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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SELP Gene

protein-coding GIFtS: 71
GCID: GC01M169558

selectin P (granule membrane protein 140kDa, antigen CD62)

(Previous names: selectin P (granule membrane protein 140kD, antigen CD62)...)
(Previous symbol: GRMP)

Explore 213 diseases affiliated with
SELP via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Selectin P (Granule Membrane Protein 140kDa, Antigen CD62)¹ ²		GMP-140² ³
GRMP¹ ² ³ ⁵		LECAM3² ³
PADGEM¹ ² ³		CD62 Antigen-Like Family Member P² ³
CD62¹ ²		Selectin P (Granule Membrane Protein 140kD, Antigen CD62)¹
CD62P¹ ²		P-Selectin¹
GMP140¹ ²		Granulocyte Membrane Protein²
PSEL¹ ²		Platelet Alpha-Granule Membrane Protein²
Granule Membrane Protein 140² ³		GMRP³
Leukocyte-Endothelial Cell Adhesion Molecule 3² ³		CD62P Antigen³
Platelet Activation Dependent Granule-External Membrane Protein² ³

External Ids:	HGNC: 10721¹	Entrez Gene: 6403²	Ensembl: ENSG00000174175⁷	OMIM: 173610⁵	UniProtKB: P16109³

Export aliases for SELP gene to outside databases

Previous GC identifers: GC01M167186 GC01M165208 GC01M166254 GC01M166745 GC01M166290 GC01M167824 GC01M140780

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SELP:

This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of

endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and

mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a

calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils

and monocytes. Alternative splice variants may occur but are not well documented. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: LYAM3_HUMAN, P16109

Function: Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes.

Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is

sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in

inflammation through interaction with PSGL1

summary for SELP:

Cellular adhesion molecules (CAMs) are a large family of proteins that attach the cytoskeleton and

intracellular signalling cascades with the extracellular environment. CAMs have roles in cell proliferation,

differentiation, motility, trafficking, apoptosis and tissue architecture, and their dysregulation is common

in cancer. The selectins are Ca2+-dependent CAMs that bind fucosylated carbohydrates (e.g. mucins). There

are three types of selectins, E-selectin (endothelial), L-selectin (leukocyte) and P-selectin (platelet).

Gene Wiki entry for SELP (P-selectin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SELP gene promoter:
c-Fos AP-1 ATF-2 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SELP promoter sequence

Search SABiosciences Chromatin IP Primers for SELP

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SELP

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22-q25 Ensembl cytogenetic band: 1q24.2 HGNC cytogenetic band: 1q22-q25

SELP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SELP gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M169558: view genomic region (about GC identifiers)

Start:	169,558,037 bp from pter	End:	169,599,380 bp from pter
Size:	41,344 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: LYAM3_HUMAN, P16109 (See protein sequence)

Recommended Name: P-selectin precursor

Size: 830 amino acids; 90834 Da

Subunit: Interacts with SNX17. Interacts with PSGL1/SEPL and PODXL2 and mediates neutrophil adhesion and leukocyte

rolling. This interaction requires the sialyl-Lewis X epitope of PSGL1 and PODXL2, and specific tyrosine sulfation on

PSGL1

Subcellular location: Membrane; Single-pass type I membrane protein

6 PDB 3D structures from and Proteopedia for SELP:

1FSB (3D)

1G1Q (3D)

1G1R (3D)

1G1S (3D)

1HES (3D)

1KJD (3D)

Secondary accessions: Q5R344 Q8IVD1

Explore the universe of human proteins at neXtProt for SELP: NX_P16109

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P16109

SELP Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002996.2

ENSEMBL proteins:

ENSP00000356769 ENSP00000388683 ENSP00000356764 ENSP00000391694 ENSP00000356763

ENSP00000356762 ENSP00000356760 ENSP00000399368 ENSP00000263686 ENSP00000356767

ENSP00000356768 ENSP00000356766 ENSP00000356765

Reactome Protein details: P16109
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for SELP (P-Selectin/CD62P)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: SELP OriGene Protein Over-expression Lysate: SELP OriGene Custom Protein Services for SELP
	GenScript Custom Purified and Recombinant Proteins Services for SELP
	Novus Biologicals SELP Proteins Novus Biologicals SELP Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for SELP
	Uscn Proteins for SELP

Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	IDA	9290466
GO:0005625	soluble fraction	--	--
GO:0005634	nucleus	IDA	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	IDA	--

