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Aliases for TUBA3C Gene

Aliases for TUBA3C Gene

  • Tubulin, Alpha 3c 2 3
  • TUBA2 3 4 6
  • Tubulin Alpha-2 Chain 3 4
  • Alpha-Tubulin 3C/D 3 4
  • Tubulin, Alpha 2 2 3
  • Alpha-Tubulin 2 3 4
  • Tubulin Alpha-3C/D Chain 3
  • BA408E5.3 3

External Ids for TUBA3C Gene

Previous HGNC Symbols for TUBA3C Gene

  • TUBA2

Previous GeneCards Identifiers for TUBA3C Gene

  • GC13M018646
  • GC13M019747
  • GC13M000553

Summaries for TUBA3C Gene

Entrez Gene Summary for TUBA3C Gene

  • Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. This gene is an alpha tubulin gene that encodes a protein 99% identical to the mouse testis-specific Tuba3 and Tuba7 gene products. This gene is located in the 13q11 region, which is associated with the genetic diseases Clouston hidrotic ectodermal dysplasia and Kabuki syndrome. [provided by RefSeq, Jul 2008]

GeneCards Summary for TUBA3C Gene

TUBA3C (Tubulin, Alpha 3c) is a Protein Coding gene. Diseases associated with TUBA3C include dfnb1. Among its related pathways are ERK Signaling and GPCR Pathway. An important paralog of this gene is TUBA1C.

UniProtKB/Swiss-Prot for TUBA3C Gene

  • Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain

Tocris Summary for TUBA3C Gene

  • Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized, at one end alpha-subunits are exposed (-) and at the other beta-subunits are exposed (+). Microtubules act as a scaffold to determine cell shape, and provide a backbone for cell organelles and vesicles to move on, a process that requires motor proteins. The major microtubule motor proteins are kinesin, which generally moves towards the (+) end of the microtubule, and dynein, which generally moves towards the (-) end. Microtubules also form the spindle fibers for separating chromosomes during mitosis.

Gene Wiki entry for TUBA3C Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUBA3C Gene

Genomics for TUBA3C Gene

Regulatory Elements for TUBA3C Gene

Genomic Location for TUBA3C Gene

19,173,770 bp from pter
19,181,852 bp from pter
8,083 bases
Minus strand

Genomic View for TUBA3C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TUBA3C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUBA3C Gene

Proteins for TUBA3C Gene

  • Protein details for TUBA3C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tubulin alpha-3C/D chain
    Protein Accession:
    Secondary Accessions:
    • A6NJQ0
    • Q5W099
    • Q6PEY3
    • Q96F18

    Protein attributes for TUBA3C Gene

    450 amino acids
    Molecular mass:
    49960 Da
    Quaternary structure:
    • Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells

    Alternative splice isoforms for TUBA3C Gene


neXtProt entry for TUBA3C Gene

Proteomics data for TUBA3C Gene at MOPED

Post-translational modifications for TUBA3C Gene

  • Acetylation of alpha chains at Lys-40 stabilizes microtubules and affects affinity and processivity of microtubule motors. This modification has a role in multiple cellular functions, ranging from cell motility, cell cycle progression or cell differentiation to intracellular trafficking and signaling (By similarity).
  • Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of such modifications is still unclear but they regulate the assembly and dynamics of axonemal microtubules (Probable).
  • Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (TTCP) and tubulin tyrosine ligase (TTL), respectively.
  • Ubiquitination at Lys60, Lys96, Lys163, Lys280, Lys304, Lys326, Lys336, Lys338, Lys352, Lys370, Lys394, and Lys401
  • Glycosylation at Asn380
  • Modification sites at PhosphoSitePlus

Other Protein References for TUBA3C Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TUBA3C Gene

Domains for TUBA3C Gene

Gene Families for TUBA3C Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tubulin family.
  • Belongs to the tubulin family.
genes like me logo Genes that share domains with TUBA3C: view

