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SLC6A3 Gene

protein-coding GIFtS: 72

GC05M001423

solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: DAT1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DAT ^¹, ², ³
DAT1 ^², ³, ⁵

Descriptions
DA transporter ^³
Solute carrier family 6 member 3 ^³
dopamine transporter ^²
solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 ^²
variable number tandem repeat (VNTR) ^²

External Ids
HGNC: 11049¹
Entrez Gene: 6531²
UniProtKB: Q01959³
Ensembl: ENSG00000142319⁷

Search outside databases for aliases for SLC6A3 gene

Previous GC identifers: GC05P001491 GC05M001531 GC05M001425 GC05M001445

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for SLC6A3:

The dopamine transporter (DAT1) mediates the active reuptake of dopamine from the synapse and is a

principal regulator of dopaminergic neurotransmission. The DAT1 gene has been implicated in human

disorders such as parkinsonism, Tourette syndrome, and substance abuse (Vandenbergh et al., 1992

[PubMed 1359373]).[supplied by OMIM]

UniProtKB/Swiss-Prot: SC6A3_HUMAN, Q01959

Function: Amine transporter. Terminates the action of dopamine by its high affinity

sodium-dependent reuptake into presynaptic terminals

Gene Wiki entry for SLC6A3 (Dopamine_transporter)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the SLC6A3 gene

Entrez Gene cytogenetic band: 5p15.3 Ensembl cytogenetic band: 5p15.33 HGNC cytogenetic band: 5p15.3

SLC6A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M001423: (about GC identifiers)

Start:	1,445,909 bp from pter
End:	1,498,545 bp from pter
Size:	52,637 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000005.8 NT_006576.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: SC6A3_HUMAN, Q01959 (See protein sequence)

Recommended Name: Sodium-dependent dopamine transporter

Size: 620 amino acids; 68495 Da

Subunit: Homooligomer; disulfide-linked. Interacts with PRKCABP and TGFB1I1

Subcellular location: Membrane; Multi-pass membrane protein

Miscellaneous: This protein is the target of psychomotor stimulants such as amphetamines or cocaine

Secondary accessions: Q14996

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001035.1

ENSEMBL proteins:

ENSP00000270349

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant SLC6A3 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Dopamine Transporter)
	Human Recombinant Proteins from Abnova (SLC6A3)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	TAS	10823899
GO:0005886	plasma membrane	IDA	11343649
GO:0005887	integral to plasma membrane	IEA	--

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Antibodies for SLC6A3:

	Invitrogen Antibodies for SLC6A3
	Millipore Mono- and Polyclonal Antibodies for the study of SLC6A3
	Sigma-Aldrich Antibodies for SLC6A3
	R&D Systems Antibodies for SLC6A3 (Dopamine Transporter)
	Antibodies from Abcam (Dopamine Transporter), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (SLC6A3)
	Novus Biologicals Antibody for SLC6A3

Assays for SLC6A3:

	Browse Invitrogen for biochemical assays
	Millipore Kits and Assays for the Analysis of SLC6A3
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q01959

ProtoNet protein and cluster: Q01959

1 Blocks protein family: IPB002436 Dopamine neurotransmitter transporter signature

UniProtKB/Swiss-Prot: SC6A3_HUMAN, Q01959

Similarity: Belongs to the sodium:neurotransmitter symporter (SNF) family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SLC6A3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SLC6A3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001044

Applied Biosystems Silencer® siRNAs for SLC6A3

Sigma-Aldrich siRNA and siRNA Panels for SLC6A3

Sigma-Aldrich shRNA for SLC6A3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001044
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001044
untagged cDNA clone in CMV expression vector: NM_001044

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001044

UniProtKB/Swiss-Prot: SC6A3_HUMAN, Q01959

Function: Amine transporter. Terminates the action of dopamine by its high affinity

sodium-dependent reuptake into presynaptic terminals

Genatlas biochemistry entry for SLC6A3:

solute carrier family 6,member A3,neurotransmitter transporter,dopamine,unlikely involved in Gilles

de la Tourette syndrome,inconsistent evidence for involvement in bipolar effective disorder

