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SLC1A4 Gene

protein-coding   GIFtS: 63
GCID: GC02P065216

Solute Carrier Family 1 (Glutamate/Neutral Amino Acid Transporter),...

  See SLC1A4-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 1 (Glutamate/Neutral Amino Acid Transporter),
Member 41 2
     ASCT-12 3
ASCT12 3 5     Alanine/Serine/Cysteine/Threonine Transporter1
SATT2 3 5     Glutamate/Neutral Amino Acid Transporter2
Alanine/Serine/Cysteine/Threonine Transporter 12 3     Neutral Amino Acid Transporter A2
Solute Carrier Family 1 Member 42 3     

External Ids:    HGNC: 109421   Entrez Gene: 65092   Ensembl: ENSG000001159027   OMIM: 6002295   UniProtKB: P430073   

Export aliases for SLC1A4 gene to outside databases

Previous GC identifers: GC02P065350 GC02P065173 GC02P065191 GC02P065128 GC02P065070 GC02P064949


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SLC1A4 Gene:
SLC1A4 (solute carrier family 1 (glutamate/neutral amino acid transporter), member 4) is a protein-coding gene. Diseases associated with SLC1A4 include hartnup disease, and cystinuria. GO annotations related to this gene include chloride channel activity and L-alanine transmembrane transporter activity. An important paralog of this gene is SLC1A3.

UniProtKB/Swiss-Prot: SATT_HUMAN, P43007
Function: Transporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence

Gene Wiki entry for SLC1A4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC1A4 gene promoter:
         C/EBPbeta   STAT5A   AP-2gamma   YY1   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC1A4 promoter sequence
   Search Chromatin IP Primers for SLC1A4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC1A4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p15-p13   Ensembl cytogenetic band:  2p14   HGNC cytogenetic band: 2p15-p13

SLC1A4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC1A4 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P065216:  view genomic region     (about GC identifiers)

Start:
65,215,579 bp from pter      End:
65,250,999 bp from pter
Size:
35,421 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SATT_HUMAN, P43007 (See protein sequence)
Recommended Name: Neutral amino acid transporter A  
Size: 532 amino acids; 55723 Da
Secondary accessions: B7Z3C0 D6W5F0
Alternative splicing: 2 isoforms:  P43007-1   P43007-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC1A4: NX_P43007

Explore proteomics data for SLC1A4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn201, Asn206
  • Modification sites at PhosphoSitePlus

  • See SLC1A4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001180422.1  NP_003029.2  

    ENSEMBL proteins: 
     ENSP00000431942   ENSP00000234256  
    Reactome Protein details: P43007

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    antibodies-online proteins for SLC1A4 (2 products) 

     
    antibodies-online peptides for SLC1A4

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Alanine/serine/cysteine transporter 1
    Alanine/serine/cysteine transporter subfamily

    2 InterPro protein domains:
     IPR001991 Na-dicarboxylate_symporter
     IPR018107 Na-dicarboxylate_symporter_CS

    Graphical View of Domain Structure for InterPro Entry P43007

    ProtoNet protein and cluster: P43007

    1 Blocks protein domain: IPB001991 Sodium:dicarboxylate symporter

    UniProtKB/Swiss-Prot: SATT_HUMAN, P43007
    Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A4 subfamily


    Find genes that share domains with SLC1A4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SATT_HUMAN, P43007
    Function: Transporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence

         Genatlas biochemistry entry for SLC1A4:
    solute carrier family 1,member A4,glutamate/neutral amino acid transporter

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005254chloride channel activity IDA8910405
    GO:0015175neutral amino acid transmembrane transporter activity ----
    GO:0015180L-alanine transmembrane transporter activity IDA8101838
    GO:0015184NOT L-cystine transmembrane transporter activity IDA8340364
    GO:0015186L-glutamine transmembrane transporter activity TAS--
         
