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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

QPRT Gene

protein-coding   GIFtS: 62
GCID: GC16P029690

quinolinate phosphoribosyltransferase

 Explore 14 diseases affiliated with
QPRT via our new
 Human Malady Compendium 
Biological research products
for QPRT
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Quinolinate Phosphoribosyltransferase1 2     Nicotinate-Nucleotide Pyrophosphorylase (Carboxylating)2
QPRTase1 2 3     Nicotinate-Nucleotide Pyrophosphorylase [Carboxylating]2
QAPRTase2 3     Quinolinate Phosphoribosyltransferase [Decarboxylating]3
EC 2.4.2.193 8     

External Ids:    HGNC: 97551   Entrez Gene: 234752   Ensembl: ENSG000001034857   OMIM: 6062485   UniProtKB: Q152743   

Export aliases for QPRT gene to outside databases

Previous GC identifers: GC16M028713 GC16P030014 GC16P029688 GC16P029728 GC16P029597 GC16P027351 GC16P029675


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for QPRT:
This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine
dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate
levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's
disease, and Huntington's disease. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: NADC_HUMAN, Q15274
Function: Involved in the catabolism of quinolinic acid (QA)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the QPRT gene promoter:
         Egr-2   FOXI1   HFH-3   p53   XBP-1   MIF-1   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidQPRT promoter sequence
   Search SABiosciences Chromatin IP Primers for QPRT

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat QPRT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

QPRT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
QPRT gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P029690:  view genomic region     (about GC identifiers)

Start:
29,690,329 bp from pter      End:
29,710,020 bp from pter
Size:
19,692 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NADC_HUMAN, Q15274 (See protein sequence)
Recommended Name: Nicotinate-nucleotide pyrophosphorylase [carboxylating]  
Size: 297 amino acids; 30846 Da
Subunit: Hexamer formed by 3 homodimers
2 PDB 3D structures from and Proteopedia for QPRT:
2JBM (3D)        3LAR (3D)    
Secondary accessions: Q53XW7 Q96G22 Q9BSG6

Explore the universe of human proteins at neXtProt for QPRT: NX_Q15274

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q15274

  • 3 DME Specific Peptides for QPRT (Q15274)
     TRKTTPG  LKVEVECSSL  LWAKSPGVLAG 

    QPRT Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_055113.2  
    ENSEMBL proteins: 
     ENSP00000378782   ENSP00000455183  
    Reactome Protein details: Q15274
    Human Recombinant Protein Products: 
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    ProSpec Recombinant Protein for QPRT
    Uscn Proteins for QPRT

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--


    QPRT for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for QPRT


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    QPRT for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR013785 Aldolase_TIM
     IPR004393 NadC
     IPR002638 Quinolinate_PRibosylTrfase_C
     IPR022412 Quinolinate_PRibosylTrfase_N

    Graphical View of Domain Structure for InterPro Entry Q15274

    ProtoNet protein and cluster: Q15274

    1 Blocks protein family: IPB002638 Quinolinate phosphoribosyl transferase

    UniProtKB/Swiss-Prot: NADC_HUMAN, Q15274
    Similarity: Belongs to the NadC/ModD family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: NADC_HUMAN, Q15274
    Function: Involved in the catabolism of quinolinic acid (QA)
    Catalytic activity: Beta-nicotinate D-ribonucleotide + diphosphate + CO(2) = pyridine-2,3-dicarboxylate +
    5-phospho-alpha-D-ribose 1-diphosphate
    Enzyme regulation: Activity toward QA is slightly repressed by phosphoribosylpyrophosphate (PRPP) in both a competitive
    and a non-competitive manner
    Biophysicochemical properties: Kinetic parameters: KM=21 uM for QA (at 0.1 mM PRPP); KM=23 uM for QA (at 0.3 mM PRPP);
    Vmax=1.2 uM/min/mg enzyme (at 0.3 mM QA and 0.1 mM PRPP); Vmax=0.93 uM/min/mg enzyme (at 0.3 mM QA and 0.3 mM PRPP);

    Enzyme Number (IUBMB): EC 2.4.2.191 2

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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004514nicotinate-nucleotide diphosphorylase (carboxylating) activity IDA9473669
    GO:0042803protein homodimerization activity IDA17868694


    QPRT for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for QPRT:
     Decreased cilium length after  


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1NAD metabolism
    NAD metabolism1.00
    Nicotinate and nicotinamide metabolism0.43
    NAD metabolism1.00
    2Nicotinate metabolism
    Nicotinate metabolism1.00
    NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde0.62
    3Metabolism
    Metabolism1.00
    Metabolic pathways0.38
    4Vitamin B5 (pantothenate) metabolism
    Metabolism of vitamins and cofactors0.21
    Metabolism of water-soluble vitamins and cofactors0.21
    5tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde
    NAD biosynthesis II (from tryptophan)0.50

