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SLC6A2 Gene

protein-coding GIFtS: 63

GC16P054247

solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: NET1, NAT1, SLC6A5)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
NAT1 ^², ³, ⁵
NET ^², ³
NET1 ^², ³, ⁵
SLC6A5 ^², ³

Descriptions
Norepinephrine transporter ^², ³
Solute carrier family 6 member 2 ^², ³
noradrenaline transporter ^²
solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 ^²
solute carrier family 6 (neurotransmitter transporter, norepinephrine), member 5 ^²

External Ids
HGNC: 11048¹
Entrez Gene: 6530²
UniProtKB: P23975³
Ensembl: ENSG00000103546⁷

Search outside databases for aliases for SLC6A2 gene

Previous GC identifers: GC16M046129 GC16P055745 GC16P055428 GC16P055469

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for SLC6A2:

The SLC6A2 gene encodes a norepinephrine (noradrenaline) transporter, which is responsible for

reuptake of norepinephrine into presynaptic nerve terminals and is a regulator of norepinephrine

homeostasis (Kim et al., 2006 [PubMed 17146058]).[supplied by OMIM]

UniProtKB/Swiss-Prot: SC6A2_HUMAN, P23975

Function: Amine transporter. Terminates the action of noradrenaline by its high affinity

sodium-dependent reuptake into presynaptic terminals

Gene Wiki entry for SLC6A2 (Norepinephrine_transporter)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the SLC6A2 gene

Entrez Gene cytogenetic band: 16q12.2 Ensembl cytogenetic band: 16q12.2 HGNC cytogenetic band: 16q12.2

SLC6A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P054247: (about GC identifiers)

Start:	54,248,057 bp from pter
End:	54,296,685 bp from pter
Size:	48,629 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000016.8 NT_010498.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: SC6A2_HUMAN, P23975 (See protein sequence)

Recommended Name: Sodium-dependent noradrenaline transporter

Size: 617 amino acids; 69332 Da

Subunit: Interacts with PRKCABP

Subcellular location: Membrane; Multi-pass membrane protein

Miscellaneous: This protein is the target of psychomotor stimulants such as amphetamines or cocaine

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001034.1

ENSEMBL proteins:

ENSP00000369237 ENSP00000219833

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant SLC6A2 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Noradrenaline transporter)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	TAS	2008212
GO:0005737	cytoplasm	IDA	18029348
GO:0005739	mitochondrion	IDA	18029348
GO:0005887	integral to plasma membrane	TAS	2008212
GO:0016020	membrane	IEA	--

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Antibodies for SLC6A2:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of SLC6A2
	Sigma-Aldrich Antibodies for SLC6A2
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Noradrenaline transporter), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for SLC6A2

Assays for SLC6A2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P23975

ProtoNet protein and cluster: P23975

1 Blocks protein family: IPB002435 Noradrenaline neurotransmitter transporter signature

UniProtKB/Swiss-Prot: SC6A2_HUMAN, P23975

Similarity: Belongs to the sodium:neurotransmitter symporter (SNF) family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SLC6A2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SLC6A2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001043

Applied Biosystems Silencer® siRNAs for SLC6A2

Sigma-Aldrich siRNA and siRNA Panels for SLC6A2

Sigma-Aldrich shRNA for SLC6A2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001043
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001043
untagged cDNA clone in CMV expression vector: NM_001043

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001043

UniProtKB/Swiss-Prot: SC6A2_HUMAN, P23975

Function: Amine transporter. Terminates the action of noradrenaline by its high affinity

sodium-dependent reuptake into presynaptic terminals

Genatlas biochemistry entry for SLC6A2:

solute carrier family 6,member 2,neurotransmitter transporter,noradrenalin/morepinephrine

5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Slc6a2):

behavior/neurological

growth/size

homeostasis/metabolism

nervous system

touch/vibrissae

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005334	norephinephrine:sodium symporter activity	TAS	2008212
GO:0005515	protein binding	IPI	11343649
GO:0008504	monoamine transmembrane transporter activity	IDA	16024787
GO:0015293	symporter activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for SLC6A2

5/15 Interacting proteins for SLC6A2 (P23975² ENSP00000219833³) via UniProtKB, MINT, and/or STRING (see all 15 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PICK1	Q9NRD5², ENSP00000349465³	MINT-73297 MINT-73299 MINT-73295 STRING (score=.715)
NGF	ENSP00000358525³	STRING (score=.91)
TSPAN1	ENSP00000361072³	STRING (score=.898)
STX1A	ENSP00000222812³	STRING (score=.866)
SLC18A2	ENSP00000298472³	STRING (score=.786)