SELP for ontologies About GeneDecksing

SELP Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for SELP (P-Selectin/CD62P)
	Browse OriGene Antibodies OriGene Custom Antibody Services for SELP
	GenScript Custom Superior Antibodies Services for SELP
	Novus Biologicals SELP Antibodies
	Search for Antibodies for SELP at Abcam
	Uscn Antibodies for SELP
	ThermoFisher Antibodies for SELP

Assay Products for SELP:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for SELP (P-Selectin/CD62P) (see first)
	R&D Systems Multiplex/Array Assay Kits & Reagents for SELP (P-Selectin/CD62P)
	See all other biochemical assays at R&D Systems
	GenScript Custom Assay Services for SELP
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SELP

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SELP for domains About GeneDecksing

5/8 InterPro domains/families (see all 8):

IPR016187 C-type_lectin_fold

IPR002396 Selectin_superfamily

IPR000742 EG-like_dom

IPR018378 C-type_lectin_CS

IPR016186 C-type_lectin-like

Graphical View of Domain Structure for InterPro Entry P16109

ProtoNet protein and cluster: P16109

3 Blocks protein families:

IPB000436 Sushi domain/SCR domain/CCP module

IPB002396 Selectin superfamily complement-binding repeat signature

IPB006210 Type I EGF

UniProtKB/Swiss-Prot: LYAM3_HUMAN, P16109

Similarity: Belongs to the selectin/LECAM family

Similarity: Contains 1 C-type lectin domain

Similarity: Contains 1 EGF-like domain

Similarity: Contains 9 Sushi (CCP/SCR) domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: LYAM3_HUMAN, P16109

Function: Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes.

Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is

sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in

inflammation through interaction with PSGL1

Genatlas biochemistry entry for SELP:

P selectin,leukocyte adhesion molecule,granule membrane protein (platelet,endothelium),induced by

thrombin,histamine,peroxides from platelet alpha granule,high expressed in atherosclerotic plaques

miRNA Products:		OriGene 3'-UTR Clone: SELP Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SELP
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate SELP:
		hsa-miR-875-3p hsa-miR-3202 hsa-miR-548q hsa-miR-1299
		SwitchGear 3'UTR luciferase reporter plasmid: SELP 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SELP (see all 7) OriGene shRNA RFP: SELP OriGene siRNA: SELP
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SELP

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SELP

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SELP (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SELP OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SELP (NM_003005)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SELP
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SELP

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SELP
		Search LifeMap BioReagents cell lines for SELP

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SELP

Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001530	lipopolysaccharide binding	IMP	16514062
GO:0001948	glycoprotein binding	IEA	--
GO:0005515	protein binding	IPI	18606703
GO:0008201	heparin binding	IDA	7680663
GO:0030246	carbohydrate binding	--	--

SELP for ontologies About GeneDecksing

4 GenomeRNAi human phenotypes for SELP:

Decreased viability of wild-ty

G0/1 arrest

Increased G1 DNA content

Increased cell number in G2M,

Animal Models:
Mouse knock-outs for SELP: Selp^tm1Bay Selp^tm1Hyn Selp^tm2Hyn
15 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Selp):

behavior/neurological	cardiovascular system	cellular	growth/size	hematopoietic system
homeostasis/metabolism	immune system	integument	liver/biliary system	mortality/aging
nervous system	renal/urinary system	respiratory system	skeleton	vision/eye

SELP for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Platelet activation, signaling and aggregation

Platelet activation, signaling and aggregation

1.00

Hemostasis

0.43

Platelet degranulation

Platelet degranulation

1.00

Response to elevated platelet cytosolic Ca2+

0.94

Immune response IL-12 signaling pathway

Immune response IL-12 signaling pathway

1.00

Immune response_IL-12 signaling pathway

0.96

IL-3 Signaling Pathway

IL-3 Signaling Pathway

1.00

amb2 Integrin signaling

amb2 Integrin signaling

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for SELP

Immune response IL-12 signaling pathway

1 GeneGo (Thomson Reuters) Pathway for SELP

Immune response IL-12 signaling pathway

3 BioSystems Pathways for SELP

	IL-3 Signaling Pathway
	IL4-mediated signaling events
	amb2 Integrin signaling

5 Reactome Pathways for SELP

	Hemostasis
	Platelet degranulation
	Platelet activation, signaling and aggregation
	Response to elevated platelet cytosolic Ca2+
	Cell surface interactions at the vascular wall

