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Aliases for RPUSD3 Gene

Aliases for RPUSD3 Gene

  • RNA Pseudouridylate Synthase Domain Containing 3 2 3

External Ids for RPUSD3 Gene

Previous GeneCards Identifiers for RPUSD3 Gene

  • GC03M009855
  • GC03M009856
  • GC03M009817
  • GC03M009879

Summaries for RPUSD3 Gene

GeneCards Summary for RPUSD3 Gene

RPUSD3 (RNA Pseudouridylate Synthase Domain Containing 3) is a Protein Coding gene. GO annotations related to this gene include RNA binding and pseudouridine synthase activity. An important paralog of this gene is RPUSD4.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPUSD3 Gene

Genomics for RPUSD3 Gene

Regulatory Elements for RPUSD3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RPUSD3 Gene

Start:
9,837,849 bp from pter
End:
9,844,602 bp from pter
Size:
6,754 bases
Orientation:
Minus strand

Genomic View for RPUSD3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPUSD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPUSD3 Gene

Proteins for RPUSD3 Gene

  • Protein details for RPUSD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P087-RUSD3_HUMAN
    Recommended name:
    RNA pseudouridylate synthase domain-containing protein 3
    Protein Accession:
    Q6P087
    Secondary Accessions:
    • B4DS39
    • Q6P6A9
    • Q8N1B2
    • Q8NAV3

    Protein attributes for RPUSD3 Gene

    Size:
    351 amino acids
    Molecular mass:
    38461 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH62362.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH65741.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for RPUSD3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RPUSD3 Gene

Proteomics data for RPUSD3 Gene at MOPED

Post-translational modifications for RPUSD3 Gene

  • Ubiquitination at Lys68
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RPUSD3 Gene

Domains for RPUSD3 Gene

Gene Families for RPUSD3 Gene

HGNC:
  • RPUSD :RNA pseudouridylate synthase domain containing

Protein Domains for RPUSD3 Gene

Graphical View of Domain Structure for InterPro Entry

Q6P087

UniProtKB/Swiss-Prot:

RUSD3_HUMAN :
  • Q6P087
Family:
  • Belongs to the pseudouridine synthase RluA family.
genes like me logo Genes that share domains with RPUSD3: view

Function for RPUSD3 Gene

Gene Ontology (GO) - Molecular Function for RPUSD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding --
GO:0005515 protein binding IPI 25416956
GO:0009982 pseudouridine synthase activity IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPUSD3: view

Animal Model Products

CRISPR Products

miRNA for RPUSD3 Gene

miRTarBase miRNAs that target RPUSD3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RPUSD3 Gene

Localization for RPUSD3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPUSD3 Gene COMPARTMENTS Subcellular localization image for RPUSD3 gene
Compartment Confidence
cytosol 2
nucleus 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RPUSD3 Gene

Pathways for RPUSD3 Gene

SuperPathways for RPUSD3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RPUSD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001522 pseudouridine synthesis IEA --
GO:0009451 RNA modification --
genes like me logo Genes that share ontologies with RPUSD3: view

No data available for Pathways by source for RPUSD3 Gene

Compounds for RPUSD3 Gene

(1) HMDB Compounds for RPUSD3 Gene

Compound Synonyms Cas Number PubMed IDs
Pseudouridine
  • 5-(b-D-Ribofuranosyl)uracil
1445-07-4
genes like me logo Genes that share compounds with RPUSD3: view

Transcripts for RPUSD3 Gene

Unigene Clusters for RPUSD3 Gene

RNA pseudouridylate synthase domain containing 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPUSD3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPUSD3 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a ·
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - - - - - - - - -
SP9: - - -
SP10: - - - - - - - - -
SP11: - -
SP12: - - -
SP13: - - -
SP14: -
SP15: - -
SP16: -

ExUns: 11b · 11c · 11d ^ 12a · 12b · 12c
SP1: - -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: - - -
SP9:
SP10:
SP11:
SP12: - - -
SP13:
SP14:
SP15:
SP16:

Relevant External Links for RPUSD3 Gene

GeneLoc Exon Structure for
RPUSD3
ECgene alternative splicing isoforms for
RPUSD3

Expression for RPUSD3 Gene

mRNA expression in normal human tissues for RPUSD3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RPUSD3 Gene

SOURCE GeneReport for Unigene cluster for RPUSD3 Gene Hs.33719

genes like me logo Genes that share expressions with RPUSD3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPUSD3 Gene

Orthologs for RPUSD3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RPUSD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPUSD3 35
  • 92.77 (n)
  • 92.08 (a)
RPUSD3 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RPUSD3 35
  • 84.06 (n)
  • 81.34 (a)
RPUSD3 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPUSD3 35
  • 85.75 (n)
  • 80.63 (a)
RPUSD3 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rpusd3 35
  • 78.04 (n)
  • 72.89 (a)
Rpusd3 16
Rpusd3 36
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RPUSD3 36
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPUSD3 36
  • 51 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rpusd3 35
  • 77.32 (n)
  • 73.67 (a)
chicken
(Gallus gallus)
Aves RPUSD3 35
  • 57.4 (n)
  • 49.11 (a)
lizard
(Anolis carolinensis)
Reptilia RPUSD3 36
  • 46 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3147 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rpusd3 35
  • 53.26 (n)
  • 45.77 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3295 36
  • 17 (a)
OneToMany
Species with no ortholog for RPUSD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RPUSD3 Gene

ENSEMBL:
Gene Tree for RPUSD3 (if available)
TreeFam:
Gene Tree for RPUSD3 (if available)

Paralogs for RPUSD3 Gene

Paralogs for RPUSD3 Gene

genes like me logo Genes that share paralogs with RPUSD3: view

Variants for RPUSD3 Gene

Sequence variations from dbSNP and Humsavar for RPUSD3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs2426 -- 9,841,337(+) GAGAC(A/G)GGGTC intron-variant
rs1133340 -- 9,841,346(-) CCTGA(A/G)TGAGA intron-variant
rs2290306 -- 9,843,931(+) GGGCG(C/G)ACACC reference, synonymous-codon
rs3846165 -- 9,843,338(-) GGGAC(A/G)AGCCA intron-variant
rs3846166 -- 9,844,079(-) ATTCC(C/G)ATTGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPUSD3 Gene

Variant ID Type Subtype PubMed ID
nsv834615 CNV Loss 17160897

Relevant External Links for RPUSD3 Gene

HapMap Linkage Disequilibrium report
RPUSD3
Human Gene Mutation Database (HGMD)
RPUSD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPUSD3 Gene

Disorders for RPUSD3 Gene

No disorders were found for RPUSD3 Gene.

No data available for UniProtKB/Swiss-Prot for RPUSD3 Gene

Publications for RPUSD3 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. A germline-specific class of small RNAs binds mammalian Piwi proteins. (PMID: 16751776) Girard A. … Carmell M.A. (Nature 2006) 3
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PMID: 20186120) Richter R. … Chrzanowska-Lightowlers Z.M. (EMBO J. 2010) 3

Products for RPUSD3 Gene

Sources for RPUSD3 Gene

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