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Aliases for UGT1A8 Gene

Aliases for UGT1A8 Gene

  • UDP Glucuronosyltransferase Family 1 Member A8 2 3
  • UDP Glucuronosyltransferase 1 Family, Polypeptide A8 3 5
  • UDP Glycosyltransferase 1 Family, Polypeptide A8 2 3
  • UDP-Glucuronosyltransferase 1-H 3 4
  • UDP-Glucuronosyltransferase 1A8 3 4
  • EC 2.4.1.17 4 63
  • UDPGT 1-8 3 4
  • UGT1-08 3 4
  • UGT-1H 3 4
  • UGT1.8 3 4
  • UGT1H 3 4
  • UDP-Glucuronosyltransferase 1 Family Polypeptide A8s 3
  • UGT1A8S 3
  • UGT1*8 4
  • UDPGT 3
  • UGT1 4
  • GNT1 4

External Ids for UGT1A8 Gene

Previous GeneCards Identifiers for UGT1A8 Gene

  • GC02P232535
  • GC02U900011
  • GC02P234821
  • GC02P234884
  • GC02P234308
  • GC02P234199
  • GC02P234207
  • GC02P234213
  • GC02P234219
  • GC02P234225
  • GC02P234227
  • GC02P234526
  • GC02P226326

Summaries for UGT1A8 Gene

Entrez Gene Summary for UGT1A8 Gene

  • This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity with many substrates including coumarins, phenols, anthraquinones, flavones, and some opioids. [provided by RefSeq, Jul 2008]

GeneCards Summary for UGT1A8 Gene

UGT1A8 (UDP Glucuronosyltransferase Family 1 Member A8) is a Protein Coding gene. Diseases associated with UGT1A8 include pericholangitis and cholelithiasis. Among its related pathways are Metabolism and Phase II conjugation. GO annotations related to this gene include protein homodimerization activity and enzyme binding. An important paralog of this gene is UGT2B15.

UniProtKB/Swiss-Prot for UGT1A8 Gene

  • UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.

Gene Wiki entry for UGT1A8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UGT1A8 Gene

Genomics for UGT1A8 Gene

Regulatory Elements for UGT1A8 Gene

Genomic Location for UGT1A8 Gene

Chromosome:
2
Start:
233,617,645 bp from pter
End:
233,773,310 bp from pter
Size:
155,666 bases
Orientation:
Plus strand

Genomic View for UGT1A8 Gene

Genes around UGT1A8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UGT1A8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UGT1A8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGT1A8 Gene

Proteins for UGT1A8 Gene

  • Protein details for UGT1A8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HAW9-UD18_HUMAN
    Recommended name:
    UDP-glucuronosyltransferase 1-8
    Protein Accession:
    Q9HAW9
    Secondary Accessions:
    • B2R8S3
    • B8K290
    • O14928
    • Q8TEX4
    • Q8WTQ9
    • Q8WX85

    Protein attributes for UGT1A8 Gene

    Size:
    530 amino acids
    Molecular mass:
    59742 Da
    Quaternary structure:
    • Isoform 1 interacts with isoform 2/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 2. Isoform 1 also interacts with respective i2 isoforms of UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A9 and UGT1A10.
    Miscellaneous:
    • The gene is part of the UGT1A complex locus which displays alternative use of promoters, first exons and terminal exons. The locus is defined by 13 first exons, which are alternatively spliced to 3 other common exons and 2 alternative terminal exons 5. From the 27 possible mRNA isoforms, 9 produce functionally active polypeptides (UGT1A1, 1A3, 1A4, 1A5, 1A6, 1A7, 1A8, 1A9 and 1A10) called isoforms 1 (i1). Use of an alternative exon 5 (5b) as terminal exon is leading to 9 additional alternatively spliced products termed isoforms i2 and which lack transferase activity.

