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Aliases for QPRT Gene

Aliases for QPRT Gene

  • Quinolinate Phosphoribosyltransferase 2 3 5
  • Nicotinate-Nucleotide Pyrophosphorylase (Carboxylating) 2 3
  • EC 2.4.2.19 4 63
  • QPRTase 3 4
  • Quinolinate Phosphoribosyltransferase [Decarboxylating] 4
  • Epididymis Secretory Sperm Binding Protein Li 90n 3
  • HEL-S-90n 3
  • QAPRTase 4

External Ids for QPRT Gene

Previous GeneCards Identifiers for QPRT Gene

  • GC16M028713
  • GC16P030014
  • GC16P029688
  • GC16P029728
  • GC16P029597
  • GC16P027351
  • GC16P029675
  • GC16P029690

Summaries for QPRT Gene

Entrez Gene Summary for QPRT Gene

  • This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

GeneCards Summary for QPRT Gene

QPRT (Quinolinate Phosphoribosyltransferase) is a Protein Coding gene. Diseases associated with QPRT include seizure disorder. Among its related pathways are Metabolism and NAD metabolism. GO annotations related to this gene include protein homodimerization activity and transferase activity, transferring pentosyl groups. An important paralog of this gene is ENSG00000277669.

UniProtKB/Swiss-Prot for QPRT Gene

  • Involved in the catabolism of quinolinic acid (QA).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for QPRT Gene

Genomics for QPRT Gene

Regulatory Elements for QPRT Gene

Enhancers for QPRT Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around QPRT on UCSC Golden Path with GeneCards custom track

Genomic Location for QPRT Gene

Chromosome:
16
Start:
29,669,840 bp from pter
End:
29,698,699 bp from pter
Size:
28,860 bases
Orientation:
Plus strand

Genomic View for QPRT Gene

Genes around QPRT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
QPRT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for QPRT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for QPRT Gene

Proteins for QPRT Gene

  • Protein details for QPRT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15274-NADC_HUMAN
    Recommended name:
    Nicotinate-nucleotide pyrophosphorylase [carboxylating]
    Protein Accession:
    Q15274
    Secondary Accessions:
    • Q53XW7
    • Q96G22
    • Q9BSG6

    Protein attributes for QPRT Gene

    Size:
    297 amino acids
    Molecular mass:
    30846 Da
    Quaternary structure:
    • Hexamer formed by 3 homodimers.

    Three dimensional structures from OCA and Proteopedia for QPRT Gene

neXtProt entry for QPRT Gene

Proteomics data for QPRT Gene at MOPED

Selected DME Specific Peptides for QPRT Gene

Post-translational modifications for QPRT Gene

  • Ubiquitination at Lys 183 and Lys 288
  • Modification sites at PhosphoSitePlus

Other Protein References for QPRT Gene

Domains & Families for QPRT Gene

Suggested Antigen Peptide Sequences for QPRT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15274

UniProtKB/Swiss-Prot:

NADC_HUMAN :
  • Belongs to the NadC/ModD family.
Family:
  • Belongs to the NadC/ModD family.
genes like me logo Genes that share domains with QPRT: view

No data available for Gene Families for QPRT Gene

Function for QPRT Gene

Molecular function for QPRT Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=21 uM for QA (at 0.1 mM PRPP) {ECO:0000269 PubMed:17868694}; KM=23 uM for QA (at 0.3 mM PRPP) {ECO:0000269 PubMed:17868694}; Vmax=1.2 uM/min/mg enzyme (at 0.3 mM QA and 0.1 mM PRPP) {ECO:0000269 PubMed:17868694}; Vmax=0.93 uM/min/mg enzyme (at 0.3 mM QA and 0.3 mM PRPP) {ECO:0000269 PubMed:17868694};
UniProtKB/Swiss-Prot CatalyticActivity:
Beta-nicotinate D-ribonucleotide + diphosphate + CO(2) = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activity toward QA is slightly repressed by phosphoribosylpyrophosphate (PRPP) in both a competitive and a non-competitive manner.
UniProtKB/Swiss-Prot Function:
Involved in the catabolism of quinolinic acid (QA).