No data available for Suggested Antigen Peptide Sequences for TUBA3C Gene

Function for TUBA3C Gene

Molecular function for TUBA3C Gene

UniProtKB/Swiss-Prot Function:
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain

Gene Ontology (GO) - Molecular Function for TUBA3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005200 structural constituent of cytoskeleton IEA --
GO:0005515 protein binding IPI 16189514
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with TUBA3C: view

Phenotypes for TUBA3C Gene

GenomeRNAi human phenotypes for TUBA3C:
genes like me logo Genes that share phenotypes with TUBA3C: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TUBA3C

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TUBA3C Gene

Localization for TUBA3C Gene

Subcellular locations from UniProtKB/Swiss-Prot for TUBA3C Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

Jensen Localization Image for TUBA3C Gene COMPARTMENTS Subcellular localization image for TUBA3C gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 1

Gene Ontology (GO) - Cellular Components for TUBA3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IEA --
GO:0005874 microtubule IEA --
GO:0043234 protein complex --
genes like me logo Genes that share ontologies with TUBA3C: view

Pathways for TUBA3C Gene

genes like me logo Genes that share pathways with TUBA3C: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for TUBA3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006457 protein folding TAS --
GO:0007017 microtubule-based process IEA --
GO:0044267 cellular protein metabolic process TAS --
GO:0051084 de novo posttranslational protein folding TAS --
genes like me logo Genes that share ontologies with TUBA3C: view

Drugs for TUBA3C Gene

(3) Drugbank Compounds for TUBA3C Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
Epothilone B
  • EPO 906
152044-54-7 46936553 Target experimental, investigational
Epothilone D
  • KOS-862
189453-10-9 46936246 Target experimental, investigational
Target investigational

(5) Tocris Compounds for TUBA3C Gene

Compound Action Cas Number
ABT 751 Inhibitor of microtubule polymerization; antimitotic and antitumor [141430-65-1]
Colchicine Inhibitor of tubulin [64-86-8]
Docetaxel Microtubule stabilizer [114977-28-5]
Harmine Potent and selective Dyrk1A inhibitor [442-51-3]
Vinblastine sulfate Disrupts microtubules [143-67-9]

(11) ApexBio Compounds for TUBA3C Gene

Compound Action Cas Number
Cabazitaxel [183133-96-2]
CK-636 Arp2/3 complex inhibitor [442632-72-6]
Colchicine Tubulin Inhibitor [64-86-8]
CYT997 (Lexibulin) [917111-44-5]
Epothilone A Microtubule stabilizing macrolide [152044-53-6]
Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium [168555-66-6]
Griseofulvin [126-07-8]
INH6 [1001753-24-7]
MPC 6827 hydrochloride Potent microtubule inhibitor [917369-31-4]
Plinabulin (NPI-2358) Tumor cell lines inhibitor [714272-27-2]
Vinflunine Tartrate [1201898-17-0]

(1) HMDB Compounds for TUBA3C Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
genes like me logo Genes that share compounds with TUBA3C: view

Transcripts for TUBA3C Gene

mRNA/cDNA for TUBA3C Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(48) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TUBA3C Gene

Tubulin, alpha 3c:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TUBA3C

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TUBA3C Gene

No ASD Table

Relevant External Links for TUBA3C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TUBA3C Gene

mRNA expression in normal human tissues for TUBA3C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TUBA3C Gene

This gene is overexpressed in Testis (52.6).

