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TOP2A Gene

protein-coding GIFtS: 71

GC17M035798

topoisomerase (DNA) II alpha 170kDa
(Previous name: topoisomerase (DNA) II alpha (170kD) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: TOP2)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 5.99.1.3 ^³
TOP2 ^², ³, ⁵
TP2A ^²

Descriptions
DNA topoisomerase II, 170 kD ^²
DNA topoisomerase II, alpha isozyme ^², ³
topoisomerase (DNA) II alpha (170kD) ^¹, ²
topoisomerase (DNA) II alpha 170kDa ^²
topoisomerase II alpha 170kDa ^¹

External Ids
HGNC: 11989¹
Entrez Gene: 7153²
UniProtKB: P11388³
Ensembl: ENSG00000131747⁷

Search outside databases for aliases for TOP2A gene

Previous GC identifers: GC17M038044 GC17M040720 GC17M038453 GC17M038919 GC17M038920

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for TOP2A:

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of

DNA during transcription. This nuclear enzyme is involved in processes such as chromosome

condensation, chromatid separation, and the relief of torsional stress that occurs during DNA

transcription and replication. It catalyzes the transient breaking and rejoining of two strands of

duplex DNA which allows the strands to pass through one another, thus altering the topology of

DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene

encoding this form, alpha, is localized to chromsome 17 and the beta gene is localized to

chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents

and a variety of mutations in this gene have been associated with the development of drug

resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.

[provided by RefSeq]

UniProtKB/Swiss-Prot: TOP2A_HUMAN, P11388

Function: Control of topological states of DNA by transient breakage and subsequent rejoining of

DNA strands. Topoisomerase II makes double-strand breaks

Gene Wiki entry for TOP2A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the TOP2A gene

Entrez Gene cytogenetic band: 17q21-q22 Ensembl cytogenetic band: 17q21.2 HGNC cytogenetic band: 17q21-q22

TOP2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M035798: (about GC identifiers)

Start:	35,798,321 bp from pter
End:	35,827,934 bp from pter
Size:	29,614 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000017.9 NT_010755.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: TOP2A_HUMAN, P11388 (See protein sequence)

Recommended Name: DNA topoisomerase 2-alpha

Size: 1531 amino acids; 174385 Da

Subunit: Homodimer. Interacts with COPS5

Subcellular location: Cytoplasm. Nucleus, nucleoplasm. Note=Generally located in the nucleoplasm

Miscellaneous: Eukaryotic topoisomerase I and II can relax both negative and positive supercoils,

whereas prokaryotic enzymes relax only negative supercoils

PDB structures from and Proteopedia :

1LWZ (3D)

1ZXM (3D)

1ZXN (3D)

Secondary accessions: Q71UN1 Q71UQ5 Q9HB24 Q9HB25 Q9HB26 Q9UP44 Q9UQP9

Alternative splicing: 4 isoforms: P11388-1 P11388-2 P11388-3 P11388-4

Post-translational modifications:

Phosphorylation has no effect on catalytic activity¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001058.2

ENSEMBL proteins:

ENSP00000350217 ENSP00000269577 ENSP00000342944

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for TOP2A
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Topoisomerase II alpha)
	Human Recombinant Proteins from Abnova (TOP2A)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/8 Gene Ontology (GO) cellular component terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	10788521 10959840 16611985
GO:0005654	nucleoplasm	IDA	9049244
GO:0005694	colocalizes with chromosome	IDA	9049244
GO:0005730	NOT nucleolus	IDA	9049244
GO:0005737	cytoplasm	IEA	--

About this table

Antibodies for TOP2A:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of TOP2A
	Sigma-Aldrich Antibodies for TOP2A
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for TOP2A (TopoII alpha)
	Antibodies from Abcam (Topoisomerase II alpha), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (TOP2A)
	Novus Biologicals Antibodies for TOP2A

Assays for TOP2A:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P11388

ProtoNet protein and cluster: P11388

5/6 Blocks protein families (see all 6 ):

