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TSPO Gene

protein-coding GIFtS: 56

GC22P041877

translocator protein (18kDa)
(Previous name: benzodiazapine receptor (peripheral) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: BZRP)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
BZRP ^², ³
DBI ^¹, ²
IBP ^¹, ²
MBR ^¹, ², ³
OTTHUMP00000028891 ^²
PBR ^¹, ², ³
PKBS ^¹, ², ³
PTBR ^²
mDRC ^¹, ²
pk18 ^¹, ²

Descriptions
Mitochondrial benzodiazepine receptor ^², ³
Peripheral-type benzodiazepine receptor ^², ³
benzodiazapine receptor (peripheral) ^¹
benzodiazepine peripheral binding site ^²
peripheral benzodiazepine receptor ^²
translocator protein ^²
translocator protein (18kDa) ^²

External Ids
HGNC: 1158¹
Entrez Gene: 706²
UniProtKB: P30536³
Ensembl: ENSG00000100300⁷

Search outside databases for aliases for TSPO gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for TSPO:

Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this

gene interacts with some benzodiazepines and has different affinities than its endogenous

counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit

the initiation of steroid hormone synthesis. Alternate transcriptional splice variants, encoding

different isoforms, have been characterized. [provided by RefSeq]

UniProtKB/Swiss-Prot: TSPO_HUMAN, P30536

Function: Responsible for the manifestation of peripheral-type benzodiazepine recognition sites and

is most likely to comprise binding domains for benzodiazepines and isoquinoline carboxamides. May

play a role in the transport of porphyrins and heme. Plays a role in the transport of cholesterol

across mitochondrial membranes in steroidogenic cells (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the TSPO gene

Entrez Gene cytogenetic band: 22q13.31 Ensembl cytogenetic band: 22q13.2 HGNC cytogenetic band: 22q13.3

TSPO Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22P041877: (about GC identifiers)

Start:	41,877,479 bp from pter
End:	41,889,192 bp from pter
Size:	11,714 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000022.9 NT_011520.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: TSPO_HUMAN, P30536 (See protein sequence)

Recommended Name: Translocator protein

Size: 169 amino acids; 18779 Da

Subunit: Interacts with BZRAP1 (By similarity). May interact with STAR (By similarity). Interacts

with MOST-1

Subcellular location: Mitochondrion membrane; Multi-pass membrane protein

Secondary accessions: Q53Y59 Q6ICF9 Q96TF6

REFSEQ proteins (2 alternative transcripts):

NP_000705.2 NP_009295.2

ENSEMBL proteins:

ENSP00000379563 ENSP00000355074 ENSP00000328973 ENSP00000338004

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (PBR)
	Human Recombinant Proteins from Abnova (TSPO)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	IEA	--
GO:0005741	mitochondrial outer membrane	NAS	8307574
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

About this table

Antibodies for TSPO:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for TSPO
	R&D Systems Antibodies for TSPO (PBR)
	Antibodies from Abcam (PBR), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (TSPO)
	Novus Biologicals Antibodies for TSPO

Assays for TSPO:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P30536

ProtoNet protein and cluster: P30536

1 Blocks protein family: IPB004307 TspO and MBR related proteins

UniProtKB/Swiss-Prot: TSPO_HUMAN, P30536

Similarity: Belongs to the TspO/BZRP family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TSPO)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TSPO)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_000714

Applied Biosystems Silencer® siRNAs for TSPO

Sigma-Aldrich siRNA and siRNA Panels for TSPO

Sigma-Aldrich shRNA for TSPO

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for TSPO
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000714
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000714
untagged cDNA clones in CMV expression vector (see all 2): NM_000714

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000714

UniProtKB/Swiss-Prot: TSPO_HUMAN, P30536

Function: Responsible for the manifestation of peripheral-type benzodiazepine recognition sites and

is most likely to comprise binding domains for benzodiazepines and isoquinoline carboxamides. May

play a role in the transport of porphyrins and heme. Plays a role in the transport of cholesterol

across mitochondrial membranes in steroidogenic cells (By similarity)

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0008503	benzodiazepine receptor activity	TAS	1326278
GO:0015485	cholesterol binding	TAS	16822554

