.43
    4Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    		Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)1.00
    		Fatty acid, triacylglycerol, and ketone body metabolism0.52
    		PPARA Activates Gene Expression0.74
    5Metabolism
    		Metabolism1.00
    		Metabolism of lipids and lipoproteins0.34
    		Metabolic pathways0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 EMD Millipore Pathways for UGT1A9
        2-Naphthylamine and 2-Nitronaphtalene metabolism
    Acetaminophen metabolism
    Benzo[a]pyrene metabolism


    3 GeneGo (Thomson Reuters) Pathways for UGT1A9
        2-Naphthylamine and 2-Nitronaphtalene metabolism
    Benzo[a]pyrene metabolism
    Acetaminophen metabolism

    5/6 BioSystems Pathways for UGT1A9 (see all 6) 
        Glucuronidation
    Irinotecan Pathway
    Nicotine metabolism
    Estrogen metabolism
    Arylamine metabolism

    5/9        Reactome Pathways for UGT1A9 (see all 9)
        Metabolism
    Expression of UGT1A9
    Fatty acid, triacylglycerol, and ketone body metabolism
    Glucuronidation
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)

    5/12 PharmGKB Pathways for UGT1A9 (see all 12)
        Acetaminophen Pathway, Pharmacokinetics
    Artemisinin and Derivatives Pathway, Pharmacokinetics
    Benzodiazepine Pathway, Pharmacokinetics
    Estrogen Metabolism Pathway
    Irinotecan Pathway, Pharmacodynamics

    5/11         Kegg Pathways  (Kegg details for UGT1A9) (see all 11):
        Pentose and glucuronate interconversions
    Ascorbate and aldarate metabolism
    Steroid hormone biosynthesis
    Starch and sucrose metabolism
    Other types of O-glycan biosynthesis


    UGT1A9 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UGT1A9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/56 Interacting proteins for UGT1A9 (ENSP000003467684) via UniProtKB, MINT, STRING, and/or I2D (see all 56)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADH1BENSP000003066064STRING: ENSP00000306606
    ADH4ENSP000002655124STRING: ENSP00000265512
    AKR1C4ENSP000002631264STRING: ENSP00000263126
    ALDH1A1ENSP000002977854STRING: ENSP00000297785
    BLVRAENSP000002655234STRING: ENSP00000265523
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006805xenobiotic metabolic process IDA1910331
    GO:0008152metabolic process NAS--
    GO:0017144drug metabolic process IDA--
    GO:0042573retinoic acid metabolic process IC--
    GO:0043086negative regulation of catalytic activity IDA--

    UGT1A9 for ontologies           About GeneDecksing



    Drugs & Compounds
    for UGT1A9 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    UGT1A9 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UGT1A9

    10/87 HMDB Compounds for UGT1A9 (see all 87)    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acidIbuprofen acyl glucuronide;(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[2-[4-(2-methylpropyl)phenyl]propanoyloxy]oxane-2-carboxylic acid (see all 5)115075-59-715843492
    Acetaminophen glucuronide4-acetamidophenyl b-D-glucopyranosiduronic acid (see all 8)16110-10-411714888
    Ethyl glucuronide 17685-04-016139098
    Hydroxycotinine(3R-trans)-3-hydroxy-1-methyl-5-(3-pyridinyl)-2-Pyrrolidinone (see all 5)34834-67-815470160
    Ketoprofen glucuronide1-(3-benzoyl-alpha-methylbenzeneacetate) beta-D-glucopyranuronic acid (see all 4)76690-94-315843492
    Nicotine glucuronide(S)-1-alpha-D-glucopyranuronosyl-3-(1-methyl-2-pyrrolidinyl)-Pyridinium inner salt (see all 11)152306-59-714570768
    Retinyl beta-glucuronideRetinyl b-glucuronide (see all 2)--8600986
    Valproic acid glucuronide1-(2-propylpentanoate) beta-D-Glucopyranuronate (see all 18)60113-83-912732356
    (23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)(23S)-23,25-dihydroxy-24-oxovitamin D3 23-(beta-glucuronide) (see all 5)----
    1-Salicylate glucuronide1-salicylic acid glucuronide ----

    10/23 DrugBank Compounds for UGT1A9 (see all 23)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    EntacaponeEntacapona [INN-Spanish] (see all 3)130929-57-6enzymesubstrate12435745 15802387 11038168
    Sorafenib-- 284461-73-0enzymesubstrate20706860 19228077 19733976
    Mycophenolic acid-- 24280-93-1enzymesubstrate21123165 15470161
    Propofol2,6-Diisopropylphenol (see all 2)2078-54-8enzymesubstrate18816295 19515014
    Troglitazone-- 97322-87-7enzymesubstrate12433820 12582161
    BuprenorphineBuprenophine (see all 4)52485-79-7enzymesubstrate19515014
    Etodolac-- 41340-25-4enzymesubstrate19515014
    FlurbiprofenFLP (see all 5)5104-49-4enzymesubstrate19515014
    Haloperidol-- 52-86-8enzymesubstrate19515014
    Human Serum Albumin-- 9048-49-1enzymeinducer18362158

