Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UGT1A8 Gene

protein-coding   GIFtS: 53
GCID: GC02P234526

UDP glucuronosyltransferase 1 family, polypeptide A8

(Previous names: UDP glycosyltransferase 1 family, polypeptide A8 )
 Explore 10 diseases affiliated with
UGT1A8 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for UGT1A8    

Aliases
for UGT1A8 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
UDP Glucuronosyltransferase 1 Family, Polypeptide A81 2     EC 2.4.1.173 8
UGT1H1 2 3     UDPGT2
UDP Glycosyltransferase 1 Family, Polypeptide A81 2     UGT1A8S2
UGT-1H2 3     UDP-Glucuronosyltransferase 1 Family Polypeptide A8s2
UGT1-082 3     UDP-Glucuronosyltransferase 1-82
UGT1.82 3     GNT13
UDP-Glucuronosyltransferase 1-H2 3     UGT13
UDP-Glucuronosyltransferase 1A82 3     UGT1*83
UDPGT 1-82 3     

External Ids:    HGNC: 125401   Entrez Gene: 545762   Ensembl: ENSG000002423667   OMIM: 6064335   UniProtKB: Q9HAW93   

Export aliases for UGT1A8 gene to outside databases

Previous GC identifers: GC02P232535 GC02U900011 GC02P234821 GC02P234884 GC02P234308 GC02P234199 GC02P234207 GC02P234213 GC02P234219 GC02P234225 GC02P234227 GC02P226326


Summaries
for UGT1A8 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for UGT1A8:
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small
lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites.
This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen
unique alternate first exons followed by four common exons. Four of the alternate first exons are considered
pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins
with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated
by its own promoter. The enzyme encoded by this gene has glucuronidase activity with many substrates including
coumarins, phenols, anthraquinones, flavones, and some opioids. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: UD18_HUMAN, Q9HAW9
Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics
and endogenous compounds

Gene Wiki entry for UGT1A8


Genomic Views
for UGT1A8 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
 Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UGT1A8 gene promoter:
         SRF   PPAR-alpha   NF-AT4   PPAR-gamma1   NF-AT2   SRF (504 AA)   NF-AT3   PPAR-gamma2   LCR-F1   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 7): UGT1A8 promoter sequence
   Search SABiosciences Chromatin IP Primers for UGT1A8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UGT1A8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37   Ensembl cytogenetic band:  2q37.1   HGNC cytogenetic band: 2q37

UGT1A8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UGT1A8 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P234526:  view genomic region     (about GC identifiers)

Start:
 234,526,291 bp from pter      End:
 234,681,956 bp from pter
Size:
 155,666 bases      Orientation:
 plus strand

Proteins
for UGT1A8 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: UD18_HUMAN, Q9HAW9 (See protein sequence)
Recommended Name: UDP-glucuronosyltransferase 1-8 precursor  
Size: 530 amino acids; 59742 Da
Subcellular location: Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein (Potential)
Secondary accessions: B2R8S3 O14928 Q8TEX4 Q8WTQ9 Q8WX85
Alternative splicing: 1 isoform:  Q9HAW9-1   

Explore the universe of human proteins at neXtProt for UGT1A8: NX_Q9HAW9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9HAW9

    • 4/24 DME Specific Peptides for UGT1A8 (Q9HAW9) (see all 24)
     PEVSWQL  FWVEFVM  WLLRTDF  QYHSLDV 

    UGT1A8 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_061949.3  
    ENSEMBL proteins: 
     ENSP00000362549  
    Reactome Protein details: Q9HAW9
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: UGT1A8
    OriGene Protein Over-expression Lysate: UGT1A8
    OriGene Custom Protein Services for UGT1A8 
    GenScript Custom Purified and Recombinant Proteins Services for UGT1A8
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for UGT1A8

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005792microsome ----
    GO:0016021integral to membrane IEA--
    GO:0043231intracellular membrane-bounded organelle IDA--


    UGT1A8 for ontologies           About GeneDecksing



    UGT1A8 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for UGT1A8 
    GenScript Custom Superior Antibodies Services for UGT1A8
    Search for Antibodies for UGT1A8 at Abcam  
    Uscn Antibodies for UGT1A8
    Search ThermoFisher Antibodies for UGT1A8

    Assay Products for UGT1A8: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for UGT1A8
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for UGT1A8

    Protein Domains /
    Families
    for UGT1A8 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    UGT1A8 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR002213 UDP_glucos_trans

