Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TUBA1B Gene

protein-coding GIFtS: 60
GCID: GC12M049523

tubulin, alpha 1b

Explore 64 diseases affiliated with
TUBA1B via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Tubulin, Alpha 1b¹ ²		Tubulin K-Alpha-1² ³
K-ALPHA-1¹ ²		Alpha Tubulin²
Alpha-Tubulin Ubiquitous² ³		Tubulin Alpha-1B Chain²
Tubulin Alpha-Ubiquitous Chain² ³		Tubulin, Alpha, Ubiquitous²

External Ids:	HGNC: 18809¹	Entrez Gene: 10376²	Ensembl: ENSG00000123416⁷	OMIM: 602530⁵	UniProtKB: P68363³

Export aliases for TUBA1B gene to outside databases

Previous GC identifers: GC12M047809 GC12M046552

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TBA1B_HUMAN, P68363

Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on

the beta chain and one at a non-exchangeable site on the alpha chain

summary for TUBA1B:

Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in

turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized, at one end alpha-subunits

are exposed (-) and at the other beta-subunits are exposed (+). Microtubules act as a scaffold to determine

cell shape, and provide a backbone for cell organelles and vesicles to move on, a process that requires

motor proteins. The major microtubule motor proteins are kinesin, which generally moves towards the (+) end

of the microtubule, and dynein, which generally moves towards the (-) end. Microtubules also form the

spindle fibers for separating chromosomes during mitosis.

Gene Wiki entry for TUBA1B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_029419.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TUBA1B gene promoter:
TBP C/EBPbeta p53 HNF-1 HNF-1A C/EBPalpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TUBA1B promoter sequence

Search SABiosciences Chromatin IP Primers for TUBA1B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TUBA1B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.12 Ensembl cytogenetic band: 12q13.12 HGNC cytogenetic band: 12q13.12

TUBA1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TUBA1B gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M049523: view genomic region (about GC identifiers)

Start:	49,521,565 bp from pter	End:	49,525,304 bp from pter
Size:	3,740 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TBA1B_HUMAN, P68363 (See protein sequence)

Recommended Name: Tubulin alpha-1B chain

Size: 451 amino acids; 50152 Da

Subunit: Dimer of alpha and beta chains

Subcellular location: Cytoplasm, cytoskeleton

1 PDB 3D structure from and Proteopedia for TUBA1B:

2E4H (3D)

Secondary accessions: P04687 P05209 Q27I68

Explore the universe of human proteins at neXtProt for TUBA1B: NX_P68363

Post-translational modifications:

Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by

the enzymes tubulin tyrosine carboxypeptidase (TTCP) and tubulin tyrosine ligase (TTL), respectively (By similarity)¹

Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate

residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not polyglycylated

due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into

axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the

mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering glycylation

levels increases polyglutamylation, and reciprocally. The precise function of such modifications is still unclear but

they regulate the assembly and dynamics of axonemal microtubules (Probable)¹

Acetylation of alpha chains at Lys-40 stabilizes microtubules and affects affinity and processivity of microtubule

motors. This modification has a role in multiple cellular functions, ranging from cell motility, cell cycle

progression or cell differentiation to intracellular trafficking and signaling (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P68363

TUBA1B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_006073.2

ENSEMBL proteins:

ENSP00000336799 ENSP00000448045 ENSP00000447816 ENSP00000449325 ENSP00000449460

ENSP00000449748 ENSP00000448648

Reactome Protein details: P68363
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: TUBA1B OriGene Protein Over-expression Lysate: TUBA1B OriGene Custom Protein Services for TUBA1B
	GenScript Custom Purified and Recombinant Proteins Services for TUBA1B
	Novus Biologicals TUBA1B Proteins Novus Biologicals TUBA1B Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005874	microtubule	TAS	12090300
GO:0005881	cytoplasmic microtubule	IEA	--
GO:0015630	microtubule cytoskeleton	IDA	--

