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Aliases for SCGB1A1 Gene

Aliases for SCGB1A1 Gene

  • Secretoglobin Family 1A Member 1 2 3 4
  • Secretoglobin, Family 1A, Member 1 (Uteroglobin) 3 5
  • Clara Cell Phospholipid-Binding Protein 3 4
  • Clara Cells 10 KDa Secretory Protein 3 4
  • Urinary Protein 1 3 4
  • Urine Protein 1 3 4
  • CCPBP 3 4
  • CC10 3 4
  • CCSP 3 4
  • UP-1 3 4
  • UGB 3 4
  • UP1 3 4
  • Uteroglobin (Clara-Cell Specific 10-KD Protein) 2
  • Uteroglobin 2
  • Blastokinin 3
  • CC16 3

External Ids for SCGB1A1 Gene

Previous HGNC Symbols for SCGB1A1 Gene

  • UGB

Previous GeneCards Identifiers for SCGB1A1 Gene

  • GC11P064700
  • GC11P063762
  • GC11P061961
  • GC11P061943
  • GC11P062188
  • GC11P058514

Summaries for SCGB1A1 Gene

Entrez Gene Summary for SCGB1A1 Gene

  • This gene encodes a member of the secretoglobin family of small secreted proteins. The encoded protein has been implicated in numerous functions including anti-inflammation, inhibition of phospholipase A2 and the sequestering of hydrophobic ligands. Defects in this gene are associated with a susceptibility to asthma. [provided by RefSeq, May 2010]

GeneCards Summary for SCGB1A1 Gene

SCGB1A1 (Secretoglobin Family 1A Member 1) is a Protein Coding gene. Diseases associated with SCGB1A1 include meconium aspiration syndrome and bronchiolitis obliterans. Among its related pathways are FOXA1 transcription factor network and Prostaglandin Synthesis and Regulation. GO annotations related to this gene include binding and phospholipase A2 inhibitor activity.

UniProtKB/Swiss-Prot for SCGB1A1 Gene

  • Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.

Gene Wiki entry for SCGB1A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCGB1A1 Gene

Genomics for SCGB1A1 Gene

Regulatory Elements for SCGB1A1 Gene

Genomic Location for SCGB1A1 Gene

Chromosome:
11
Start:
62,405,103 bp from pter
End:
62,423,206 bp from pter
Size:
18,104 bases
Orientation:
Plus strand

Genomic View for SCGB1A1 Gene

Genes around SCGB1A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCGB1A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCGB1A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCGB1A1 Gene

Proteins for SCGB1A1 Gene

  • Protein details for SCGB1A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11684-UTER_HUMAN
    Recommended name:
    Uteroglobin
    Protein Accession:
    P11684
    Secondary Accessions:
    • B2R5F2
    • Q6FHH3
    • Q9UCM2
    • Q9UCM4

    Protein attributes for SCGB1A1 Gene

    Size:
    91 amino acids
    Molecular mass:
    9994 Da
    Quaternary structure:
    • Homodimer; antiparallel disulfide-linked.

neXtProt entry for SCGB1A1 Gene

Proteomics data for SCGB1A1 Gene at MOPED

Post-translational modifications for SCGB1A1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SCGB1A1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for SCGB1A1 (Uteroglobin/SCGB1A1)

No data available for DME Specific Peptides for SCGB1A1 Gene

Domains & Families for SCGB1A1 Gene

Gene Families for SCGB1A1 Gene

Protein Domains for SCGB1A1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SCGB1A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P11684

UniProtKB/Swiss-Prot:

UTER_HUMAN :
  • Belongs to the secretoglobin family.
Family:
  • Belongs to the secretoglobin family.
genes like me logo Genes that share domains with SCGB1A1: view

Function for SCGB1A1 Gene

Molecular function for SCGB1A1 Gene

UniProtKB/Swiss-Prot Function:
Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.
genes like me logo Genes that share phenotypes with SCGB1A1: view

Animal Models for SCGB1A1 Gene

MGI Knock Outs for SCGB1A1:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SCGB1A1 Gene

Localization for SCGB1A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCGB1A1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCGB1A1 Gene COMPARTMENTS Subcellular localization image for SCGB1A1 gene
Compartment Confidence
extracellular 5
nucleus 3
cytoskeleton 2
endoplasmic reticulum 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SCGB1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0030141 secretory granule IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with SCGB1A1: view

Pathways & Interactions for SCGB1A1 Gene

genes like me logo Genes that share pathways with SCGB1A1: view

Pathways by source for SCGB1A1 Gene

Gene Ontology (GO) - Biological Process for SCGB1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0007565 female pregnancy NAS 10587371
GO:0009410 response to xenobiotic stimulus IEA --
GO:0010033 response to organic substance IEA --
GO:0010193 response to ozone IEA --
genes like me logo Genes that share ontologies with SCGB1A1: view

No data available for SIGNOR curated interactions for SCGB1A1 Gene

Drugs & Compounds for SCGB1A1 Gene

(15) Drugs for SCGB1A1 Gene - From: Novoseek and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
4,4'-BIS([H]METHYLSULFONYL)-2,2',5,5'-TETRACHLOROBIPHENYL Experimental Pharma Target 0