    Graphical View of Domain Structure for InterPro Entry Q9HAW9

    ProtoNet protein and cluster: Q9HAW9

    1 Blocks protein family: IPB002213 UDP-glucoronosyl/UDP-glucosyl transferase

    UniProtKB/Swiss-Prot: UD18_HUMAN, Q9HAW9
    Similarity: Belongs to the UDP-glycosyltransferase family


    Function
    for UGT1A8 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: UD18_HUMAN, Q9HAW9
    Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics
    and endogenous compounds
    Catalytic activity: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

    Enzyme Number (IUBMB): EC 2.4.1.171 2

    miRNA
    Products:            		 OriGene 3'-UTR Clone: UGT1A8
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UGT1A8
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate UGT1A8:
    hsa-miR-1260b hsa-miR-616* hsa-miR-371-5p hsa-miR-1260 hsa-miR-373*
    SwitchGear 3'UTR luciferase reporter plasmid: UGT1A8 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UGT1A8
    OriGene shRNA RFP: UGT1A8
    OriGene siRNA: UGT1A8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UGT1A8

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for UGT1A8

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UGT1A8 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UGT1A8
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: UGT1A8 (NM_019076)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UGT1A8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UGT1A8 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for UGT1A8
    Search LifeMap BioReagents cell lines for UGT1A8

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UGT1A8

    Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001972retinoic acid binding IC--
    GO:0004857enzyme inhibitor activity IDA--
    GO:0005496steroid binding IDA19996319
    GO:0005504fatty acid binding IDA19996319
    GO:0008144drug binding IC--


    UGT1A8 for ontologies           About GeneDecksing



    Pathways & Interactions
    for UGT1A8 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/14 super-pathways (see all 14) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Glucuronidation
    		Glucuronidation1.00
    		Porphyrin and chlorophyll metabolism0.38
    		Glucuronidation0.67
    		Other types of O-glycan biosynthesis0.36
    		Starch and sucrose metabolism0.42
    		Drug metabolism - other enzymes0.32
    2Drug metabolism - cytochrome P450
    		Drug metabolism - cytochrome P4501.00
    		Retinol metabolism0.40
    		Metabolism of xenobiotics by cytochrome P4500.73
    3Retinol metabolism
    		Retinol metabolism1.00
    		Retinol metabolism0.95
    42-Naphthylamine and 2-Nitronaphtalene metabolism
    		2-Naphthylamine and 2-Nitronaphtalene metabolism1.00
    		2-Naphthylamine and 2-Nitronaphtalene metabolism0.95
    5Metabolism
    		Metabolism1.00
    		Metabolic pathways0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for UGT1A8
        2-Naphthylamine and 2-Nitronaphtalene metabolism
    Retinol metabolism


    2 GeneGo (Thomson Reuters) Pathways for UGT1A8
        Retinol metabolism
    2-Naphthylamine and 2-Nitronaphtalene metabolism

    3 BioSystems Pathways for UGT1A8 
        Glucuronidation
    Tamoxifen metabolism
    thyroid hormone metabolism II (via conjugation and/or degradation)

    4        Reactome Pathways for UGT1A8
        Metabolism
    Biological oxidations
    Phase II conjugation
    Glucuronidation

    5/6 PharmGKB Pathways for UGT1A8 (see all 6)
        Estrogen Metabolism Pathway
    Irinotecan Pathway, Pharmacodynamics
    Mycophenolic acid Pathway, Pharmacokinetics
    Tamoxifen Pathway, Pharmacokinetics
    Tramadol Pharmacokinetics

    5/11         Kegg Pathways  (Kegg details for UGT1A8) (see all 11):
        Pentose and glucuronate interconversions
    Ascorbate and aldarate metabolism
    Steroid hormone biosynthesis
    Starch and sucrose metabolism
    Other types of O-glycan biosynthesis


    UGT1A8 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UGT1A8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/56 Interacting proteins for UGT1A8 (ENSP000003625494) via UniProtKB, MINT, STRING, and/or I2D (see all 56)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADH1BENSP000003066064STRING: ENSP00000306606
    ADH4ENSP000002655124STRING: ENSP00000265512
    AKR1C4ENSP000002631264STRING: ENSP00000263126
    BLVRAENSP000002655234STRING: ENSP00000265523
    CES2ENSP000003178424STRING: ENSP00000317842
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006631fatty acid metabolic process IDA--
    GO:0008202steroid metabolic process IC19996319
    GO:0009804coumarin metabolic process IC19996319
    GO:0017144drug metabolic process IDA--
    GO:0031324negative regulation of cellular metabolic process IDA--


