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SLC6A4 Gene

protein-coding GIFtS: 69

GC17M025549

solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: HTT)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
5-HTT ^¹, ²
5-HTTLPR ^²
5HTT ^², ³
HTT ^², ³, ⁵
OCD1 ^², ⁵
SERT ^², ³
hSERT ^²

Descriptions
5-hydroxytryptamine transporter ^²
5HT transporter ^², ³
Na+/Cl- dependent serotonin transporter ^²
Solute carrier family 6 member 4 ^², ³
sodium-dependent serotonin transporter ^²
solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 ^²

External Ids
HGNC: 11050¹
Entrez Gene: 6532²
UniProtKB: P31645³
Ensembl: ENSG00000108576⁷

Search outside databases for aliases for SLC6A4 gene

Previous GC identifers: GC17M028278 GC17M030431 GC17M028670

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for SLC6A4:

This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from

synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin

and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants,

such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family.

A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of

serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in

Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma.

[provided by RefSeq]

UniProtKB/Swiss-Prot: SC6A4_HUMAN, P31645

Function: Terminates the action of serotonin by its high affinity sodium-dependent reuptake into

presynaptic terminals

Gene Wiki entry for SLC6A4 (Serotonin_transporter)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the SLC6A4 gene

Entrez Gene cytogenetic band: 17q11.1-q12 Ensembl cytogenetic band: 17q11.2 HGNC cytogenetic band: 17q11.2

SLC6A4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M025549: (about GC identifiers)

Start:	25,545,463 bp from pter
End:	25,586,841 bp from pter
Size:	41,379 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000017.9 NT_010799.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: SC6A4_HUMAN, P31645 (See protein sequence)

Recommended Name: Sodium-dependent serotonin transporter

Size: 630 amino acids; 70325 Da

Subunit: Interacts with TGFB1I1

Subcellular location: Membrane; Multi-pass membrane protein

Miscellaneous: This protein is the target of psychomotor stimulants such as amphetamines or cocaine

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001036.1

ENSEMBL proteins:

ENSP00000261707 ENSP00000378298 ENSP00000385822

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant SLC6A4 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Serotonin transporter)
	Human Recombinant Proteins from Abnova (SLC6A4)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005887	integral to plasma membrane	TAS	7681602
GO:0016020	membrane	IEA	--

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Antibodies for SLC6A4:

	Invitrogen Antibodies for SLC6A4
	Millipore Mono- and Polyclonal Antibodies for the study of SLC6A4
	Sigma-Aldrich Antibodies for SLC6A4
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Serotonin transporter), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for SLC6A4

Assays for SLC6A4:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P31645

ProtoNet protein and cluster: P31645

1 Blocks protein family: IPB013086 Serotonin (5-HT) neurotransmitter transporter signature

UniProtKB/Swiss-Prot: SC6A4_HUMAN, P31645

Similarity: Belongs to the sodium:neurotransmitter symporter (SNF) family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SLC6A4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SLC6A4)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001045

Applied Biosystems Silencer® siRNAs for SLC6A4

Sigma-Aldrich siRNA and siRNA Panels for SLC6A4

Sigma-Aldrich shRNA for SLC6A4

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for SLC6A4
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001045
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001045
untagged cDNA clone in CMV expression vector: NM_001045

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001045

UniProtKB/Swiss-Prot: SC6A4_HUMAN, P31645

Function: Terminates the action of serotonin by its high affinity sodium-dependent reuptake into

presynaptic terminals

Genatlas biochemistry entry for SLC6A4:

solute carrier family 6,member A4,neurotransmitter transporter,serotonin

10 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Slc6a4):

	behavior/neurological	endocrine/exocrine gland	growth/size	homeostasis/metabolism
life span-post-weaning/aging	muscle	nervous system	normal	touch/vibrissae

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005335	serotonin:sodium symporter activity	IEA	--
GO:0005515	protein binding	IPI	11343649
GO:0015222	serotonin transmembrane transporter activity	TAS	7681602
GO:0015293	symporter activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for SLC6A4 (Your Favorite Gene powered by Ingenuity)