About this table

3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006836	neurotransmitter transport	IEA	--
GO:0007268	synaptic transmission	TAS	2008212
GO:0015844	monoamine transport	IDA	16024787

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for SLC6A2:

Antagonist Inhibitor

Browse Tocris compounds for SLC6A2
10/37 Novoseek chemical compound relationships for SLC6A2 gene (see all 37 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
nisoxetine	90.20	16	8848002 (2), 10447954 (2), 8218295 (1), 16361258 (1) (see all 11)
lortalamine	87.67	7	15914010 (2), 15998285 (1), 17073682 (1)
m-tyramine	79.44	2	9681456 (1), 12814837 (1)
6-fluorodopamine	77.09	4	11107129 (2), 10899926 (1)
catecholamine	68.17	14	16573647 (2), 18674600 (1), 8794928 (1), 7576974 (1) (see all 10)
indatraline	66.66	1	11123996 (1)
diphenyl sulfide	61.34	1	11881994 (1)
tropane	58.66	2	11714608 (1)
1 methyl 4 phenylpyridinium	55.44	8	8667208 (4), 10494878 (1), 10411589 (1), 7700252 (1)
amine	51.23	10	11606618 (2), 12787070 (1), 12954796 (1), 16885432 (1) (see all 7)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SLC6A2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SLC6A2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001043

Sigma-Aldrich siRNA and siRNA Panels for SLC6A2

Sigma-Aldrich shRNA for SLC6A2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001043

REFSEQ mRNAs for SLC6A2 gene:

NM_001043.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001043

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001043
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001043
                                 untagged cDNA clone in CMV expression vector: NM_001043

Additional cDNA sequence:

AB022846.1 AB022847.1 AK301811.1 AK310410.1 AK312793.1 BC000563.2 BC039309.1 BC060831.1

CR611590.1 M65105.1

9 DOTS entries:

DT.100748456 DT.40281724 DT.111177 DT.95281015 DT.91706962 DT.100711624 DT.100741072 DT.120668967

DT.100705791

24/74 AceView cDNA sequences (see all 74 ):

NM_001043 CB989013 AI399889 BX479214 AA610011 BC000563 M65105 R21410

CB989377 BC060831 BQ026494 BX396703 AI765218 BF448911 BX117731 AA369327

BQ022169 CB991203 CB990905 BE313934 BQ022097 BV199236 BF445572 BF111741

highest scoring ESTs for SLC6A2:

AB022846 AB022847 AI247485 AI765218 BC000563 BC039309 BC060831 BE313934 BI199432 BI199870

Unigene Cluster for SLC6A2:

Solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2

Hs.78036 [show with all ESTs]

Unigene Representative Sequence: NM_001043

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for SLC6A2

ExUns:	1	^	2	^	3a	·	3b	^	4	^	5a	·	5b	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13a	·	13b	^	14	^	15	^	16
SP1:
SP2:			-		-
SP3:					-
SP4:																																	-

About this scheme

ECgene alternative splicing isoforms for SLC6A2

2 Ensembl transcripts including schematic representations:

ENST00000379906 ENST00000219833

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

SLC6A2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for SLC6A2

¹ / ² / ³

13 probe-sets matching SLC6A2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
40402_at²^{, 3}	U95-A	1	1.00	1.00	0.77	1.38	X91117	0.20	1.00	0.72	1
31653_at²^{, 3}	U95-A	1	1.00	1.00	0.92	0.68	AB022847	0.80	1.00	0.91	1
70572_at²^{, 3}	U95-E	1	1.00	1.00	0.58	1.02	AI765218	0.80	1.00	0.91	1
215715_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC000563	0.80	1.00	0.91	1
216611_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AB022847	0.80	1.00	0.91	1
239394_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI765218	0.80	1.00	0.91	1
216610_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AB022847	0.80	1.00	0.91	1
210353_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M65105	0.80	1.00	0.91	1
215715_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
216611_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
239394_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
216610_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210353_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.78036
Expression variation in blood from EXPOLDB for SLC6A2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for SLC6A2 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	SLC6A2¹	--	solute carrier family 6 (neurotransmitter transporter, more	89.63(n) 92.8(a)	487272 XM_544398.2 XP_544398.2
chimpanzee (Pan troglodytes)	SLC6A2¹	--	solute carrier family 6 (neurotransmitter transporter, more	99.73(n) 99.68(a)	454096 XM_001167680.1 XP_001167680.1
cow (Bos taurus)	SLC6A2¹	--	solute carrier family 6 (neurotransmitter transporter, more	90.19(n) 93.5(a)	282363 NM_174608.2 NP_777033.1
rat (Rattus norvegicus)	Slc6a2¹	--	solute carrier family 6 (neurotransmitter transporter, more	87.32(n) 94.33(a)	83511 NM_031343.1 NP_112633.1
mouse (Mus musculus)	Slc6a2^{1, 5}	8 (45.00 cM)⁵	solute carrier family 6 (neurotransmitter transporter, more^{1, 5}	86.76(n)¹ 94.49(a)¹	20538¹ NM_009209.2¹ NP_033235.2¹ AJ439987⁵ AK078616⁵ (see all 17)

