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SRD5A1 Gene

protein-coding GIFtS: 63

GC05P006686

steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 1.3.99.5 ^³
OTTHUMP00000115519 ^²
S5AR ^³

Descriptions
3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1 ^²
5-alpha reductase ^²
SR type 1 ^³
Steroid 5-alpha-reductase 1 ^³
steroid 5-alpha-reductase type I ^²
steroid-5-alpha-reductase 1 ^²
steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) ^²

External Ids
HGNC: 11284¹
Entrez Gene: 6715²
UniProtKB: P18405³
Ensembl: ENSG00000145545⁷

Search outside databases for aliases for SRD5A1 gene

Previous GC identifers: GC05P006782 GC05P006666

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for SRD5A1:

Steroid 5-alpha-reductase (EC 1.3.99.5) catalyzes the conversion of testosterone into the more

potent androgen, dihydrotestosterone (DHT). Also see SRD5A2 (MIM 607306).[supplied by OMIM]

UniProtKB/Swiss-Prot: S5A1_HUMAN, P18405

Function: Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone

into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation

and androgen physiology

Gene Wiki entry for SRD5A1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the SRD5A1 gene

Entrez Gene cytogenetic band: 5p15 Ensembl cytogenetic band: 5p15.31 HGNC cytogenetic band: 5p15.31

SRD5A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P006686: (about GC identifiers)

Start:	6,686,500 bp from pter
End:	6,722,675 bp from pter
Size:	36,176 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000005.8 NT_006576.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: S5A1_HUMAN, P18405 (See protein sequence)

Recommended Name: 3-oxo-5-alpha-steroid 4-dehydrogenase 1

Size: 259 amino acids; 29459 Da

Subcellular location: Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum

membrane; Multi-pass membrane protein (Potential)

Secondary accessions: Q9UHY4 Q9UP36 Q9UP37

REFSEQ proteins: NP_001038.1

ENSEMBL proteins:

ENSP00000274192

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (SRD5A1)
	Human Recombinant Proteins from Abnova (SRD5A1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005783	endoplasmic reticulum	IEA	--
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0005792	microsome	IEA	--
GO:0016020	membrane	IEA	--

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Antibodies for SRD5A1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (SRD5A1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (SRD5A1)
	Novus Biologicals Antibodies for SRD5A1

Assays for SRD5A1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P18405

ProtoNet protein and cluster: P18405

1 Blocks protein family: IPB001104 3-oxo-5-alpha-steroid 4-dehydrogenase

UniProtKB/Swiss-Prot: S5A1_HUMAN, P18405

Similarity: Belongs to the steroid 5-alpha reductase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SRD5A1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SRD5A1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001047

Applied Biosystems Silencer® siRNAs for SRD5A1

Sigma-Aldrich siRNA and siRNA Panels for SRD5A1

Sigma-Aldrich shRNA for SRD5A1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for SRD5A1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001047
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001047
untagged cDNA clone in CMV expression vector: NM_001047

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001047

UniProtKB/Swiss-Prot: S5A1_HUMAN, P18405

Function: Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone

into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation

and androgen physiology

Catalytic activity: A 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-Delta(4)-steroid + reduced

acceptor

Biophysicochemical properties: pH dependence: Optimally active at alkaline pHs;

Induction: Its expression is regulated by androgens such as testosterone

Enzyme Number (IUBMB): EC 1.3.99.5

Genatlas biochemistry entry for SRD5A1:

steroid 5 alpha-reductase (3-oxo-5 alpha-steroid delta 4-dehydrogenase) alpha polypeptide

1,catalyzing the conversion of testosterone to dihydrotestosterone

2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Srd5a1):

endocrine/exocrine gland

reproductive system

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003865	3-oxo-5-alpha-steroid 4-dehydrogenase activity	IEA	--
GO:0009055	electron carrier activity	TAS	1686016
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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3 Sigma-Aldrich "Your Favorite Gene" Pathways for SRD5A1 (Your Favorite Gene powered by Ingenuity)

Androgen and Estrogen Metabolism
Bile Acid Biosynthesis
Prostate Cancer Signaling

GeneDecks SRD5A1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for SRD5A1

5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006629	lipid metabolic process	IEA	--
GO:0006702	androgen biosynthetic process	IEA	--
GO:0007530	sex determination	NAS	1686016
GO:0008202	steroid metabolic process	IEA	--
GO:0030154	cell differentiation	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for SRD5A1:

Inhibitor

Compounds for SRD5A1 available from Tocris Bioscience

Compound	Action	CAS number
Finasteride	Type II 5alpha-reductase inhibitor	[98319-26-7]

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10/42 Novoseek chemical compound relationships for SRD5A1 gene (see all 42 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
mk 386	89.97	1	8903421 (1)
17beta-hydroxysteroid	86.91	69	10490108 (4), 2158194 (2), 12161528 (2), 15514087 (2) (see all 55)
3-alpha-androstanediol glucuronide	86.85	11	8941077 (2), 11699123 (1), 7769052 (1), 1424180 (1) (see all 6)
androstanedione	86.71	11	2362429 (1), 9558487 (1), 12161528 (1), 12466325 (1) (see all 11)
androsterone glucuronide	85.71	16	7962311 (2), 12398233 (1), 1424180 (1), 1426314 (1) (see all 7)
ly 191704	84.52	6	8389478 (4), 12466325 (1), 8964828 (1)
turosteride	84.52	6	8240976 (3), 17326010 (1), 8142301 (1), 9029321 (1)
androstenedione	82.83	32	12161528 (2), 1426314 (2), 2158194 (1), 2362429 (1) (see all 28)
3alpha-hydroxysteroid	82.75	25	12742591 (2), 2362429 (1), 1379259 (1), 9558487 (1) (see all 24)
epristeride	82.11	5	8636334 (1), 10357260 (1), 17961376 (1), 9288184 (1) (see all 5)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SRD5A1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SRD5A1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001047

Sigma-Aldrich siRNA and siRNA Panels for SRD5A1

Sigma-Aldrich shRNA for SRD5A1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001047

REFSEQ mRNAs for SRD5A1 gene:

NM_001047.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001047

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001047
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001047
                                 untagged cDNA clone in CMV expression vector: NM_001047

Additional cDNA sequence:

AF052126.1 AF113128.1 AK297208.1 AK297511.1 AK313070.1 AK315996.1 BC006373.2 BC007033.1

BC008673.2 BT006834.1 M32313.1

9 DOTS entries:

DT.444034 DT.95292639 DT.92051061 DT.99946639 DT.100783025 DT.91874314 DT.120829790 DT.120829832

DT.95376374

24/102 AceView cDNA sequences (see all 102 ):

BE857592 BF508186 BC008673 AA488669 BG675027 BC006373 AA917839 BM783945

AF113128 BF968451 BX284105 AI363117 AU148545 BC007033 AU280630 BU838844

BV191614 BU195899 M32313 AI140805 BE252370 BX423623 AF052126 AA765264

highest scoring ESTs for SRD5A1:

M32313 AA114145 AA193188 AA223485 AA251020 AA251021 AA263107 AA400662 AA400714 AA486052

Unigene Cluster for SRD5A1:

Steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)

Hs.552 [show with all ESTs]

Unigene Representative Sequence: NM_001047

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000274192

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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SRD5A1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for SRD5A1

¹ / ² / ³

7 probe-sets matching SRD5A1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
589_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	M32313	1.00	1.00	1.00	1
211056_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC006373	0.80	1.00	0.91	1
204675_at²^{, 3}	U133-A	2	1.00	0.95	--	--	NM_001047	0.60	1.00	0.82	1
210959_s_at²^{, 3}	U133-A	2	1.00	0.91	--	--	AF113128	0.60	1.00	0.82	1
211056_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204675_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--
210959_s_at²	U133Plus2	2	1.00	0.91	--	--	--	--	--	--	--

GeneDecks SRD5A1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ACTTGAATTC

SOURCE GeneReport for Unigene cluster: Hs.552
Expression variation in blood from EXPOLDB for SRD5A1
UniProtKB/Swiss-Prot: S5A1_HUMAN, P18405
Tissue specificity: Liver and prostate (at a low level)