11 MGI mutant phenotypes (inferred from 10 alleles) (MGI details for Slc6a3):

behavior/neurological	endocrine/exocrine gland	growth/size	homeostasis/metabolism	life span-post-weaning/aging
limbs/digits/tail	muscle	nervous system	normal	reproductive system
skeleton

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005330	dopamine:sodium symporter activity	IEA	--
GO:0005515	protein binding	IPI	11343649
GO:0015293	symporter activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for SLC6A3 (Your Favorite Gene powered by Ingenuity)

Dopamine Receptor Signaling

GeneDecks SLC6A3 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for SLC6A3

5/32 Interacting proteins for SLC6A3 (ENSP00000270349³ Q01959²) via UniProtKB, MINT, and/or STRING (see all 32 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DRD2	P14416²	STRING (score=.985) MINT-4789680 MINT-4789661 MINT-4789619 MINT-4789636
PICK1	Q9NRD5²	STRING (score=.872) MINT-73279 MINT-73284 MINT-73280 MINT-73281
SNCA	ENSP00000338345³	STRING (score=.997)
TH	ENSP00000370571³	STRING (score=.924)
DRD4	ENSP00000176183³	STRING (score=.904)

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5/12 Gene Ontology (GO) biological process terms (links to tree view) (see all 12 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006836	neurotransmitter transport	IEA	--
GO:0007595	lactation	IEA	--
GO:0007608	sensory perception of smell	IEA	--
GO:0007626	locomotory behavior	IEA	--
GO:0015844	monoamine transport	IDA	16024787

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for SLC6A3

Sigma-Aldrich Small Molecules for SLC6A3:

Antagonist Blocker Inhibitor

Compounds for SLC6A3 available from Tocris Bioscience

Compound	Action	CAS number
Tetrabenazine	Potent inhibitor of vesicular monoamine transport; depletes dopamine stores	[58-46-8]
Indatraline hydrochloride	Potent 5-HT uptake inhibitor. Also inhibits dopamine and noradrenalin uptake	[86939-10-8]
GBR 12909 dihydrochloride	Selective DA uptake inhibitor. Also sigma ligand	[67469-78-7]
GBR 12783 dihydrochloride	Potent, selective dopamine uptake inhibitor	[67469-57-2]
GBR 12935 dihydrochloride	Selective dopamine uptake inhibitor	[76778-22-8]

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10/17 Novoseek chemical compound relationships for SLC6A3 gene (see all 17 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
(123i)fp-cit	92.60	38	9396871 (3), 11315592 (3), 9744331 (2), 10319746 (2) (see all 21)
(123i)-2beta-carbomethoxy-3beta-(4-iodophenyl)tropane	91.13	19	8657833 (1), 8110440 (1), 11440745 (1), 15872345 (1) (see all 16)
2beta-carbomethoxy-3beta-(4-iodophenyl)tropane	86.94	17	7607268 (1), 8748670 (1), 10348466 (1), 7607266 (1) (see all 10)
tropane	86.81	30	16385509 (3), 11714608 (2), 9880583 (2), 10881032 (1) (see all 20)
(123i)ipt	82.87	7	14513291 (3), 8523122 (2), 15165667 (1), 9374337 (1)
gbr 12935	81.65	9	10585212 (1), 8941383 (1), 10952077 (1), 1987318 (1) (see all 7)
altropane	77.20	5	9593103 (2), 11687754 (1), 17511972 (1)
1 methyl 4 phenylpyridinium	77.04	103	8667208 (5), 10517700 (4), 18342443 (3), 12495785 (3) (see all 31)
nisoxetine	74.29	7	11959795 (1), 8523122 (1), 8848002 (1), 10541838 (1) (see all 5)
ipcit	71.29	2	10755641 (1), 7698153 (1)