Serotonin Receptor Signaling

GeneDecks SLC6A4 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for SLC6A4

5/34 Interacting proteins for SLC6A4 (ENSP00000261707³ P31645²) via UniProtKB, MINT, and/or STRING (see all 34 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PICK1	Q9NRD5²	MINT-73296
DRD4	ENSP00000176183³	STRING (score=.966)
DNTT	ENSP00000360216³	STRING (score=.964)
DRD2	ENSP00000347474³	STRING (score=.964)
ITGB3	ENSP00000262017³	STRING (score=.96)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001504	neurotransmitter uptake	TAS	7681602
GO:0006837	serotonin transport	TAS	7681602
GO:0015844	monoamine transport	IDA	16024787

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Enzo Life Sciences drugs & compounds for SLC6A4

Sigma-Aldrich Small Molecules for SLC6A4:

Antagonist Inhibitor Ligand

Compounds for SLC6A4 available from Tocris Bioscience

Compound	Action	CAS number
Tetrabenazine	Potent inhibitor of vesicular monoamine transport; depletes dopamine stores	[58-46-8]
Sertraline hydrochloride	5-HT re-uptake inhibitor	[79559-97-0]
Citalopram hydrobromide	Highly potent and selective 5-HT uptake inhibitor	[59729-33-8]
Fluoxetine hydrochloride	5-HT re-uptake inhibitor	[56296-78-7]
Sibutramine hydrochloride	5-HT and noradrenalin re-uptake inhibitor (SNRI)	[84485-00-7]

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10/31 Novoseek chemical compound relationships for SLC6A4 gene (see all 31 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
dasb	87.86	22	14610240 (4), 15312176 (2), 12439295 (1), 17437611 (1) (see all 9)
(r)-citalopram	87.53	32	15037515 (5), 16918708 (2), 15695064 (2), 17499240 (2) (see all 15)
(123i)-2beta-carbomethoxy-3beta-(4-iodophenyl)tropane	86.90	10	10664833 (2), 10715354 (1), 8110440 (1), 14992979 (1) (see all 8)
2beta-carbomethoxy-3beta-(4-iodophenyl)tropane	73.91	6	8748670 (1), 9169564 (1), 15770240 (1), 15205968 (1) (see all 5)
tropane	73.70	12	15755646 (2), 16385509 (2), 11714608 (1), 11334561 (1) (see all 5)
(2-(trimethylammonium)ethyl)methanethiosulfonate	71.98	5	15728187 (1), 11408487 (1), 10655481 (1)
nisoxetine	70.29	3	11959795 (1), 16650830 (1)
carbon-11	65.36	8	15820756 (1), 15974579 (1), 16250668 (1), 17154506 (1) (see all 7)
vilazodone	62.76	1	15978574 (1)
diphenyl sulfide	61.84	2	16337793 (2)

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4 PharmGKB drug compound relationships for SLC6A4 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
antidepressants	CO PD GN	12746735 15037864
fluvoxamine	PD	9857976 12082589
glucocorticoids	FA	12911615
xenobiotics	GN	11279528

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SLC6A4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SLC6A4)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001045

Sigma-Aldrich siRNA and siRNA Panels for SLC6A4

Sigma-Aldrich shRNA for SLC6A4

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001045

REFSEQ mRNAs for SLC6A4 gene:

NM_001045.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001045

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001045
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001045
                                 untagged cDNA clone in CMV expression vector: NM_001045

Additional cDNA sequence:

AK308014.1 AK309538.1 AK313166.1 AY902473.1 BC069484.1 L05568.1 X70697.1

2 DOTS entries:

DT.207569 DT.100682832

15 AceView cDNA sequences:

L05568 NM_001045 BC069484 X70697 BQ017574 AU138385 BX360891 BU619456

BQ017027 BX399758 BX339773 AA700070 AA700086 BM990651 BX329107

highest scoring ESTs for SLC6A4:

AU138385 L05568 AA700070 AA700086 BC069484 BX339773 BX360891 BX399757 BX399758 NM_001045

Unigene Cluster for SLC6A4:

Solute carrier family 6 (neurotransmitter transporter, serotonin), member 4

Hs.134662 [show with all ESTs]

