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SLC4A10 Gene

protein-coding   GIFtS: 61
GCID: GC02P162281

Solute Carrier Family 4, Sodium Bicarbonate Transporter,...

(Previous names: solute carrier family 4, sodium bicarbonate transporter-like,...)
  See SLC4A10-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Solute Carrier Family 4, Sodium Bicarbonate Transporter, Member 101 2     Sodium-Driven Chloride Bicarbonate Exchanger2
NCBE2 3     Solute Carrier Family 4, Sodium Bicarbonate Cotransporter-Like, Member 102
Solute Carrier Family 4, Sodium Bicarbonate Transporter-Like, Member 101     Solute Carrier Family 4 Member 103
NBCn22     

External Ids:    HGNC: 138111   Entrez Gene: 572822   Ensembl: ENSG000001442907   OMIM: 6055565   UniProtKB: Q6U8413   
ORGUL members:         

Export aliases for SLC4A10 gene to outside databases

Previous GC identifers: GC02P160534 GC02P161009 GC02P162444 GC02P162683 GC02P162306 GC02P162189 GC02P154363


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC4A10 Gene:
This gene belongs to a small family of sodium-coupled bicarbonate transporters (NCBTs) that regulate the
intracellular pH of neurons, the secretion of bicarbonate ions across the choroid plexus, and the pH of the brain
extracellular fluid. The protein encoded by this gene was initially identified as a sodium-driven chloride
bicarbonate exchanger (NCBE) though there is now evidence that its sodium/bicarbonate cotransport activity is
independent of any chloride ion countertransport under physiological conditions. This gene is now classified as a
member A10 of the SLC4 family of transmembrane solute carriers. Alternative splicing results in multiple
transcript variants encoding distinct isoforms.(provided by RefSeq, May 2010)

GeneCards Summary for SLC4A10 Gene:
SLC4A10 (solute carrier family 4, sodium bicarbonate transporter, member 10) is a protein-coding gene. Diseases associated with SLC4A10 include complex partial epilepsy. GO annotations related to this gene include inorganic anion exchanger activity and symporter activity. An important paralog of this gene is SLC4A7.

UniProtKB/Swiss-Prot: S4A10_HUMAN, Q6U841
Function: Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important
role in regulating intracellular pH (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC4A10 gene promoter:
         AML1a   AP-4   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   Evi-1   AREB6   POU2F1   HSF2   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC4A10 promoter sequence
   Search Chromatin IP Primers for SLC4A10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC4A10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q24.2   Ensembl cytogenetic band:  2q24.2   HGNC cytogenetic band: 2q24.2

SLC4A10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC4A10 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P162281:  view genomic region     (about GC identifiers)

Start:
162,280,843 bp from pter      End:
162,841,792 bp from pter
Size:
560,950 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: S4A10_HUMAN, Q6U841 (See protein sequence)
Recommended Name: Sodium-driven chloride bicarbonate exchanger  
Size: 1118 amino acids; 125946 Da
Secondary accessions: B7Z1R0 B7ZLC5 B9EG69 F8W675 Q4ZFX6 Q8TCP2 Q9HCQ6
Alternative splicing: 3 isoforms:  Q6U841-1   Q6U841-2   Q6U841-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC4A10: NX_Q6U841

Explore proteomics data for SLC4A10 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn697
  • Modification sites at PhosphoSitePlus

  • See SLC4A10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001171486.1  NP_001171487.1  NP_071341.2  

    ENSEMBL proteins: 
     ENSP00000395797   ENSP00000272716   ENSP00000393066   ENSP00000389180   ENSP00000404486  
     ENSP00000437527   ENSP00000364664  
    Reactome Protein details: Q6U841

    SLC4A10 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Electroneutral sodium bicarbonate cotransporter 2
    Sodium-dependent HCO3- transporters

    5 InterPro protein domains:
     IPR003020 HCO3_transpt_euk
     IPR003024 Na/HCO3_transpt
     IPR011531 HCO3_transpt_C
     IPR016152 PTrfase/Anion_transptr
     IPR013769 Band3_cytoplasmic_dom