3 Kegg Pathways (Kegg details for SELP):

	Cell adhesion molecules (CAMs)
	Malaria
	Staphylococcus aureus infection

SELP for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SELP

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/30 Interacting proteins for SELP (P16109³ ENSP00000263686⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 30)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EZR	P15311³, ENSP00000338934⁴	I2D: score=3 STRING: ENSP00000338934
SELPLG	Q14242³, ENSP00000373614⁴	I2D: score=3 STRING: ENSP00000373614
SERPING1	P05155³, ENSP00000278407⁴	I2D: score=3 STRING: ENSP00000278407
VCAN	P13611³, ENSP00000265077⁴	I2D: score=3 STRING: ENSP00000265077
FUT4	P22083³, ENSP00000351602⁴	I2D: score=2 STRING: ENSP00000351602

About this table

Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002576	platelet degranulation	TAS	--
GO:0002687	positive regulation of leukocyte migration	IEA	--
GO:0002691	regulation of cellular extravasation	--	--
GO:0006954	inflammatory response	IEA	--
GO:0007155	cell adhesion	TAS	2466574

SELP for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SELP for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for SELP available from Tocris Bioscience About this table

Compound	Action	CAS #
KF 38789	Selective inhibitor of P-selectin-mediated cell adhesion	[257292-29-8]

3 HMDB Compounds for SELP About this table

Compound	Synonyms	CAS #	PubMed Ids
3-O-Sulfogalactosylceramide (d18:1/24:0)	Sulfatide (d18:1/24:0) (see all 16)	151122-71-3	9851547
Clopidogrel	(+)-(S)-Clopidogrel (see all 6)	113665-84-2	--
Sialyl-Lewis X	3'-Sialyl-Lewis X (see all 8)	98603-84-0	--

4 DrugBank Compounds for SELP About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Heparin	Alpha-Heparin (see all 8)	9005-49-6	target	inhibitor	17629851 15995351 9466983 7694675 17458940 17651117 17549299
Nadroparin	--	9041-08-1	target	inhibitor	17629851 16525583
O-Sialic Acid	--	--	target	--	17139284 17016423
Dalteparin	Daltepariininatrium (see all 13)	9041-08-1	target	inhibitor	11044537

10/138 Novoseek chemical compound relationships for SELP gene (see all 138) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
adp	86.4	371	7687162 (4), 7506054 (3), 15972139 (3), 17482663 (3) (see all 99)
slex	84.1	94	12847092 (4), 15996105 (4), 8923785 (3), 10920004 (3) (see all 43)
fibrinogen	83.2	457	11511124 (7), 7544916 (6), 7506054 (5), 10802004 (5) (see all 99)
clopidogrel	79.2	111	12621388 (3), 16411409 (3), 12353080 (3), 19440925 (3) (see all 61)
aspirin	74.7	138	8835129 (5), 18413191 (5), 12621388 (4), 9723822 (3) (see all 77)
ac 12	70.4	4	8950496 (1), 7686899 (1)
mdmp	69.6	6	15136063 (2), 12581566 (1), 15668187 (1), 14691580 (1) (see all 5)
tyrosine sulfate	68.7	3	7559387 (1), 9725249 (1), 10978329 (1)
abciximab	67.8	32	11152927 (3), 11422017 (3), 9869172 (2), 10674406 (2) (see all 21)
4-f-glcnac	67.1	3	16691194 (2), 18056398 (1)

Search CenterWatch for drugs/clinical trials and news about SELP / LYAM3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SELP gene:

NM_003005.3

Unigene Cluster for SELP:

Selectin P (granule membrane protein 140kDa, antigen CD62)

Hs.73800 [show with all ESTs]

Unigene Representative Sequence: NM_003005

14 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000367795 ENST00000446728 ENST00000367790 ENST00000426706(uc001ggh.3)

ENST00000367789 ENST00000367788 ENST00000466167 ENST00000367786 ENST00000458599

ENST00000263686(uc001ggi.4 uc009wvr.3) ENST00000367793 ENST00000367794

ENST00000367792 ENST00000367791

miRNA Products:		OriGene 3'-UTR Clone: SELP Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SELP
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate SELP:
		hsa-miR-875-3p hsa-miR-3202 hsa-miR-548q hsa-miR-1299
		SwitchGear 3'UTR luciferase reporter plasmid: SELP 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SELP (see all 7) OriGene shRNA RFP: SELP OriGene siRNA: SELP
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SELP

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SELP (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SELP OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SELP (NM_003005)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SELP
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SELP

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SELP Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SELP
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SELP
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SELP