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1 PharmGKB drug compound relationship for SLC6A3 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
methylphenidate	CO PD	12172219 12619042

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SLC6A3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SLC6A3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001044

Sigma-Aldrich siRNA and siRNA Panels for SLC6A3

Sigma-Aldrich shRNA for SLC6A3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001044

REFSEQ mRNAs for SLC6A3 gene:

NM_001044.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001044

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001044
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001044
                                 untagged cDNA clone in CMV expression vector: NM_001044

Additional cDNA sequence:

AK310589.1 BC132977.1 BC133003.1 EF174603.1 L24178.1 M95167.1 M96670.1 S44626.1

S46955.1

1 DOTS entry:

DT.308308

18 AceView cDNA sequences:

M96670 AI375850 NM_001044 S46955 L24178 M95167 AI760659 AI769875

S44626 AI863737 AA912294 BF509749 AI091004 AI768774 AI949407 AU127295

AW887557 AI586989

highest scoring ESTs for SLC6A3:

M95167 S46955 AA912294 AI091004 AI375850 AI586989 AI760659 AI768774 AI769875 AI863737

Unigene Cluster for SLC6A3:

Solute carrier family 6 (neurotransmitter transporter, dopamine), member 3

Hs.406 [show with all ESTs]

Unigene Representative Sequence: M95167

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000270349

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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SLC6A3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for SLC6A3

¹ / ² / ³

3 probe-sets matching SLC6A3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36305_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	M95167	1.00	1.00	1.00	1
206836_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001044	0.60	1.00	0.82	1
206836_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GCTGTCCCCT

SOURCE GeneReport for Unigene cluster: Hs.406
Expression variation in blood from EXPOLDB for SLC6A3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for SLC6A3 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	SLC6A3¹	--	solute carrier family 6 (neurotransmitter transporter, more	84.33(n) 87.25(a)	609304 XM_846543.1 XP_851636.1
chimpanzee (Pan troglodytes)	SLC6A3¹	--	solute carrier family 6 (neurotransmitter transporter, more	92.9(n) 91.95(a)	750842 XM_001175202.1 XP_001175202.1
rat (Rattus norvegicus)	Slc6a3¹	--	solute carrier family 6 (neurotransmitter transporter, more	87.84(n) 93.68(a)	24898 NM_012694.1 NP_036826.1
mouse (Mus musculus)	Slc6a3^{1, 5}	13 (41.00 cM)⁵	solute carrier family 6 (neurotransmitter transporter, more^{1, 5}	87.56(n)¹ 93.7(a)¹	13162¹ NM_010020.3¹ NP_034150.1¹ AF109072⁵ AF109391⁵ (see all 12)
zebrafish (Danio rerio)	slc6a3²	--	solute carrier family 6 (neurotransmitter transporter, more	79.21(n)	80787 AF318177.1

About this table Species with no ortholog for SLC6A3

ENSEMBL Gene Tree for SLC6A3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for SLC6A3 gene

SLC6A4² SLC6A2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/771 NCBI SNPs in SLC6A3 are shown (see all 771 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 401)

AB	SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs27072^1,2	A,C,F,H	1447522(+)	`AGAGCC/TGGGAG`	1	--	ut3¹ ese³		8	EU NA NS EA WA	1054
--	rs1042098^1,2	A,C,F,H	1447815(-)	`CATCCT/CGCAAT`	1	--	ut3¹		8	MN NS EU EA WA NA	1250
	rs7732456^1,2	A,C,F,H	1445965(+)	`AATAGA/CGATTG`	1	--	ut3¹ ese³		8	NA NS EU WA	754
	rs10064525^1,2	A,C,F,H	1445721(+)	`GGATGT/GGTTAT`	1	--	ng5¹		3	EU EA	262
	rs403798^1,2	C,F,O	1447660(+)	`ACGGCG/AAGGTG`	1	--	ut3¹		4	MN NA	314
	rs3797200^1,2	A,C,F	1446344(-)	`CCTACG/ATGCTG`	1	--	ut3¹ ese³		2	NS NA	222
	rs3863145^1,2	C,F,H	1445711(-)	`CACTAC/TGCTCC`	1	--	ng5¹		8	EU EA WA	828
	rs16877691^1,2	C,F,H	1446454(+)	`CCTTCA/GCTCAG`	1	--	ut3¹		9	NA NS EU EA WA	788
--	rs1809939^1,2	A,C,F	1446063(-)	`CCTTCT/CGGCTG`	1	--	ut3¹ ese³		3	NA NS	462
--	rs2617596^1,2	C,F	1499719(-)	`ggagcG/Cgggga`	1	--	ng3¹		1	NA	24