Unigene Representative Sequence: NM_001045

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for SLC6A4

ExUns:	1a	·	1b	^	2	^	3a	·	3b	·	3c	^	4	^	5	^	6	^	7	^	8	^	9	^	10a	·	10b	^	11	^	12	^	13	^	14a	·	14b	^	15a	·	15b
SP1:																																			-
SP2:																															-				-
SP3:
SP4:					-
SP5:

About this scheme

ECgene alternative splicing isoforms for SLC6A4

3 Ensembl transcripts including schematic representations:

ENST00000261707 ENST00000394821 ENST00000401766

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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SLC6A4 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for SLC6A4

¹ / ² / ³

8 probe-sets matching SLC6A4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
53297_r_at²	U95-B	1	1.00	1.00	0.95	0.78	--	--	--	--	--
75016_at²	U95-E	1	1.00	1.00	0.95	1.05	--	--	--	--	--
34604_at²^{, 3}	U95-A	1	1.00	1.00	0.94	1.20	L05568	0.80	1.00	0.91	1
241811_x_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
207519_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001045	0.60	1.00	0.82	1
242009_at²	U133-B	2	1.00	0.95	--	--	--	--	--	--	--
207519_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
242009_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--

GeneDecks SLC6A4 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.134662
Expression variation in blood from EXPOLDB for SLC6A4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for SLC6A4 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	SLC6A4¹	--	solute carrier family 6 (neurotransmitter transporter, more	90.44(n) 94.26(a)	491184 XM_548304.2 XP_548304.2
chimpanzee (Pan troglodytes)	SLC6A4¹	--	solute carrier family 6 (neurotransmitter transporter, more	99.26(n) 99.37(a)	468201 XM_001135146.1 XP_001135146.1
cow (Bos taurus)	SLC6A4¹	--	solute carrier family 6 (neurotransmitter transporter, more	89.74(n) 93.02(a)	282365 NM_174609.2 NP_777034.1
rat (Rattus norvegicus)	Slc6a4¹	--	solute carrier family 6 (neurotransmitter transporter, more	88.15(n) 91.75(a)	25553 NM_013034.2 NP_037166.2
mouse (Mus musculus)	Slc6a4^{1, 5}	11 (42.00 cM)⁵	solute carrier family 6 (neurotransmitter transporter, more^{1, 5}	87.88(n)¹ 92.54(a)¹	15567¹ NM_010484.1¹ NP_034614.1¹ AF013604⁵ AI323329⁵ (see all 25)

About this table Species with no ortholog for SLC6A4

ENSEMBL Gene Tree for SLC6A4

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for SLC6A4 gene

SLC6A3² SLC6A2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

UniProtKB/Swiss-Prot: SC6A4_HUMAN, P31645

Polymorphism: A polymorphism in the promoter region (5-HTT gene-linked polymorphic region,

5-HTTLPR) is located approximately 1 kb upstream of the transcription initiation site and is

composed of 16 repeat elements. The polymorphism consists of a 44-bp insertion or deletion

involving repeat elements 6 to 8. The short allele is associated with lower transcriptional

efficiency of the promoter compared with the long allele. Over half of the Caucasian population

has a short allele. Individuals with one or two copies of the short allele exhibit more depressive

symptoms, diagnosable depression and suicidality in relation to stressful life events than

individuals homozygous for the long allele

Polymorphism: The polymorphism Val-425 seems to be linked to a susceptibility to

obsessive-compulsive disorder (OCD) [MIM:164230]

Polymorphism: Genetic variations in SLC6A4 determine the genetic susceptibility to alcoholism

[MIM:103780]

