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Aliases for SETD7 Gene

Aliases for SETD7 Gene

  • SET Domain Containing (Lysine Methyltransferase) 7 2 3
  • SET7 3 4 6
  • Histone H3-K4 Methyltransferase SETD7 3 4
  • SET Domain-Containing Protein 7 3 4
  • Lysine N-Methyltransferase 7 3 4
  • H3-K4-HMTase SETD7 3 4
  • KIAA1717 4 6
  • SET7/9 3 4
  • KMT7 3 4
  • SET9 3 4
  • Histone H3-Lysine 4-Specific Methyltransferase 3
  • Histone-Lysine N-Methyltransferase SETD7 3
  • EC 2.1.1.43 4

External Ids for SETD7 Gene

Previous GeneCards Identifiers for SETD7 Gene

  • GC04M140646
  • GC04M140417
  • GC04M136156

Summaries for SETD7 Gene

GeneCards Summary for SETD7 Gene

SETD7 (SET Domain Containing (Lysine Methyltransferase) 7) is a Protein Coding gene. Among its related pathways are Chromatin Regulation / Acetylation and FoxO signaling pathway. GO annotations related to this gene include p53 binding and protein-lysine N-methyltransferase activity.

UniProtKB/Swiss-Prot for SETD7 Gene

  • Histone methyltransferase that specifically monomethylates Lys-4 of histone H3. H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates Lys-189 of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates Lys-372 of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.

Gene Wiki entry for SETD7 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SETD7 Gene

Genomics for SETD7 Gene

Regulatory Elements for SETD7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SETD7 Gene

Start:
139,495,941 bp from pter
End:
139,606,699 bp from pter
Size:
110,759 bases
Orientation:
Minus strand

Genomic View for SETD7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SETD7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SETD7 Gene

Proteins for SETD7 Gene

  • Protein details for SETD7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WTS6-SETD7_HUMAN
    Recommended name:
    Histone-lysine N-methyltransferase SETD7
    Protein Accession:
    Q8WTS6
    Secondary Accessions:
    • B5WWL3
    • Q0VAH3
    • Q4W5A9
    • Q9C0E6

    Protein attributes for SETD7 Gene

    Size:
    366 amino acids
    Molecular mass:
    40721 Da
    Quaternary structure:
    • Interacts with IPF1/PDX-1.
    Miscellaneous:
    • Monomethyltransferase activity is achieved by disrupting the formation at near-attack conformations for the dimethylation reaction
    SequenceCaution:
    • Sequence=BAB21808.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SETD7 Gene

neXtProt entry for SETD7 Gene

Proteomics data for SETD7 Gene at MOPED

Post-translational modifications for SETD7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SETD7 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SETD7 (SETD7)

No data available for DME Specific Peptides for SETD7 Gene

Domains for SETD7 Gene

Gene Families for SETD7 Gene

HGNC:
  • KMT :Chromatin-modifying enzymes / K-methyltransferases

Protein Domains for SETD7 Gene

Suggested Antigen Peptide Sequences for SETD7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WTS6

UniProtKB/Swiss-Prot:

SETD7_HUMAN :
  • Q8WTS6
Domain:
  • The SET domain is necessary but not sufficient for histone methyltransferase activity
  • Contains 1 SET domain.
Family:
  • Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET7 subfamily.
Similarity:
  • Contains 3 MORN repeats.
genes like me logo Genes that share domains with SETD7: view

Function for SETD7 Gene

Molecular function for SETD7 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=29 uM for histone H3 {ECO:0000269 PubMed:16415881}; KM=12 uM for TAF10 {ECO:0000269 PubMed:16415881}; KM=69 uM for p53/TP53 {ECO:0000269 PubMed:16415881};
UniProtKB/Swiss-Prot CatalyticActivity: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
UniProtKB/Swiss-Prot Function: Histone methyltransferase that specifically monomethylates Lys-4 of histone H3. H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates Lys-189 of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates Lys-372 of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.

Enzyme Numbers (IUBMB) for SETD7 Gene

Gene Ontology (GO) - Molecular Function for SETD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IPI 17108971
GO:0005515 protein binding IPI 12540855
GO:0016279 protein-lysine N-methyltransferase activity IDA 16415881
GO:0018024 histone-lysine N-methyltransferase activity NAS 12514135
genes like me logo Genes that share ontologies with SETD7: view
genes like me logo Genes that share phenotypes with SETD7: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SETD7

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for SETD7 Gene

Localization for SETD7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SETD7 Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SETD7 Gene COMPARTMENTS Subcellular localization image for SETD7 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SETD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome IEA --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with SETD7: view

Pathways for SETD7 Gene

genes like me logo Genes that share pathways with SETD7: view

Pathways by source for SETD7 Gene

1 Cell Signaling Technology pathway for SETD7 Gene
1 BioSystems pathway for SETD7 Gene
2 KEGG pathways for SETD7 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Epigenetic Chromatin Modification Enzymes in human,mouse,rat

Gene Ontology (GO) - Biological Process for SETD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006974 cellular response to DNA damage stimulus IDA 23509280
GO:0016568 chromatin modification NAS 12514135
genes like me logo Genes that share ontologies with SETD7: view