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HapMap Linkage Disequilibrium images for SLC6A3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 126455 disorders: 143465 188890 125480

10/84 Novoseek disease relationships for SLC6A3 gene (see all 84 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
parkinson disease	87.40	288	9703165 (4), 17886297 (4), 11403185 (3), 9048712 (3) (see all 99)
attention-deficit hyperactivity disorder	87.32	135	10609822 (3), 16526026 (2), 18174826 (2), 15572278 (2) (see all 91)
parkinsonism	80.66	85	7695230 (4), 11315592 (3), 14531041 (2), 9399211 (2) (see all 57)
cocaine abuse	71.66	26	8674469 (2), 10881032 (1), 11408518 (1), 17897630 (1) (see all 14)
cocaine addiction	70.70	12	2111866 (1), 19226282 (1), 9466707 (1), 10375632 (1) (see all 10)
essential tremor	69.83	19	17260170 (2), 11487195 (2), 14531042 (2), 18317299 (2) (see all 10)
multiple system atrophy	67.53	18	14598060 (2), 11748733 (2), 14673877 (1), 19089314 (1) (see all 12)
tourette syndrome	61.55	27	7653693 (3), 16969259 (3), 8825631 (2), 8725745 (2) (see all 14)
parkinsonism drug-induced	60.89	3	19131852 (1), 17969308 (1)
movement disorders	59.63	12	12971118 (2), 17398272 (2), 12411832 (1), 18638039 (1) (see all 9)

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6 PharmGKB disease relationships for SLC6A3 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
ADHD	PD	12619042
Alcoholism	GN	10889531
Attention Deficit Disorder with Hyperactivity	GN	7717410 10889531
Cocaine-Related Disorders	FA	9736005
Substance-Related Disorders	GN	10889531
attention deficit hyperactivity disorder	CO PD	12172219

About this table

Human Gene Mutation Database: SLC6A3
Genetic Association Database: SLC6A3
Human Genome Epidemiology Navigator: SLC6A3 (249 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/1155 PubMed articles for SLC6A3 gene (see all 1155 ):

Human dopamine transporter gene: coding region conservation among normal, Tourette's disorder, alcohol dependence and attention-deficit hyperactivity disorder populations. (PubMed id 10889531)^{1, 3, 4, 7} Vandenbergh D.J.... Uhl G.R. (2000)
Dopamine transporter gene and response to methylphenidate in attention-deficit/hyperactivity disorder. (PubMed id 12172219)^{3, 6, 7} Roman T....Hutz M.H. (2002)
Association of attention-deficit disorder and the dopamine transporter gene. (PubMed id 7717410)^{1, 3, 7} Cook E.H....Leventhal B.L. (1995)
Cloning, pharmacological characterization, and chromosome assignment of the human dopamine transporter. (PubMed id 1406597)^{2, 3, 4} Giros B....Caron M.G. (1992)
Increased dopamine transporter availability associated with the 9-repeat allele of the SLC6A3 gene. (PubMed id 15872345)^{1, 3, 6} van Dyck C.H....Gelernter J. (2005)
The multiple LIM domain-containing adaptor protein Hic-5 synaptically colocalizes and interacts with the dopamine transporter. (PubMed id 12177201)^{1, 3, 4} Carneiro A.M.D.... Torres G.E. (2002)
Dissecting the attention deficit hyperactivity disorder (ADHD) phenotype: sustained attention, response variability and spatial attentional asymmetries in relation to dopamine transporter (DAT1) genotype. (PubMed id 16168728)^{1, 3, 6} Bellgrove M.A....Robertson I.H. (2005)
Dopamine transporter (SLC6A3) 5' region haplotypes significantly affect transcriptional activity in vitro but are not associated with Parkinson's disease. (PubMed id 16041244)^{1, 3, 6} Kelada S.N....Costa L.G. (2005)
Association study of dopamine transporter gene and schizophrenia in Korean population using multiple single nucleotide polymorphism markers. (PubMed id 15380858)^{1, 3, 6} Jeong S.H....Kim Y.S. (2004)
[Association studies of dopamine D4 receptor gene and dopamine transporter gene polymorphisms in Han Chinese patients with attention deficit hyperactivity disorder] (PubMed id 12947560)^{1, 3, 6} Qian Q....Zhou R. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 6531	HGNC: 11049	AceView: SLC6A3	Ensembl:ENSG00000142319	euGenes: HUgn6531
ECgene: SLC6A3	H-InvDB: SLC6A3