    Graphical View of Domain Structure for InterPro Entry Q6U841

    ProtoNet protein and cluster: Q6U841

    2 Blocks protein domains:
    IPB003024 Na+/HCO3- co-transporter signature
    IPB013769 HCO3- transporter


    UniProtKB/Swiss-Prot: S4A10_HUMAN, Q6U841
    Similarity: Belongs to the anion exchanger (TC 2.A.31) family


    Find genes that share domains with SLC4A10           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S4A10_HUMAN, Q6U841
    Function: Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important
    role in regulating intracellular pH (By similarity)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity ----
    GO:0005452inorganic anion exchanger activity IEA--
    GO:0008509anion transmembrane transporter activity ----
    GO:0015293symporter activity IEA--
    GO:0015301anion:anion antiporter activity ----
         
    Find genes that share ontologies with SLC4A10           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Slc4a10):
     behavior/neurological  growth/size/body  homeostasis/metabolism  mortality/aging  nervous system 

    Find genes that share phenotypes with SLC4A10           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Slc4a10tm1.1Cahb for SLC4A10

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC4A10
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC4A10
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLC4A10

    miRNA
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    miRTarBase miRNAs that target SLC4A10:
    hsa-mir-30a-5p (MIRT005129)

    Block miRNA regulation of human, mouse, rat SLC4A10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLC4A10 (see all 32):
    hsa-miR-376b hsa-miR-25 hsa-miR-4325 hsa-miR-330-3p hsa-miR-92b hsa-miR-181b hsa-miR-505 hsa-miR-92a
    SwitchGear 3'UTR luciferase reporter plasmidSLC4A10 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SLC4A10

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    GenScript: all cDNA clones in your preferred vector (see all 3): SLC4A10 (NM_022058)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC4A10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC4A10

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC4A10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    S4A10_HUMAN, Q6U841: Cell membrane; Multi-pass membrane protein. Note=Localizes to the basolateral membrane (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane NAS10993873
    GO:0016323basolateral plasma membrane IEA--

    Find genes that share ontologies with SLC4A10           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC4A10 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transport of inorganic cations/anions and amino acids/oligopeptides0.38
    Transmembrane transport of small molecules0.47
    Bicarbonate transporters0.00


    Find genes that share SuperPaths with SLC4A10           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SLC4A10
        Bicarbonate transporters


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC4A10
    Interactions:

        Search GeneGlobe Interaction Network for SLC4A10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for SLC4A10 (Q6U8413 ENSP000003957974) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CBFBQ139513I2D: score=1 
    FOSP011003I2D: score=1 
    YWHABP319463I2D: score=1 
    F10ENSP000003647094STRING: ENSP00000364709
    NSFENSP000003812934STRING: ENSP00000381293
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0006811ion transport TAS--
    GO:0006814sodium ion transport IEA--
    GO:0006820anion transport ----
    GO:0006821chloride transport NAS10993873

    Find genes that share ontologies with SLC4A10           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC4A10 (S4A10)

    3 HMDB Compounds for SLC4A10    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChlorineCl2 (see all 13)16887-00-6--
    Hydrogen carbonateBicarbonate (see all 19)71-52-3--
    SodiumSodium (see all 2)7440-23-5--

    1 DrugBank Compound for SLC4A10    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Sodium bicarbonateBicarbonate of soda (see all 6)144-55-8transportersubstrate15014910 17071329 12847417 12027220



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC4A10 gene (3 alternative transcripts): 
    NM_001178015.1  NM_001178016.1  NM_022058.3  

    Unigene Cluster for SLC4A10:

    Solute carrier family 4, sodium bicarbonate transporter, member 10
    Hs.333958  [show with all ESTs]
    Unigene Representative Sequence: NM_001178016
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000482861 ENST00000605990 ENST00000606386 ENST00000415876 ENST00000493021(uc010fpa.1)
    ENST00000461456 ENST00000272716 ENST00000446997 ENST00000481721 ENST00000446228
    ENST00000421911 ENST00000535165(uc010zcr.1) ENST00000375514(uc002ubx.4 uc010zcs.2 uc002uby.4)