    UGT1A8 for ontologies           About GeneDecksing



    Drugs & Compounds
    for UGT1A8 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    UGT1A8 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UGT1A8

    10/84 HMDB Compounds for UGT1A8 (see all 84)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Ethyl glucuronide 17685-04-016139098
    (23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)(23S)-23,25-dihydroxy-24-oxovitamin D3 23-(beta-glucuronide) (see all 5)----
    1-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acidIbuprofen acyl glucuronide;(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[2-[4-(2-methylpropyl)phenyl]propanoyloxy]oxane-2-carboxylic acid (see all 5)115075-59-7--
    1-Salicylate glucuronide1-salicylic acid glucuronide ----
    11-Hydroxyprogesterone 11-glucuronide11-hydroxyprogesterone 11-glucuronoside (see all 5)77710-64-6--
    11-Oxo-androsterone glucuronide11-oxo-etiocholanolone glucuronide (see all 3)----
    11-beta-hydroxyandrosterone-3-glucuronide11-beta-hydroxyetiocholanolone-3-glucuronide ----
    15-hydroxynorandrostene-3,17-dione glucuronide15-HNADG (see all 5)131749-23-0--
    16-alpha,17-beta-estriol 17-beta-D-glucuronideestra-1,3,5(10)-triene-3,16alpha,17beta-triol 17-D-glucuronide (see all 7)7219-89-8--
    17-alpha-estradiol-3-glucuronide ----

    5 DrugBank Compounds for UGT1A8    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Diflunisal-- 22494-42-4enzymesubstrate10497143
    Morphine(-)-Heroin hydrochloride (see all 12)57-27-2enzymesubstrate18187562
    Mycophenolate mofetil-- 128794-94-5enzymesubstrate11817210
    Propofol2,6-Diisopropylphenol (see all 2)2078-54-8enzymesubstrate19515014
    Troglitazone-- 97322-87-7enzymesubstrate12433820

    10/12 Novoseek chemical compound relationships for UGT1A8 gene (see all 12)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    udp glucuronic acid 86.9 1 16595710 (1)
    n-hydroxy phip 77.4 2 11375903 (1)
    mycophenolic acid 66.8 8 17339869 (3), 18568343 (2), 17924828 (1), 16790554 (1)
    imipramine 51 1 12019188 (1)
    mycophenolate mofetil 38.2 4 17339869 (2), 16790554 (1)
    cotinine 37 2 12433823 (1), 12167564 (1)
    estrone 34.5 1 16397224 (1)
    morphine 33.1 1 18187562 (1)
    estradiol 31 1 16397224 (1)
    dihydrotestosterone 29 6 16595710 (4)

    1 PharmGKB related drug/compound annotation for UGT1A8 gene
    Drug/compound PharmGKB Annotation
    valproic acidCA  
    About this table

    Search CenterWatch for drugs/clinical trials and news about UGT1A8 / UD18 

    Transcripts
    for UGT1A8 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for UGT1A8 gene: 
    NM_019076.4  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000373450(uc010zmv.1 uc002vup.3 uc002vva.3)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: UGT1A8
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UGT1A8
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate UGT1A8:
    hsa-miR-1260b hsa-miR-616* hsa-miR-371-5p hsa-miR-1260 hsa-miR-373*
    SwitchGear 3'UTR luciferase reporter plasmid: UGT1A8 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UGT1A8
    OriGene shRNA RFP: UGT1A8
    OriGene siRNA: UGT1A8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UGT1A8
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UGT1A8 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UGT1A8
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: UGT1A8 (NM_019076)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UGT1A8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UGT1A8 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UGT1A8
    Browse OriGene validated miRNA SYBR primer pairs
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat UGT1A8
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UGT1A8
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UGT1A8

    24/271 AceView cDNA sequences (see all 271):

    AK025403 NM_019075 CB157019 BE464379 AI913618 AY435140 BI764371 AI479279 
    BE464422 BE464186 NM_019078 AW297730 AV650286 AY435143 AY435144 AI701383 
    BC043491 AI767337 AY435142 AY435137 NM_019093 AU076863 CB163341 AY435139 

    GeneLoc Exon Structure


    Expression
    for UGT1A8 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UGT1A8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See UGT1A8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UGT1A8

    UniProtKB/Swiss-Prot: UD18_HUMAN, Q9HAW9
    Tissue specificity: Colon specific

        SABiosciences Custom PCR Arrays for UGT1A8
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UGT1A8
    Browse OriGene validated miRNA SYBR primer pairs
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat UGT1A8
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UGT1A8
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UGT1A8
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UGT1A8