(17) Additional Compounds for SCGB1A1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PC(18:1(9Z)e/2:0)
  • (2-acetyloxy-3-octadec-9-enoxypropyl) 2-trimethylazaniumylethyl phosphate
  • 2-Acetyl-1-(9Z-octadecenyl)-sn-glycero-3-phosphocholine
  • PC(O-18:1(9Z)/2:0)
Phosphatidylcholines Group A
  • (R)-4-hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxohexadecyl)oxy]-3,5,9-Trioxa-4-phosphapentacosan-1-aminium 4-oxide hydroxide inner salt
  • (R)-4-hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxohexadecyl)oxy]-3,5,9-Trioxa-4-phosphapentacosan-1-aminium 4-oxide inner salt
  • 1,2-Bis(hexadecanoyl)-sn-glycero-3-phosphocholine
  • 1,2-Bis(palmitoyl)-sn-glycero-3-phosphocholine
  • 1,2-Dihexadecanoyl-sn-glycerol-3-phosphorylcholine
63-89-8, 68737-67-7
Phosphatidylcholines Group B
  • 1-(1-Enyl-palmitoyl)-2-stearidonoyl-sn-glycero-3-phosphocholine
  • GPCho(16:0/18:4)
  • GPCho(16:0/18:4n3)
  • GPCho(16:0/18:4w3)
  • GPCho(34:4)
88542-95-4
genes like me logo Genes that share compounds with SCGB1A1: view

Transcripts for SCGB1A1 Gene

mRNA/cDNA for SCGB1A1 Gene

Unigene Clusters for SCGB1A1 Gene

Secretoglobin, family 1A, member 1 (uteroglobin):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCGB1A1 Gene

No ASD Table

Relevant External Links for SCGB1A1 Gene

GeneLoc Exon Structure for
SCGB1A1
ECgene alternative splicing isoforms for
SCGB1A1

Expression for SCGB1A1 Gene

mRNA expression in normal human tissues for SCGB1A1 Gene

mRNA differential expression in normal tissues according to GTEx for SCGB1A1 Gene

This gene is overexpressed in Lung (x49.8).

Protein differential expression in normal tissues from HIPED for SCGB1A1 Gene

This gene is overexpressed in Urine (30.9), Nasal epithelium (22.2), and Neutrophil (10.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SCGB1A1 Gene



SOURCE GeneReport for Unigene cluster for SCGB1A1 Gene Hs.523732

mRNA Expression by UniProt/SwissProt for SCGB1A1 Gene

P11684-UTER_HUMAN
Tissue specificity: Clara cells (nonciliated cells of the surface epithelium of the pulmonary airways).
genes like me logo Genes that share expression patterns with SCGB1A1: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for SCGB1A1 Gene

Orthologs for SCGB1A1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SCGB1A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCGB1A1 35
  • 98.53 (n)
  • 98.9 (a)
SCGB1A1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SCGB1A1 36
  • 53 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCGB1A1 36
  • 54 (a)
OneToOne
SCGB1A1 35
  • 75.93 (n)
  • 60 (a)
mouse
(Mus musculus)
Mammalia Scgb1a1 35
  • 70.74 (n)
  • 55.56 (a)
Scgb1a1 36
  • 52 (a)
OneToOne
Scgb1a1 16
platypus
(Ornithorhynchus anatinus)
Mammalia SCGB1A1 36
  • 34 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Scgb1a1 35
  • 70 (n)
  • 55.56 (a)
Species with no ortholog for SCGB1A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SCGB1A1 Gene

ENSEMBL:
Gene Tree for SCGB1A1 (if available)
TreeFam:
Gene Tree for SCGB1A1 (if available)

Paralogs for SCGB1A1 Gene

(1) SIMAP similar genes for SCGB1A1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SCGB1A1: view

No data available for Paralogs for SCGB1A1 Gene

Variants for SCGB1A1 Gene

Sequence variations from dbSNP and Humsavar for SCGB1A1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_012045 -
VAR_012046 -

Variation tolerance for SCGB1A1 Gene

Residual Variation Intolerance Score: 59.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.12; 22.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCGB1A1 Gene

HapMap Linkage Disequilibrium report
SCGB1A1
Human Gene Mutation Database (HGMD)
SCGB1A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SCGB1A1 Gene

Disorders for SCGB1A1 Gene

MalaCards: The human disease database

(17) MalaCards diseases for SCGB1A1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
meconium aspiration syndrome
  • meconium aspiration
bronchiolitis obliterans
  • bronchiolitis exudativa
pulmonary edema
toxic pneumonitis
  • acute chemical fume pulmonary edema
silicosis
  • pneumoconiosis due to silicates
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SCGB1A1

Genetic Association Database (GAD)
SCGB1A1
Human Genome Epidemiology (HuGE) Navigator
SCGB1A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SCGB1A1
genes like me logo Genes that share disorders with SCGB1A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SCGB1A1 Gene

Publications for SCGB1A1 Gene

  1. Human CC10, the homologue of rabbit uteroglobin: genomic cloning, chromosomal localization and expression in endometrial cell lines. (PMID: 1284526) Wolf M. … Suske G. (Hum. Mol. Genet. 1992) 2 3 4 23 67
  2. Update of the human secretoglobin (SCGB) gene superfamily and an example of 'evolutionary bloom' of androgen-binding protein genes within the mouse Scgb gene superfamily. (PMID: 22155607) Jackson B.C. … Vasiliou V. (Hum. Genomics 2011) 2 3
  3. Clara cell secretory protein in tracheobronchial aspirates and umbilical cord serum of extremely premature infants with systemic inflammation. (PMID: 19887851) Thomas W. … Speer C.P. (Neonatology 2010) 3 23
  4. Cross-sectional and longitudinal association of the secretoglobin 1A1 gene A38G polymorphism with asthma phenotype in the Perth Infant Asthma Follow-up cohort. (PMID: 19128353) Laing I.A. … Le SouAf P.N. (Clin. Exp. Allergy 2009) 3 23
  5. Clara cell 10-kDa protein expression in chronic rhinosinusitis and its cytokine-driven regulation in sinonasal mucosa. (PMID: 19076932) Liu Z. … Cui Y.H. (Allergy 2009) 3 23

Products for SCGB1A1 Gene

Sources for SCGB1A1 Gene

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