    Alternative splice isoforms for UGT1A8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UGT1A8 Gene

Proteomics data for UGT1A8 Gene at MOPED

Post-translational modifications for UGT1A8 Gene

  • Glycosylation at Asn 71, Asn 292, and Asn 344
  • Modification sites at PhosphoSitePlus

Other Protein References for UGT1A8 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for UGT1A8 Gene

Gene Families for UGT1A8 Gene

Protein Domains for UGT1A8 Gene

Graphical View of Domain Structure for InterPro Entry

Q9HAW9

UniProtKB/Swiss-Prot:

UD18_HUMAN :
  • Belongs to the UDP-glycosyltransferase family.
Family:
  • Belongs to the UDP-glycosyltransferase family.
genes like me logo Genes that share domains with UGT1A8: view

Function for UGT1A8 Gene

Molecular function for UGT1A8 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
UniProtKB/Swiss-Prot Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.

Enzyme Numbers (IUBMB) for UGT1A8 Gene

Gene Ontology (GO) - Molecular Function for UGT1A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001972 retinoic acid binding IC 20308471
GO:0015020 NOT glucuronosyltransferase activity IGI,IDA 20610558
genes like me logo Genes that share ontologies with UGT1A8: view

Phenotypes for UGT1A8 Gene

GenomeRNAi human phenotypes for UGT1A8:
genes like me logo Genes that share phenotypes with UGT1A8: view

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UGT1A8 Gene

Localization for UGT1A8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGT1A8 Gene

Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UGT1A8 Gene COMPARTMENTS Subcellular localization image for UGT1A8 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 2
nucleus 2
lysosome 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for UGT1A8 Gene

Pathways & Interactions for UGT1A8 Gene

genes like me logo Genes that share pathways with UGT1A8: view

Interacting Proteins for UGT1A8 Gene

Gene Ontology (GO) - Biological Process for UGT1A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006631 fatty acid metabolic process IDA 20610558
GO:0008152 metabolic process IEA --
GO:0017144 NOT drug metabolic process IDA 20610558
GO:0043086 negative regulation of catalytic activity IDA 19996319
GO:0051552 flavone metabolic process IDA 18052087
genes like me logo Genes that share ontologies with UGT1A8: view

No data available for SIGNOR curated interactions for UGT1A8 Gene

Drugs & Compounds for UGT1A8 Gene

(29) Drugs for UGT1A8 Gene - From: HMDB, PharmGKB, DrugBank, Novoseek, and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Mycophenolate mofetil Approved, Investigational Pharma Enzyme, substrate IMPDH inhibitor 898
Morphine Approved, Investigational Pharma Full agonist, Agonist, Enzyme, substrate 855
Valproic Acid Approved, Investigational Pharma Enzyme, substrate HDAC1 inhibitor, Histone deacetylase (HDAC)inhibitors 311
Diflunisal Approved Pharma Enzyme, substrate 4
Propofol Approved, Investigational Pharma Enzyme, substrate 931

(86) Additional Compounds for UGT1A8 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)
  • (23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronoside)
  • (23S)-23,25-dihydroxy-24-oxocholecalciferol 23-(beta-glucuronide)
  • (23S)-23,25-dihydroxy-24-oxovitamin D3 23-(beta-glucuronide)
  • (5Z,7E)-(3S,23S)-24-oxo-9,10-seco-5,7,10(19)-cholestatriene-3,23,25-triol 23-D-glucuronide
  • (5Z,7E)-(3S,23S)-24-oxo-9,10-seco-5,7,10(19)-cholestatriene-3,23,25-triol 23-delta-glucuronide
1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acid
  • (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[2-[4-(2-methylpropyl)phenyl]propanoyloxy]oxane-2-carboxylic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) b-D-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) b-delta-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) beta-D-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) beta-delta-Glucopyranuronic acid
115075-59-7
11-beta-Hydroxyandrosterone-3-glucuronide
  • 11-beta-Hydroxyetiocholanolone-3-glucuronide
  • 11beta-hydroxyandrosterone 3-glucuronide
11-Hydroxyprogesterone 11-glucuronide
  • 11-Hpg
  • 11-Hydroxyprogesterone 11-glucuronoside
  • 11alpha-Glucuronylprogesterone
  • 11alpha-Hydroxyprogesterone 11-glucuronide
  • 11alpha-Hydroxyprogesterone 11-glucuronoside
77710-64-6
11-Oxo-androsterone glucuronide
  • 11-Oxo-etiocholanolone glucuronide
  • 11-Oxoandrosterone glucuronide
  • 11-Oxoetiocholanolone glucuronide
genes like me logo Genes that share compounds with UGT1A8: view