IPB001154 Topoisomerase II signature

IPB002205 DNA gyrase/topoisomerase IV

IPB003594 ATP-binding region

IPB003957 CCAAT-binding transcription factor subunit A signature

IPB011558 DNA topoisomerase

UniProtKB/Swiss-Prot: TOP2A_HUMAN, P11388

Similarity: Belongs to the type II topoisomerase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TOP2A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TOP2A)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001067

Applied Biosystems Silencer® siRNAs for TOP2A

Sigma-Aldrich siRNA and siRNA Panels for TOP2A

Sigma-Aldrich shRNA Panels and shRNA for TOP2A

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001067
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001067
untagged cDNA clone in CMV expression vector: NM_001067

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001067

UniProtKB/Swiss-Prot: TOP2A_HUMAN, P11388

Function: Control of topological states of DNA by transient breakage and subsequent rejoining of

DNA strands. Topoisomerase II makes double-strand breaks

Catalytic activity: ATP-dependent breakage, passage and rejoining of double-stranded DNA

Enzyme regulation: Specifically inhibited by the intercalating agent amsacrine

Enzyme Number (IUBMB): EC 5.99.1.3

Genatlas biochemistry entry for TOP2A:

DNA topoisomerase II alpha (170kDa),ubiquitous,markely upregulated in proliferating

cells,catalyzing the ATP dependent breakage and rejoining of double strand of DNA,relaxing both

positively and negatively supercoiled DNA,inhibited by Rb during cell cycle,target of several

drugs widely used in the treatment of human cancers,including a variant associated with drug

resistance,deleted or amplified simultaneously with ERBB2 in breast cancers

5/12 Gene Ontology (GO) molecular function terms (links to tree view) (see all 12 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003682	chromatin binding	IDA	9049244
GO:0003918	DNA topoisomerase (ATP-hydrolyzing) activity	IDA	16611985
GO:0005080	protein kinase C binding	IPI	16611985
GO:0005524	ATP binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for TOP2A (Your Favorite Gene powered by Ingenuity)

Cell Cycle: G2/M DNA Damage Checkpoint Regulation

GeneDecks TOP2A for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for TOP2A

5/18 Interacting proteins for TOP2A (ENSP00000269577³ P11388^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 18 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RANBP2	P49792¹	STRING (score=.728) EBI-539628, EBI-973138
PIN1	Q13526²	MINT-15316
BRCA1	ENSP00000350283³	STRING (score=.898)
SUMO1	ENSP00000264281³	STRING (score=.898)
HDAC1	ENSP00000362649³	STRING (score=.872)

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5/10 Gene Ontology (GO) biological process terms (links to tree view) (see all 10 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006260	DNA replication	NAS	15504738
GO:0006265	DNA topological change	IEA	--
GO:0006266	DNA ligation	IDA	15491148
GO:0006281	DNA repair	NAS	15504738
GO:0006974	response to DNA damage stimulus	IDA	16611985

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for TOP2A

Sigma-Aldrich Small Molecules for TOP2A:

Inhibitor

Compounds for TOP2A available from Tocris Bioscience

Compound	Action	CAS number
Epirubicin hydrochloride	Inhibits DNA synthesis and function. Inhibits DNA topoisomerase II.	[56390-09-1]
Doxorubicin hydrochloride	Antitumor antibiotic agent. Inhibits DNA topoisomerase II	[25316-40-9]
Etoposide	Topoisomerase II inhibitor	[33419-42-0]

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10/18 Novoseek chemical compound relationships for TOP2A gene (see all 18 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
azatoxin	78.81	2	7763310 (2)
(glc)4	52.25	12	8041119 (3), 8980384 (2)
gal 1	38.94	3	9025779 (1), 8393377 (1), 10447574 (1)
vanadate	21.04	1	16053917 (1)
atp	20.24	27	11278845 (5), 12480934 (3), 12911317 (1), 10451375 (1) (see all 6)
deoxycytidine	14.61	2	14973057 (1), 12008078 (1)
carbamate	8.45	1	8194167 (1)
phenylalanine	0.00	1	15647268 (1)
spermine	0.00	1	15068901 (1)
p002	0.00	1	12237772 (1)

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2 PharmGKB drug compound relationships for TOP2A gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
etoposide	CO FA	2934259 9748598 3030329 7979257
thioguanine	FA	11053256