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
NIEHS-SNPs	http://egp.gs.washington.edu/data/slc6a3/
Wikipedia	http://en.wikipedia.org/wiki/Dopamine_transporter

Licensable Technologies for SLC6A3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for SLC6A3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for SLC6A3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

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Antibodies for SLC6A3

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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SLC6A3 Gene at Home site.
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SLC6A3 Gene

protein-coding GIFtS: 72

Aliases &
Descriptions
for SLC6A3

Summaries
for SLC6A3

Genomic Location
for SLC6A3

Proteins
for SLC6A3

Protein Domains/
Families
for SLC6A3

Gene Function
for SLC6A3

Pathways & Interactions
for SLC6A3

Drugs & Compounds
for SLC6A3

Transcripts
for SLC6A3

Expression
for SLC6A3

Orthologs
for SLC6A3

Paralogs
for SLC6A3

SNPs/Variants
for SLC6A3

Disorders & Mutations
for SLC6A3

Medical News
for SLC6A3

Publications
for SLC6A3

Search for SLC6A3

Genome Databases showing SLC6A3

Other Databases showing SLC6A3

Specialized Databases showing SLC6A3

Licensable Technologies
for SLC6A3

Services
for SLC6A3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

SLC6A3 Gene

protein-coding GIFtS: 72

Aliases & Descriptionsfor SLC6A3

Summariesfor SLC6A3

Genomic Locationfor SLC6A3

Proteinsfor SLC6A3

Protein Domains/Familiesfor SLC6A3

Gene Functionfor SLC6A3

Pathways & Interactionsfor SLC6A3

Drugs & Compoundsfor SLC6A3

Transcriptsfor SLC6A3

Expression for SLC6A3

Orthologsfor SLC6A3

Paralogsfor SLC6A3

SNPs/Variantsfor SLC6A3

Disorders & Mutationsfor SLC6A3

Medical Newsfor SLC6A3

Publicationsfor SLC6A3

Search for SLC6A3

Genome Databases showing SLC6A3

Other Databases showing SLC6A3

Specialized Databases showing SLC6A3

Licensable Technologiesfor SLC6A3

Servicesfor SLC6A3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for SLC6A3

Summaries
for SLC6A3

Genomic Location
for SLC6A3

Proteins
for SLC6A3

Protein Domains/
Families
for SLC6A3

Gene Function
for SLC6A3

Pathways & Interactions
for SLC6A3

Drugs & Compounds
for SLC6A3

Transcripts
for SLC6A3

Expression
for SLC6A3

Orthologs
for SLC6A3

Paralogs
for SLC6A3

SNPs/Variants
for SLC6A3

Disorders & Mutations
for SLC6A3

Medical News
for SLC6A3

Publications
for SLC6A3

Licensable Technologies
for SLC6A3

Services
for SLC6A3