Transcripts for UGT1A8 Gene

mRNA/cDNA for UGT1A8 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for UGT1A8 Gene

No ASD Table

Relevant External Links for UGT1A8 Gene

GeneLoc Exon Structure for
UGT1A8
ECgene alternative splicing isoforms for
UGT1A8

Expression for UGT1A8 Gene

mRNA expression in normal human tissues for UGT1A8 Gene

mRNA differential expression in normal tissues according to GTEx for UGT1A8 Gene

This gene is overexpressed in Liver (x49.3).

mRNA Expression by UniProt/SwissProt for UGT1A8 Gene

Q9HAW9-UD18_HUMAN
Tissue specificity: Colon specific. Isoform 1 and 2 are expressed in liver, kidney, colon and small intestine; isoform 2 but not isoform 1 is expressed in liver (PubMed:18004212).
genes like me logo Genes that share expression patterns with UGT1A8: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for UGT1A8 Gene

Orthologs for UGT1A8 Gene

This gene was present in the common ancestor of animals.

Orthologs for UGT1A8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UGT1A1 36
  • 87 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UGT1A6 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ugt1a1 36
  • 78 (a)
OneToOne
Ugt1a9 35
  • 80.59 (n)
  • 80.08 (a)
oppossum
(Monodelphis domestica)
Mammalia UGT1A1 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 66 (a)
OneToMany
-- 36
  • 53 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ugt1a8 35
  • 81.57 (n)
  • 79.43 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 64 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.15808 35
zebrafish
(Danio rerio)
Actinopterygii fads2 35
ugt1a7 36
  • 49 (a)
ManyToMany
ugt1b1 36
  • 48 (a)
ManyToMany
ugt1b2 36
  • 45 (a)
ManyToMany
ugt1b3 36
  • 46 (a)
ManyToMany
ugt1b4 36
  • 46 (a)
ManyToMany
ugt1b5 36
  • 46 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta BEST:GH06505 37
  • 28 (a)
BEST:GH09393 37
  • 31 (a)
CG10170 37
  • 24 (a)
CG10178 37
  • 26 (a)
CG11289 37
  • 35 (a)
CG16732 37
  • 25 (a)
CG17323 37
  • 27 (a)
CG5724 37
  • 27 (a)
CG6475 37
  • 32 (a)
Dot 37
  • 25 (a)
Ugt36Ba 37
  • 28 (a)
Ugt36Bb 37
  • 29 (a)
Ugt37b1 37
  • 27 (a)
Ugt37c1 37
  • 30 (a)
Ugt86Da 37
  • 33 (a)
Ugt86Dc 37
  • 34 (a)
Ugt86De 37
  • 30 (a)
Ugt86Dh 37
  • 27 (a)
Ugt86Di 37
  • 33 (a)
worm
(Caenorhabditis elegans)
Secernentea AC3.2 37
  • 25 (a)
AC3.8 37
  • 22 (a)
C08B6.1 37
  • 25 (a)
C08F11.8 37
  • 26 (a)
C10H11.4 37
  • 24 (a)
C10H11.5 37
  • 26 (a)
C10H11.6 37
  • 24 (a)
C17G1.3 37
  • 24 (a)
C33A12.6 37
  • 24 (a)
C49A9.8 37
  • 24 (a)
F01D4.1 37
  • 23 (a)
F01D4.2 37
  • 22 (a)
F09G2.6 37
  • 25 (a)
F39G3.1 37
  • 28 (a)
K08B4.4 37
  • 23 (a)
M88.1 37
  • 28 (a)
T01G5.2 37
  • 25 (a)
Y37E11AR.5 37
  • 26 (a)
ZC443.5 37
  • 27 (a)
ZC455.3 37
  • 22 (a)
Species with no ortholog for UGT1A8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for UGT1A8 Gene