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TOP2A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TOP2A)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001067

Sigma-Aldrich siRNA and siRNA Panels for TOP2A

Sigma-Aldrich shRNA Panels and shRNA for TOP2A

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001067

REFSEQ mRNAs for TOP2A gene:

NM_001067.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001067

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001067
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001067
                                 untagged cDNA clone in CMV expression vector: NM_001067

Additional cDNA sequence:

AK024080.1 BC013429.1 BC062677.1 BC140791.1 CR625760.1 J04088.1 L47276.1 L47277.1

21 DOTS entries:

DT.99953788 DT.451782 DT.95300834 DT.99932666 DT.100683187 DT.100689464 DT.100825552 DT.100825545

DT.120991746 DT.91761832 DT.100038117 DT.100825557 DT.91761835 DT.95282052 DT.95300818 DT.100648081

DT.100825546 DT.102832750 DT.120991718 DT.40106389 DT.120991769

24/471 AceView cDNA sequences (see all 471 ):

AW675045 AI760467 BQ008257 BU186513 BM710690 AI186928 AI613495 BQ946025

BP356439 BF223254 BM468714 AA806022 BQ012547 AA550969 CB140758 BM749174

BQ428509 AK024080 BU542942 AL519920 AU125735 BU618677 BM804164 AW074313

highest scoring ESTs for TOP2A:

J04088 AI375913 BC013429 L47276 AA047124 AA095051 AA104024 AA127259 AA129533 AA216786

Unigene Cluster for TOP2A:

Topoisomerase (DNA) II alpha 170kDa

Hs.156346 [show with all ESTs]

Unigene Representative Sequence: NM_001067

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for TOP2A

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11a	·	11b	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^	22	^	23	^	24	^	25a	·
SP1:																					-																														-
SP2:
SP3:
SP4:

ExUns:	25b	^	26	^	27	^	28a	·	28b	^	29	^	30	^	31	^	32	^	33	^	34a	·	34b	^	35
SP1:
SP2:
SP3:
SP4:

About this scheme

ECgene alternative splicing isoforms for TOP2A

3 Ensembl transcripts including schematic representations:

ENST00000357601 ENST00000269577 ENST00000348049

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

TOP2A expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for TOP2A

¹ / ² / ³

8 probe-sets matching TOP2A gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
40145_at²^{, 3}	U95-A	1	1.00	1.00	0.98	0.95	AI375913	0.80	1.00	0.91	1
904_s_at²^{, 3}	U95-A	1	1.00	1.00	0.98	0.87	L47276	0.80	1.00	0.91	1
1592_at²^{, 3}	U95-A	1	1.00	1.00	0.96	1.16	J04088	1.00	0.90	0.95	1
74096_at²^{, 3}	U95-D	1	0.94	1.00	0.85	1.09	AW003286	0.60	1.00	0.82	1
201291_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AU159942	0.60	1.00	0.82	1
201292_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AL561834	0.60	1.00	0.82	1
201291_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
201292_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks TOP2A for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTCAGCAATG

SOURCE GeneReport for Unigene cluster: Hs.156346
Expression variation in blood from EXPOLDB for TOP2A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TOP2A gene from 5/20 species (see all 20 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	TOP2A¹	--	topoisomerase (DNA) II alpha 170kDa	92.09(n) 93.86(a)	480525 XM_537646.2 XP_537646.2
cow (Bos taurus)	TOP2A¹	--	topoisomerase (DNA) II alpha 170kDa	92.14(n) 92.94(a)	787696 XM_001254457.1 XP_001254458.1
rat (Rattus norvegicus)	Top2a¹	--	topoisomerase (DNA) II alpha	86.54(n) 89.18(a)	360243 NM_022183.2 NP_071519.2
mouse (Mus musculus)	Top2a^{1, 5}	11 (57.00 cM)⁵	topoisomerase (DNA) II alpha^{1, 5}	86.99(n)¹ 89.62(a)¹	21973¹ NM_011623.1¹ NP_035753.1¹ AB006446⁵ AI452035⁵ (see all 21)
chicken (Gallus gallus)	TOP2A¹	--	topoisomerase (DNA) II alpha 170kDa	73.25(n) 78.32(a)	395570 NM_204791.1 NP_990122.1