    Find genes that share ontologies with SLC1A4           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SLC1A4

    miRNA
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    miRTarBase miRNAs that target SLC1A4:
    hsa-mir-215-5p (MIRT024856), hsa-mir-484 (MIRT042374), hsa-mir-124-3p (MIRT022372), hsa-mir-335-5p (MIRT017309), hsa-mir-192-5p (MIRT026286), hsa-mir-615-3p (MIRT039636), hsa-let-7b-5p (MIRT001595)

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    Selected qRT-PCR Assays for microRNAs that regulate SLC1A4 (see all 31):
    hsa-miR-579 hsa-miR-3910 hsa-miR-642a hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-3921 hsa-miR-759
    SwitchGear 3'UTR luciferase reporter plasmidSLC1A4 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SATT_HUMAN, P43007: Membrane; Multi-pass membrane protein. Melanosome. Note=Identified by mass spectrometry in
    melanosome fractions from stage I to stage IV
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    plasma membrane4

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005813centrosome IDA--
    GO:0005815microtubule organizing center IDA--
    GO:0005882intermediate filament ISS--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IC8910405

    Find genes that share ontologies with SLC1A4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC1A4 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transport of inorganic cations/anions and amino acids/oligopeptides0.38
    Transmembrane transport of small molecules0.47
    Amino acid transport across the plasma membrane0.32
    2Neuroscience
    Neuroscience


    Find genes that share SuperPaths with SLC1A4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for SLC1A4
        Neuroscience


    1 Reactome Pathway for SLC1A4
        Amino acid transport across the plasma membrane


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC1A4
    Interactions:

        GeneGlobe Interaction Network for SLC1A4

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for SLC1A4 (P430073 ENSP000002342564) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERVW-1Q9UQF03, ENSP000004199454I2D: score=1 STRING: ENSP00000419945
    UBCENSP000003448184STRING: ENSP00000344818
    MYCENSP000003672074STRING: ENSP00000367207
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport TAS--
    GO:0006821chloride transport IDA8910405
    GO:0006835dicarboxylic acid transport ----
    GO:0006865amino acid transport TAS--
    GO:0006868glutamine transport TAS--

    Find genes that share ontologies with SLC1A4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for SLC1A4 (SATT)

    6 HMDB Compounds for SLC1A4    About this table
    CompoundSynonyms CAS #PubMed Ids
    Hydroxyproline(2S,4R)-4-hydroxy-2-pyrrolidinecarboxylic acid (see all 21)51-35-4--
    L-Alanine(2S)-2-Aminopropanoate (see all 35)56-41-7--
    L-Cystine(-)-Cystine (see all 31)56-89-3--
    L-Serine(-)-Serine (see all 26)56-45-1--
    L-Threonine(2S,3R)-(-)-Threonine (see all 21)72-19-5--
    SodiumSodium (see all 2)7440-23-5--

    1 DrugBank Compound for SLC1A4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Alanine(2S)-2-Aminopropanoic acid (see all 15)56-41-7target--17510490 17195090 17475673 17311416 17237199

    10 Novoseek inferred chemical compound relationships for SLC1A4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glutamate 57.2 21 10964674 (2), 17106422 (1), 7702599 (1), 9266331 (1) (see all 14)
    glutamine 54.6 6 11746424 (1), 11331400 (1), 17311416 (1)
    alanine 50.4 6 11824937 (2), 17311416 (2), 10811809 (1)
    serine 46.5 5 15099708 (2), 12846552 (1), 10357852 (1)
    phenylalanine 43 2 2109147 (1), 16046863 (1)
    leucine 25.3 1 2109147 (1)
    gaba 20.5 2 12477895 (1)
    threonine 15.2 1 11746424 (1)
    histidine 4.88 1 2109147 (1)
    tyrosine 0 1 2109147 (1)



    Find genes that share compounds with SLC1A4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC1A4 gene (3 alternative transcripts): 
    NM_001135581.1  NM_001193493.1  NM_003038.4  

    Unigene Cluster for SLC1A4:

    Solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
    Hs.654352  [show with all ESTs]
    Unigene Representative Sequence: AK126636
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000493121 ENST00000471551 ENST00000531327 ENST00000234256(uc010ypz.2 uc010yqa.2)
    ENST00000480594(uc002sdh.3)
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    hsa-miR-579 hsa-miR-3910 hsa-miR-642a hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-3921 hsa-miR-759
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    Additional mRNA sequence: 

    AB026689.1 AK126636.1 AK223486.1 AK295687.1 AK298472.1 AK313052.1 AK315986.1 AL833067.1 
    BC007350.2 BC026216.1 BC072423.1 L14595.1 L19444.1 

    6 DOTS entries:

    DT.95138598  DT.65285317  DT.99945225  DT.432311  DT.100816432  DT.95307098 

    Selected AceView cDNA sequences (see all 295):

    CB153934 AI168787 N41953 BQ447532 CB121011 AK126636 BQ446476 F06366 
    BC072423 BQ053962 BU076736 BI909657 BQ181988 BP379274 AI458503 BQ059378 
    BP335460 AI869213 CN484106 BF811099 BQ447681 BQ056703 AW204539 H38800 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC1A4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGACAATTGC
    SLC1A4 Expression
    About this image


    SLC1A4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Line H9 (Naive)
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Epithelial Cells
             Outer Root Sheath Cells Outer Root Sheath
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             PureStem E15, Meso-prx/latp Progenitor
    SLC1A4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC1A4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654352

    UniProtKB/Swiss-Prot: SATT_HUMAN, P43007
    Tissue specificity: Expressed mostly in brain, muscle, and pancreas but detected in all tissues examined

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC1A4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SLC1A4 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc1a41 , 5 solute carrier family 1 (glutamate/neutral amino acid more1, 5 86.15(n)1
    89.85(a)1
      11 (12.97 cM)5
    559631  NM_018861.31  NP_061349.31 
     203022055 
    chicken
    (Gallus gallus)
    Aves SLC1A41 solute carrier family 1 (glutamate/neutral amino acid more 76.25(n)
    80.84(a)
      769612  XM_001232899.3  XP_001232900.3 
    lizard
    (Anolis carolinensis)
    Reptilia SLC1A46
    solute carrier family 1 (glutamate/neutral amino a...
    76(a)
    1 ↔ 1
    1(124379453-124418441)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia slc1a41 solute carrier family 1 (glutamate/neutral amino acid more 70.78(n)
    75.9(a)
      100124992  NM_001102921.1  NP_001096391.1 
    zebrafish
    (Danio rerio)
    Actinopterygii slc1a41 solute carrier family 1 (glutamate/neutral amino acid more 72.06(n)
    79.21(a)
      368885  NM_001002513.2  NP_001002513.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Eaat13 sodium/excitatory glutamate
    cotransporter
    37(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea T22E5.23 sodium-dependent glutamate/aspartate
    transporter
    39(a)
    (best of 2)
      X(6437359-6441747)   --


    ENSEMBL Gene Tree for SLC1A4 (if available)
    TreeFam Gene Tree for SLC1A4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC1A4 gene
    SLC1A32  SLC1A52  SLC1A72  SLC1A12  SLC1A22  SLC1A62  
    6 SIMAP similar genes for SLC1A4 using alignment to 1 protein entry:     SATT_HUMAN:
    SLC1A5    SLC1A3    SLC1A1    SLC1A2    SLC1A6    SLC1A7

    Find genes that share paralogs with SLC1A4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC1A4 (see all 833)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs722046911,2
    C--64948551(+) GCCCA-/CCCCC 
            