TUBA1B for ontologies About GeneDecksing

TUBA1B Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for TUBA1B
	OriGene Antibodies (see all 4): TUBA1B OriGene Custom Antibody Services for TUBA1B
	GenScript Custom Superior Antibodies Services for TUBA1B
	Novus Biologicals TUBA1B Antibodies
	Abcam antibodies for TUBA1B
	Browse Antibodies at Uscn
	ThermoFisher Antibody for TUBA1B

Assay Products for TUBA1B:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TUBA1B
	Cell Signaling Technology (CST) Sandwich ELISA Kits for TUBA1B
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TUBA1B for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR002452 Alpha_tubulin

IPR000217 Tubulin

IPR003008 Tubulin_FtsZ_GTPase

IPR023123 Tubulin_C

IPR008280 Tub_FtsZ_C

Graphical View of Domain Structure for InterPro Entry P68363

ProtoNet protein and cluster: P68363

1 Blocks protein family: IPB002452 Alpha tubulin signature

UniProtKB/Swiss-Prot: TBA1B_HUMAN, P68363

Similarity: Belongs to the tubulin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TBA1B_HUMAN, P68363

Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on

the beta chain and one at a non-exchangeable site on the alpha chain

miRNA Products:		OriGene 3'-UTR Clone: TUBA1B Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TUBA1B
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TUBA1B
		SwitchGear 3'UTR luciferase reporter plasmid: TUBA1B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TUBA1B (see all 4) OriGene shRNA RFP: TUBA1B Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TUBA1B

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for TUBA1B

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TUBA1B (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TUBA1B (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TUBA1B (NM_006082)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TUBA1B
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TUBA1B

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TUBA1B
		Search LifeMap BioReagents cell lines for TUBA1B

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for TUBA1B

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003924	GTPase activity	IEA	--
GO:0005198	structural molecule activity	TAS	12090300
GO:0005200	structural constituent of cytoskeleton	IEA	--
GO:0005515	protein binding	IPI	11698390
GO:0005525	GTP binding	IEA	--

TUBA1B for ontologies About GeneDecksing

6 GenomeRNAi human phenotypes for TUBA1B:

Cell division defect	Decreased cell number, increas	Decreased homologous recombina	Decreased viability of wild-ty
Increased circadian period len	Increased number of mitotic ce

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/34 super-pathways (see all 34) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

M Phase

M Phase	1.00	Mitotic Anaphase	0.85
Mitotic M-M/G1 phases	0.88	Separation of Sister Chromatids	0.80
Mitotic Metaphase and Anaphase	0.85

Recruitment of mitotic centrosome proteins and complexes

	Recruitment of mitotic centrosome proteins and complexes	1.00			G2/M Transition	0.83
	Centrosome maturation	1.00			Mitotic G2-G2/M phases	0.81

Axon guidance

	Axon guidance	1.00			L1CAM interactions	0.39
	Developmental Biology	0.69			Recycling pathway of L1	0.15

Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane

	Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	1.00			Post-chaperonin tubulin folding pathway	0.67
	Transport of connexons to the plasma membrane	0.93			Recruitment of NuMA to mitotic centrosomes	0.50

Resolution of Sister Chromatid Cohesion

	Resolution of Sister Chromatid Cohesion	1.00			Mitotic Prometaphase	0.93
	Kinetochore assembly	0.96

Pathway sources
See GeneCards unified pathways
Show all pathways

5/9 EMD Millipore Pathways for TUBA1B (see all 9)

	Cytoskeleton remodeling Neurofilaments
	Cytoskeleton remodeling Slit-Robo signaling
	Cytoplasmic microtubules
	Cytoskeleton remodeling Reverse signaling by ephrin B
	Cytoskeleton remodeling Keratin filaments

3 Cell Signaling Technology (CST) Pathways for TUBA1B

	Chromatin Regulation / Acetylation
	Neuroscience
	Cytoskeletal Signaling

5/10 GeneGo (Thomson Reuters) Pathways for TUBA1B (see all 10)

	Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
	Cell cycle Spindle assembly and chromosome separation
	Regulation of CFTR activity (norm and CF)
	Neurophysiological process Receptor-mediated axon growth repulsion
	Cytoskeleton remodeling Keratin filaments

5 BioSystems Pathways for TUBA1B

	Parkin-Ubiquitin Proteasomal System pathway
	Pathogenic Escherichia coli infection
	Signaling events mediated by HDAC Class III
	Signaling events mediated by HDAC Class II
	Signaling events mediated by PRL

5/40 Reactome Pathways for TUBA1B (see all 40)

	L1CAM interactions
	Mitotic Prometaphase
	Membrane Trafficking
	Protein folding
	Recruitment of mitotic centrosome proteins and complexes

3 Kegg Pathways (Kegg details for TUBA1B):

	Phagosome
	Gap junction
	Pathogenic Escherichia coli infection

TUBA1B for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TUBA1B

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/109 Interacting proteins for TUBA1B (P68363^{2, 3} ENSP00000336799⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 109)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TOM1L1	O75674²^,³, ENSP00000408958⁴	MINT-8276020 I2D: score=2 STRING: ENSP00000408958
YWHAZ	P63104²^,³, ENSP00000309503⁴	MINT-3297730 I2D: score=1 STRING: ENSP00000309503
PIK3R1	P27986³, ENSP00000274335⁴	I2D: score=3 STRING: ENSP00000274335
STARD13	Q9Y3M8³, ENSP00000338785⁴	I2D: score=3 STRING: ENSP00000338785
FYN	P06241³, ENSP00000357656⁴	I2D: score=2 STRING: ENSP00000357656

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000226	microtubule cytoskeleton organization	IEA	--
GO:0006457	protein folding	TAS	--
GO:0007017	microtubule-based process	TAS	12090300
GO:0007018	microtubule-based movement	IEA	--
GO:0030705	cytoskeleton-dependent intracellular transport	TAS	12090300

TUBA1B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TUBA1B for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for TUBA1B available from Tocris Bioscience About this table

Compound	Action	CAS #
XRP44X	Ras-Net pathway inhibitor	[729605-21-4]
Taxol	Promotes assembly and inhibits disassembly of microtubules	[33069-62-4]
Vincristine sulfate	Disrupts microtubules	[2068-78-2]
Vinblastine sulfate	Disrupts microtubules	[143-67-9]
Nocodazole	Microtubule inhibitor	[31430-18-9]

1 HMDB Compound for TUBA1B About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

3 DrugBank Compounds for TUBA1B About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Epothilone B	EPO 906 (see all 3)	152044-54-7	target	--	17139284 17016423
Epothilone D	--	189453-10-9	target	--	17139284 17016423
2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE	--	--	target	--	10592235

10/63 Novoseek chemical compound relationships for TUBA1B gene (see all 63) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
dinitroaniline	71.5	2	12681297 (1), 16913711 (1)
nocodazole	69.7	13	18485433 (2), 17161375 (1), 8478694 (1), 18592005 (1) (see all 11)
pironetin	69.5	4	15217613 (3), 17465195 (1)
paclitaxel	68.9	36	9571153 (4), 10930805 (2), 12649178 (2), 18485433 (2) (see all 23)
lbh-589	61.1	1	16728695 (1)
colchicine	59.3	10	2011590 (2), 9500839 (2), 12716939 (1), 17711308 (1) (see all 8)
ixabepilone	55.7	12	18094432 (3), 15837987 (1)
epothilone b	53.1	1	18723488 (1)
suberoylanilide hydroxamic acid	51.5	2	19621389 (2)
vinblastine	50.5	3	15865430 (1), 2011590 (1), 15917812 (1)

Search CenterWatch for drugs/clinical trials and news about TUBA1B / TBA1B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TUBA1B gene:

NM_006082.2

Unigene Cluster for TUBA1B:

Tubulin, alpha 1b

Hs.524390 [show with all ESTs]

Unigene Representative Sequence: AK094717

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000336023(uc001rtm.3) ENST00000332858(uc001rtl.3) ENST00000547765

ENST00000551373 ENST00000550367 ENST00000551324 ENST00000549870 ENST00000547476

ENST00000552984

miRNA Products:		OriGene 3'-UTR Clone: TUBA1B Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TUBA1B
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TUBA1B
		SwitchGear 3'UTR luciferase reporter plasmid: TUBA1B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TUBA1B (see all 4) OriGene shRNA RFP: TUBA1B Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TUBA1B

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TUBA1B (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TUBA1B (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TUBA1B (NM_006082)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TUBA1B
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TUBA1B

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TUBA1B Browse OriGene validated miRNA SYBR primer pairs
		Search SABiosciences RT² qPCR Primer Assays in human, mouse, rat TUBA1B
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TUBA1B
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TUBA1B

Additional cDNA sequence:

AF081484.1 AK026516.1 AK026632.1 AK056693.1 AK057773.1 AK094717.1 AK098357.1 AK098635.1

AK098771.1 AK289354.1 AK293337.1 AY533484.1 BC000696.2 BC001128.1 BC006379.2 BC006481.1

BC008659.2 BC009314.2 BC009509.2 BC009512.2 BC009513.2 BC010494.1 BC011572.1 BC015883.2

BC017004.1 BC018948.2 BC021564.1 BC030820.1 BC071904.1 DQ400107.1 K00558.1 S62639.1

Z36832.1

24/235 DOTS entries (see all 235):

DT.92475285 DT.95320022 DT.92366709 DT.99926637 DT.100848485 DT.100744378 DT.100052773 DT.100744363

DT.91934824 DT.95174416 DT.100862142 DT.100744304 DT.100744270 DT.102844043 DT.100744484 DT.92475438

DT.121135794 DT.100744530 DT.100744436 DT.121134919 DT.100769967 DT.100744333 DT.100744403 DT.99926616

24/279 AceView cDNA sequences (see all 279):

CR613561 CR593171 CR603658 CR595471 CR592985 CR619248 CR596951 CR591119

CR600315 CR616313 CR613007 CR599735 CR606298 CR621408 BC021564 CR622622

CR606942 CR590547 CR597298 CR617067 CR600193 BC071904 CR598224 BC001128

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TUBA1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTACCTGTA

About this image

TUBA1B expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Endoderm-like cells (Generation of hepato...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TUBA1B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TUBA1B

SOURCE GeneReport for Unigene cluster: Hs.524390

SABiosciences Custom PCR Arrays for TUBA1B

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TUBA1B Browse OriGene validated miRNA SYBR primer pairs
		Search SABiosciences RT² qPCR Primer Assays in human, mouse, rat TUBA1B
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TUBA1B
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TUBA1B

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for TUBA1B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for TUBA1B gene from 6/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	F1NW97_CHICK⁶	Uncharacterized protein	99(a)	1 ↔ 1	7(23586546-23763395)
tropical clawed frog (Xenopus tropicalis)	Amphibia	BC061297.1²	--	87.12(n)		BC061297.1
zebrafish (Danio rerio)	Actinopterygii	BC042319.1²	--	84.93(n)		373080 BC042319.1
worm (Caenorhabditis elegans)	Secernentea	tba-2¹	Protein TBA-2	76.34(n) 88.84(a)		173167 NM_001025879.2 NP_001021050.1
thale cress (Arabidopsis thaliana)	eudicotyledons	TUA3¹	tubulin alpha-3/alpha-5 chain	72.07(n) 83.56(a)		832097 NM_121982.3 NP_197478.1
rice (Oryza sativa)	Liliopsida	Os07g0574800¹	hypothetical protein	77.33(n) 82.67(a)		4343694 NM_001066610.1 NP_001060075.1

