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Aliases for SCGB1A1 Gene

Aliases for SCGB1A1 Gene

  • Secretoglobin, Family 1A, Member 1 (Uteroglobin) 2 3
  • CC10 3 4 6
  • UGB 3 4 6
  • Clara Cell Phospholipid-Binding Protein 3 4
  • Clara Cells 10 KDa Secretory Protein 3 4
  • Urinary Protein 1 3 4
  • Urine Protein 1 3 4
  • Uteroglobin 2 3
  • CCPBP 3 4
  • CCSP 3 4
  • UP-1 3 4
  • UP1 3 4
  • Uteroglobin (Clara-Cell Specific 10-KD Protein) 2
  • Secretoglobin Family 1A Member 1 4
  • Blastokinin 3
  • CCSP, 6
  • CC16 3

External Ids for SCGB1A1 Gene

Previous HGNC Symbols for SCGB1A1 Gene

  • UGB

Previous GeneCards Identifiers for SCGB1A1 Gene

  • GC11P064700
  • GC11P063762
  • GC11P061961
  • GC11P061943
  • GC11P062188
  • GC11P058514

Summaries for SCGB1A1 Gene

Entrez Gene Summary for SCGB1A1 Gene

  • This gene encodes a member of the secretoglobin family of small secreted proteins. The encoded protein has been implicated in numerous functions including anti-inflammation, inhibition of phospholipase A2 and the sequestering of hydrophobic ligands. Defects in this gene are associated with a susceptibility to asthma. [provided by RefSeq, May 2010]

GeneCards Summary for SCGB1A1 Gene

SCGB1A1 (Secretoglobin, Family 1A, Member 1 (Uteroglobin)) is a Protein Coding gene. Diseases associated with SCGB1A1 include bronchiolitis obliterans and silicosis. Among its related pathways are FOXA1 transcription factor network and Prostaglandin Synthesis and Regulation. GO annotations related to this gene include phospholipase A2 inhibitor activity.

UniProtKB/Swiss-Prot for SCGB1A1 Gene

  • Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2

Gene Wiki entry for SCGB1A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCGB1A1 Gene

Genomics for SCGB1A1 Gene

Regulatory Elements for SCGB1A1 Gene

Genomic Location for SCGB1A1 Gene

Start:
62,405,103 bp from pter
End:
62,423,206 bp from pter
Size:
18,104 bases
Orientation:
Plus strand

Genomic View for SCGB1A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCGB1A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCGB1A1 Gene

Proteins for SCGB1A1 Gene

  • Protein details for SCGB1A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11684-UTER_HUMAN
    Recommended name:
    Uteroglobin
    Protein Accession:
    P11684
    Secondary Accessions:
    • B2R5F2
    • Q6FHH3
    • Q9UCM2
    • Q9UCM4

    Protein attributes for SCGB1A1 Gene

    Size:
    91 amino acids
    Molecular mass:
    9994 Da
    Quaternary structure:
    • Homodimer; antiparallel disulfide-linked

neXtProt entry for SCGB1A1 Gene

Proteomics data for SCGB1A1 Gene at MOPED

Post-translational modifications for SCGB1A1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SCGB1A1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SCGB1A1 Gene

Domains for SCGB1A1 Gene

Gene Families for SCGB1A1 Gene

HGNC:
  • SCGB :Secretoglobins

Protein Domains for SCGB1A1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SCGB1A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P11684

UniProtKB/Swiss-Prot:

UTER_HUMAN :
  • P11684
Family:
  • Belongs to the secretoglobin family.
genes like me logo Genes that share domains with SCGB1A1: view

Function for SCGB1A1 Gene

Molecular function for SCGB1A1 Gene

UniProtKB/Swiss-Prot Function: Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2

Gene Ontology (GO) - Molecular Function for SCGB1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 18243143
GO:0019834 phospholipase A2 inhibitor activity IEA --
genes like me logo Genes that share ontologies with SCGB1A1: view
genes like me logo Genes that share phenotypes with SCGB1A1: view

Animal Models for SCGB1A1 Gene

MGI Knock Outs for SCGB1A1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SCGB1A1 Gene

Localization for SCGB1A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCGB1A1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCGB1A1 Gene COMPARTMENTS Subcellular localization image for SCGB1A1 gene
Compartment Confidence
extracellular 5
cytoskeleton 2
endoplasmic reticulum 2
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for SCGB1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005622 intracellular --
GO:0005635 nuclear envelope IEA --
GO:0005737 cytoplasm --
GO:0005783 endoplasmic reticulum --
genes like me logo Genes that share ontologies with SCGB1A1: view

Pathways for SCGB1A1 Gene

genes like me logo Genes that share pathways with SCGB1A1: view

Pathways by source for SCGB1A1 Gene

Gene Ontology (GO) - Biological Process for SCGB1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0007165 signal transduction IEA --
GO:0007565 female pregnancy NAS 10587371
GO:0007566 embryo implantation TAS 10587371
GO:0009410 response to xenobiotic stimulus IEA --
genes like me logo Genes that share ontologies with SCGB1A1: view

Compounds for SCGB1A1 Gene

(1075) HMDB Compounds for SCGB1A1 Gene

Compound Synonyms Cas Number PubMed IDs
PC(14:0/14:0)
  • Phosphatidylcholine(14:0/14:0)
Not Available
PC(14:0/14:1(9Z))
  • Phosphatidylcholine(14:0/14:1)
Not Available
PC(14:0/15:0)
  • GPCho(14:0/15:0)
Not Available
PC(14:0/16:0)
  • GPCho(30:0)
Not Available
PC(14:0/16:1(9Z))
  • 1-myristoyl-2-palmitoleoyl-sn-glycero-3-phosphocholine
Not Available