About this table Species with no ortholog for SLC6A2

ENSEMBL Gene Tree for SLC6A2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for SLC6A2 gene

SLC6A3² SLC6A4²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/367 NCBI SNPs in SLC6A2 are shown (see all 367 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 226)

AB	SNP ID	Valid	Chr 16 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs15534^1,2	A,C,F,H	54294028(+)	`CTCTCC/TCACTT`	1	--	ut3¹ ese³		6	MN EU EA WA	788
	rs2242446^1,2	A,C,F,H	54247926(+)	`CGCGCT/CCTTTT`	1	--	ng5¹ tfbs³		5	EA EU WA	1896
	rs42460^1,2	A,C,F,H	54295157(-)	`GATCCT/CGCAAC`	1	--	ut3¹ ese³		9	EA EU WA	2338
	rs7194256^1,2	A,C,F,H	54295192(+)	`GCATTC/TGCACG`	1	--	ut3¹ ese³		11	NA EU EA WA	980
	rs1805066^1,2	C,F,H	54276644(+)	`TCGTCG/ATCATC`	1	I/V	mis¹		8	MN EU EA WA	904
	rs5558^1,2	C,F,H	54291060(+)	`TGCCTT/GCCTCC`	1	C/F	mis¹ trp³		7	MN EU EA WA	854
	rs1805065^1,2	C,F,H	54260999(+)	`GTACAC/TACTGT`	1	T/I	mis¹		7	EU EA WA	720
	rs5559^1,2	C,F,H	54291603(+)	`ACGACT/CACATC`	1	H/Y	mis¹ ese³		10	MN EU EA WA	1096
	rs3743788^1,2	C,F,H	54291607(+)	`CTACAT/CCTTCC`	1	T/I	mis¹ ese³		12	EA EU WA NA	2474
	rs5566^1,2	C,F,H	54286773(+)	`ACATGG/CCCCAT`	1	P/A	mis¹ ese³		10	MN EU EA WA	1100

About this table

HapMap Linkage Disequilibrium images for SLC6A2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 163970 disorders: 604715

UniProtKB/Swiss-Prot: SC6A2_HUMAN, P23975

Defects in SLC6A2 are a cause of orthostatic intolerance (OI) [MIM:604715]. OI is a

syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. It is

associated with postural tachycardia. Plasma norepinephrine concentration is abnormally high

10/37 Novoseek disease relationships for SLC6A2 gene (see all 37 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
attention-deficit hyperactivity disorder	68.61	21	16969268 (2), 12716261 (1), 16896954 (1), 18480678 (1) (see all 14)
mitral valve prolapse	54.15	14	12391111 (2), 11804991 (2), 12805287 (2), 14726430 (1) (see all 9)
autonomic disorder	52.39	1	12805287 (1)
major depression	48.54	46	10512149 (4), 11927173 (4), 15118352 (4), 17353941 (4) (see all 12)
pheochromocytoma	46.57	15	17102094 (3), 16047163 (2), 19088695 (2), 12574193 (1) (see all 7)
neuroendocrine tumors	43.27	5	15154969 (1), 17979223 (1), 18196892 (1)
panic disorder	39.32	9	15722184 (4), 16785272 (1), 12401556 (1)
mood disorders	35.86	5	11927173 (1), 11606618 (1), 17654409 (1)
oppositional defiant disorder	21.95	1	15801334 (1)
tachycardia	19.22	3	15946904 (1), 11458707 (1)

About this table

Human Gene Mutation Database: SLC6A2
Genetic Association Database: SLC6A2
Human Genome Epidemiology Navigator: SLC6A2 (57 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/392 PubMed articles for SLC6A2 gene (see all 392 ):