ENSEMBL Gene Tree for TUBA1B (if available)
TreeFam Gene Tree for TUBA1B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TUBA1B gene

TUBA3C² TUBA4A² TUBA1A² TUBAL3² TUBA3E² TUBA1C² TUBA3D² TUBA8²

18/29 SIMAP similar genes for TUBA1B using alignment to 8 protein entries: TBA1B_HUMAN (see all proteins) (see all similar genes):

TUBA1 TUBA4A TUBA1C TUBA1A TUBA3E TUBA4B

DKFZp686L04275 TUBA8 TUBA2 TUBA3C TUBA3D TUBAL3

TUBB6 TUBB3 TUBB2A XTP3TPATP1 MGC16703 TUBB8

TUBA1B for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for TUBA1B
PGOHUM00000257918 PGOHUM00000246745

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs187412389^1,2		--	49521146(+)	`TCTCCC/TAGGCT`	1	--	int¹		0	--	--	--	--
rs191826539^1,2		--	49521267(+)	`CTCAGA/TGGATA`	1	--	int¹		0	--	--	--	--
rs144575210^1,2		--	49521348(+)	`CTTTAA/GATTAG`	1	--	int¹		0	--	--	--	--
rs148466807^1,2		--	49521374(+)	`CACCCC/GCTATG`	1	--	int¹		0	--	--	--	--
rs182912027^1,2		--	49521424(+)	`TCCTGC/GCTTTC`	1	--	int¹		0	--	--	--	--
rs186678126^1,2		--	49521458(+)	`CTAGAA/GGTGCC`	1	--	int¹		0	--	--	--	--
rs191339573^1,2		--	49521491(+)	`ACACCA/GGACTC`	1	--	int¹		0	--	--	--	--
rs182797553^1,2		--	49521516(+)	`ATAGAG/TGAATC`	1	--	int¹		0	--	--	--	--
rs57622540^1,2	C,F,	--	49521579(+)	`TAATGA/GCTTTA`	1	--	ut3¹		1		EA	120
rs2753^1,2	C,F,O,A,H,	--	49521672(-)	`ACAGAT/CGTTAA`	1	--	ut3¹ ese³		25		MN NS EA NA WA CSA	2536

HapMap Linkage Disequilibrium report for TUBA1B (49521565 - 49525304 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TUBA1B: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TUBA1B

DNA2.0 Custom Variant and Variant Library Synthesis for TUBA1B

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TUBA1B for disorders           About GeneDecksing

OMIM gene information: 602530    OMIM disorders: --

20/64 diseases for TUBA1B (see all 64):    About MalaCards

distal hereditary motor neuropathy distal hereditary motor neuropathy, type ii estrogen-receptor positive breast cancer cerebral amyloid angiopathy

non-small cell lung carcinoma sclerosing hemangioma dengue hemorrhagic fever pulmonary sclerosing hemangioma

non-hodgkin lymphoma transient cerebral ischemia hemorrhagic fever bronchiolitis obliterans

pachygyria mantle cell lymphoma hemangioma squamous cell carcinoma of the head and neck

squamous cell carcinoma differentiating neuroblastoma hodgkin's lymphoma alcohol dependence

1 disease from the University of Copenhagen DISEASES database for TUBA1B:

Bronchiolitis obliterans

10/27 Novoseek disease relationships for TUBA1B gene (see all 27) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
lung carcinoma	21.3	5	20510079 (3), 11329278 (1), 7543053 (1)
glioma	18.8	2	18543212 (1), 16181609 (1)
cancer	17.2	7	19407367 (1), 15033907 (1), 16541425 (1), 20510079 (1)
glioblastoma	16.1	1	16257120 (1)
breast cancer	13.8	3	19548283 (1), 18085226 (1), 18424035 (1)
tumors	12.2	15	9731740 (2), 15837987 (2), 17606971 (1), 18632620 (1) (see all 12)
leukemia	11.3	2	15937340 (1), 17447750 (1)
shock	11.2	10	18347185 (1), 18790094 (1), 18607586 (1), 8255174 (1) (see all 7)
neurofibrillary tangles	10.2	1	18487604 (1)
alzheimers disease	7.64	7	17336290 (1), 18487604 (1), 19457097 (1), 7479369 (1) (see all 5)