Additional cDNA sequence:

AK312884.1 AY367063.1 BC028067.2 BC068533.1 M25322.1

7 DOTS entries:

DT.100000000 DT.411391 DT.100019088 DT.100644300 DT.100754970 DT.121415788 DT.92418041

24/50 AceView cDNA sequences (see all 50):

BQ771982 BG400761 BC068533 BC028067 AI659868 BX110929 AY367063 AA953436

BQ003632 CB270009 BX952293 CD250696 CB961616 H30141 BU741375 CB989951

CB994899 R50714 CB991376 CD704975 AL603469 NM_003005 T70540 M25322

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for SELP About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12a	·	12b	^	13	^	14	^	15a	·	15b	^	16	^	17a	·	17b	·	17c	·	17d
SP1:																																	-						-
SP2:																																	-						-
SP3:																															-		-
SP4:																															-		-						-
SP5:

ECgene alternative splicing isoforms for SELP

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SELP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCACCGTGGA

About this image

SELP expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 4 LifeMap Cells

Name

Category

Intermediate limb mesenchymal cells (ILM cells) (Primary Cell)

Bone, Cartilage, Limb

PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)

Endothelium

Endothelial-like cells (Derivation and purif...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SELP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SELP

SOURCE GeneReport for Unigene cluster: Hs.73800

UniProtKB/Swiss-Prot: LYAM3_HUMAN, P16109

Tissue specificity: Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell

activation by agonists, P-selectin is transported rapidly to the cell surface

SABiosciences Expression via Pathway-Focused PCR Arrays including SELP:

Extracellular Matrix & Adhesion Molecules in human mouse rat

Cell Surface Markers in human mouse rat

NFKB Signaling Targets in human mouse rat

Endothelial Cell Biology in human mouse rat

Atherosclerosis in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SELP Browse OriGene validated miRNA SYBR primer pairs
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SELP gene from 4/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SELP¹	selectin P (granule membrane protein 140kDa, antigen more	53.61(n) 44.11(a)		424364 XM_422207.3 XP_422207.3
lizard (Anolis carolinensis)	Reptilia	-- SELP⁶	--	47(a)	possible ortholog 1 ↔ 1	GL343567.1(230131-410791) 4(71138269-71169022)
zebrafish (Danio rerio)	Actinopterygii	selp¹	selectin P	50.57(n) 42.48(a)		796481 XM_001336788.3 XP_001336824.3
fruit fly (Drosophila melanogaster)	Insecta	fw³	cell adhesion cell adhesion molecule	25(a)		11A1 --

ENSEMBL Gene Tree for SELP (if available)
TreeFam Gene Tree for SELP (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SELP gene

CSMD1² SEZ6L2² C4BPA² CR2² SELL² CR1L² CSMD3² SEZ6²

SELE² SEZ6L² CSMD2² CR1² CD55² CD46² SVEP1²

2 SIMAP similar genes for SELP using alignment to 10 protein entries: LYAM3_HUMAN (see all proteins):

SELL SELE

SELP for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs6136^1,2	C,F,O,H,	non-pathogenic	213423865(-)	`GGTCAA/CCTACC`	2	T P	mis¹ ese³		33	MN NS NA EA EU	11641
rs6133^1,2	C,F,A,H,	other	213422470(-)	`CAGGGC/G/TTGCAA`	3	L V	mis¹ ese³		40	MN NS NA EA WA CSA EU	11609
rs3917838^1,2	C,F,	--	140783478(-)	`AATCAG/TTCTAC`	1	--	int¹		2	NS	90
rs79153887^1,2	F,	--	140783730(+)	`TGTTTT/GTCCTC`	1	--	int¹		1	EA	120
rs3917837^1,2	C,H,	--	140783839(-)	`GATTTT/CAGGCT`	1	--	int¹		6	NS EA	514
rs3917836^1,2	C,F,H,	--	140783958(-)	`TCCAGA/GGGACC`	1	--	int¹		22	NS EA NA WA CSA	4539
rs73037471^1,2	C,F,	--	140784548(+)	`TTCCCA/GTCTTT`	1	--	int¹		6	WA CSA NA	245
rs3917835^1,2	C,F,H,	--	140784859(-)	`CCATCA/GGAGAA`	1	--	int¹		15	NS NA EA WA CSA	779
rs3917834^1,2	C,F,	--	140784944(-)	`CAGACT/CGGCAG`	1	--	int¹		5	NS CSA WA	207
rs3917833^1,2	C,F,H,	--	140784970(-)	`AGAACA/TTAGAC`	1	--	int¹		7	NS EA WA	618

