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Aliases for UGT1A8 Gene

Aliases for UGT1A8 Gene

  • UDP Glucuronosyltransferase Family 1 Member A8 2 3 5
  • UDP Glycosyltransferase 1 Family, Polypeptide A8 2 3
  • UDP-Glucuronosyltransferase 1-H 3 4
  • UDP-Glucuronosyltransferase 1A8 3 4
  • EC 4 58
  • UDPGT 1-8 3 4
  • UGT1-08 3 4
  • UGT-1H 3 4
  • UGT1.8 3 4
  • UGT1H 3 4
  • UDP Glucuronosyltransferase 1 Family, Polypeptide A8 3
  • UDP-Glucuronosyltransferase 1 Family Polypeptide A8s 3
  • UDP-Glucuronosyltransferase 1-8 3
  • UGT1A8S 3
  • UGT1*8 4
  • UDPGT 3
  • UGT1 4
  • GNT1 4

External Ids for UGT1A8 Gene

Previous GeneCards Identifiers for UGT1A8 Gene

  • GC02P232535
  • GC02U900011
  • GC02P234821
  • GC02P234884
  • GC02P234308
  • GC02P234199
  • GC02P234207
  • GC02P234213
  • GC02P234219
  • GC02P234225
  • GC02P234227
  • GC02P234526
  • GC02P226326

Summaries for UGT1A8 Gene

Entrez Gene Summary for UGT1A8 Gene

  • This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity with many substrates including coumarins, phenols, anthraquinones, flavones, and some opioids. [provided by RefSeq, Jul 2008]

GeneCards Summary for UGT1A8 Gene

UGT1A8 (UDP Glucuronosyltransferase Family 1 Member A8) is a Protein Coding gene. Diseases associated with UGT1A8 include Pericholangitis. Among its related pathways are Metabolism and Irinotecan Pathway. GO annotations related to this gene include protein homodimerization activity and enzyme binding. An important paralog of this gene is UGT1A10.

UniProtKB/Swiss-Prot for UGT1A8 Gene

  • UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.

Gene Wiki entry for UGT1A8 Gene

Additional gene information for UGT1A8 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UGT1A8 Gene

Genomics for UGT1A8 Gene

Regulatory Elements for UGT1A8 Gene

Genomic Locations for UGT1A8 Gene

Genomic Locations for UGT1A8 Gene
155,666 bases
Plus strand

Genomic View for UGT1A8 Gene

Genes around UGT1A8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UGT1A8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UGT1A8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGT1A8 Gene

Proteins for UGT1A8 Gene

  • Protein details for UGT1A8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UDP-glucuronosyltransferase 1-8
    Protein Accession:
    Secondary Accessions:
    • B2R8S3
    • B8K290
    • O14928
    • Q8TEX4
    • Q8WTQ9
    • Q8WX85

    Protein attributes for UGT1A8 Gene

    530 amino acids
    Molecular mass:
    59742 Da
    Quaternary structure:
    • Isoform 1 interacts with isoform 2/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 2. Isoform 1 also interacts with respective i2 isoforms of UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A9 and UGT1A10.
    • The gene is part of the UGT1A complex locus which displays alternative use of promoters, first exons and terminal exons. The locus is defined by 13 first exons, which are alternatively spliced to 3 other common exons and 2 alternative terminal exons 5. From the 27 possible mRNA isoforms, 9 produce functionally active polypeptides (UGT1A1, 1A3, 1A4, 1A5, 1A6, 1A7, 1A8, 1A9 and 1A10) called isoforms 1 (i1). Use of an alternative exon 5 (5b) as terminal exon is leading to 9 additional alternatively spliced products termed isoforms i2 and which lack transferase activity.

    Alternative splice isoforms for UGT1A8 Gene


neXtProt entry for UGT1A8 Gene

Selected DME Specific Peptides for UGT1A8 Gene


Post-translational modifications for UGT1A8 Gene

  • Glycosylation at Asn71, posLast=292292, and posLast=344344
  • Modification sites at PhosphoSitePlus

Other Protein References for UGT1A8 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for UGT1A8 Gene

Gene Families for UGT1A8 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for UGT1A8 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UDP-glycosyltransferase family.
  • Belongs to the UDP-glycosyltransferase family.
genes like me logo Genes that share domains with UGT1A8: view

Function for UGT1A8 Gene

Molecular function for UGT1A8 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
UniProtKB/Swiss-Prot Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.