About this table Species with no ortholog for TOP2A

ENSEMBL Gene Tree for TOP2A

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for TOP2A gene

TOP2B²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/122 NCBI SNPs in TOP2A are shown (see all 122 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 47)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs13695^1,2	A,C,F,H,O	35798719(-)	`AGGCCG/AAAGAA`	1	--	ut3¹ ese³		13	MN EU EA WA NA	1574
	rs525812^1,2	A,C,F,H,O	35828818(-)	`CAAAAC/GTAGCC`	1	--	ng3¹		11	EU EA WA NA	954
	rs2715555^1,2	A,C,F,H	35798150(-)	`TAAGAC/TCTAAT`	1	--	ng5¹		8	EU EA WA	840
	rs11540720^1,2	C,F,H	35799350(-)	`TACGGG/TCAAAG`	1	A/S	mis¹ ese³		9	EU EA WA NA	892
	rs12941974^1,2	C,F,H	35798251(+)	`ATATTT/CTAGAA`	1	--	ng5¹		4	EU EA WA	418
	rs34300454^1,2	C,F	35801394(+)	`CACTGC/TCCTTA`	1	G/D	mis¹		5	NA EU EA WA	486
	rs11656816^1,2	C,H	35814654(+)	`TTTTGC/ATAAAG`	1	I/S	mis¹		4	EU EA WA	416
	rs2012732^1,2	C,H	35829492(+)	`AGTAGT/GGTGAG`	1	--	ng3¹		4	EU EA WA	414
	rs28742572^1,2	F	35828473(-)	`TCTCCG/TATCCC`	1	--	ng3¹		1	EU	96
	rs4890113^1,2	H	35828181(+)	`CTTGGT/CTGAAG`	1	--	ng3¹		4	EU EA WA	414

About this table

HapMap Linkage Disequilibrium images for TOP2A (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 126430

10/75 Novoseek disease relationships for TOP2A gene (see all 75 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
breast cancer	60.94	97	15891995 (4), 18465341 (3), 18340528 (3), 19365520 (3) (see all 47)
tumors	56.15	132	14978790 (6), 14566826 (5), 10469452 (5), 19158039 (4) (see all 61)
mpnst	48.70	8	14673046 (3), 16721726 (2), 14508395 (1), 18522746 (1)
small cell lung cancer	45.03	4	8306338 (1), 9713494 (1), 8041119 (1), 12906927 (1)
malignant peripheral nerve sheath tumors	43.84	1	14673046 (1)
leukemia	39.49	13	8914817 (2), 9494516 (2), 7643627 (1), 7873386 (1) (see all 11)
invasive ductal breast carcinoma	39.10	3	7745115 (2), 16097435 (1)
carcinoma	39.08	13	10597187 (1), 9310953 (1), 12556100 (1), 15068318 (1) (see all 10)
cancer	38.58	31	14632727 (2), 17363613 (2), 7641205 (2), 10652607 (2) (see all 22)
breast carcinoma	36.83	15	15628907 (2), 14632728 (2), 17013533 (2), 12011253 (1) (see all 10)

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2 PharmGKB disease relationships for TOP2A gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	CO	9748598
Leukemia, Myelocytic, Acute	CO	9748598

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Genetic Association Database: TOP2A
Human Genome Epidemiology Navigator: TOP2A (4 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/458 PubMed articles for TOP2A gene (see all 458 ):