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    Selected qRT-PCR Assays for microRNAs that regulate SLC4A10 (see all 32):
    hsa-miR-376b hsa-miR-25 hsa-miR-4325 hsa-miR-330-3p hsa-miR-92b hsa-miR-181b hsa-miR-505 hsa-miR-92a
    SwitchGear 3'UTR luciferase reporter plasmidSLC4A10 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat SLC4A10
      QuantiFast Probe-based Assays in human, mouse, rat SLC4A10

    Additional mRNA sequence: 

    AK293793.1 AK294767.1 AK308529.1 AK309839.1 AL713680.1 AL832525.1 AY376402.1 BC036415.2 
    BC038298.1 BC051190.1 BC136269.1 BC143714.1 

    5 DOTS entries:

    DT.100730828  DT.102842626  DT.102842625  DT.40293654  DT.100674496 

    Selected AceView cDNA sequences (see all 102):

    BX951604 CD631089 BM664443 BM696161 AL832525 AY376402 CD631074 BC036415 
    AL713680 AA629334 CA841736 CD631064 BX955341 CD631067 AL539940 BE702100 
    BX952927 BQ067691 CD631072 CD631069 CD631065 CD631060 CD631063 CD631078 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SLC4A10    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b
    SP1:                          -               
    SP2:                                          


    ECgene alternative splicing isoforms for SLC4A10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC4A10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCACCTATT
    SLC4A10 Expression
    About this image


    SLC4A10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Cerebral Cortex
             brain/forebrain/telencephalon   
     
     Epithelial Cells
             Mature Choroid Plexus Cells Choroid Plexus
     
     Neural Tube (Nervous System)
             Telencephalon
    SLC4A10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC4A10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.333958
        Custom PCR Arrays for SLC4A10
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat SLC4A10
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC4A10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SLC4A10 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc4a101 , 5 solute carrier family 4, sodium bicarbonate cotransporter-like, more1, 5 90.27(n)1
    97.74(a)1
      2 (35.79 cM)5
    942291  NM_001242382.11  NP_001229311.11 
     620464625 
    chicken
    (Gallus gallus)
    Aves SLC4A101 solute carrier family 4, sodium bicarbonate transporter, more 82.9(n)
    92.95(a)
      424188  XM_004942823.1  XP_004942880.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLC4A106
    solute carrier family 4, sodium bicarbonate transp...
    88(a)
    1 ↔ 1
    GL343359.1(718134-959976)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.193382 Xenopus laevis transcribed sequence with moderate similarity more 76(n)    BQ384734.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5576421 novel protein similar to vertebrate solute carrier more 72.94(n)
    83.35(a)
      557642  XM_003199252.2  XP_003199300.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ndae13 sodium:bicarbonate cotransporter 53(a)   27E6   --
    worm
    (Caenorhabditis elegans)
    Secernentea F52B5.13 anion exchange protein 47(a)
    (best of 2)
      I(8305353-8315575)   --


    ENSEMBL Gene Tree for SLC4A10 (if available)
    TreeFam Gene Tree for SLC4A10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC4A10 gene
    SLC4A72  SLC4A42  SLC4A112  SLC4A12  SLC4A52  SLC4A82  SLC4A22  SLC4A92  
    SLC4A32  
    12 SIMAP similar genes for SLC4A10 using alignment to 6 protein entries:     S4A10_HUMAN (see all proteins):
    DKFZp781H1314    SLC4A8    SLC4A7    SLC4A4    NBC    SLC4A5
    SLC4A9    SLC4A2    SLC4A1    SLC4A3    AE    AE1

