Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SUOX Gene

Aliases for SUOX Gene

  • Sulfite Oxidase 2 3
  • EC 1.8.3.1 4 63

External Ids for SUOX Gene

Previous GeneCards Identifiers for SUOX Gene

  • GC12M056183
  • GC12P056958
  • GC12P056107
  • GC12P054681
  • GC12P054651
  • GC12P054677
  • GC12P056391
  • GC12P053429

Summaries for SUOX Gene

Entrez Gene Summary for SUOX Gene

  • Sulfite oxidase is a homodimeric protein localized to the intermembrane space of mitochondria. Each subunit contains a heme domain and a molybdopterin-binding domain. The enzyme catalyzes the oxidation of sulfite to sulfate, the final reaction in the oxidative degradation of the sulfur amino acids cysteine and methionine. Sulfite oxidase deficiency results in neurological abnormalities which are often fatal at an early age. Alternative splicing results in multiple transcript variants encoding identical proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for SUOX Gene

SUOX (Sulfite Oxidase) is a Protein Coding gene. Diseases associated with SUOX include sulfite oxidase deficiency and schimke immunoosseous dysplasia. Among its related pathways are Metabolism and Metabolism of amino acids and derivatives. GO annotations related to this gene include electron carrier activity and molybdopterin cofactor binding.

Gene Wiki entry for SUOX Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUOX Gene

Genomics for SUOX Gene

Genomic Location for SUOX Gene

Start:
55,997,180 bp from pter
End:
56,006,641 bp from pter
Size:
9,462 bases
Orientation:
Plus strand

Genomic View for SUOX Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SUOX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUOX Gene

Proteins for SUOX Gene

  • Protein details for SUOX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51687-SUOX_HUMAN
    Recommended name:
    Sulfite oxidase, mitochondrial
    Protein Accession:
    P51687
    Secondary Accessions:

    Protein attributes for SUOX Gene

    Size:
    545 amino acids
    Molecular mass:
    60283 Da
    Cofactor:
    Name=heme b; Xref=ChEBI:CHEBI:60344; Note=Binds 1 heme b (iron(II)-protoporphyrin IX) group non-covalently per subunit.;
    Cofactor:
    Name=Mo-molybdopterin; Xref=ChEBI:CHEBI:71302; Note=Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.;
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=AAA74886.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAL08048.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SUOX Gene

neXtProt entry for SUOX Gene

Proteomics data for SUOX Gene at MOPED

Selected DME Specific Peptides for SUOX Gene

Post-translational modifications for SUOX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for SUOX Gene

Suggested Antigen Peptide Sequences for SUOX Gene

Graphical View of Domain Structure for InterPro Entry

P51687

UniProtKB/Swiss-Prot:

SUOX_HUMAN :
  • P51687
Domain:
  • Contains 1 cytochrome b5 heme-binding domain.
genes like me logo Genes that share domains with SUOX: view

No data available for Gene Families for SUOX Gene

Function for SUOX Gene

Molecular function for SUOX Gene

UniProtKB/Swiss-Prot CatalyticActivity: Sulfite + O(2) + H(2)O = sulfate + H(2)O(2)

Enzyme Numbers (IUBMB) for SUOX Gene

Gene Ontology (GO) - Molecular Function for SUOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008482 sulfite oxidase activity TAS --
GO:0009055 electron carrier activity IEA --
GO:0016491 oxidoreductase activity --
GO:0020037 heme binding IEA --
GO:0030151 molybdenum ion binding IEA --
genes like me logo Genes that share ontologies with SUOX: view

Phenotypes for SUOX Gene

genes like me logo Genes that share phenotypes with SUOX: view

miRNA for SUOX Gene

miRTarBase miRNAs that target SUOX

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for SUOX Gene

Localization for SUOX Gene

Subcellular locations from UniProtKB/Swiss-Prot for SUOX Gene

Mitochondrion intermembrane space.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SUOX Gene COMPARTMENTS Subcellular localization image for SUOX gene
Compartment Confidence
mitochondrion 5
cytosol 2
peroxisome 2
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SUOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005758 mitochondrial intermembrane space IEA --
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with SUOX: view

Pathways for SUOX Gene

genes like me logo Genes that share pathways with SUOX: view

UniProtKB/Swiss-Prot P51687-SUOX_HUMAN

  • Pathway: Energy metabolism; sulfur metabolism

Gene Ontology (GO) - Biological Process for SUOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000096 sulfur amino acid metabolic process TAS --
GO:0000098 sulfur amino acid catabolic process TAS --
GO:0034641 cellular nitrogen compound metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0055114 oxidation-reduction process --
genes like me logo Genes that share ontologies with SUOX: view

Compounds for SUOX Gene

(7) HMDB Compounds for SUOX Gene

Compound Synonyms Cas Number PubMed IDs
Heme
  • (protoporphyrinato)iron
14875-96-8
Hydrogen peroxide
  • Hydrogen peroxide
7722-84-1
Molybdenum
  • Mo
7439-98-7
Oxygen
  • Oxygen
7782-44-7
Sulfate
  • Sulfate (ion 2-)
14808-79-8

(2) Drugbank Compounds for SUOX Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
(Molybdopterin-S,S)-Dioxo-Thio-Molybdenum(V)
target
Heme
target

(34) Novoseek inferred chemical compound relationships for SUOX Gene

Compound -log(P) Hits PubMed IDs
molybdenum 93.3 46
s-sulfocysteine 90.2 2
moco 85.8 5
molybdopterin 84.7 7
xanthine 78.7 25
genes like me logo Genes that share compounds with SUOX: view

