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Aliases & Descriptions for SQLE
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EC 1.14.99.7 3 | | ERG1 3 | | FLJ30795 2 | | SE 3 |
| | | Descriptions |
|---|
| squalene epoxidase 2, 3 | | squalene monooxygenase 2 |
|
| | Search outside databases for aliases for SQLE genePrevious GC identifers: GC08P125035 GC08P126015 GC08P125679 GC08P125968 |
Summaries for SQLE(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for SQLE: Squalene epoxidase catalyzes the first oxygenation step in sterol biosynthesis and is thought to be one of the rate-limiting enzymes in this pathway. [provided by RefSeq] UniProtKB/Swiss-Prot: ERG1_HUMAN, Q14534Function: Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway |
Genomic Location for SQLE
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the SQLE gene 
Entrez Gene cytogenetic band: 8q24.1 Ensembl cytogenetic band: 8q24.13 HGNC cytogenetic band: 8q24.1SQLE Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P126079:
(about GC identifiers)
Start:
|
126,079,901 bp from pter |
End:
|
126,103,707 bp from pter |
Size:
|
23,807 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000008.9 NT_008046.15
| Proteins for SQLE
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: ERG1_HUMAN, Q14534 (See
protein sequence)Recommended Name: Squalene monooxygenase Size: 574 amino acids; 63939 Da
Cofactor: FAD
Subunit: May form a complex with squalene synthase
Subcellular location: Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein
Secondary accessions: Q9UEK6REFSEQ proteins: NP_003120.2
ENSEMBL proteins: ENSP00000265896
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
5 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for SQLE: Assays for SQLE: | Protein
Domains/ Families for SQLE(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q14534
ProtoNet protein and cluster: Q14534 1 Blocks protein family: IPB013698 Squalene epoxidase
UniProtKB/Swiss-Prot: ERG1_HUMAN, Q14534Similarity: Belongs to the squalene monooxygenase family | Gene Function for SQLE
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003129
Applied Biosystems Silencer® siRNAs for SQLE
Sigma-Aldrich siRNA and siRNA Panels for SQLE  Sigma-Aldrich shRNA for SQLE  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003129                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003129                                  untagged cDNA clones in CMV expression vector (see all 2): NM_003129 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_003129
UniProtKB/Swiss-Prot: ERG1_HUMAN, Q14534Function: Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathwayCatalytic activity: Squalene + AH(2) + O(2) = (S)-squalene-2,3-epoxide + A + H(2)OEnzyme Number (IUBMB): EC 1.14.99.7 Genatlas biochemistry entry for SQLE:squalene epoxidase catalyzing the first oxygenation step in sterol biosynthesis3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for SQLE
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 1 Sigma-Aldrich "Your Favorite Gene" Pathway for SQLE (Your Favorite Gene powered by Ingenuity) 
UniProtKB/Swiss-Prot: ERG1_HUMAN, Q14534Pathway: Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl-PP: step 2/3 Gene Network CentralTM Interacting Genes and Proteins Network for SQLE 
5/13 Interacting proteins for SQLE (ENSP000002658963) via UniProtKB, MINT, and/or STRING (see all 13
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for SQLE(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  |
Enzo Life Sciences drugs & compounds for SQLE |
Browse Tocris compounds for SQLE 10/14 Novoseek chemical compound relationships for SQLE gene (see all 14
)
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| squalene |
97.18 |
152 |
1964954 (7), 11181753 (6), 9324936 (5), 9300786 (4) (see all 71) |
| dimethyltelluride |
89.80 |
1 |
11181753 (1) |
| ergosterol |
84.08 |
16 |
18096502 (2), 12477372 (2), 16466954 (2), 1287164 (1) (see all 9) |
| lanosterol |
82.12 |
5 |
16079485 (1), 7791529 (1), 15893902 (1) |
| sterol |
74.67 |
10 |
8626488 (1), 7791529 (1), 1803242 (1), 9286711 (1) (see all 8) |
| tellurium |
69.31 |
9 |
11181753 (5), 8090356 (1) |
| 25-hydroxycholesterol |
64.01 |
2 |
8626488 (1), 16098143 (1) |
| mevalonate |
63.80 |
2 |
1964954 (1), 10082320 (1) |