Enzyme Numbers (IUBMB) for UGT1A8 Gene

Phenotypes From GWAS Catalog for UGT1A8 Gene

Gene Ontology (GO) - Molecular Function for UGT1A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001972 retinoic acid binding IC 20308471
GO:0004857 enzyme inhibitor activity IDA 19996319
GO:0005496 steroid binding IDA 19996319
GO:0005504 fatty acid binding IDA 19996319
GO:0015020 glucuronosyltransferase activity IDA 18052087
genes like me logo Genes that share ontologies with UGT1A8: view

Phenotypes for UGT1A8 Gene

GenomeRNAi human phenotypes for UGT1A8:
genes like me logo Genes that share phenotypes with UGT1A8: view

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UGT1A8 Gene

Localization for UGT1A8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGT1A8 Gene

Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UGT1A8 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for UGT1A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA,IEA 17179145
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IEA --
genes like me logo Genes that share ontologies with UGT1A8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for UGT1A8 Gene

Pathways & Interactions for UGT1A8 Gene

genes like me logo Genes that share pathways with UGT1A8: view

Gene Ontology (GO) - Biological Process for UGT1A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006631 fatty acid metabolic process IC 19996319
GO:0008152 metabolic process IEA --
GO:0008202 steroid metabolic process IC 19996319
GO:0009804 coumarin metabolic process IC 19996319
GO:0042573 retinoic acid metabolic process IC 20308471
genes like me logo Genes that share ontologies with UGT1A8: view

No data available for SIGNOR curated interactions for UGT1A8 Gene

Drugs & Compounds for UGT1A8 Gene

(34) Drugs for UGT1A8 Gene - From: DrugBank, PharmGKB, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Mycophenolate mofetil Approved, Investigational Pharma Enzyme, substrate IMPDH inhibitor 972
Morphine Approved, Investigational Pharma Full agonist, Agonist, Enzyme, substrate 1051
Valproic Acid Approved, Investigational Pharma Enzyme, substrate HDAC1 inhibitor, Histone deacetylase (HDAC)inhibitors 331
Diflunisal Approved Pharma Enzyme, substrate 4
Propofol Approved, Investigational, Vet_approved Pharma Enzyme, substrate 1130

(85) Additional Compounds for UGT1A8 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)
  • (23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronoside)
  • (23S)-23,25-dihydroxy-24-oxocholecalciferol 23-(beta-glucuronide)
  • (23S)-23,25-dihydroxy-24-oxovitamin D3 23-(beta-glucuronide)
  • (5Z,7E)-(3S,23S)-24-oxo-9,10-seco-5,7,10(19)-cholestatriene-3,23,25-triol 23-D-glucuronide
  • (5Z,7E)-(3S,23S)-24-oxo-9,10-seco-5,7,10(19)-cholestatriene-3,23,25-triol 23-delta-glucuronide
1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acid
  • (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[2-[4-(2-methylpropyl)phenyl]propanoyloxy]oxane-2-carboxylic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) b-D-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) b-delta-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) beta-D-Glucopyranuronic acid
  • 1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate) beta-delta-Glucopyranuronic acid
  • 11-beta-Hydroxyetiocholanolone-3-glucuronide
  • 11beta-hydroxyandrosterone 3-glucuronide
11-Hydroxyprogesterone 11-glucuronide
  • 11-Hpg
  • 11-Hydroxyprogesterone 11-glucuronoside
  • 11alpha-Glucuronylprogesterone
  • 11alpha-Hydroxyprogesterone 11-glucuronide
  • 11alpha-Hydroxyprogesterone 11-glucuronoside
11-Oxo-androsterone glucuronide
  • 11-Oxo-etiocholanolone glucuronide
  • 11-Oxoandrosterone glucuronide
  • 11-Oxoetiocholanolone glucuronide
genes like me logo Genes that share compounds with UGT1A8: view

Transcripts for UGT1A8 Gene

mRNA/cDNA for UGT1A8 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UGT1A8 Gene

No ASD Table

Relevant External Links for UGT1A8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UGT1A8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UGT1A8 Gene

mRNA differential expression in normal tissues according to GTEx for UGT1A8 Gene

This gene is overexpressed in Liver (x49.3).