Protein differential expression in normal tissues for TUBA3C Gene

This gene is overexpressed in Brain (54.0) and Lung (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TUBA3C Gene

SOURCE GeneReport for Unigene cluster for TUBA3C Gene Hs.349695

mRNA Expression by UniProt/SwissProt for TUBA3C Gene

Tissue specificity: Testis specific.
genes like me logo Genes that share expressions with TUBA3C: view

Expression partners for TUBA3C Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for TUBA3C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TUBA3C Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TUBA1D 35
  • 85.98 (n)
  • 97.73 (a)
  • 100 (a)
(Canis familiaris)
Mammalia LOC100855995 35
  • 82.33 (n)
  • 88.81 (a)
-- 36
  • 77 (a)
(Pan troglodytes)
Mammalia TUBA3E 35
  • 96 (n)
  • 100 (a)
  • 100 (a)
(Monodelphis domestica)
Mammalia TUBA3C 36
  • 100 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 100 (a)
(Gallus gallus)
Aves -- 36
  • 99 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 100 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490289 35
  • 84.85 (n)
  • 97.73 (a)
(Danio rerio)
Actinopterygii tuba1l 35
  • 83.56 (n)
  • 97.73 (a)
si:ch73-199e17.1 36
  • 88 (a)
tuba4l 36
  • 87 (a)
fruit fly
(Drosophila melanogaster)
Insecta alphaTub84B 36
  • 98 (a)
(Caenorhabditis elegans)
Secernentea tba-2 36
  • 87 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TUB1 36
  • 74 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons TUA5 35
  • 71.84 (n)
  • 84.25 (a)
(Oryza sativa)
Liliopsida Os07g0574800 35
  • 74.66 (n)
  • 83.79 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11340 36
  • 98 (a)
Species with no ortholog for TUBA3C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TUBA3C Gene

Gene Tree for TUBA3C (if available)
Gene Tree for TUBA3C (if available)

Paralogs for TUBA3C Gene

Paralogs for TUBA3C Gene

genes like me logo Genes that share paralogs with TUBA3C: view

Variants for TUBA3C Gene

Sequence variations from dbSNP and Humsavar for TUBA3C Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs567736715 -- 19,175,676(+) CTATC(C/T)GACAG intron-variant
rs566926254 -- 19,179,766(+) TAAGT(G/T)CCAGA intron-variant
rs566106544 -- 19,176,171(+) CCCAA(C/T)ATTTT intron-variant
rs565841540 -- 19,177,948(+) CTCAA(A/G)CCATT intron-variant
rs565156516 -- 19,177,149(+) TTCTC(A/G)GCTGA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for TUBA3C Gene

Variant ID Type Subtype PubMed ID
nsv523647 CNV Loss 19592680
nsv899844 CNV Loss 21882294
nsv455824 CNV Loss 19166990
nsv528089 CNV Loss 19592680
nsv482166 CNV Gain 20164927
esv2663766 CNV Deletion 23128226
nsv826573 CNV Loss 20364138
esv2673339 CNV Deletion 23128226
nsv455825 CNV Loss 19166990
nsv515683 CNV Loss 19592680
dgv1548n71 CNV Gain 21882294

Relevant External Links for TUBA3C Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TUBA3C Gene

Disorders for TUBA3C Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for TUBA3C Gene in MalaCards »

(1) Disease for TUBA3C Gene

(1) Novoseek inferred disease relationships for TUBA3C Gene

Disease -log(P) Hits PubMed IDs
hidrotic ectodermal dysplasia 92 1

Relevant External Links for TUBA3C

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with TUBA3C: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for TUBA3C Gene

Publications for TUBA3C Gene

  1. Sequence characterization of a newly identified human alpha-tubulin gene (TUBA2). (PMID: 9465305) Dode C. … Petit C. (Genomics 1998) 2 3 4 23
  2. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4
  3. A radiation hybrid map of 48 loci including the clouston hidrotic ectodermal dysplasia locus in the pericentromeric region of chromosome 13q. (PMID: 10036193) Kibar Z. … Rouleau G.A. (Genomics 1999) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. HIV-1 Tat protein enhances microtubule polymerization. (PMID: 15691386) de Mareuil J. … Loret E.P. (Retrovirology 2005) 3

Products for TUBA3C Gene

Sources for TUBA3C Gene

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