HapMap Linkage Disequilibrium report for SELP (169558037 - 169599380 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SELP
2 CNVs: 48174 65206
Human Gene Mutation Database (HGMD): SELP

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SELP for disorders           About GeneDecksing

OMIM gene information: 173610
OMIM disorders: 147050
UniProtKB/Swiss-Prot: LYAM3_HUMAN, P16109

Defects in SELP may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:601367]; also known as

cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural

tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting

from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders

with multiple genetic and environmental risk factors

20/213 diseases for SELP (see all 213): About MalaCards

platelet alpha/delta storage pool deficiency heparin-induced thrombocytopenia gray platelet syndrome immune-complex glomerulonephritis

intermittent claudication paroxysmal nocturnal hemoglobinuria von willebrand's disease pre-eclampsia

mitral valve prolapse arterial occlusive disease end stage renal failure hypersensitivity reaction type ii disease

quebec platelet disorder thrombotic thrombocytopenic purpura severe pre-eclampsia proliferative diabetic retinopathy

deep vein thrombosis arteriosclerosis obliterans hemolytic-uremic syndrome polycythemia vera

7 diseases from the University of Copenhagen DISEASES database for SELP:

Vascular disease Heart disease Thrombocytopenia Brain disease

Diabetes mellitus Kidney disease Peritonitis

10/98 Novoseek disease relationships for SELP gene (see all 98) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
thrombosis	74.4	72	15217633 (2), 15004723 (2), 19840484 (2), 7543539 (1) (see all 56)
inflammation	73.7	176	10410991 (5), 8691152 (3), 15991175 (2), 19125345 (2) (see all 99)
gray platelet syndrome	72.7	1	9042822 (1)
platelet dysfunction	71.5	5	8949396 (1), 18432525 (1), 11071121 (1), 17599498 (1) (see all 5)
atherosclerosis	65.5	82	9391718 (4), 9241735 (3), 9034560 (3), 8584997 (2) (see all 51)
abnormal platelets	64.5	1	10611541 (1)
platelet aggregation, spontaneous	62.1	4	8870174 (1), 11246548 (1), 19297212 (1), 17845921 (1)
coronary artery disease	59	39	14640893 (3), 19487018 (3), 8957206 (2), 10493220 (2) (see all 28)
arterial thrombosis	53.4	6	15568145 (4), 19850970 (1), 15168594 (1)
cardiovascular diseases	53.3	21	11726042 (2), 16449250 (1), 12370220 (1), 15136493 (1) (see all 18)

Genetic Association Database (GAD): SELP
Human Genome Epidemiology (HuGE) Navigator: SELP (120 documents)

Export disorders for SELP gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SELP gene, integrated from 9 sources (see all 2242):
(articles sorted by number of sources associating them with SELP)

Utopia: connect your pdf to the dynamic
world of online information

Polymorphisms in the P-selectin (CD62P) and P-selectin glycoprotein ligand-1 (PSGL-1) genes and coronary heart disease. (PubMed id 15497463)^{1, 4, 9} Bugert P....Kluter H. (2004)
Association between P-selectin gene polymorphisms and soluble P-selectin levels and their relation to coronary artery disease. (PubMed id 11597943)^{1, 4, 9} Barbaux S.C....Tiret L. (2001)
SELPLG and SELP single-nucleotide polymorphisms in multiple sclerosis. (PubMed id 16257118)^{1, 4, 9} Fenoglio C....Sawcer S. (2006)
P-selectin is acylated with palmitic acid and stearic acid at cysteine 766 through a thioester linkage. (PubMed id 7684381)^{1, 2, 9} Fujimoto T.... McEver R.P. (1993)
Endoglycan, a member of the CD34 family of sialomucins, is a ligand for the vascular selectins. (PubMed id 18606703)^{1, 2, 9} Kerr S.C....Rosen S.D. (2008)
P-selectin Thr715Pro polymorphism predicts P-selectin levels but not risk of incident coronary heart disease or ischemic stroke in a cohort of 14595 participants: the Atherosclerosis Risk in Communities Study. (PubMed id 16125711)^{1, 4, 9} Volcik K.A....Boerwinkle E. (2006)
Polymorphism in the P-selectin and interleukin-4 genes as determinants of stroke: a population-based, prospective genetic analysis. (PubMed id 14681304)^{1, 2, 9} Zee R.Y.L.... Ridker P.M. (2004)
Soluble P-selectin levels, P-selectin polymorphisms and cardiovascular disease. (PubMed id 12911583)^{1, 4, 9} Carter A.M....Grant P.J. (2003)
Genetic risk factors for cerebrovascular disease in children with sickle cell disease: design of a case-control association study and genomewide screen. (PubMed id 12871600)^{1, 4, 9} Adams G.T....Kutlar A. (2003)
Specific haplotypes of the P-selectin gene are associated with myocardial infarction. (PubMed id 12165563)^{1, 4, 9} Tregouet D.A....Cambien F. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6403	HGNC: 10721	AceView: SELP	Ensembl:ENSG00000174175	euGenes: HUgn6403
ECgene: SELP	Kegg: 6403	H-InvDB: SELP