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for QPRT
        NAD metabolism


    1 GeneGo (Thomson Reuters) Pathway for QPRT
        NAD metabolism

    2 BioSystems Pathways for QPRT 
        NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde
    NAD biosynthesis II (from tryptophan)

    4        Reactome Pathways for QPRT
        Nicotinate metabolism
    Metabolism
    Metabolism of vitamins and cofactors
    Metabolism of water-soluble vitamins and cofactors


    2         Kegg Pathways  (Kegg details for QPRT):
        Nicotinate and nicotinamide metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: NADC_HUMAN, Q15274
    Pathway: Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1


    QPRT for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for QPRT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/32 Interacting proteins for QPRT (Q152742, 3 ENSP000003787824) via UniProtKB, MINT, STRING, and/or I2D (see all 32)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    SUFUQ9UMX12, 3, ENSP000003589184MINT-66091 I2D: score=5 STRING: ENSP00000358918
    KRTAP4-12Q9BQ662, 3, ENSP000003775824MINT-66042 I2D: score=5 STRING: ENSP00000377582
    IDH3GP515533, ENSP000002179014I2D: score=1 STRING: ENSP00000217901
    IDH3AP502133, ENSP000002995184I2D: score=1 STRING: ENSP00000299518
    KPNA6O606843I2D: score=5 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006766vitamin metabolic process TAS--
    GO:0006767water-soluble vitamin metabolic process TAS--
    GO:0009435NAD biosynthetic process IEA--
    GO:0019674NAD metabolic process TAS--
    GO:0034213quinolinate catabolic process IDA9473669


    QPRT for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    QPRT for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for QPRT

    8 HMDB Compounds for QPRT    About this table
    CompoundSynonyms CAS #PubMed Ids
    Carbon dioxideCarbon oxide (see all 5)124-38-9--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    Nicotinic acid mononucleotide3-Carboxy-1-beta-D-ribofuranosylpyridinium hydroxide 5'-phosphate inner salt (see all 23)321-02-8--
    Phosphoribosyl pyrophosphate5-Phospho-a-D-ribose-1-diphosphate (see all 37)7540-64-9--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    PyridineAzabenzene (see all 6)110-86-1--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
    Quinolinic acidpyridine-2,3-carboxylate (see all 10)89-00-9--

    1 DrugBank Compound for QPRT    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Niacin3-Pyridinecarboxylic acid (see all 9)59-67-6targetbinder15837705 15753098 11758903

    3 Novoseek chemical compound relationships for QPRT gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    namn 96.7 4 9016724 (2), 11145065 (1)
    quinolinic acid 89.9 26 9016724 (3), 11145065 (2), 17868694 (2), 16472078 (2) (see all 11)
    niacin 52.4 3 15837705 (1), 9473669 (1)

    Search CenterWatch for drugs/clinical trials and news about QPRT / NADC 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for QPRT gene: 
    NM_014298.3  

    Unigene Cluster for QPRT:

    Quinolinate phosphoribosyltransferase
    Hs.513484  [show with all ESTs]
    Unigene Representative Sequence: NM_014298
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000219771 ENST00000395384(uc002dto.3 uc010vdu.2) ENST00000562473
    ENST00000564967

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    Additional cDNA sequence: 

    AK293195.1 BC005060.1 BC010033.2 BC018910.2 BT007231.1 D78177.1 

    14 DOTS entries:

    DT.120696423  DT.414520  DT.120696998  DT.95137093  DT.100784782  DT.100659515  DT.100784778  DT.120696260 
    DT.95082378  DT.100009582  DT.120695401  DT.120696832  DT.455060  DT.92430926 

    24/264 AceView cDNA sequences (see all 264):

    BP373131 BU501237 CR608816 X60502 CR600977 AW059610 BX283118 CR603957 
    AA421560 BI822033 AW263079 BQ223326 BC010033 AL531128 CR601465 CR594408 
    CR595386 BU501515 BM711970 J04536 BX104943 AW293885 BC018910 NM_014298 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for QPRT    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
    SP1:                                                                              
    SP2:                                                                              
    SP3:                                      -     -     -                           
    SP4:        -                                                                     
    SP5:                                -     -     -     -                           


    ECgene alternative splicing isoforms for QPRT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    QPRT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGTTAACGTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See QPRT Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for QPRT

    SOURCE GeneReport for Unigene cluster: Hs.513484
        SABiosciences Custom PCR Arrays for QPRT
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for QPRT