Export disorders for TUBA1B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TUBA1B gene, integrated from 9 sources (see all 482):
(articles sorted by number of sources associating them with TUBA1B)

Utopia: connect your pdf to the dynamic
world of online information

Expression of human alpha-tubulin genes: interspecies conservation of 3' untranslated regions. (PubMed id 6646120)^{1, 2, 3} Cowan N.J....Cleveland D.W. (1983)
Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry. (PubMed id 18781797)^{1, 2} Meierhofer D.... Kaiser P. (2008)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Increased levels of tyrosinated alpha-, beta(III)-, and beta(IV)-tubulin isotypes in paclitaxel-resistant MCF-7 breast cancer cells. (PubMed id 12054644)^{1, 3} Banerjee A. (2002)
C-terminal fragments of alpha- and beta-tubulin form amyloid fibrils in vitro and associate with amyloid deposits of familial cerebral amyloid angiopathy, British type. (PubMed id 8619814)^{1, 2} Baumann M.H.... Ghiso J. (1996)
Anti-leukaemic effects of two extract types of Lactuc a sativa correlate with the activation of Chk2, induction of p21, downregulatio n of cyclin D1 and acetylation of alpha-tubulin. (PubMed id 20204303)^{1, 9} Gridling M....Krupitza G. (2010)
alpha-Synuclein aggregates interfere with Parkin solubility and distribution: role in the pathogenesis of Parkinson disease. (PubMed id 18195004)^{1, 9} Kawahara K....Masliah E. (2008)
ADP-ribosylation factor like 7 (ARL7) interacts with alpha-tubulin and modulates intracellular vesicular transport. (PubMed id 19409876)^{1, 9} Wei S.M....Cai J.T. (2009)
SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis. (PubMed id 11146551)^{1, 9} Germani A.... Calvo F. (2000)
The N-terminal domain of c-Myc associates with alpha-tubulin and microtubules in vivo and in vitro. (PubMed id 7651436)^{1, 9} Alexandrova N....Zajac-Kaye M. (1995)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 10376	HGNC: 18809	AceView: K-ALPHA-1	Ensembl:ENSG00000123416	euGenes: HUgn10376
ECgene: TUBA1B	Kegg: 10376	H-InvDB: TUBA1B

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TUBA1B	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TUBA1B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TUBA1B gene:
Search GeneIP for patents involving TUBA1B

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for TUBA1B		OriGene shRNA RFP for TUBA1B
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TUBA1B		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TUBA1B
	OriGene Protein Over-expression Lysate for TUBA1B		Browse OriGene Fluorogenic Cell Assay Kits
	Browse OriGene siRNAs		OriGene 3'-UTR Clone for TUBA1B
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TUBA1B		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TUBA1B
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for TUBA1B		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for TUBA1B		OriGene Custom Protein Services for TUBA1B
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TUBA1B
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TUBA1B
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TUBA1B
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TUBA1B
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TUBA1B
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TUBA1B

	GenScript Custom Purified and Recombinant Proteins Services for TUBA1B		GenScript cDNA clones with any tag delivered in your preferred vector for TUBA1B
	GenScript Custom Assay Services for TUBA1B		GenScript Custom Superior Antibodies Services for TUBA1B
	GenScript Custom overexpressing Cell Line Services for TUBA1B		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Antibodies & Assays for TUBA1B

	Regulatory tfbs in TUBA1B promoter
	Search Chromatin IP Primers for TUBA1B
	RT² qPCR Primer Assay in human, mouse / rat TUBA1B
	GNC Network for TUBA1B
	SABiosciences Custom PCR Arrays for TUBA1B