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/12 Interacting proteins for TSPO (ENSP00000338004³) via UniProtKB, MINT, and/or STRING (see all 12 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BCL2	ENSP00000329623³	STRING (score=.966)
ACBD3	ENSP00000355777³	STRING (score=.95)
BZRAP1	ENSP00000347929³	STRING (score=.95)
DBI	ENSP00000311117³	STRING (score=.914)
SATB1	ENSP00000333367³	STRING (score=.907)

About this table

5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006626	protein targeting to mitochondrion	TAS	1326278
GO:0006783	heme biosynthetic process	TAS	16822554
GO:0006820	anion transport	TAS	16822554
GO:0006915	apoptosis	TAS	16822554
GO:0008202	steroid metabolic process	TAS	16822554

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for TSPO:

Antagonist

Browse Tocris compounds for TSPO
10/19 Novoseek chemical compound relationships for TSPO gene (see all 19 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
benzodiazepine	98.55	2614	8306240 (10), 10664825 (9), 17027961 (8), 8868371 (7) (see all 99)
iomazenil	93.26	17	7662908 (1), 12440611 (1), 8691270 (1), 9212889 (1) (see all 16)
benzodiazepines	86.58	72	1980690 (3), 1637606 (2), 8262176 (2), 14678758 (2) (see all 60)
triakontatetraneuropeptide	73.82	3	8380885 (1), 9460762 (1)
sarmazenil	71.99	3	9586852 (2), 9839004 (1)
beta-carboline	68.57	7	1365658 (1), 2155806 (1), 2158440 (1), 8851918 (1) (see all 7)
l-ornithine l-aspartate	61.01	1	17295849 (1)
ptpc	59.00	4	11355954 (1), 15033708 (1)
carbon-11	57.76	3	8635180 (1), 9323267 (1), 8586102 (1)
lonidamine	52.22	2	9752269 (1), 10353597 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TSPO)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TSPO)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_000714

Sigma-Aldrich siRNA and siRNA Panels for TSPO

Sigma-Aldrich shRNA for TSPO

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000714 NM_007311

REFSEQ mRNAs for TSPO gene (2 alternative transcripts):

NM_000714.4 NM_007311.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000714 NM_007311

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000714
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000714
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_000714

Additional cDNA sequence:

AF075589.1 AF075590.1 AY998017.1 BC001110.2 BT006949.1 CR456409.1 CR457007.1 CR590116.1

CR607955.1 CR609727.1 CR617902.1 CR619651.1 CR621254.1 L21950.1 M36035.1

7 DOTS entries:

DT.40127929 DT.98131737 DT.100801819 DT.100643566 DT.97855685 DT.97855686 DT.97821978

24/442 AceView cDNA sequences (see all 442 ):

BM549915 BQ773690 CR619651 BM853651 CR456409 BG171507 CD370271 AA314709

CR617902 CR609727 CR607955 BM014524 BM761374 AW469169 BE908317 BM810547

CA307061 AW328575 AF075590 BG575252 BU625404 BX391144 BM784742 BU177060

highest scoring ESTs for TSPO:

M36035 AA007504 AA036726 AA037186 AA056606 AA069479 AA070923 AA099285 AA100452 AA158134

Unigene Cluster for TSPO:

Translocator protein (18kDa)

Hs.202 [show with all ESTs]

Unigene Representative Sequence: BM924710

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for TSPO

ExUns:	1	^	2a	·	2b	·	2c	^	3a	·	3b	·	3c	^	4	^	5a	·	5b	·	5c
SP1:			-		-		-
SP2:							-
SP3:													-
SP4:			-		-		-		-		-		-
SP5:

About this scheme

ECgene alternative splicing isoforms for TSPO

4 Ensembl transcripts including schematic representations:

ENST00000396265 ENST00000361449 ENST00000329563 ENST00000337554

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

TSPO expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for TSPO

¹ / ² / ³

3 probe-sets matching TSPO gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
32806_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	M36035	1.00	1.00	1.00	1
202096_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000714	0.60	1.00	0.82	1
202096_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GAATTTTATA