Structural organization of the human TOP2A and TOP2B genes. (PubMed id 9795238)^{1, 3, 4} Lang A.J.... Cole S.P. (1998)
Mitotic phosphorylation of DNA topoisomerase II alpha by protein kinase CK2 creates the MPM-2 phosphoepitope on Ser-1469. (PubMed id 10942766)^{1, 3, 4} Escargueil A.E.... Larsen A.K. (2000)
Use of yeast in the study of anticancer drugs targeting DNA topoisomerases: expression of a functional recombinant human DNA topoisomerase II alpha in yeast. (PubMed id 8393377)^{1, 3, 4} Wasserman R.A.... Wang J.C. (1993)
Germline variations of the topoisomerase IIalpha gene as risk factors for primary gastric B-cell lymphoma. (PubMed id 16139951)^{3, 6} Hellmig S....Schreiber S. (2006)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{3, 4} Beausoleil S.A.... Gygi S.P. (2006)
Phosphoproteome analysis of the human mitotic spindle. (PubMed id 16565220)^{3, 4} Nousiainen M.... Koerner R. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)^{3, 4} Beausoleil S.A....Gygi S.P. (2004)
Interaction between glucose-regulated destruction domain of DNA topoisomerase IIalpha and MPN domain of Jab1/CSN5. (PubMed id 15126503)^{3, 4} Yun J.... Tsuruo T. (2004)
Identification of functional nuclear export sequences in human topoisomerase IIalpha and beta. (PubMed id 12821127)^{3, 4} Mirski S.E.... Cole S.P. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 7153	HGNC: 11989	AceView: TOP2A	Ensembl:ENSG00000131747	euGenes: HUgn7153
ECgene: TOP2A	H-InvDB: TOP2A

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for TOP2A	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for TOP2A
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for TOP2A:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for TOP2A-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for TOP2A		Antibodies for TOP2A
	Explore super-pooled esiRNAs		Proteins for TOP2A
	Lentivirus-delivered shRNAs for TOP2A		Small molecules for TOP2A
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (TOP2A)
	Antibodies (TOP2A)
	Chimera RNAi (TOP2A)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for TOP2A (TopoII alpha)

	Recombinant Proteins (Topoisomerase II alpha)
	Antibodies (Topoisomerase II alpha)

Search OriGene for TOP2A

Tocris compounds for TOP2A

	Drugs for TOP2A
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for TOP2A

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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TOP2A Gene at Home site.
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TOP2A Gene

protein-coding GIFtS: 71

Aliases &
Descriptions
for TOP2A

Summaries
for TOP2A

Genomic Location
for TOP2A

Proteins
for TOP2A

Protein Domains/
Families
for TOP2A

Gene Function
for TOP2A

Pathways & Interactions
for TOP2A

Drugs & Compounds
for TOP2A

Transcripts
for TOP2A

Expression
for TOP2A

Orthologs
for TOP2A

Paralogs
for TOP2A

SNPs/Variants
for TOP2A

Disorders & Mutations
for TOP2A

Medical News
for TOP2A

Publications
for TOP2A

Search for TOP2A

Genome Databases showing TOP2A

Other Databases showing TOP2A

Specialized Databases showing TOP2A

Licensable Technologies
for TOP2A

Services
for TOP2A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

TOP2A Gene

protein-coding GIFtS: 71

Aliases & Descriptionsfor TOP2A

Summariesfor TOP2A

Genomic Locationfor TOP2A

Proteinsfor TOP2A

Protein Domains/Familiesfor TOP2A

Gene Functionfor TOP2A

Pathways & Interactionsfor TOP2A

Drugs & Compoundsfor TOP2A

Transcriptsfor TOP2A

Expression for TOP2A

Orthologsfor TOP2A

Paralogsfor TOP2A

SNPs/Variantsfor TOP2A

Disorders & Mutationsfor TOP2A

Medical Newsfor TOP2A

Publicationsfor TOP2A

Search for TOP2A

Genome Databases showing TOP2A

Other Databases showing TOP2A

Specialized Databases showing TOP2A

Licensable Technologiesfor TOP2A

Servicesfor TOP2A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for TOP2A

Summaries
for TOP2A

Genomic Location
for TOP2A

Proteins
for TOP2A

Protein Domains/
Families
for TOP2A

Gene Function
for TOP2A

Pathways & Interactions
for TOP2A

Drugs & Compounds
for TOP2A

Transcripts
for TOP2A

Expression
for TOP2A

Orthologs
for TOP2A

Paralogs
for TOP2A

SNPs/Variants
for TOP2A

Disorders & Mutations
for TOP2A

Medical News
for TOP2A

Publications
for TOP2A

Licensable Technologies
for TOP2A

Services
for TOP2A