NURSA nuclear receptor signaling pathways regulating expression of UGT1A8 Gene:


mRNA Expression by UniProt/SwissProt for UGT1A8 Gene:

Tissue specificity: Colon specific. Isoform 1 and 2 are expressed in liver, kidney, colon and small intestine; isoform 2 but not isoform 1 is expressed in liver (PubMed:18004212).

Evidence on tissue expression from TISSUES for UGT1A8 Gene

  • Liver(4.5)
  • Intestine(4.4)
genes like me logo Genes that share expression patterns with UGT1A8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for UGT1A8 Gene

Orthologs for UGT1A8 Gene

This gene was present in the common ancestor of animals.

Orthologs for UGT1A8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia UGT1A1 34
  • 87 (a)
(Rattus norvegicus)
Mammalia Ugt1a8 33
  • 81.57 (n)
(Mus musculus)
Mammalia Ugt1a9 33
  • 80.59 (n)
Ugt1a1 34
  • 78 (a)
(Bos Taurus)
Mammalia UGT1A6 34
  • 79 (a)
(Monodelphis domestica)
Mammalia UGT1A1 34
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 66 (a)
-- 34
  • 53 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 64 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15808 33
(Danio rerio)
Actinopterygii ugt1a7 34
  • 49 (a)
ugt1b1 34
  • 48 (a)
ugt1b3 34
  • 46 (a)
ugt1b4 34
  • 46 (a)
ugt1b5 34
  • 46 (a)
ugt1b2 34
  • 45 (a)
fads2 33
fruit fly
(Drosophila melanogaster)
Insecta CG11289 35
  • 35 (a)
Ugt86Dc 35
  • 34 (a)
Ugt86Da 35
  • 33 (a)
Ugt86Di 35
  • 33 (a)
CG6475 35
  • 32 (a)
BEST:GH09393 35
  • 31 (a)
Ugt37c1 35
  • 30 (a)
Ugt86De 35
  • 30 (a)
Ugt36Bb 35
  • 29 (a)
BEST:GH06505 35
  • 28 (a)
Ugt36Ba 35
  • 28 (a)
CG17323 35
  • 27 (a)
CG5724 35
  • 27 (a)
Ugt37b1 35
  • 27 (a)
Ugt86Dh 35
  • 27 (a)
CG10178 35
  • 26 (a)
CG16732 35
  • 25 (a)
Dot 35
  • 25 (a)
CG10170 35
  • 24 (a)
(Caenorhabditis elegans)
Secernentea F39G3.1 35
  • 28 (a)
M88.1 35
  • 28 (a)
ZC443.5 35
  • 27 (a)
C08F11.8 35
  • 26 (a)
C10H11.5 35
  • 26 (a)
Y37E11AR.5 35
  • 26 (a)
AC3.2 35
  • 25 (a)
C08B6.1 35
  • 25 (a)
F09G2.6 35
  • 25 (a)
T01G5.2 35
  • 25 (a)
C10H11.4 35
  • 24 (a)
C10H11.6 35
  • 24 (a)
C17G1.3 35
  • 24 (a)
C33A12.6 35
  • 24 (a)
C49A9.8 35
  • 24 (a)
F01D4.1 35
  • 23 (a)
K08B4.4 35
  • 23 (a)
AC3.8 35
  • 22 (a)
F01D4.2 35
  • 22 (a)
ZC455.3 35
  • 22 (a)
Species where no ortholog for UGT1A8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for UGT1A8 Gene

Gene Tree for UGT1A8 (if available)
Gene Tree for UGT1A8 (if available)

Paralogs for UGT1A8 Gene

Variants for UGT1A8 Gene

Sequence variations from dbSNP and Humsavar for UGT1A8 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs111033539 Pathogenic 233,767,160(+) TCCCT(C/T)AGACA reference, stop-gained
rs111033541 Pathogenic 233,760,331(+) GGGCC(G/T)GCTGC intron-variant, reference, missense
rs281865418 Pathogenic 233,761,127(+) AACTG(A/C/G)CTTCA intron-variant, reference, missense, stop-gained
rs28934877 Pathogenic 233,768,333(+) TGGAC(A/C/G)ATGCA reference, missense
rs34983651 Pathogenic 233,760,233(+) TTGCC(-/AT)ATATA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for UGT1A8 Gene