    10/38 Novoseek chemical compound relationships for UGT1A9 gene (see all 38)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    n-hydroxy-n'-acetylbenzidine 84.5 1 10506112 (1)
    sn38 glucuronide 82.5 2 12944498 (1), 16595709 (1)
    glucuronide 81.7 6 9762354 (1), 17359941 (1), 12582161 (1), 10051052 (1) (see all 6)
    uridine diphosphate 81.7 4 17924828 (1), 12201491 (1), 19644937 (1), 18816295 (1)
    mycophenolic acid 80.2 58 17529886 (4), 17924828 (4), 16198654 (3), 17339869 (3) (see all 16)
    sn 38 79.7 8 12944498 (2), 16595709 (2), 20196838 (1)
    n-acetylbenzidine 76.7 1 10506112 (1)
    n-hydroxy phip 76.1 5 11375903 (1), 11408353 (1)
    4-methylumbelliferone 70.3 7 10220484 (1), 16545899 (1), 16278927 (1), 19850672 (1) (see all 5)
    irinotecan 70.1 13 15709193 (2), 12944498 (2), 15864130 (2), 12730278 (1) (see all 10)

    2 PharmGKB related drug/compound annotations for UGT1A9 gene    About this table
    Drug/compound PharmGKB Annotation
    propofolCA  
    valproic acidCA  
    Search CenterWatch for drugs/clinical trials and news about UGT1A9 / UD19 

    Transcripts
    for UGT1A9 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for UGT1A9 gene: 
    NM_021027.2  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000354728(uc010zmw.1 uc002vus.3)

    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate UGT1A9:
    hsa-miR-1260b hsa-miR-616* hsa-miR-371-5p hsa-miR-1260 hsa-miR-373*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UGT1A9 (see all 7)
    OriGene shRNA RFP: UGT1A9
    OriGene siRNA: UGT1A9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UGT1A9
    Sirion Biotech Custom design and validation of potent shRNA sequences against UGT1A9 
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UGT1A9
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    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UGT1A9
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    24/271 AceView cDNA sequences (see all 271):

    BM829535 BG165230 AI767337 BE464379 NM_019076 NM_021027 AI479279 AY435143 
    NM_019077 BI764371 AY435140 NM_019075 NM_205862 AY435137 NM_001072 BE463503 
    NM_007120 AY435136 NM_019078 CB157019 BE464186 NM_000463 AI701383 AV660038 

    GeneLoc Exon Structure


    Expression
    for UGT1A9 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UGT1A9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --
    UGT1A9 Expression
    About this image
    See UGT1A9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UGT1A9

    UniProtKB/Swiss-Prot: UD19_HUMAN, O60656
    Tissue specificity: Liver

        SABiosciences Expression via Pathway-Focused PCR Array including UGT1A9: 
              Drug Metabolism: Phase II Enzymes in human mouse rat

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    Orthologs
    for UGT1A9 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for UGT1A9 gene from 3/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves F1P1M7_CHICK6
    --
    (see all 5)    		 Uncharacterized protein
    (see all 5)    		 58(a)
    47(a)
    (see all 5)    		 possible ortholog
    possible ortholog
    (see all 5)    		 7(5795449-5817899)
    7(5844610-5845328)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    UGT1A66
    (see all 3)    		 --
    		 56(a)
    43(a)
    (see all 3)    		 possible ortholog
    possible ortholog
    (see all 3)    		 1(118894319-118901649)
    1(118848249-118849106)
    zebrafish
    (Danio rerio)    		 Actinopterygii ugt1ab6
    ugt1b46
    		 UDP glucuronosyltransferase 1 family a, b
    UDP glucuronosyltransferase 1 family, polypeptide ...
    		 50(a)
    46(a)
    		 many ↔ many
    many ↔ many
    		 9(10194767-10228512)
    11(31171792-31204741)


    ENSEMBL Gene Tree for UGT1A9 (if available)
    TreeFam Gene Tree for UGT1A9 (if available) 

    Paralogs
    for UGT1A9 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UGT1A9 gene
    UGT1A81 2  UGT1A71 2  UGT1A101 2  UGT2A22  UGT3A12  UGT2B72  UGT2B112  UGT1A32  
    UGT1A12  UGT1A52  UGT3A22  UGT2B102  UGT1A62  UGT82  UGT2B152  UGT2B42  
    UGT2B172  UGT2A32  UGT2B282  UGT1A42  
    18/30 SIMAP similar genes for UGT1A9 using alignment to 8 protein entries:     UD19_HUMAN (see all proteins) (see all similar genes):
    UGT1A9S    UGT1A8S    UGT1A10    UGT1J    UGT1A8    UGT1A3S
    UGT1H    UGT1A7    UGT1G    UGT1A6    BILIQTL1    UGT1A1
    UGT1A6S    UGT1    UGT1A4S    UGT2A3    UGT1A4    UGT1A3