Transcripts for SUOX Gene

Unigene Clusters for SUOX Gene

Sulfite oxidase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SUOX Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d · 9e · 9f ·
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - - - -
SP6: - - - - - - - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - - - - -
SP9: - - - -
SP10: - - - - - - - -
SP11: - - - - - -
SP12: - -
SP13: -
SP14: - - - - - - - - - - -
SP15: - - - - - -
SP16: -
SP17: -
SP18:

ExUns: 9g · 9h · 9i · 9j ^ 10a · 10b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: - - - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for SUOX Gene

GeneLoc Exon Structure for
SUOX
ECgene alternative splicing isoforms for
SUOX

Expression for SUOX Gene

mRNA expression in normal human tissues for SUOX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SUOX Gene

SOURCE GeneReport for Unigene cluster for SUOX Gene Hs.558403

genes like me logo Genes that share expressions with SUOX: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SUOX Gene

Orthologs for SUOX Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SUOX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SUOX 35
  • 99.45 (n)
  • 99.45 (a)
SUOX 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SUOX 35
  • 88.38 (n)
  • 85.32 (a)
SUOX 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SUOX 35
  • 89.4 (n)
  • 88.97 (a)
SUOX 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Suox 35
  • 85.5 (n)
  • 85.69 (a)
Suox 16
Suox 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Suox 35
  • 84.99 (n)
  • 85.24 (a)
lizard
(Anolis carolinensis)
Reptilia SUOX 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia suox 35
  • 61.13 (n)
  • 60.63 (a)
zebrafish
(Danio rerio)
Actinopterygii suox 35
  • 60.92 (n)
  • 63.29 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010877 35
  • 56.6 (n)
  • 56.46 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7280 35
  • 56.22 (n)
  • 53.86 (a)
CG7280 36
  • 44 (a)
OneToOne
CG7280 37
  • 52 (a)
worm
(Caenorhabditis elegans)
Secernentea suox-1 35
  • 54.73 (n)
  • 50.22 (a)
suox-1 36
  • 44 (a)
OneToOne
H13N06.4 37
  • 48 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons SOX 35
  • 52.9 (n)
  • 47.28 (a)
rice
(Oryza sativa)
Liliopsida Os08g0530400 35
  • 54.14 (n)
  • 48.07 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06931 35
  • 51.95 (n)
  • 43.71 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
OneToOne
Species with no ortholog for SUOX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SUOX Gene

ENSEMBL:
Gene Tree for SUOX (if available)
TreeFam:
Gene Tree for SUOX (if available)

Paralogs for SUOX Gene

Selected SIMAP similar genes for SUOX Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for SUOX Gene

genes like me logo Genes that share paralogs with SUOX: view

No data available for Paralogs for SUOX Gene

Variants for SUOX Gene

Sequence variations from dbSNP and Humsavar for SUOX Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs705703 -- 55,997,702(+) TAGTA(C/T)AAACA utr-variant-5-prime, intron-variant
rs773115 Likely benign 56,004,670(-) ATGGC(A/C/G)GACTG synonymous-codon, reference
rs773125 -- 56,001,170(+) cccag(A/G)ctgga intron-variant
rs773126 -- 56,001,636(+) AGAGA(A/T)GAGGA intron-variant
rs1081975 -- 55,999,553(+) tcgtg(C/G)tcttg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SUOX Gene

Variant ID Type Subtype PubMed ID
nsv832424 CNV Loss 17160897
nsv832427 CNV Loss 17160897

Relevant External Links for SUOX Gene

HapMap Linkage Disequilibrium report
SUOX
Human Gene Mutation Database (HGMD)
SUOX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUOX Gene

Disorders for SUOX Gene

(1) OMIM Diseases for SUOX Gene (606887)

UniProtKB/Swiss-Prot

SUOX_HUMAN
  • Isolated sulfite oxidase deficiency (ISOD) [MIM:272300]: Characterized by neurological abnormalities including multicystic leukoencephalopathy with brain atrophy. Patients often suffer from seizures. Often leads to death at an early age. {ECO:0000269 PubMed:10519592, ECO:0000269 PubMed:12112661, ECO:0000269 PubMed:12368985, ECO:0000269 PubMed:9428520, ECO:0000269 PubMed:9600976}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(12) Novoseek inferred disease relationships for SUOX Gene

Disease -log(P) Hits PubMed IDs
sulfite oxidase deficiency 98.8 62
molybdenum cofactor deficiency 94.5 12
xanthinuria, type i 85.9 2
ectopia lentis 76.8 1
lens dislocation 67.7 1

Relevant External Links for SUOX

Genetic Association Database (GAD)
SUOX
Human Genome Epidemiology (HuGE) Navigator
SUOX
genes like me logo Genes that share disorders with SUOX: view

Publications for SUOX Gene

  1. Molecular cloning of human liver sulfite oxidase. (PMID: 7599189) Garrett R.M. … Rajagopalan K.V. (Biochim. Biophys. Acta 1995) 2 3 4 23
  2. Human sulfite oxidase R160Q: identification of the mutation in a sulfite oxidase-deficient patient and expression and characterization of the mutant enzyme. (PMID: 9600976) Garrett R.M. … Rajagopalan K.V. (Proc. Natl. Acad. Sci. U.S.A. 1998) 3 4 23
  3. A novel mutation in neonatal isolated sulphite oxidase deficiency. (PMID: 12368985) Lee H.F. … Shu S.G. (Neuropediatrics 2002) 3 4 23
  4. The 1.2 A structure of the human sulfite oxidase cytochrome b(5) domain. (PMID: 12832761) Rudolph M.J. … Kisker C. (Acta Crystallogr. D 2003) 3 4 23
  5. Isolated sulfite oxidase deficiency: review of two cases in one family. (PMID: 10519592) Edwards M.C. … MacDonald I.M. (Ophthalmology 1999) 3 4 23

Products for SUOX Gene

Sources for SUOX Gene

Back to Top

Content