| cholesterol |
60.75 |
40 |
1649182 (3), 9300786 (2), 8347152 (2), 11181753 (2) (see all 26) |
| triacylglycerol |
35.60 |
2 |
8504141 (2) |
About this table
|
Transcripts for SQLE(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003129
Sigma-Aldrich siRNA and siRNA Panels for SQLE  Sigma-Aldrich shRNA for SQLE  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_003129 REFSEQ mRNAs for SQLE gene: NM_003129.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_003129               OriGene GFP tagged cDNA clone in CMV expression vector: NM_003129                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003129                                  untagged cDNA clones in CMV expression vector (see all 2): NM_003129  Additional cDNA sequence: AF098865.1 AK225085.1 AK295302.1 AK301792.1 AK313384.1 BC017033.1 BX647400.1 BX647605.1 CR599266.1 D78129.1 D78130.1 11 DOTS entries: DT.97857247 DT.117824 DT.40299615 DT.95210936 DT.100757709 DT.92441125 DT.95210960 DT.75155650 DT.92441126 DT.92473475 DT.95210930 24/265 AceView cDNA sequences (see all 265
):AA341650 F05344 AI802289 AK055357 BP872774 AI341546 AL041945 AA580614 AI810962 AI084342 BP368846 AI937469 BC017033 AL046067 BU631333 W80742 BF154931 Z38352 AU136459 BI492283 CK300375 AI143944 AA132213 BI324843
highest scoring ESTs for SQLE:D78130 AA076231 AA101516 AA113270 AA114251 AA152331 AA158138 AA232318 AA286783 AA400196 Unigene Cluster for SQLE: Squalene epoxidase Hs.71465 [show with all ESTs]Unigene Representative Sequence: NM_003129
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000265896
|
Expression for SQLE
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| SQLE expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for SQLE
1 / 2 / 3 8 probe-sets matching SQLE gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CAAATAAAAT
SOURCE GeneReport for Unigene cluster: Hs.71465
Expression variation in blood from EXPOLDB for SQLE |
Orthologs for SQLE
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for SQLE gene from 5/19 species (see all 19
)
About this table Species with no ortholog for SQLE
ENSEMBL Gene Tree for SQLE | Paralogs for SQLE(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for SQLE(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for SQLE (up to first 250kb)
|
Disorders & Mutations for SQLE
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 602019
3 Novoseek disease relationships for SQLE gene
About this table
Human Genome Epidemiology Navigator: SQLE (1 document)
|
Medical News for SQLE(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for SQLE (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/82 PubMed articles for SQLE gene (see all 82
):- Localization of the squalene epoxidase gene (SQLE) to human chromosome region 8q24.1. (PubMed id 9286711)1, 2, 3, 4 Nagai M.... Ono T. (1997)
- Transcriptional regulation of squalene epoxidase by sterols and inhibitors in HeLa cells. (PubMed id 8626488)1, 3, 4 Nakamura Y.... Ono T. (1996)
- Squalene epoxidase, located on chromosome 8q24.1, is upregulated in 8q+ breast cancer and indicates poor clinical outcome in stage I and II disease. (PubMed id 18728668)1, 3 Helms M.W....Brandt B.H. (2008)
- Cloning, heterologous expression, and enzymological characterization of human squalene monooxygenase. (PubMed id 10666321)1, 3 Laden B.P....Porter T.D. (2000)
- Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)3 Lu Y....Boer J.M. (2008)
- Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects. (PubMed id 16806233)3 Ma J....Liew C.C. (2007)
- Identification of genes differentially expressed in human primary lung squamous cell carcinoma. (PubMed id 17316888)3 Liu Y....Cheng S. (2007)
- The LIFEdb database in 2006. (PubMed id 16381901)3 Mehrle A....Wiemann S. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3 Ota T....Sugano S. (2004)
- From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)3 Wiemann S....Poustka A. (2004)
|
Search for SQLE
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing SQLE
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing SQLE
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SQLE(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for SQLE(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for SQLE:

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