Orthostatic intolerance and tachycardia associated with norepinephrine-transporter deficiency. (PubMed id 10684912)^{1, 3, 4, 6} Shannon J.R.... Robertson D. (2000)
Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter. (PubMed id 2008212)^{2, 3, 4} Pacholczyk T.... Amara S.G. (1991)
Norepinephrine transporter (NET) promoter and 5'-UTR polymorphisms: association analysis in panic disorder. (PubMed id 15722184)^{1, 3, 6} Lee Y.J....Deckert J. (2005)
Association between norepinephrine transporter gene polymorphism and major depression. (PubMed id 15118352)^{1, 3, 6} Ryu S.H....Lee M.S. (2004)
A screen of candidate genes and influence of beta2-adrenergic receptor genotypes in postural tachycardia syndrome. (PubMed id 15946904)^{1, 3, 6} Nickander K.K....Low P.A. (2005)
Norepinephrine transporter gene (NET) variants in patients with panic disorder. (PubMed id 12401556)^{1, 3, 6} Sand P.G....Deckert J. (2002)
Prediction of antidepressant response to milnacipran by norepinephrine transporter gene polymorphisms. (PubMed id 15337646)^{1, 3, 6} Yoshida K....Nemeroff C.B. (2004)
Association of distinct alpha(2) adrenoceptor and serotonin transporter polymorphisms with constipation and somatic symptoms in functional gastrointestinal disorders. (PubMed id 15138209)^{1, 3, 6} Kim H.J....Urrutia R. (2004)
Positive association between T-182C polymorphism in the norepinephrine transporter gene and susceptibility to major depressive disorder in a japanese population. (PubMed id 15539861)^{1, 3, 6} Inoue K....Suzuki T. (2004)
A mutation in the human norepinephrine transporter gene (SLC6A2) associated with orthostatic intolerance disrupts surface expression of mutant and wild-type transporters. (PubMed id 12805287)^{1, 3, 6} Hahn M.K....Blakely R.D. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 6530	HGNC: 11048	AceView: SLC6A2	Ensembl:ENSG00000103546	euGenes: HUgn6530
ECgene: SLC6A2	H-InvDB: SLC6A2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
GeneReviews	http://www.genetests.org/query?gene=SLC6A5

Licensable Technologies for SLC6A2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for SLC6A2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

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	Predesigned and custom siRNAs for SLC6A2		Antibodies for SLC6A2
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Search OriGene for SLC6A2

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Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for SLC6A2

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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SLC6A2 Gene at Home site.
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SLC6A2 Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for SLC6A2

Summaries
for SLC6A2

Genomic Location
for SLC6A2

Proteins
for SLC6A2

Protein Domains/
Families
for SLC6A2

Gene Function
for SLC6A2

Pathways & Interactions
for SLC6A2

Drugs & Compounds
for SLC6A2

Transcripts
for SLC6A2

Expression
for SLC6A2

Orthologs
for SLC6A2

Paralogs
for SLC6A2

SNPs/Variants
for SLC6A2

Disorders & Mutations
for SLC6A2

Medical News
for SLC6A2

Publications
for SLC6A2

Search for SLC6A2

Genome Databases showing SLC6A2

Other Databases showing SLC6A2

Specialized Databases showing SLC6A2

Licensable Technologies
for SLC6A2

Services
for SLC6A2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

SLC6A2 Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor SLC6A2

Summariesfor SLC6A2

Genomic Locationfor SLC6A2

Proteinsfor SLC6A2

Protein Domains/Familiesfor SLC6A2

Gene Functionfor SLC6A2

Pathways & Interactionsfor SLC6A2

Drugs & Compoundsfor SLC6A2

Transcriptsfor SLC6A2

Expression for SLC6A2

Orthologsfor SLC6A2

Paralogsfor SLC6A2

SNPs/Variantsfor SLC6A2

Disorders & Mutationsfor SLC6A2

Medical Newsfor SLC6A2

Publicationsfor SLC6A2

Search for SLC6A2

Genome Databases showing SLC6A2

Other Databases showing SLC6A2

Specialized Databases showing SLC6A2

Licensable Technologiesfor SLC6A2

Servicesfor SLC6A2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for SLC6A2

Summaries
for SLC6A2

Genomic Location
for SLC6A2

Proteins
for SLC6A2

Protein Domains/
Families
for SLC6A2

Gene Function
for SLC6A2

Pathways & Interactions
for SLC6A2

Drugs & Compounds
for SLC6A2

Transcripts
for SLC6A2

Expression
for SLC6A2

Orthologs
for SLC6A2

Paralogs
for SLC6A2

SNPs/Variants
for SLC6A2

Disorders & Mutations
for SLC6A2

Medical News
for SLC6A2

Publications
for SLC6A2

Licensable Technologies
for SLC6A2

Services
for SLC6A2