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for SRD5A1 gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	SRD5A1¹	--	steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 more	79.1(n) 73.02(a)	403716 XM_535799.2 XP_535799.2
chimpanzee (Pan troglodytes)	SRD5A1¹	--	steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 more	99.61(n) 100(a)	743740 XM_001144570.1 XP_001144570.1
cow (Bos taurus)	SRD5A1¹	--	steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 more	76.46(n) 69.44(a)	614612 XM_866174.2 XP_871267.2
rat (Rattus norvegicus)	Srd5a1¹	--	steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 more	71.66(n) 62.35(a)	24950 NM_017070.3 NP_058766.2
mouse (Mus musculus)	Srd5a1^{1, 5}	13 (39.00 cM)⁵	steroid 5 alpha-reductase 1^{1, 5}	72.13(n)¹ 63.2(a)¹	78925¹ NM_175283.3¹ NP_780492.2¹ AI414607⁵ AK019597⁵ (see all 11)

About this table Species with no ortholog for SRD5A1

ENSEMBL Gene Tree for SRD5A1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for SRD5A1 gene

SRD5A2²

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/324 NCBI SNPs in SRD5A1 are shown (see all 324 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 180)

AB	SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs39848^1,2	A,C,F,H,O	6722762(-)	`ACAGAA/GGAAGT`	1	--	ng3¹		13		EA NS NA EU WA	2596
--	rs13974^1,2	A,C,F	6722000(+)	`AGCCCA/GGCCCA`	1	--	ut3¹ ese³		2		NS MN	328
--	rs3297^1,2	A,C,F	6721842(-)	`CCTCTG/ATGGCC`	1	--	ut3¹ ese³		8		EA NS	2014
--	rs1042150^1,2	C,F	6721915(+)	`TGTGTG/ATAAGT`	1	--	ut3¹ ese³		1		NS	144
--	rs8192256^1,2	F,H	6722336(+)	`CCTGTT/CTGTTC`	1	--	ut3¹		5		NS EU EA WA	566
--	rs8192257^1,2	C,F	6722536(+)	`TACTTT/CGATAA`	1	--	ut3¹		7		NS	836
--	rs13185837^1,2	H	6721894(+)	`GCCAAC/ACTTCG`	1	--	ut3¹		4		EU EA WA	412
--	rs1802949^1,2	C	6722351(+)	`TTGATC/TGAAAC`	1	--	ut3¹		0	--	--	--	--
--	rs8192254^1,2	F	6722009(+)	`CACCGG/AGTGAC`	1	--	ut3¹ ese³		1		NS	150
	rs3822430^1,2	A,C,F,H	6704970(-)	`AGAAAT/CGGGTA`	1	P/P	syn¹ ese³		17		EA NS EU WA NA	3176

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HapMap Linkage Disequilibrium images for SRD5A1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 184753

10/76 Novoseek disease relationships for SRD5A1 gene (see all 76 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
benign prostatic hyperplasia	94.21	170	8381804 (2), 8636334 (2), 16515494 (2), 12426860 (2) (see all 99)
pseudohermaphroditism male	86.30	19	7584701 (2), 1879398 (1), 1944596 (1), 1505484 (1) (see all 15)
alopecia androgenetic	83.08	15	8077349 (2), 9879479 (1), 9873170 (1), 11125319 (1) (see all 13)
prostate cancer	77.80	143	8636334 (4), 18280514 (3), 1283894 (3), 16890642 (3) (see all 99)
virilization	76.66	9	2327864 (1), 9039340 (1), 8784107 (1), 17218080 (1) (see all 9)
androgen insensitivity syndrome	71.40	4	16148681 (1), 2173324 (1), 12403225 (1), 18717241 (1)
androgen insensitivity syndrome partial	70.28	3	17973056 (1), 9329414 (1), 17627743 (1)
prostatic diseases	68.74	7	17052442 (1), 8778238 (1), 18046919 (1), 19030020 (1) (see all 7)
genitalia external ambiguous	68.44	1	9745434 (1)
prostatic hyperplasia	67.81	7	9142509 (1), 19205388 (1), 12724020 (1), 12494605 (1) (see all 6)

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Genetic Association Database: SRD5A1
Human Genome Epidemiology Navigator: SRD5A1 (10 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/662 PubMed articles for SRD5A1 gene (see all 662 ):