SOURCE GeneReport for Unigene cluster: Hs.202

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TSPO gene from 5/13 species (see all 13 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	TSPO¹	--	translocator protein (18kDa)	85.8(n) 81.66(a)	474475 XM_531704.2 XP_531704.2
chimpanzee (Pan troglodytes)	TSPO¹	--	translocator protein (18kDa)	98.82(n) 97.63(a)	458887 XM_001171791.1 XP_001171791.1
cow (Bos taurus)	TSPO¹	--	translocator protein (18kDa)	82.45(n) 74.56(a)	281033 NM_175776.2 NP_786970.1
rat (Rattus norvegicus)	Tspo¹	--	translocator protein	81.26(n) 79.88(a)	24230 NM_012515.1 NP_036647.1
mouse (Mus musculus)	Tspo^{1, 5}	15 (43.30 cM)⁵	translocator protein^{1, 5}	80.87(n)¹ 79.88(a)¹	12257¹ NM_009775.3¹ NP_033905.2¹ AA472650⁵ AI841615⁵ (see all 30)

About this table Species with no ortholog for TSPO

ENSEMBL Gene Tree for TSPO

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for TSPO gene

BZRPL1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/143 NCBI SNPs in TSPO are shown (see all 143 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 88)

AB	SNP ID	Valid	Chr 22 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1005658^1,2	A,C,F,H,O	41889681(+)	`TCAGAA/GGCAGG`	2	--	ng3¹		14	NA EA WA EU NS MN CSAM	1382
	rs6973^1,2	A,C,F,H	41889081(+)	`GAGGTG/TGCCCC`	2	--	ut3¹ ese³		20	MN NA EA WA EU NS	2288
	rs138918^1,2	A,C,F,H	41889395(+)	`CTGGGG/ACCCAC`	2	--	ng3¹		8	EA NA NS WA	630
	rs6971^1,2	A,C,F,H	41888870(-)	`GGTCGC/TGAAGG`	2	T/A H/R	mis¹ ese³		28	MN NA EA WA EU CSAM NS	2968
	rs6972^1,2	A,C,F,H	41888916(+)	`CTGGCG/ATGGGG`	2	A/A H/R	syn¹ mis¹		21	MN NA EA WA EU CSAM NS	2190
	rs5996279^1,2	A,F,H	41876677(+)	`CTTGGA/CCCCTG`	2	--	ng5¹		4	EU EA WA	418
--	rs6003081^1,2	A,C,F	41889230(+)	`CCACAG/AGGAAG`	2	--	ng3¹		1	NS	180
	rs9333347^1,2	C,F,H	41889656(+)	`AACACC/TCAGTT`	2	--	ng3¹		14	NS MN CSAM EA EU WA	1374
	rs9333348^1,2	C,F,H	41889666(+)	`TGGCTC/TGAGGG`	2	--	ng3¹		9	NS EU EA WA	956
--	rs1005657^1,2	C,F	41889424(+)	`GGGGCC/G/TGTGGG`	2	--	ng3¹		4	NA EA WA NS	490

About this table

HapMap Linkage Disequilibrium images for TSPO (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 109610

10/94 Novoseek disease relationships for TSPO gene (see all 94 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
hepatic encephalopathy	78.94	53	8276347 (5), 11687160 (4), 15106178 (4), 2172467 (3) (see all 31)
chronic insomnia	61.88	1	19201632 (1)
hepatic coma	61.26	5	2161396 (1), 9347201 (1), 16563564 (1), 7748297 (1) (see all 5)
epilepsy temporal lobe	58.98	17	11893007 (2), 12199729 (2), 11518000 (2), 10599778 (1) (see all 14)
panic disorder	54.75	29	10664825 (5), 10023509 (3), 7624108 (3), 9928900 (3) (see all 16)
epilepsies partial	53.93	14	10390953 (2), 1317662 (2), 8956845 (1), 9795703 (1) (see all 12)
anxiety disorders	48.76	10	8748388 (1), 1324584 (1), 10103141 (1), 1687977 (1) (see all 10)
glioma	48.06	40	16026165 (4), 7714547 (3), 9540054 (3), 15276076 (3) (see all 21)
epilepsy	46.65	11	11882054 (2), 9237052 (1), 8797068 (1), 10390953 (1) (see all 7)
stage iii colorectal cancer	46.26	3	12374690 (3)

About this table

Human Gene Mutation Database: TSPO
Human Genome Epidemiology Navigator: TSPO (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/541 PubMed articles for TSPO gene (see all 541 ):

Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function. (PubMed id 16822554)^{2, 3, 4} Papadopoulos V....Gavish M. (2006)
Molecular cloning and chromosomal localization of a human peripheral-type benzodiazepine receptor. (PubMed id 1847678)^{2, 3, 4} Riond J....Ferrara P. (1991)
Peripheral benzodiazepine receptor: characterization in human T- lymphoma Jurkat cells. (PubMed id 16189298)^{1, 3, 4} Costa B.... Martini C. (2006)
Cloning and characterization of PRAX-1. A new protein that specifically interacts with the peripheral benzodiazepine receptor. (PubMed id 9915832)^{1, 3, 4} Galiegue S....Casellas P. (1999)
The human "peripheral-type" benzodiazepine receptor: regional mapping of the gene and characterization of the receptor expressed from cDNA. (PubMed id 1326278)^{1, 2, 3} Chang Y.J....Strauss J.F. (1992)
No association of two missense variations of the benzodiazepine receptor (peripheral) gene and mood disorders in a Japanese sample. (PubMed id 11304832)^{1, 3, 4} Kurumaji A.... Toru M. (2001)
An association study between two missense variations of the benzodiazepine receptor (peripheral) gene and schizophrenia in a Japanese sample. (PubMed id 11215759)^{1, 3, 4} Kurumaji A.... Toru M. (2000)
A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)^{3, 4} Collins J.E.... Dunham I. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The DNA sequence of human chromosome 22. (PubMed id 10591208)^{3, 4} Dunham I....O'Brien K.P. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 706	HGNC: 1158	AceView: BZRP	Ensembl:ENSG00000100300	euGenes: HUgn706
ECgene: TSPO	H-InvDB: TSPO

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
NIEHS-SNPs	http://egp.gs.washington.edu/data/bzrp/

Licensable Technologies for TSPO
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for TSPO:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for TSPO-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for TSPO		Antibodies for TSPO
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for TSPO		Small molecules for TSPO
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (TSPO)
	Antibodies (TSPO)
	Chimera RNAi (TSPO)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (PBR)
	Antibodies (PBR)

Search OriGene for TSPO

Search Tocris compounds for TSPO

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for TSPO

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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TSPO Gene

protein-coding GIFtS: 56

Aliases &
Descriptions
for TSPO

Summaries
for TSPO

Genomic Location
for TSPO

Proteins
for TSPO

Protein Domains/
Families
for TSPO

Gene Function
for TSPO

Pathways & Interactions
for TSPO

Drugs & Compounds
for TSPO

Transcripts
for TSPO

Expression
for TSPO

Orthologs
for TSPO

Paralogs
for TSPO

SNPs/Variants
for TSPO

Disorders & Mutations
for TSPO

Medical News
for TSPO

Publications
for TSPO

Search for TSPO

Genome Databases showing TSPO

Other Databases showing TSPO

Specialized Databases showing TSPO

Licensable Technologies
for TSPO

Services
for TSPO

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

TSPO Gene

protein-coding GIFtS: 56

Aliases & Descriptionsfor TSPO

Summariesfor TSPO

Genomic Locationfor TSPO

Proteinsfor TSPO

Protein Domains/Familiesfor TSPO

Gene Functionfor TSPO

Pathways & Interactionsfor TSPO

Drugs & Compoundsfor TSPO

Transcriptsfor TSPO

Expression for TSPO

Orthologsfor TSPO

Paralogsfor TSPO

SNPs/Variantsfor TSPO

Disorders & Mutationsfor TSPO

Medical Newsfor TSPO

Publicationsfor TSPO

Search for TSPO

Genome Databases showing TSPO

Other Databases showing TSPO

Specialized Databases showing TSPO

Licensable Technologiesfor TSPO

Servicesfor TSPO

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for TSPO

Summaries
for TSPO

Genomic Location
for TSPO

Proteins
for TSPO

Protein Domains/
Families
for TSPO

Gene Function
for TSPO

Pathways & Interactions
for TSPO

Drugs & Compounds
for TSPO

Transcripts
for TSPO

Expression
for TSPO

Orthologs
for TSPO

Paralogs
for TSPO

SNPs/Variants
for TSPO

Disorders & Mutations
for TSPO

Medical News
for TSPO

Publications
for TSPO

Licensable Technologies
for TSPO

Services
for TSPO