(1) Drugbank Compounds for SCGB1A1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
4,4'-BIS([H]METHYLSULFONYL)-2,2',5,5'-TETRACHLOROBIPHENYL
target

(28) Novoseek inferred chemical compound relationships for SCGB1A1 Gene

Compound -log(P) Hits PubMed IDs
hdmnkvldl 81.6 1
progesterone 36.8 22
ozone 31 2
latex 28.4 7
gp 130 24.6 4
genes like me logo Genes that share compounds with SCGB1A1: view

Transcripts for SCGB1A1 Gene

mRNA/cDNA for SCGB1A1 Gene

Unigene Clusters for SCGB1A1 Gene

Secretoglobin, family 1A, member 1 (uteroglobin):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCGB1A1 Gene

No ASD Table

Relevant External Links for SCGB1A1 Gene

GeneLoc Exon Structure for
SCGB1A1
ECgene alternative splicing isoforms for
SCGB1A1

Expression for SCGB1A1 Gene

mRNA expression in normal human tissues for SCGB1A1 Gene

mRNA differential expression in normal tissues according to GTEx for SCGB1A1 Gene

This gene is overexpressed in Lung (49.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SCGB1A1 Gene

SOURCE GeneReport for Unigene cluster for SCGB1A1 Gene Hs.523732

mRNA Expression by UniProt/SwissProt for SCGB1A1 Gene

P11684-UTER_HUMAN
Tissue specificity: Clara cells (nonciliated cells of the surface epithelium of the pulmonary airways)
genes like me logo Genes that share expressions with SCGB1A1: view

Orthologs for SCGB1A1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SCGB1A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCGB1A1 35
  • 98.53 (n)
  • 98.9 (a)
SCGB1A1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SCGB1A1 36
  • 53 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCGB1A1 35
  • 75.93 (n)
  • 60 (a)
SCGB1A1 36
  • 54 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Scgb1a1 35
  • 70.74 (n)
  • 55.56 (a)
Scgb1a1 16
Scgb1a1 36
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCGB1A1 36
  • 34 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Scgb1a1 35
  • 70 (n)
  • 55.56 (a)
Species with no ortholog for SCGB1A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SCGB1A1 Gene

ENSEMBL:
Gene Tree for SCGB1A1 (if available)
TreeFam:
Gene Tree for SCGB1A1 (if available)

Paralogs for SCGB1A1 Gene

Selected SIMAP similar genes for SCGB1A1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SCGB1A1: view

No data available for Paralogs for SCGB1A1 Gene

Variants for SCGB1A1 Gene

Sequence variations from dbSNP and Humsavar for SCGB1A1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1800593 -- 62,419,075(+) GGGCC(A/G)GAGCA utr-variant-5-prime
rs1802631 -- 62,422,261(+) ATCGA(A/G)ACCCT reference, synonymous-codon
rs1802632 - 62,422,367(+) TGGAC(A/G)CCCTC reference, missense
rs1802633 -- 62,422,222(+) TCCGC(C/T)TCTGC reference, frameshift-variant
rs1802634 - 62,422,331(+) ACATG(A/G)GGGAG reference, missense

Relevant External Links for SCGB1A1 Gene

HapMap Linkage Disequilibrium report
SCGB1A1
Human Gene Mutation Database (HGMD)
SCGB1A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SCGB1A1 Gene

Disorders for SCGB1A1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (12) Diseases for SCGB1A1 Gene including...

Search for SCGB1A1 Gene in MalaCards »

(1) OMIM Diseases for SCGB1A1 Gene (192020)

(60) Novoseek inferred disease relationships for SCGB1A1 Gene

Disease -log(P) Hits PubMed IDs
nephropathy iga 61.3 10
bronchoalveolar lavage fluid 58.1 11
bronchopulmonary dysplasia 52.9 4
asthma 52 57
lung diseases 49.4 16

Relevant External Links for SCGB1A1

Genetic Association Database (GAD)
SCGB1A1
Human Genome Epidemiology (HuGE) Navigator
SCGB1A1
genes like me logo Genes that share disorders with SCGB1A1: view

No data available for UniProtKB/Swiss-Prot for SCGB1A1 Gene

Publications for SCGB1A1 Gene

  1. Human CC10, the homologue of rabbit uteroglobin: genomic cloning, chromosomal localization and expression in endometrial cell lines. (PMID: 1284526) Wolf M. … Suske G. (Hum. Mol. Genet. 1992) 2 3 4 23
  2. A polymorphism of the CC16 gene is associated with an increased risk of asthma. (PMID: 9643286) Laing I.A. … Le SouAf P.N. (J. Med. Genet. 1998) 3 23 48
  3. Structure of a human Clara cell phospholipid-binding protein-ligand complex at 1.9-A resolution. (PMID: 7664082) Umland T.C. … Sax M. (Nat. Struct. Biol. 1994) 3 4 23
  4. Human CC10 gene expression in airway epithelium and subchromosomal locus suggest linkage to airway disease. (PMID: 7733299) Hay J.G. … Crystal R.G. (Am. J. Physiol. 1995) 3 4 23
  5. Uteroglobin gene polymorphisms affect the progression of immunoglobulin A nephropathy by modulating the level of uteroglobin expression. (PMID: 11434507) Kim Y.S. … Lee J.S. (Pharmacogenetics 2001) 3 23 48

Products for SCGB1A1 Gene

Sources for SCGB1A1 Gene

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