    UGT1A9 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for UGT1A9
    PGOHUM00000241147


    Genomic Variants
    for UGT1A9 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 10 variations for UGT1A9
         10 CNVs: 90342 90341 61892 35795 50416 39282 37520 39281 63332 90340
    Human Gene Mutation Database (HGMD): UGT1A9
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    Disorders / Diseases
    for UGT1A9 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    UGT1A9 for disorders           About GeneDecksing

    OMIM gene information: 606434    OMIM disorders: --

    20/22 diseases for UGT1A9 (see all 22):    About MalaCards
    crigler-najjar syndrome    crigler najjar syndrome, type 2    neonatal jaundice    kawasaki disease
    gilbert syndrome    kernicterus    hearing loss    hepatitis c
    hepatocellular carcinoma    jaundice    neutropenia    colorectal cancer
    breast cancer    liver disease    hepatitis    colon cancer
    carcinoma    pancreatic cancer    lung cancer    pancreatitis

    7 Novoseek disease relationships for UGT1A9 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatitis autoimmune 21.8 1 11343231 (1)
    cancer 13.8 6 12730278 (2), 17406868 (2), 17700594 (1), 16595709 (1)
    colorectal cancer 7.4 2 15709193 (1), 19364970 (1)
    colon carcinoma 6.96 1 10220484 (1)
    breast cancer 0 1 18430559 (1)
    hepatocellular carcinoma 0 1 11677206 (1)
    hepatitis c 0 1 11343231 (1)

    Genetic Association Database (GAD): UGT1A9
    Human Genome Epidemiology (HuGE) Navigator: UGT1A9 (53 documents)

    Export disorders for UGT1A9 gene to outside databases

    Publications
    for UGT1A9 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UGT1A9 gene, integrated from 9 sources (see all 235):
    (articles sorted by number of sources associating them with UGT1A9)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and stable expression of a new member of the human liver phenol/bilirubin: UDP-glucuronosyltransferase cDNA family. (PubMed id 1910331)1, 2, 3 Wooster R....Burchell B. (1991)
    2. Identification of common polymorphisms in the promoter of the UGT1A9 gene: evidence that UGT1A9 protein and activity levels are strongly genetically controlled in the liver. (PubMed id 15284532)1, 4, 9 Girard H.... Guillemette C. (2004)
    3. N-Glycosylation plays a role in protein folding of hu man UGT1A9. (PubMed id 19951703)1, 2, 9 Nakajima M....Yokoi T. (2010)
    4. Effect of D256N and Y483D on propofol glucuronidation by human uridine 5'-diphosphate glucuronosyltransferase (UGT1A9). (PubMed id 18816295)1, 7, 9 Takahashi H....Takeuchi Y. (2008)
    5. The impact of uridine diphosphate-glucuronosyltransferase 1A9 (UGT1A9) gene promoter region single-nucleotide polymorphisms T-275A and C-2152T on early mycophenolic acid dose-interval exposure in de novo renal allograft recipients. (PubMed id 16198654)1, 4, 9 Kuypers D.R....Vanrenterghem Y. (2005)
    6. A novel polymorphism in the promoter region of human UGT1A9 gene (UGT1A9*22) and its effects on the transcriptional activity. (PubMed id 15115919)1, 4, 9 Yamanaka H....Yokoi T. (2004)
    7. The UDP-glucuronosyltransferase 1A9 enzyme is a peroxisome proliferator-activated receptor alpha and gamma target gene. (PubMed id 12582161)1, 7, 9 Barbier O....Staels B. (2003)
    8. Characterization of common UGT1A8, UGT1A9, and UGT2B7 variants with different capacities to inactivate mutagenic 4-hydroxylated metabolites of estradiol and estrone. (PubMed id 16397224)1, 4, 9 Thibaudeau J....Guillemette C. (2006)
    9. Influence of genetic variants in UGT1A1 and UGT1A9 on the in vivo glucuronidation of SN-38. (PubMed id 15286088)1, 4, 9 Paoluzzi L....Sparreboom A. (2004)
    10. UGT1A7 and UGT1A9 polymorphisms predict response and toxicity in colorectal cancer patients treated with capecitabine/irinotecan. (PubMed id 15709193)1, 4, 9 Carlini L.E....Blanchard R.L. (2005)

    External Searches for UGT1A9 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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    OMIM
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    Genome Databases showing UGT1A9 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54600 HGNC: 12541 AceView: UGT1A1 Ensembl:ENSG00000241119 euGenes: HUgn54600
    ECgene: UGT1A9 Kegg: 54600 H-InvDB: UGT1A9

    Other Databases showing UGT1A9 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing UGT1A9 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UGT1A9 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for UGT1A9 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for UGT1A9 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for UGT1A9 gene:
    Search GeneIP for patents involving UGT1A9

    GeneCards and IP:
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