    Find genes that share paralogs with SLC4A10           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC4A10 (see all 6225)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs725302581,2
    C--154369753(+) TGACA-/CCCCATT 3 -- int11Minor allele frequency- CC:0.00CSA 2
    rs1995917641,2
    C--154389141(+) AGACA-/TTTTTTT 3 -- int10--------
    rs671460031,2
    C--154396467(+) TTTAG-/AATAAT 3 -- int12Minor allele frequency- A:0.00NA CSA 4
    rs677505831,2
    C--154412658(+) TTAAA-/CAATAT 3 -- int10--------
    rs339658301,2
    C--154415000(+) TGCCT-/ATTAAA 3 -- int10--------
    rs1430021181,2
    C--154424256(+) CAGAA-/AAAC  
            
    AAACA
    3 -- int10--------
    rs767634461,2
    C--154587505(+) TTTTAC/TCTTCT 3 -- int11Minor allele frequency- T:0.50NA 2
    rs58358861,2
    C--154610957(+) TATTC-/AAAAAA 3 -- int1 trp31Minor allele frequency- A:0.00NA 2
    rs113223951,2
    C--154705131(+) GTCTC-/AAAAAA 3 -- int1 trp30--------
    rs1175409221,2
    F--161876048(+) TTCTCC/TACTTT 3 -- us2k11Minor allele frequency- T:0.01EA 120

    HapMap Linkage Disequilibrium report for SLC4A10 (162280843 - 162530843 bp, first 250kb of SLC4A10)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SLC4A10 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1338019CNV Deletion17803354
    esv2646896CNV Deletion19546169
    esv2721050CNV Deletion23290073
    esv268607CNV Insertion20981092
    nsv3008CNV Insertion18451855
    esv268701CNV Insertion20981092
    nsv3006CNV Insertion18451855
    nsv3007CNV Loss18451855
    nsv875352CNV Loss21882294
    nsv875350CNV Loss21882294

    Human Gene Mutation Database (HGMD): SLC4A10
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC4A10
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC4A10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605556    OMIM disorders: --

    1 disease for SLC4A10:    
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    complex partial epilepsy

    1 disease from the University of Copenhagen DISEASES database for SLC4A10:
    Complex partial epilepsy

    Find genes that share disorders with SLC4A10           About GenesLikeMe

    Genetic Association Database (GAD): SLC4A10
    Human Genome Epidemiology (HuGE) Navigator: SLC4A10 (3 documents)

    Export disorders for SLC4A10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC4A10 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with SLC4A10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PubMed id 20331378)1, 4 Mosbruger T.L....Thio C.L. (J. Infect. Dis. 2010)
    3. AQP1 and SLC4A10 as candidate genes for primary open-angle glaucoma. (PubMed id 20101282)1, 4 Liu W....Allingham R.R. (Mol. Vis. 2010)
    4. Characterization of human SLC4A10 as an electroneutral Na/HCO3 cotransporter (NBCn2) with Cl- self-exchange activity. (PubMed id 18319254)1, 3 Parker M.D....Boron W.F. (J. Biol. Chem. 2008)
    5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    6. The Na+-driven Cl-/HCO3- exchanger. Cloning, tissue distribution, and functional characterization. (PubMed id 10993873)1, 2 Wang C.-Z.... Seino S. (J. Biol. Chem. 2000)
    7. Assignment of the human solute carrier family 4, sodium bicarbonate cotransporter-like, member 10 gene (SLC4A10) to 2q23--&gt;q24 by in situ hybridization and radiation hybrid mapping. (PubMed id 10965143)1, 9 Yano H....Seino S. (Cytogenet. Cell Genet. 2000)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. Mice with targeted Slc4a10 gene disruption have small brain ventricles and show reduced neuronal excitability. (PubMed id 18165320)1 Jacobs S....HA1bner C.A. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    10. Disruption of sodium bicarbonate transporter SLC4A10 in a patient with complex partial epilepsy and mental retardation. (PubMed id 18413482)1 Gurnett C.A....Bowcock A. (Arch. Neurol. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57282 HGNC: 13811 AceView: SLC4A10 Ensembl:ENSG00000144290 euGenes: HUgn57282
    ECgene: SLC4A10 H-InvDB: SLC4A10

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC4A10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC4A10 gene:
    Search GeneIP for patents involving SLC4A10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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