    Orthologs
    for UGT1A8 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for UGT1A8 gene from 4/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves F1P1M7_CHICK6
    --
    (see all 5)    		 Uncharacterized protein
    (see all 5)    		 58(a)
    47(a)
    (see all 5)    		 possible ortholog
    possible ortholog
    (see all 5)    		 7(5795449-5817899)
    7(5844610-5845328)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    UGT1A66
    (see all 3)    		 --
    		 55(a)
    42(a)
    (see all 3)    		 possible ortholog
    possible ortholog
    (see all 3)    		 1(118894319-118901649)
    1(118848249-118849106)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.158082 Xenopus laevis transcribed sequence with weak similarity more 75.69(n)    BJ060547.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii fads22 Danio rerio cDNA clone MGC66393 IMAGE5914298, complete more 73.71(n)    BC055635.1 


    ENSEMBL Gene Tree for UGT1A8 (if available)
    TreeFam Gene Tree for UGT1A8 (if available) 

    Paralogs
    for UGT1A8 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UGT1A8 gene
    UGT1A91 2  UGT1A101 2  UGT1A71 2  UGT2A22  UGT3A12  UGT2B72  UGT2B112  UGT1A32  
    UGT1A12  UGT1A52  UGT3A22  UGT2B102  UGT1A62  UGT82  UGT2B152  UGT2B42  
    UGT2B172  UGT2A32  UGT2B282  UGT1A42  
    18/30 SIMAP similar genes for UGT1A8 using alignment to 5 protein entries:     UD18_HUMAN (see all proteins) (see all similar genes):
    UGT1H    UGT1A8S    UGT1A10    UGT1A9S    UGT1A9    UGT1A3S
    UGT1J    UGT1A7    UGT1G    UGT2A3    UGT1A6    BILIQTL1
    UGT1A6S    UGT1A1    UGT1    UGT1A4S    UGT2B17    UGT2B11

    UGT1A8 for paralogs           About GeneDecksing



    Genomic Variants
    for UGT1A8 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/65 NCBI SNPs in UGT1A8 are shown (see all 65)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs11267831,2
    		C,H,--226326383(+) TGTTTC/GTCTGC 2 S C mis16Minor allele frequency- G:0.00NS EA NA 542
    rs11267851,2
    		C,H,--226326622(+) TCGCCG/CATGCT 2 /H /D mis14Minor allele frequency- C:0.00NS EA NA 4852
    rs11267881,2
    		C,H,--226326652(+) GAAGTT/ATGTTT 2 /M /L mis16Minor allele frequency- A:0.00NS EA NA 600
    rs11267901,2
    		C,H,--226326654(+) AGTNTG/ATTTTC 2 /L syn13Minor allele frequency- A:0.00NS NA EA 300
    rs11267921,2
    		C,H,--226326666(+) CTATTT/ACTGAG 2 /L /F mis13Minor allele frequency- A:0.00NS EA NA 298
    rs11267931,2
    		C,H,--226326667(+) TATTNC/ATGAGT 2 /M /L mis13Minor allele frequency- A:0.00NS NA EA 302
    rs11267981,2
    		C,H,--226326691(+) TTTTTA/GACTTA 2 N D mis15Minor allele frequency- G:0.00NS EA NA 408
    rs11268001,2
    		H--226326813(+) GTTGCC/TAAATA 2 A syn14Minor allele frequency- T:0.00NS EA 418
    rs2000030871,2
    		F--226326964(+) TACGGA/GACCAC 2 N D mis11Minor allele frequency- G:0.00EA 506
    rs11268031,2
    		C--226326973(+) ACATCA/GTGCAC 2 M V mis11Minor allele frequency- G:0.00NA 2

    HapMap Linkage Disequilibrium report for UGT1A8 (234526291 - 234681956 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 12 variations for UGT1A8
         12 CNVs: 90342 90341 61892 35795 50416 39282 37520 39281 63330 63332 90340 63331
    Human Gene Mutation Database (HGMD): UGT1A8

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UGT1A8
    DNA2.0 Custom Variant and Variant Library Synthesis for UGT1A8

    Disorders / Diseases
    for UGT1A8 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    UGT1A8 for disorders           About GeneDecksing

    OMIM gene information: 606433    OMIM disorders: --

    10 diseases for UGT1A8:    About MalaCards
    neonatal jaundice    kernicterus    hearing loss    jaundice
    colorectal cancer    esophagitis    cholesterol    adenocarcinoma
    pancreatitis    hepatitis

