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SLC13A1 Gene

protein-coding   GIFtS: 50

GC07M122540
solute carrier family 13 (sodium/sulfate symporters), member 1
(Previous names: solute carrier family 13 (sodium/sulphate symporters), member 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for SLC13A1

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
NAS1 1, 2, 3, 5
NASI1 3
NaSi-1 1, 2
hNaSi-1 3
Descriptions
Na(+)/sulfate cotransporter 3
Renal sodium/sulfate cotransporter 3
solute carrier family 13 (sodium/sulfate symporters),
member 1 2
solute carrier family 13 (sodium/sulphate symporters),
member 1 1, 2
External Ids
HGNC: 109161
Entrez Gene: 65612
UniProtKB: Q9BZW23
Ensembl: ENSG000000818007
Search outside databases for aliases for SLC13A1 gene

Previous GC identifers: GC07M121231 GC07M122294 GC07M122308 GC07M122347

Summaries
for SLC13A1

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: S13A1_HUMAN, Q9BZW2
Function: Sodium/sulfate cotransporter that mediates sulfate reabsorption in the kidney

Genomic Location
for SLC13A1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the SLC13A1 gene  

Entrez Gene cytogenetic band: 7q31-q32   Ensembl cytogenetic band:  7q31.32   HGNC cytogenetic band: 7q31-q32

SLC13A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M122540:     (about GC identifiers)

Start:
 122,540,824 bp from pter
End:
 122,627,261 bp from pter
Size:
 86,438 bases
Orientation:
 minus strand

1 alternative location:
Chr7-,CRA_TCAG 122,142,198-122,228,657     
RefSeq DNA sequence:
NC_000007.12  NT_007933.14  NT_079596.2  

Proteins
for SLC13A1

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: S13A1_HUMAN, Q9BZW2 (See protein sequence)
Recommended Name: Solute carrier family 13 member 1  
Size: 595 amino acids; 66134 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: Q9H5Z0

REFSEQ proteins: NP_071889.2  

ENSEMBL proteins: 
ENSP00000194130 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
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Browse Abcam for Recombinant Proteins
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0016020 membrane IEA--
GO:0016021 integral to membrane IEA--
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Antibodies for SLC13A1: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for SLC13A1

Assays for SLC13A1: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for SLC13A1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro domain/family:
 IPR001898 Na/sul_symport


   GeneDecks  SLC13A1 for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry Q9BZW2

ProtoNet protein and cluster: Q9BZW2

1 Blocks protein family: IPB001898 Sodium/sulphate symporter

UniProtKB/Swiss-Prot: S13A1_HUMAN, Q9BZW2
Similarity: Belongs to the SLC13A transporter (TC 2.A.47) family. NADC subfamily

Gene Function
for SLC13A1

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (SLC13A1)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (SLC13A1)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_022444

              Applied Biosystems Silencer® siRNAs for SLC13A1

              Sigma-Aldrich siRNA and siRNA Panels for SLC13A1  
                     Sigma-Aldrich shRNA for SLC13A1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for SLC13A1
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_022444
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_022444
                                 untagged cDNA clone in CMV expression vector: NM_022444 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_022444

UniProtKB/Swiss-Prot: S13A1_HUMAN, Q9BZW2
Function: Sodium/sulfate cotransporter that mediates sulfate reabsorption in the kidney
Induction: Inhibited by thiosulfate, selenate, molybdate, tungstate, citrate and succinate

10 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Slc13a1):

behavior/neurologicalgrowth/sizehomeostasis/metabolismlimbs/digits/tail
liver/biliary systemnervous systemrenal/urinary systemreproductive systemskeleton

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005215 transporter activity IEA--
GO:0008271 secondary active sulfate transmembrane transporter activity IEA--
GO:0015293 symporter activity IEA--
GO:0031402 sodium ion binding IEA--
About this table

Pathways & Interactions
for SLC13A1

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


 Gene Network CentralTM Interacting Genes and Proteins Network for  SLC13A1 


3 Interacting proteins for SLC13A1 (ENSP000001941303) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
SLC26A3ENSP000003458733STRING (score=.895)
SLC26A2ENSP000002862983STRING (score=.849)
SLC26A1ENSP000003547213STRING (score=.748)
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3 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006811 ion transport IEA--
GO:0006814 sodium ion transport IEA--
GO:0008272 sulfate transport IEA--
About this table

Drugs & Compounds
for SLC13A1

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for SLC13A1
3 Novoseek chemical compound relationships for SLC13A1 gene
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
nadc 87.05 2 12867358 (1), 12857732 (1)
dicarboxylate 79.18 3 12857732 (1), 10535998 (1), 9518567 (1)
sulfate 77.42 17 11231338 (3), 11161786 (2), 10998198 (2), 9486223 (1) (see all 11)
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Transcripts
for SLC13A1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (SLC13A1)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (SLC13A1)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_022444

              Sigma-Aldrich siRNA and siRNA Panels for SLC13A1  
                     Sigma-Aldrich shRNA for SLC13A1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_022444  

REFSEQ mRNAs for SLC13A1 gene: 

NM_022444.3   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_022444  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_022444
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_022444
                                 untagged cDNA clone in CMV expression vector: NM_022444 

Additional cDNA sequence: 

AF260824.1 AK026413.1 AK314537.1 BC111775.1 

3 DOTS entries:

DT.204482  DT.121105243  DT.40304031 

18 AceView cDNA sequences:

NM_022444 AI732845 AI015652 AI733589 AA858019 AI469201 AK026413 BG054487 
BG400459 AI792169 BG433404 BP382927 AI491922 AF260824 BX104566 BG430415 
BG428081 AW236701 

highest scoring ESTs for SLC13A1:

AF260824 AI733589 AK026413 AA858019 AA886292 AI015652 AI209074 AI732845 AI792169 AI792474 

Unigene Cluster for SLC13A1:

Solute carrier family 13 (sodium/sulfate symporters), member 1
Hs.489849  [show with all ESTs]
Unigene Representative Sequence: AF260824


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000194130  

Expression
for SLC13A1

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

SLC13A1 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for SLC13A1

1 / 2 / 3

5 probe-sets matching SLC13A1 gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
76702_at2, 3 U95-D 1 1.00 1.00 1.00 1.00 AI733589 0.80 1.00 0.91 1

220502_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_022444 0.60 1.00 0.82 1

220503_at2, 3 U133-A 1 1.00 1.00 -- -- AF260824 0.80 1.00 0.91 1

220502_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

220503_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  SLC13A1 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: GATGCATTTT

SOURCE GeneReport for Unigene cluster: Hs.489849

UniProtKB/Swiss-Prot: S13A1_HUMAN, Q9BZW2
Tissue specificity: Highly expressed in kidney; not detectable in the other tissues tested

Orthologs
for SLC13A1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for SLC13A1 gene from 5/15 species (see all 15 )
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 SLC13A11   -- solute carrier family 13 (sodium/sulfate symporters), more 85.21(n)
86.89(a)		 482431  XM_539548.2  XP_539548.2 
chimpanzee
(Pan troglodytes)		 SLC13A11   -- solute carrier family 13 (sodium/sulfate symporters), more 99.33(n)
98.66(a)		 463684  XM_519338.2  XP_519338.2 
cow
(Bos taurus)		 SLC13A11   -- solute carrier family 13 (sodium/sulfate symporters), more 87.79(n)
88.24(a)		 514983  XM_874281.2  XP_879374.2 
rat
(Rattus norvegicus)		 Slc13a11   -- solute carrier family 13 (sodium/sulfate symporters), more 83.98(n)
82.86(a)		 58980  NM_031651.1  NP_113839.1 
mouse
(Mus musculus)		 Slc13a11, 5 6 (4.70 cM)5
 solute carrier family 13 (sodium/sulfate symporters), more1, 5 83.5(n)1
80.98(a)1		 559611  NM_019481.11  NP_062354.11 
 AF1993655  AF1993665  (see all 32)
About this table        Species with no ortholog for SLC13A1

ENSEMBL Gene Tree for SLC13A1

Paralogs
for SLC13A1

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for SLC13A1 gene
SLC13A42  

SNPs/Variants
for SLC13A1

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/482 NCBI SNPs in SLC13A1 are shown (see all 482 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 240)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 7 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
rs21405161,2
A,C,F,H,O122596470(+) ATCCGC/TTGAAG 1 N/S mis1 ese321Minor allele frequency- N:0.00EA NA EU WA 3508
rs69620391,2
A,C,F,H122541594(+) attttG/Aggggt 1 -- ut31 ese37Minor allele frequency- A:0.27EU EA WA NA 542
rs38240261,2
C,F,H122628811(-) TGAGGC/TTCAAA 1 -- ng3111Minor allele frequency- T:0.34NA EU EA WA 978
rs102311441,2
A,C,H122574542(+) AACACG/ATAAGT 1 M/T mis1 ese35Minor allele frequency- A:0.01EU EA WA 938
--
rs64668541,2
C,F,H122542681(+) TTCACG/AGGAAT 1 -- ut31 ese312Minor allele frequency- A:0.05NA EU EA WA 1528
rs127064851,2
C,F,H122540358(+) CATGAA/GCAGAC 1 -- ng514Minor allele frequency- G:0.24EU EA WA 416
rs77985851,2
A,H122628632(+) TAGTAT/CATAGT 1 -- ng314Minor allele frequency- C:0.00EU EA WA 408
--
rs126736701,2
A,C122541284(+) caggaA/Gaatgg 1 -- ut31 ese30--------
--
rs126736691,2
A,C122541282(+) ggcagC/Gagaat 1 -- ut31 ese30--------
rs283641721,2
F122627203(-) ATCGCC/TGATTT 1 R/X non11Minor allele frequency- T:0.00--550
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HapMap Linkage Disequilibrium images for SLC13A1 (up to first 250kb)

Disorders & Mutations
for SLC13A1

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

 OMIM: 606193

1 Novoseek disease relationship for SLC13A1 gene

Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
intoxication 33.24 2 9486223 (1), 11231338 (1)
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Human Genome Epidemiology Navigator: SLC13A1 (1 document)

Medical News
for SLC13A1

(Possibly Related Articles in Doctor's Guide)
About This Section

   --

Publications
for SLC13A1

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/20 PubMed articles for SLC13A1 gene (see all 20 ):

Search for SLC13A1

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing SLC13A1

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section
Entrez Gene: 6561 HGNC: 10916 AceView: SLC13A1 Ensembl:ENSG00000081800 euGenes: HUgn6561
ECgene: SLC13A1 H-InvDB: SLC13A1

Other Databases showing SLC13A1

(According to HUGE)
About This Section

   --

Specialized Databases showing SLC13A1

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

   --

Licensable Technologies
for SLC13A1

(Available from WIS Yeda, Salk, Tufts)
About This Section

  --

Services
for SLC13A1

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for SLC13A1:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for SLC13A1 Browse small molecules at Sigma-Aldrich
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 Search Novus for antibodies for SLC13A1

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