Compounds for SETD7 Gene

(3) HMDB Compounds for SETD7 Gene

Compound Synonyms Cas Number PubMed IDs
L-Lysine
  • (+)-S-Lysine
56-87-1
S-Adenosylhomocysteine
  • (S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine
979-92-0
S-Adenosylmethionine
  • (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine
29908-03-0

(1) Drugbank Compounds for SETD7 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
S-Adenosyl-L-Homocysteine
979-92-0 target

(1) Novoseek inferred chemical compound relationships for SETD7 Gene

Compound -log(P) Hits PubMed IDs
lysine 58.8 3
genes like me logo Genes that share compounds with SETD7: view

Transcripts for SETD7 Gene

Unigene Clusters for SETD7 Gene

SET domain containing (lysine methyltransferase) 7:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SETD7

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SETD7 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1: - - -
SP2:
SP3: -

Relevant External Links for SETD7 Gene

GeneLoc Exon Structure for
SETD7
ECgene alternative splicing isoforms for
SETD7

Expression for SETD7 Gene

mRNA expression in normal human tissues for SETD7 Gene

mRNA differential expression in normal tissues according to GTEx for SETD7 Gene

This gene is overexpressed in Muscle - Skeletal (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SETD7 Gene

SOURCE GeneReport for Unigene cluster for SETD7 Gene Hs.480792

mRNA Expression by UniProt/SwissProt for SETD7 Gene

Q8WTS6-SETD7_HUMAN
Tissue specificity: Widely expressed. Expressed in pancreatic islets
genes like me logo Genes that share expressions with SETD7: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SETD7 Gene

Orthologs for SETD7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SETD7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SETD7 35
  • 99.62 (n)
  • 99.72 (a)
SETD7 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SETD7 35
  • 92.44 (n)
  • 98.09 (a)
SETD7 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SETD7 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Setd7 35
  • 87.98 (n)
  • 95.36 (a)
Setd7 16
Setd7 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SETD7 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SETD7 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Setd7 35
  • 88.43 (n)
  • 95.9 (a)
chicken
(Gallus gallus)
Aves SETD7 35
  • 80.97 (n)
  • 88.25 (a)
SETD7 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SETD7 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia setd7 35
  • 76.78 (n)
  • 82.79 (a)
Str.15687 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8415 35
zebrafish
(Danio rerio)
Actinopterygii Dr.12876 35
setd7 35
  • 69.41 (n)
  • 73.35 (a)
setd7 36
  • 71 (a)
OneToOne
Species with no ortholog for SETD7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SETD7 Gene

ENSEMBL:
Gene Tree for SETD7 (if available)
TreeFam:
Gene Tree for SETD7 (if available)

Paralogs for SETD7 Gene

Selected SIMAP similar genes for SETD7 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SETD7: view

No data available for Paralogs for SETD7 Gene

Variants for SETD7 Gene

Sequence variations from dbSNP and Humsavar for SETD7 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1881 -- 139,506,890(+) GAGGA(C/T)GTCTC utr-variant-3-prime
rs11631 -- 139,506,341(+) TAACC(A/G)TGATG utr-variant-3-prime
rs706308 -- 139,555,060(-) CCACT(A/C)CATAC intron-variant
rs706309 -- 139,557,324(-) GCCCA(A/G)TGGTT upstream-variant-2KB
rs767427 -- 139,514,163(+) cctgt(C/T)ggtac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SETD7 Gene

Variant ID Type Subtype PubMed ID
nsv830085 CNV Loss 17160897
nsv830086 CNV Gain 17160897
nsv819236 CNV Gain 19587683
esv27698 CNV Loss 19812545

Relevant External Links for SETD7 Gene

HapMap Linkage Disequilibrium report
SETD7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SETD7 Gene

Disorders for SETD7 Gene

(1) Novoseek inferred disease relationships for SETD7 Gene

Disease -log(P) Hits PubMed IDs
leukemia 56.8 3

Relevant External Links for SETD7

Genetic Association Database (GAD)
SETD7
Human Genome Epidemiology (HuGE) Navigator
SETD7
genes like me logo Genes that share disorders with SETD7: view

No data available for UniProtKB/Swiss-Prot for SETD7 Gene

Publications for SETD7 Gene

  1. Purification and functional characterization of a histone H3-lysine 4-specific methyltransferase. (PMID: 11779497) Wang H. … Zhang Y. (Mol. Cell 2001) 2 3 4 23
  2. Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation. (PMID: 11850410) Nishioka K. … Reinberg D. (Genes Dev. 2002) 2 3 4 23
  3. Methylation-acetylation interplay activates p53 in response to DNA damage. (PMID: 17646389) Ivanov G.S. … Barlev N.A. (Mol. Cell. Biol. 2007) 3 23
  4. Gene-specific modulation of TAF10 function by SET9-mediated methylation. (PMID: 15099517) Kouskouti A. … Talianidis I. (Mol. Cell 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SETD7 Gene

  • Addgene plasmids for SETD7

Sources for SETD7 Gene

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