ENSEMBL:
Gene Tree for UGT1A8 (if available)
TreeFam:
Gene Tree for UGT1A8 (if available)

Paralogs for UGT1A8 Gene

genes like me logo Genes that share paralogs with UGT1A8: view

Variants for UGT1A8 Gene

Sequence variations from dbSNP and Humsavar for UGT1A8 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_015543 -
VAR_015544 -
rs1042597 -, - 233,618,225(+) AATAG(C/G/T)TTGCC reference, missense
VAR_015546 -
VAR_015547 -

Structural Variations from Database of Genomic Variants (DGV) for UGT1A8 Gene

Variant ID Type Subtype PubMed ID
nsv876013 CNV Gain 21882294
nsv7336 OTHER Inversion 18451855
nsv876014 CNV Gain 21882294
nsv876015 CNV Loss 21882294
esv2721663 CNV Deletion 23290073
esv2721664 CNV Deletion 23290073
esv2657145 CNV Deletion 23128226
esv22295 CNV Loss 19812545
esv2721665 CNV Deletion 23290073
esv24647 CNV Gain 19812545
esv2721666 CNV Deletion 23290073
nsv876016 CNV Gain 21882294
nsv876017 CNV Loss 21882294
esv2721667 CNV Deletion 23290073
nsv3215 CNV Loss 18451855
esv2721668 CNV Deletion 23290073
esv2661542 CNV Deletion 23128226
esv25622 CNV Loss 19812545
nsv498958 CNV Loss 21111241
dgv769e199 CNV Deletion 23128226
nsv433211 CNV Loss 18776910
esv2422005 CNV Deletion 20811451
nsv519815 CNV Loss 19592680
nsv514125 CNV Loss 21397061
esv8142 CNV Loss 19470904
esv2721669 CNV Deletion 23290073
nsv876018 CNV Gain 21882294

Variation tolerance for UGT1A8 Gene

Residual Variation Intolerance Score: 26.8% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UGT1A8 Gene

HapMap Linkage Disequilibrium report
UGT1A8
Human Gene Mutation Database (HGMD)
UGT1A8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UGT1A8 Gene

Disorders for UGT1A8 Gene

MalaCards: The human disease database

(4) MalaCards diseases for UGT1A8 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
pericholangitis
cholelithiasis
crigler-najjar syndrome, type i
  • crigler-najjar syndrome
bilirubin metabolic disorder
  • hereditary hyperbilirubinemia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for UGT1A8

Genetic Association Database (GAD)
UGT1A8
Human Genome Epidemiology (HuGE) Navigator
UGT1A8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UGT1A8
genes like me logo Genes that share disorders with UGT1A8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UGT1A8 Gene

Publications for UGT1A8 Gene

  1. Identification and functional characterization of UDP- glucuronosyltransferases UGT1A8*1, UGT1A8*2 and UGT1A8*3. (PMID: 12042666) Huang Y.-H. … Tukey R.H. (Pharmacogenetics 2002) 2 3 4 67
  2. Contribution of UDP-glucuronosyltransferase 1A1 and 1A8 to morphine-6-glucuronidation and its kinetic properties. (PMID: 18187562) Ohno S. … Nakajin S. (Drug Metab. Dispos. 2008) 23 25 26
  3. Troglitazone glucuronidation in human liver and intestine microsomes: high catalytic activity of UGT1A8 and UGT1A10. (PMID: 12433820) Watanabe Y. … Yokoi T. (Drug Metab. Dispos. 2002) 3 23 25
  4. Studies on the substrate specificity of human intestinal UDP- lucuronosyltransferases 1A8 and 1A10. (PMID: 10497143) Cheng Z. … Tephly T.R. (Drug Metab. Dispos. 1999) 3 25 26
  5. Modulation of the human glucuronosyltransferase UGT1A pathway by splice isoform polypeptides is mediated through protein-protein interactions. (PMID: 19996319) Bellemare J. … Guillemette C. (J. Biol. Chem. 2010) 3 23

Products for UGT1A8 Gene

Sources for UGT1A8 Gene

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