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SELP	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for SELP	Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPs	http://pga.gs.washington.edu/data/selp/
Functional Glycomics Gateway - Glycan Binding	http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_354

Intellectual Property for SELP gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SELP gene:
Search GeneIP for patents involving SELP

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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SELP Gene

selectin P (granule membrane protein 140kDa, antigen CD62)

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SELP (Gene Symbol)
Selectin P (Granule Membrane Protein 140kDa, Antigen CD62)
GRMP
PADGEM
CD62
CD62P
GMP140
PSEL
Granule Membrane Protein 140
Leukocyte-Endothelial Cell Adhesion Molecule 3
Platelet Activation Dependent Granule-External Membrane Protein
GMP-140
LECAM3
CD62 Antigen-Like Family Member P
Selectin P (Granule Membrane Protein 140kD, Antigen CD62)
P-Selectin
Granulocyte Membrane Protein
Platelet Alpha-Granule Membrane Protein
GMRP
CD62P Antigen

Intermittent Claudication
LUNG TUMOR
ABNORMAL PLATELETS
essential hypertension
sepsis
Peripheral Vascular Diseases
Hepatitis Chronic
UREMIC SYNDROME
coagulopathy
Acute myocardial infarction
Dermatitis Atopic
Autoimmune Thrombocytopenia
Colitis Ulcerative
Hyperlipidemia
COLON CARCINOMA
Myocardial Ischemia
Atherosclerosis
Ischemia
Purpura Thrombotic Thrombocytopenic
TRANSFUSION REACTION
PLATELET AGGREGATION, SPONTANEOUS
Hypercholesterolemia
Antiphospholipid Syndrome
Malaria Cerebral
Coronary Stenosis
cell damage
Internal Carotid Artery Stenosis
Hemolysis
Thrombocytopenia
Cardiomyopathy
Miscarriage
Pathological Processes
Myeloproliferative Disorders
Shock
Pancreatitis
Nasal Polyps
Cerebral Infarction
ARTERIAL THROMBOSIS
Colorectal Cancer
Inflammation
Monocytic leukemia
SICKLE CELL DISEASE
Hyperhomocysteinemia
Psoriasis
Sarcoidosis
Rheumatoid Arthritis
Cardiovascular Diseases
Tumors
Thrombosis
Metastasis
Necrosis
Carotid Atherosclerosis
Preeclampsia
Coronary Heart Disease
Thrombocytosis
HYPERTENSION ARTERIAL
Vasculitis
Carotid Stenosis
Venous Thrombosis
atherosclerotic plaque
Atrial Fibrillation
Hodgkin Disease
INFARCT
Infarction Lacunar
Myeloid Leukemia Chronic
Diabetes Mellitus
Arterial Occlusive Diseases
Purpura Thrombocytopenic Idiopathic
Stroke Acute
Carcinoma Renal Cell
Proliferative glomerulonephritis
Inflammatory Bowel Diseases
Myocardial Infarction
Coronary Artery Disease
Polycythemia Vera
von Willebrand Disease
Proliferative diabetic retinopathy
Response Acute Phase
GRAY PLATELET SYNDROME
Mitral stenosis
stasis
Hemophilia A
Bleeding
restenosis
Acute respiratory distress
Blood Loss Postoperative
Thrombophilia
STROKE
PROLONGED BLEEDING TIME
Cerebral Ischemia
Vascular Diseases
Arteriosclerosis Obliterans
CEREBROVASCULAR DISEASE
Thrombocythemia Essential
reactive hyperemia
NIDDM
platelet dysfunction
Thromboembolism

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SELP Gene

selectin P (granule membrane protein 140kDa, antigen CD62)

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