    CCCCC
    2 -- us2k10--------
    rs1177246361,2
    F--65213583(+) TCCCAA/GTTGAG 1 -- us2k11Minor allele frequency- G:0.02EA 120
    rs675859831,2
    C,F--65213584(+) CCCAAT/CTGAGG 1 -- us2k15Minor allele frequency- C:0.19WA NA EA 362
    rs101941071,2
    C--65213822(+) GTAGGC/TCTCGA 1 -- us2k111Minor allele frequency- T:0.13WA NA CSA EA 372
    rs1841155051,2
    --65213829(+) TCGAAA/TGCCAG 1 -- us2k10--------
    rs751440571,2
    C,F--65213830(+) CGAATG/CCCAGG 1 -- us2k11Minor allele frequency- C:0.15WA 118
    rs1410631371,2
    --65213887(+) AACAAA/GAAGTG 1 -- us2k10--------
    rs1446617171,2
    --65213973(+) GGATGC/TCTGTG 1 -- us2k10--------
    rs739348971,2
    C,F--65214027(+) TGGTCA/GTTTGA 1 -- us2k13Minor allele frequency- G:0.12WA CSA 122
    rs1869327451,2
    --65214073(+) GTGTAC/TGACTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SLC1A4 (65215579 - 65250999 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SLC1A4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834246CNV Loss17160897
    esv275563CNV Loss21479260

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing SLC1A4
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC1A4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600229    OMIM disorders: --

    3 diseases for SLC1A4:    
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    hartnup disease    cystinuria    schizophrenia


    Find genes that share disorders with SLC1A4           About GenesLikeMe

    3 Novoseek inferred disease relationships for SLC1A4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schizophrenia 8.31 9 18638388 (4), 17106422 (1), 9034006 (1), 10994645 (1)
    cancer 4.42 1 15916903 (1)
    tumors 0 1 15916903 (1)

    Genetic Association Database (GAD): SLC1A4
    Human Genome Epidemiology (HuGE) Navigator: SLC1A4 (5 documents)

    Export disorders for SLC1A4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC1A4 gene, integrated from 10 sources (see all 112):
    (articles sorted by number of sources associating them with SLC1A4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human neutral amino acid transporter ASCT1: structure of the gene (SLC1A4) and localization to chromosome 2p13-p15. (PubMed id 7896285)1, 2, 3, 9 Hofmann K.... Stoffel W. (Genomics 1994)
    2. No association between genetic variants at the ASCT1 gene and schizophrenia or bipolar disorder in a German sample. (PubMed id 17106422)1, 4, 9 Skowronek M.H....Rietschel M. (Psychiatr. Genet. 2006)
    3. Association study of polymorphisms in the neutral amino acid transporter genes SLC1A4, SLC1A5 and the glycine transporter genes SLC6A5, SLC6A9 with schizophrenia. (PubMed id 18638388)1, 4, 9 Deng X....Fukumaki Y. (BMC Psychiatry 2008)
    4. ASCT-1 is a neutral amino acid exchanger with chloride channel activity. (PubMed id 8910405)1, 3, 9 Zerangue N. and Kavanaugh M.P. (J. Biol. Chem. 1996)
    5. Cloning and expression of a human neutral amino acid transporter with structural similarity to the glutamate transporter gene family. (PubMed id 8101838)1, 2, 9 Arriza J.L.... Amara S.G. (J. Biol. Chem. 1993)
    6. Cloning and expression of a novel Na(+)-dependent neutral amino acid transporter structurally related to mammalian Na+/glutamate cotransporters. (PubMed id 8340364)1, 2, 9 Shafqat S.... Fremeau R.T. Jr. (J. Biol. Chem. 1993)
    7. Genome-wide association study identifies multiple loci influencing human serum metabolite levels. (PubMed id 22286219)1, 4 Kettunen J....Ripatti S. (Nat. Genet. 2012)
    8. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1, 4 Yokoyama K....Hosoya T. (Nephron Clin Pract 2010)
    9. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    10. Associations between multiple system atrophy and polymorphisms of SLC1A4, SQSTM1, and EIF4EBP1 genes. (PubMed id 18442140)1, 4 Soma H....Sasaki H. (Mov. Disord. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6509 HGNC: 10942 AceView: SLC1A4 Ensembl:ENSG00000115902 euGenes: HUgn6509
    ECgene: SLC1A4 H-InvDB: SLC1A4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC1A4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC1A4 gene:
    Search GeneIP for patents involving SLC1A4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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