Characterization and chromosomal mapping of a human steroid 5 alpha- reductase gene and pseudogene and mapping of the mouse homologue. (PubMed id 1686016)^{2, 3, 4} Jenkins E.P.... Russell D.W. (1991)
New steroid 5alpha-reductase type I (SRD5A1) homologous sequences on human chromosomes 6 and 8. (PubMed id 11678334)^{1, 3, 4} Eminovic I....Komel R. (2001)
Androgenic correlates of genetic variation in the gene encoding 5alpha-reductase type 1. (PubMed id 16155734)^{1, 3, 6} Ellis J.A....Harrap S.B. (2005)
Gene analysis of steroid 5 alpha-reductase 1 in hyperandrogenic women. (PubMed id 16100771)^{1, 3, 6} Eminovic I....Heljic B. (2005)
A case-based evaluation of SRD5A1, SRD5A2, AR, and ADRA1A as candidate genes for severity of BPH. (PubMed id 15136785)^{1, 3, 6} Klotsman M....Hartmann K.E. (2004)
Analysis of genetic polymorphisms of steroid 5alpha-reductase type 1 and 2 genes in Korean men with androgenetic alopecia. (PubMed id 12670724)^{1, 3, 6} Ha S.J....Kim J.W. (2003)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)^{3, 4} Hu R.-M.... Chen J.-L. (2000)
Structural and biochemical properties of cloned and expressed human and rat steroid 5 alpha-reductases. (PubMed id 2339109)^{3, 4} Andersson S. and Russell D.W. (1990)
Variants in the 5alpha-reductase type 1 and type 2 genes are associated with polycystic ovary syndrome and the severity of hirsutism in affected women. (PubMed id 16849416)^{1, 3} Goodarzi M.O....Azziz R. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 6715	HGNC: 11284	AceView: SRD5A1	Ensembl:ENSG00000145545	euGenes: HUgn6715
ECgene: SRD5A1	H-InvDB: SRD5A1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
NIEHS-SNPs	http://egp.gs.washington.edu/data/srd5a1/
Wikipedia	http://en.wikipedia.org/wiki/5_alpha_reductase

Licensable Technologies for SRD5A1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for SRD5A1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for SRD5A1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for SRD5A1		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for SRD5A1		Small molecules for SRD5A1
	"Your Favorite Gene" Pathways		feedback

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SRD5A1 Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for SRD5A1

Summaries
for SRD5A1

Genomic Location
for SRD5A1

Proteins
for SRD5A1

Protein Domains/
Families
for SRD5A1

Gene Function
for SRD5A1

Pathways & Interactions
for SRD5A1

Drugs & Compounds
for SRD5A1

Transcripts
for SRD5A1

Expression
for SRD5A1

Orthologs
for SRD5A1

Paralogs
for SRD5A1

SNPs/Variants
for SRD5A1

Disorders & Mutations
for SRD5A1

Medical News
for SRD5A1

Publications
for SRD5A1

Search for SRD5A1

Genome Databases showing SRD5A1

Other Databases showing SRD5A1

Specialized Databases showing SRD5A1

Licensable Technologies
for SRD5A1

Services
for SRD5A1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

SRD5A1 Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor SRD5A1

Summariesfor SRD5A1

Genomic Locationfor SRD5A1

Proteinsfor SRD5A1

Protein Domains/Familiesfor SRD5A1

Gene Functionfor SRD5A1

Pathways & Interactionsfor SRD5A1

Drugs & Compoundsfor SRD5A1

Transcriptsfor SRD5A1

Expression for SRD5A1

Orthologsfor SRD5A1

Paralogsfor SRD5A1

SNPs/Variantsfor SRD5A1

Disorders & Mutationsfor SRD5A1

Medical Newsfor SRD5A1

Publicationsfor SRD5A1

Search for SRD5A1

Genome Databases showing SRD5A1

Other Databases showing SRD5A1

Specialized Databases showing SRD5A1

Licensable Technologiesfor SRD5A1

Servicesfor SRD5A1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for SRD5A1

Summaries
for SRD5A1

Genomic Location
for SRD5A1

Proteins
for SRD5A1

Protein Domains/
Families
for SRD5A1

Gene Function
for SRD5A1

Pathways & Interactions
for SRD5A1

Drugs & Compounds
for SRD5A1

Transcripts
for SRD5A1

Expression
for SRD5A1

Orthologs
for SRD5A1

Paralogs
for SRD5A1

SNPs/Variants
for SRD5A1

Disorders & Mutations
for SRD5A1

Medical News
for SRD5A1

Publications
for SRD5A1

Licensable Technologies
for SRD5A1

Services
for SRD5A1