10/377 NCBI SNPs in SLC6A4 are shown (see all 377 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 104)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1042173^1,2	A,C,F,H,O	25549137(-)	`ATATAT/GAATTT`	1	--	ut3¹ ese³		9		MN NA EU EA WA	1606
	rs6354^1,2	A,C,F,H,O	25574024(-)	`CCTCTA/CTTGCA`	1	--	ut5¹ ese³		11		MN NA EU EA WA	1686
	rs6355^1,2	C,F,H	25572936(-)	`TGCGGG/CAGATG`	1	A/G	mis¹ ese³		11		MN EU EA WA NA	1286
	rs6352^1,2	C,F,H	25554319(-)	`TTTAAA/CGAGGT`	1	K/N	mis¹ ese³		9		MN EU EA WA	1024
	rs3813034^1,2	C,F,H	25548930(+)	`TGTTAC/ATGTAA`	1	--	ng5¹		4		EU EA WA	412
--	rs2020932^1,2	A,C,F	25587625(-)	`aaaaaA/Tttttt`	1	--	ng3¹		1		NA	20
--	rs25533^1,2	C,F	25587018(-)	`CTCCCT/CGGCGA`	1	--	ng3¹		1		NA	20
--	rs956304^1,2	A,C	25587688(-)	`CCTCCA/GCCTCA`	1	--	ng3¹		0	--	--	--	--
--	rs25531^1,2	C,F	25588472(-)	`CCCCCA/GGCATC`	1	--	ng3¹		3		NA	218
	rs13306796^1,2	F,H	25549272(-)	`CCTGTA/GTCATT`	1	--	ut3¹ ese³		4		EU EA WA	420

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HapMap Linkage Disequilibrium images for SLC6A4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 182138 disorders: 607834 164230

10/92 Novoseek disease relationships for SLC6A4 gene (see all 92 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
major depression	78.59	178	10862800 (5), 10920459 (5), 18268503 (4), 16640648 (4) (see all 91)
mood disorders	75.93	114	11983185 (4), 19233297 (4), 9154246 (4), 9514579 (3) (see all 64)
obsessive-compulsive disorder	70.03	60	18354388 (3), 16139170 (2), 18186076 (2), 16112691 (2) (see all 30)
bipolar disorder	68.95	83	9514585 (4), 10490710 (4), 11772685 (3), 8723051 (3) (see all 42)
neuroticism	64.89	37	10405095 (4), 17336939 (4), 11443919 (3), 14992987 (2) (see all 22)
alcoholism	63.82	57	10064377 (3), 16288736 (2), 14574222 (2), 15635638 (2) (see all 37)
psychiatric disorder	62.32	59	12218657 (3), 7865169 (1), 8950411 (1), 9693389 (1) (see all 38)
anxiety disorders	57.35	18	11256582 (1), 12660809 (1), 18314311 (1), 10368856 (1) (see all 13)
attention-deficit hyperactivity disorder	55.60	8	14574222 (1), 17948872 (1), 12782968 (1), 16082690 (1) (see all 7)
autistic	54.66	36	10686565 (4), 15094787 (3), 12192626 (3), 11920155 (3) (see all 13)

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9 PharmGKB disease relationships for SLC6A4 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Alcoholism	GN	11857587
Anorexia Nervosa	CO GN	15211642
Autistic Disorder	GN	11920155 10490705 9152989
Bipolar Disorder	CO GN	12746735 10331118
Depression	PD	9857976 15037864
Mood Disorders	GN	10673766
Neurotic Disorders	GN	11857587
Sudden Infant Death	GN	12966525
obsessive compulsive disorder (OCD)	PD FA	12082589 9430134

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Human Gene Mutation Database: SLC6A4
Genetic Association Database: SLC6A4
Human Genome Epidemiology Navigator: SLC6A4 (788 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/1607 PubMed articles for SLC6A4 gene (see all 1607 ):