Enzyme Numbers (IUBMB) for QPRT Gene

genes like me logo Genes that share phenotypes with QPRT: view

Animal Model Products

  • Taconic Biosciences Mouse Models for QPRT

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for QPRT Gene

Localization for QPRT Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for QPRT Gene COMPARTMENTS Subcellular localization image for QPRT gene
Compartment Confidence
cytosol 5
extracellular 5
mitochondrion 2
plasma membrane 2
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for QPRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with QPRT: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for QPRT Gene

Pathways & Interactions for QPRT Gene

genes like me logo Genes that share pathways with QPRT: view

UniProtKB/Swiss-Prot Q15274-NADC_HUMAN

  • Pathway: Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.

Gene Ontology (GO) - Biological Process for QPRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009435 NAD biosynthetic process IEA --
GO:0019674 NAD metabolic process TAS --
GO:0034213 quinolinate catabolic process IDA 3409840
GO:0051259 protein oligomerization IDA 17868694
genes like me logo Genes that share ontologies with QPRT: view

No data available for SIGNOR curated interactions for QPRT Gene

Drugs & Compounds for QPRT Gene

(7) Drugs for QPRT Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Niacin Approved, Investigational Nutra Unknown, Agonist, Target, binder 854,854
quinolinic acid Experimental Pharma 0
Diphosphate Experimental Pharma 0
Phosphoribosyl pyrophosphate Experimental Pharma 0
ARI-3037MO Pharma inhibitor, agonist 0

(5) Additional Compounds for QPRT Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
carbon dioxide
  • Carbon oxide
  • Carbon-12 dioxide
  • Carbonic acid anhydride
  • Carbonic acid gas
  • Carbonic anhydride
124-38-9
nicotinate beta-D-ribonucleotide
Nicotinic acid mononucleotide
  • 3-Carboxy-1-(5-O-phosphono-b-D-ribofuranosyl)-Pyridinium inner salt
  • 3-Carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)-Pyridinium inner salt
  • 3-Carboxy-1-(5-O-phosphono-beta-delta-ribofuranosyl)-Pyridinium inner salt
  • 3-Carboxy-1-beta-D-ribofuranosylpyridinium hydroxide 5'-phosphate inner salt
  • 3-Carboxy-1-beta-delta-ribofuranosylpyridinium hydroxide 5'-phosphate inner salt
321-02-8
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
pyridine
  • Azabenzene
  • Azine
  • Piridina
  • Pirydyna
  • Pyridin
110-86-1
genes like me logo Genes that share compounds with QPRT: view

Transcripts for QPRT Gene

Unigene Clusters for QPRT Gene

Quinolinate phosphoribosyltransferase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for QPRT Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
SP1:
SP2:
SP3: - - -
SP4: -
SP5: - - - -

Relevant External Links for QPRT Gene

GeneLoc Exon Structure for
QPRT
ECgene alternative splicing isoforms for
QPRT

Expression for QPRT Gene

mRNA expression in normal human tissues for QPRT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for QPRT Gene

This gene is overexpressed in Liver (x8.6), Adrenal Gland (x5.8), and Kidney - Cortex (x5.6).

Protein differential expression in normal tissues from HIPED for QPRT Gene

This gene is overexpressed in Liver, secretome (22.1) and Kidney (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for QPRT Gene



SOURCE GeneReport for Unigene cluster for QPRT Gene Hs.513484

genes like me logo Genes that share expression patterns with QPRT: view

Protein tissue co-expression partners for QPRT Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for QPRT Gene