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for QPRT gene from 7/27 species (see all 27)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Qprt1 , 5 quinolinate phosphoribosyltransferase1, 5 81.41(n)1
    84.01(a)1
      7 (69.33 cM)5
    673751  NM_133686.11  NP_598447.11 
     1271071145 
    lizard
    (Anolis carolinensis)
    Reptilia QPRT6
    --
    57(a)
    1 ↔ 1
    GL343516.1(301415-304397)
    rainbow trout
    (Oncorhynchus mykiss)
    Actinopterygii Omy.87142 Oncorhynchus mykiss transcribed sequence with weak more 76.4(n)    BX314563.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes BNA61 Bna6p 51.44(n)
    47.57(a)
      850608   NP_602317.3 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons QPT6
    quinolinate phoshoribosyltransferase
    26(a)
    1 ↔ 1
    2(165141-167259)
    rice
    (Oryza sativa)
    Liliopsida --
    nicotinate-nucleotide pyrophosphorylase, putative,...
    26(a)
    1 ↔ 1
    9(21930510-21934482)
    E. coli
    (Escherichia coli)
    Gamma proteobacteria nadC6
    quinolinate phosphoribosyltransferase
    32(a)
    1 ↔ 1
    Chromosome(117752-118645)


    ENSEMBL Gene Tree for QPRT (if available)
    TreeFam Gene Tree for QPRT (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/15 NCBI SNPs in QPRT are shown (see all 15    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs711437481,2
    C--29688838(-) TTTTT-/TTGATGG 1 -- us2k11Minor allele frequency- TT:0.00NA 2
    rs1412474611,2
    --29702411(+) CCAGGC/TACGGT 1 -- int10--------
    rs1906204471,2
    --29702414(+) GGCACA/GGTGGC 1 -- int10--------
    rs133320011,2
    C,--29702522(+) ctctaC/Gtaaaa 1 -- int10--------
    rs1414675591,2
    C,--29703570(+) TATCC-/TTA   
       TTTAT
    TTATT
    1 -- int10--------
    rs672416131,2
    C--29703572(-) TTAAA-/AAA   
       TAAAT
    AAATA
    1 -- int11Minor allele frequency- AAATAAAT:0.00NA 2
    rs1810644511,2
    --29707153(+) TCTCAC/TTATGT 1 -- int10--------
    rs28641371,2
    C,F,A,H,--29707246(-) CAGGCG/ATGGTG 1 -- int118Minor allele frequency- A:0.04NS WA NA CSA EA 1257
    rs351413231,2
    ----29707115(-) ATCTC-/AAAAAA 1 -- int10--------
    rs1127529111,2
    ----29693527(+) ATAAAT/-TTTTT 1 -- int11Minor allele frequency- -:0.50CSA 2

    HapMap Linkage Disequilibrium report for QPRT (29690329 - 29710020 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for QPRT
         4 CNVs: 4939 35383 4000 66975

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    QPRT for disorders           About GeneDecksing

    OMIM gene information: 606248    OMIM disorders: --

    14 diseases for QPRT:    About MalaCards
    huntington's disease    alzheimer's disease    pellagra    follicular thyroid carcinoma
    seizure disorder    thyroid carcinoma    seizures    multiple sclerosis
    thyroiditis    neuronitis    pneumonia    carcinoma
    tuberculosis    mycobacterium tuberculosis

    1 disease from the University of Copenhagen DISEASES database for QPRT:
    Pellagra

    Export disorders for QPRT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for QPRT gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with QPRT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization and functional expression of the cDNA encoding human brain quinolinate phosphoribosyltransferase. (PubMed id 9473669)1, 2, 3, 9 Fukuoka S.... Shibata K. (1998)
    2. Structural and kinetic characterization of quinolinate phosphoribosyltransferase (hQPRTase) from homo sapiens. (PubMed id 17868694)1, 2, 9 Liu H....Naismith J.H. (2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. QPRT: a potential marker for follicular thyroid carcinoma including minimal invasive variant; a gene expression, RNA and immunohistochemical study. (PubMed id 19321014)1, 9 Hinsch N....Hansmann M.L. (2009)
    5. Changes in trigonelline (N-methylnicotinic acid) content and nicotinic acid metabolism during germination of mungbean (Phaseolus aureus) seeds. (PubMed id 15837705)7, 9 Zheng X.Q....Ashihara H. (2005)
    6. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    10. Crystal structure of a nicotinate phosphoribosyltrans ferase from Thermoplasma acidophilum. (PubMed id 15753098)7 Shin D.H....Kim S.H. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23475 HGNC: 9755 AceView: SPNandQPRT Ensembl:ENSG00000103485 euGenes: HUgn23475
    ECgene: QPRT Kegg: 23475 H-InvDB: QPRT

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for QPRT Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for QPRT gene:
    Search GeneIP for patents involving QPRT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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