Serotonin transporter regulatory region polymorphism is associated with anorexia nervosa. (PubMed id 15211642)^{1, 3, 6, 7} Matsushita S....Higuchi S. (2004)
Antidepressant-induced mania, rapid cycling and the serotonin transporter gene polymorphism. (PubMed id 12746735)^{1, 3, 6, 7} Rousseva A....Malafosse A. (2003)
Meta-analysis of the association of a functional serotonin transporter promoter polymorphism with alcohol dependence. (PubMed id 15635638)^{1, 3, 4, 6} Feinn R.... Kranzler H.R. (2005)
Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. (PubMed id 12869766)^{1, 3, 4, 6} Caspi A....Poulton R. (2003)
Association of the serotonin transporter gene with sudden infant death syndrome: a haplotype analysis. (PubMed id 12966525)^{3, 6, 7} Weese-Mayer D.E....Marazita M.L. (2003)
Transmission disequilibrium mapping at the serotonin transporter gene (SLC6A4) region in autistic disorder. (PubMed id 11920155)^{1, 3, 7} Kim S.J....Cook E.H. (2002)
Obsessive-Compulsive Disorder, 5-HTTLPR polymorphism and treatment response. (PubMed id 12082589)^{3, 6, 7} Di Bella D....Bellodi L. (2002)
Screening a large reference sample to identify very low frequency sequence variants: comparisons between two genes. (PubMed id 11279528)^{3, 6, 7} Glatt C.E....Freimer N.B. (2001)
Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization. (PubMed id 7681602)^{2, 3, 4} Ramamoorthy S.... Blakely R.D. (1993)
Central serotonin transporter availability measured with [123I]beta-CIT SPECT in relation to serotonin transporter genotype. (PubMed id 14992979)^{1, 3, 6} van Dyck C.H....Gelernter J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 6532	HGNC: 11050	AceView: SLC6A4	Ensembl:ENSG00000108576	euGenes: HUgn6532
ECgene: SLC6A4	H-InvDB: SLC6A4

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
GeneReviews	http://www.genetests.org/query?gene=SLC6A4
SHMPD	http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=SLC6A4
Wikipedia	http://en.wikipedia.org/wiki/Serotonin_transporter

Licensable Technologies for SLC6A4
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for SLC6A4:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for SLC6A4-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for SLC6A4		Antibodies for SLC6A4
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for SLC6A4		Small molecules for SLC6A4
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (SLC6A4)
	Search for Antibodies
	Chimera RNAi (SLC6A4)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Serotonin transporter)
	Antibodies (Serotonin transporter)

Search OriGene for SLC6A4

Tocris compounds for SLC6A4

	Drugs for SLC6A4
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for SLC6A4

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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SLC6A4 Gene at Home site.
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SLC6A4 Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for SLC6A4

Summaries
for SLC6A4

Genomic Location
for SLC6A4

Proteins
for SLC6A4

Protein Domains/
Families
for SLC6A4

Gene Function
for SLC6A4

Pathways & Interactions
for SLC6A4

Drugs & Compounds
for SLC6A4

Transcripts
for SLC6A4

Expression
for SLC6A4

Orthologs
for SLC6A4

Paralogs
for SLC6A4

SNPs/Variants
for SLC6A4

Disorders & Mutations
for SLC6A4

Medical News
for SLC6A4

Publications
for SLC6A4

Search for SLC6A4

Genome Databases showing SLC6A4

Other Databases showing SLC6A4

Specialized Databases showing SLC6A4

Licensable Technologies
for SLC6A4

Services
for SLC6A4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

SLC6A4 Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor SLC6A4

Summariesfor SLC6A4

Genomic Locationfor SLC6A4

Proteinsfor SLC6A4

Protein Domains/Familiesfor SLC6A4

Gene Functionfor SLC6A4

Pathways & Interactionsfor SLC6A4

Drugs & Compoundsfor SLC6A4

Transcriptsfor SLC6A4

Expression for SLC6A4

Orthologsfor SLC6A4

Paralogsfor SLC6A4

SNPs/Variantsfor SLC6A4

Disorders & Mutationsfor SLC6A4

Medical Newsfor SLC6A4

Publicationsfor SLC6A4

Search for SLC6A4

Genome Databases showing SLC6A4

Other Databases showing SLC6A4

Specialized Databases showing SLC6A4

Licensable Technologiesfor SLC6A4

Servicesfor SLC6A4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for SLC6A4

Summaries
for SLC6A4

Genomic Location
for SLC6A4

Proteins
for SLC6A4

Protein Domains/
Families
for SLC6A4

Gene Function
for SLC6A4

Pathways & Interactions
for SLC6A4

Drugs & Compounds
for SLC6A4

Transcripts
for SLC6A4

Expression
for SLC6A4

Orthologs
for SLC6A4

Paralogs
for SLC6A4

SNPs/Variants
for SLC6A4

Disorders & Mutations
for SLC6A4

Medical News
for SLC6A4

Publications
for SLC6A4

Licensable Technologies
for SLC6A4

Services
for SLC6A4