Orthologs for QPRT Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for QPRT Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia QPRT 35
  • 86.51 (n)
  • 88.44 (a)
QPRT 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia QPRT 35
  • 85.41 (n)
  • 86.2 (a)
QPRT 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Qprt 35
  • 81.41 (n)
  • 84.01 (a)
Qprt 16
Qprt 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia QPRT 35
  • 98.55 (n)
  • 99.13 (a)
rat
(Rattus norvegicus)
Mammalia Qprt 35
  • 81.07 (n)
  • 82.65 (a)
oppossum
(Monodelphis domestica)
Mammalia QPRT 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia QPRT 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia QPRT 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495332 35
  • 55.32 (n)
  • 54.39 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8714 35
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR271W 35
  • 52.43 (n)
  • 48.69 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BNA6 35
  • 51.44 (n)
  • 47.57 (a)
BNA6 36
  • 43 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons QPT 35
  • 45.76 (n)
  • 37.71 (a)
rice
(Oryza sativa)
Liliopsida Os09g0553600 35
  • 43.91 (n)
  • 36.57 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02998 35
  • 54.26 (n)
  • 48.18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1371 36
  • 38 (a)
OneToOne
Species with no ortholog for QPRT:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for QPRT Gene

ENSEMBL:
Gene Tree for QPRT (if available)
TreeFam:
Gene Tree for QPRT (if available)

Paralogs for QPRT Gene

Paralogs for QPRT Gene

genes like me logo Genes that share paralogs with QPRT: view

Variants for QPRT Gene

Sequence variations from dbSNP and Humsavar for QPRT Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs2303255 - 29,695,123(-) GCGAG(A/G)CGGCC intron-variant, reference, missense
rs9932770 - 29,697,029(+) ACTTC(A/G)CTCTG reference, missense
rs3862476 -- 29,676,039(+) ctcag(C/T)ggtat intron-variant
rs8063221 -- 29,673,931(+) AAAAA(A/G)AGAGA intron-variant
rs13332001 -- 29,691,201(+) ctcta(C/G)taaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for QPRT Gene

Variant ID Type Subtype PubMed ID
dgv845e1 CNV Complex 17122850
nsv833183 CNV Loss 17160897
dgv34n68 CNV Loss 17160897
esv23737 CNV Gain 19812545

Variation tolerance for QPRT Gene

Residual Variation Intolerance Score: 82.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.81; 66.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for QPRT Gene

HapMap Linkage Disequilibrium report
QPRT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for QPRT Gene

Disorders for QPRT Gene

MalaCards: The human disease database

(1) MalaCards diseases for QPRT Gene - From: GeneCards

Disorder Aliases PubMed IDs
seizure disorder
  • epilepsy
- elite association - COSMIC cancer census association via MalaCards
Search QPRT in MalaCards View complete list of genes associated with diseases

Relevant External Links for QPRT

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
QPRT
genes like me logo Genes that share disorders with QPRT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for QPRT Gene

Publications for QPRT Gene

  1. Characterization and functional expression of the cDNA encoding human brain quinolinate phosphoribosyltransferase. (PMID: 9473669) Fukuoka S. … Shibata K. (Biochim. Biophys. Acta 1998) 2 3 4 23 67
  2. Changes in trigonelline (N-methylnicotinic acid) content and nicotinic acid metabolism during germination of mungbean (Phaseolus aureus) seeds. (PMID: 15837705) Zheng X.Q. … Ashihara H. (J. Exp. Bot. 2005) 23 25 26
  3. QPRT: a potential marker for follicular thyroid carcinoma including minimal invasive variant; a gene expression, RNA and immunohistochemical study. (PMID: 19321014) Hinsch N. … Hansmann M.L. (BMC Cancer 2009) 3 23
  4. Structural and kinetic characterization of quinolinate phosphoribosyltransferase (hQPRTase) from homo sapiens. (PMID: 17868694) Liu H. … Naismith J.H. (J. Mol. Biol. 2007) 3 23
  5. Crystal structure of a nicotinate phosphoribosyltransferase from Thermoplasma acidophilum. (PMID: 15753098) Shin D.H. … Kim S.H. (J. Biol. Chem. 2005) 25 26

Products for QPRT Gene

Sources for QPRT Gene

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