Tocris compounds for TUBA1B

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	TUBA1B antibodies
	TUBA1B proteins
	TUBA1B lysates

	Antibodies for TUBA1B
	See all of Abcam's Antibodies, Kits and Proteins for TUBA1B
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn

Search LifeMap BioReagents cell lines for TUBA1B

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for TUBA1B

	SwitchGear 3'UTR luciferase reporter plasmids for TUBA1B
	SwitchGear Promoter luciferase reporter plasmids for TUBA1B

ThermoFisher Antibody for TUBA1B

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TUBA1B

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes TUBA1B gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

TUBA1B Gene

tubulin, alpha 1b

Aliases
for TUBA1B gene

Summaries
for TUBA1B gene

Genomic Views
for TUBA1B gene

Proteins
for TUBA1B gene

Protein Domains /
Families
for TUBA1B gene

Function
for TUBA1B gene

Pathways & Interactions
for TUBA1B gene

Drugs & Compounds
for TUBA1B gene

Transcripts
for TUBA1B gene

Expression
for TUBA1B gene

Orthologs
for TUBA1B gene

Paralogs
for TUBA1B gene

Genomic Variants
for TUBA1B gene

Disorders / Diseases
for TUBA1B gene

Publications
for TUBA1B gene

External Searches for TUBA1B gene

Genome Databases showing TUBA1B gene

Other Databases showing TUBA1B gene

Specialized Databases showing TUBA1B gene

Intellectual Property
for TUBA1B gene

Products
for TUBA1B gene

View Random Gene

BREAST CARCINOMA
Shock
Colon Cancer
Ovarian Cancer
Infertility
Parkinson Disease
Glioma
OVARIAN CARCINOMA
Carcinoma
Carcinoma Squamous Cell
LUNG CARCINOMA
PROSTATE CARCINOMA
Leukemia
Alzheimers Disease
Ischemia
Breast Cancer
prostate cancer
Tumors
NSCLC
Carcinoma Embryonal
Adenocarcinoma
Carcinoma Ductal
cell damage
Cancer
Glioblastoma
Cancer Lung
Neurofibrillary Tangles

Advanced Search

Export list of displayed genes

TUBA1B Gene

tubulin, alpha 1b

Aliasesfor TUBA1B gene

Summariesfor TUBA1B gene

Genomic Viewsfor TUBA1B gene

Proteinsfor TUBA1B gene

Protein Domains /Familiesfor TUBA1B gene

Functionfor TUBA1B gene

Pathways & Interactionsfor TUBA1B gene

Drugs & Compoundsfor TUBA1B gene

Transcriptsfor TUBA1B gene

Expression for TUBA1B gene

Orthologsfor TUBA1B gene

Paralogsfor TUBA1B gene

Genomic Variantsfor TUBA1B gene

Disorders / Diseasesfor TUBA1B gene

Publicationsfor TUBA1B gene

External Searches for TUBA1B gene

Genome Databases showing TUBA1B gene

Other Databases showing TUBA1B gene

Specialized Databases showing TUBA1B gene

Intellectual Propertyfor TUBA1B gene

Productsfor TUBA1B gene

View Random Gene

Aliases
for TUBA1B gene

Summaries
for TUBA1B gene

Genomic Views
for TUBA1B gene

Proteins
for TUBA1B gene

Protein Domains /
Families
for TUBA1B gene

Function
for TUBA1B gene

Pathways & Interactions
for TUBA1B gene

Drugs & Compounds
for TUBA1B gene

Transcripts
for TUBA1B gene

Expression
for TUBA1B gene

Orthologs
for TUBA1B gene

Paralogs
for TUBA1B gene

Genomic Variants
for TUBA1B gene

Disorders / Diseases
for TUBA1B gene

Publications
for TUBA1B gene

Intellectual Property
for TUBA1B gene

Products
for TUBA1B gene