Variant ID Type Subtype PubMed ID
esv2762307 CNV gain 21179565
esv3561177 CNV deletion 23714750
esv3561178 CNV deletion 23714750
esv3594678 CNV loss 21293372
esv3594679 CNV loss 21293372
esv3594680 CNV loss 21293372
esv3594681 CNV gain 21293372
esv3594682 CNV loss 21293372
esv3893573 CNV gain 25118596
esv8142 CNV loss 19470904
nsv1010936 CNV loss 25217958
nsv1013712 CNV loss 25217958
nsv1126580 CNV deletion 24896259
nsv1138902 CNV deletion 24896259
nsv3215 CNV deletion 18451855
nsv433211 CNV loss 18776910
nsv498958 CNV loss 21111241
nsv514125 CNV loss 21397061
nsv519815 CNV loss 19592680
nsv584704 CNV loss 21841781
nsv584705 CNV loss 21841781
nsv7336 OTHER inversion 18451855
nsv961572 CNV duplication 23825009
nsv979187 CNV duplication 23825009
nsv979186 CNV duplication 23825009
nsv979185 CNV duplication 23825009
nsv979184 CNV duplication 23825009
nsv963782 CNV duplication 23825009
nsv963781 CNV duplication 23825009
nsv961574 CNV duplication 23825009
nsv961573 CNV duplication 23825009
esv2760615 CNV loss 21179565
esv2760613 CNV loss 21179565
esv2721669 CNV deletion 23290073
esv2721668 CNV deletion 23290073
esv2721667 CNV deletion 23290073
esv2721666 CNV deletion 23290073
esv2721665 CNV deletion 23290073
esv2721664 CNV deletion 23290073
esv2721663 CNV deletion 23290073
esv2661542 CNV deletion 23128226
esv2657145 CNV deletion 23128226
esv25622 CNV loss 19812545
esv24647 CNV gain 19812545
esv2422005 CNV deletion 20811451
esv22295 CNV loss 19812545
dgv769e199 CNV deletion 23128226

Variation tolerance for UGT1A8 Gene

Residual Variation Intolerance Score: 26.8% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UGT1A8 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UGT1A8 Gene

Disorders for UGT1A8 Gene

MalaCards: The human disease database

(1) MalaCards diseases for UGT1A8 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for UGT1A8

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with UGT1A8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UGT1A8 Gene

Publications for UGT1A8 Gene

  1. Pharmacogenetic effect of the UGT polymorphisms on mycophenolate is modified by calcineurin inhibitors. (PMID: 18568343) Johnson LA … Jacobson PA (European journal of clinical pharmacology 2008) 3 22 45 60
  2. The impact of UGT1A8, UGT1A9, and UGT2B7 genetic polymorphisms on the pharmacokinetic profile of mycophenolic acid after a single oral dose in healthy volunteers. (PMID: 17339869) Lévesque E … Guillemette C (Clinical pharmacology and therapeutics 2007) 3 22 45 60
  3. Characterization of common UGT1A8, UGT1A9, and UGT2B7 variants with different capacities to inactivate mutagenic 4-hydroxylated metabolites of estradiol and estrone. (PMID: 16397224) Thibaudeau J … Guillemette C (Cancer research 2006) 3 22 45 60
  4. Variation of hepatic glucuronidation: Novel functional polymorphisms of the UDP-glucuronosyltransferase UGT1A4. (PMID: 15057901) Ehmer U … Strassburg CP (Hepatology (Baltimore, Md.) 2004) 3 22 45 60
  5. Functional polymorphisms of UDP-glucuronosyltransferases 1A1, 1A6 and 1A8 are not involved in chronic pancreatitis. (PMID: 15247627) Verlaan M … Drenth JP (Pharmacogenetics 2004) 3 22 45 60

Products for UGT1A8 Gene

Sources for UGT1A8 Gene

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