    Genetic Association Database (GAD): UGT1A8
    Human Genome Epidemiology (HuGE) Navigator: UGT1A8 (24 documents)

    Export disorders for UGT1A8 gene to outside databases

    Publications
    for UGT1A8 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UGT1A8 gene, integrated from 9 sources (see all 97):
    (articles sorted by number of sources associating them with UGT1A8)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and functional characterization of UDP- glucuronosyltransferases UGT1A8*1, UGT1A8*2 and UGT1A8*3. (PubMed id 12042666)1, 2, 3 Huang Y.-H.... Tukey R.H. (2002)
    2. Troglitazone glucuronidation in human liver and intestine microsomes: high catalytic activity of UGT1A8 and UGT1A10. (PubMed id 12433820)1, 7, 9 Watanabe Y....Yokoi T. (2002)
    3. Expression of the UDP-glucuronosyltransferase 1A locus in human colon. Identification and characterization of the novel extrahepatic UGT1A8. (PubMed id 9535849)1, 2, 9 Strassburg C.P.... Tukey R.H. (1998)
    4. Characterization of common UGT1A8, UGT1A9, and UGT2B7 variants with different capacities to inactivate mutagenic 4-hydroxylated metabolites of estradiol and estrone. (PubMed id 16397224)1, 4, 9 Thibaudeau J....Guillemette C. (2006)
    5. Functional polymorphisms of UDP-glucuronosyltransferases 1A1, 1A6 and 1A8 are not involved in chronic pancreatitis. (PubMed id 15247627)1, 4, 9 Verlaan M....Drenth J.P. (2004)
    6. Variation of hepatic glucuronidation: Novel functional polymorphisms of the UDP-glucuronosyltransferase UGT1A4. (PubMed id 15057901)1, 4, 9 Ehmer U....Strassburg C.P. (2004)
    7. Genetic polymorphisms in UDP-glucuronosyltransferases and glutathione S-transferases and colorectal cancer risk. (PubMed id 15319294)1, 4, 9 van der Logt E.M....Peters W.H. (2004)
    8. Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus. (PubMed id 11434514)1, 2 Gong Q.H....Popescu N.C. (2001)
    9. Studies on the substrate specificity of human intestinal UDP- lucuronosyltransferases 1A8 and 1A10. (PubMed id 10497143)1, 7 Cheng Z....Tephly T.R. (1999)
    10. The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence. (PubMed id 9295054)1, 3 Mackenzie P.I....Nebert D.W. (1997)

    External Searches for UGT1A8 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing UGT1A8 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54576 HGNC: 12540 AceView: UGT1A1 Ensembl:ENSG00000242366 euGenes: HUgn54576
    ECgene: UGT1A8 Kegg: 54576 H-InvDB: UGT1A8

    Other Databases showing UGT1A8 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing UGT1A8 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UGT1A8 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for UGT1A8 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for UGT1A8 gene:
    Search GeneIP for patents involving UGT1A8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for UGT1A8 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for UGT1A8  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UGT1A8   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UGT1A8  
     OriGene Protein Over-expression Lysate for UGT1A8   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for UGT1A8   OriGene 3'-UTR Clone for UGT1A8  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UGT1A8   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UGT1A8  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for UGT1A8   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for UGT1A8   OriGene Custom Protein Services for UGT1A8  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UGT1A8
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UGT1A8
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UGT1A8
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UGT1A8
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UGT1A8
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UGT1A8
     GenScript Custom Purified and Recombinant Proteins Services for UGT1A8 GenScript cDNA clones with any tag delivered in your preferred vector for UGT1A8
     GenScript Custom Assay Services for UGT1A8 GenScript Custom Superior Antibodies Services for UGT1A8
     GenScript Custom overexpressing Cell Line Services for UGT1A8 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in UGT1A8 promoter
     Search Chromatin IP Primers for UGT1A8
     Search RT2 qPCR Primer Assays in human, mouse, rat UGT1A8
     Search GNC Networks for UGT1A8
     SABiosciences Custom PCR Arrays for UGT1A8
     Search Tocris compounds for UGT1A8
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Biologicals
     Novus Tissue Slides
     Search for Antibodies for UGT1A8 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for UGT1A8
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     UGT1A8 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for UGT1A8
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UGT1A8
     SwitchGear 3'UTR luciferase reporter plasmids for UGT1A8
     SwitchGear Promoter luciferase reporter plasmids for UGT1A8
     Search ThermoFisher Antibodies for UGT1A8
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UGT1A8
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      UGT1A8 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4