Free for academic non-profit institutions. Other users need a Commercial license

Aliases for QPRT Gene

Aliases for QPRT Gene

  • Quinolinate Phosphoribosyltransferase 2 3 5
  • Nicotinate-Nucleotide Pyrophosphorylase (Carboxylating) 2 3
  • EC 2.4.2.19 4 61
  • QPRTase 3 4
  • Nicotinate-Nucleotide Pyrophosphorylase [Carboxylating] 3
  • Quinolinate Phosphoribosyltransferase [Decarboxylating] 4
  • Epididymis Secretory Sperm Binding Protein Li 90n 3
  • HEL-S-90n 3
  • QAPRTase 4

External Ids for QPRT Gene

Previous GeneCards Identifiers for QPRT Gene

  • GC16M028713
  • GC16P030014
  • GC16P029688
  • GC16P029728
  • GC16P029597
  • GC16P027351
  • GC16P029675
  • GC16P029690

Summaries for QPRT Gene

Entrez Gene Summary for QPRT Gene

  • This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

GeneCards Summary for QPRT Gene

QPRT (Quinolinate Phosphoribosyltransferase) is a Protein Coding gene. Among its related pathways are NAD metabolism and superpathway of tryptophan utilization. GO annotations related to this gene include protein homodimerization activity and transferase activity, transferring pentosyl groups. An important paralog of this gene is ENSG00000277669.

UniProtKB/Swiss-Prot for QPRT Gene

  • Involved in the catabolism of quinolinic acid (QA).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for QPRT Gene

Genomics for QPRT Gene

Regulatory Elements for QPRT Gene

Enhancers for QPRT Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G029626 1 Ensembl ENCODE 13.5 -42.4 -42380 1.9 HDGF PKNOX1 USF1 MAX ZNF121 ZFHX2 FOXK2 SCRT2 IKZF2 EGR2 SPN QPRT CA5AP1 PIR32473
GH16G029678 1.3 ENCODE dbSUPER 8 +10.2 10176 2.9 HDGF PKNOX1 ARNT ZFP64 WRNIP1 ARID4B DMAP1 ZNF2 YY1 ZNF766 SMG1P2 ENSG00000260853 NFATC2IP ENSG00000260367 ENSG00000198106 ZNF747 NPIPB13 ZNF764 RRN3P2 QPRT
GH16G029698 0.6 FANTOM5 5.7 +28.8 28751 0.1 PAF1 NFIC ZNF211 CBX3 CBX5 POLR2A CHD1 C16orf54 ENSG00000261766 MVP CD2BP2 ZNF785 QPRT GC16P029695 GC16M029709
GH16G029700 1.5 FANTOM5 Ensembl ENCODE 1.6 +32.1 32085 3.6 SIN3A ARID4B ZBTB7B CBX5 ZNF143 DEK REST TBX21 ZNF592 MIER3 NPIPB13 C16orf54 MVP DOC2A ENSG00000198106 NPIPB11 ENSG00000260853 ENSG00000235560 RN7SKP127 CORO1A
GH16G029673 1.3 Ensembl ENCODE dbSUPER 0.7 +4.5 4530 0.8 CTCF ZFP64 E2F7 ZMYM3 MAX RBBP5 RAD21 ZNF48 TEAD3 ZNF121 QPRT GC16P029695
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around QPRT on UCSC Golden Path with GeneCards custom track

Genomic Location for QPRT Gene

Chromosome:
16
Start:
29,669,840 bp from pter
End:
29,698,699 bp from pter
Size:
28,860 bases
Orientation:
Plus strand

Genomic View for QPRT Gene

Genes around QPRT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
QPRT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for QPRT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for QPRT Gene

Proteins for QPRT Gene

  • Protein details for QPRT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15274-NADC_HUMAN
    Recommended name:
    Nicotinate-nucleotide pyrophosphorylase [carboxylating]
    Protein Accession:
    Q15274
    Secondary Accessions:
    • Q53XW7
    • Q96G22
    • Q9BSG6

    Protein attributes for QPRT Gene

    Size:
    297 amino acids
    Molecular mass:
    30846 Da
    Quaternary structure:
    • Hexamer formed by 3 homodimers.

    Three dimensional structures from OCA and Proteopedia for QPRT Gene

neXtProt entry for QPRT Gene

Selected DME Specific Peptides for QPRT Gene

Q15274:
  • LWAKSPGVLAG
  • LKVEVECSSL
  • TRKTTPG

Post-translational modifications for QPRT Gene

  • Ubiquitination at Lys183 and Lys288
  • Modification sites at PhosphoSitePlus

Other Protein References for QPRT Gene

Domains & Families for QPRT Gene

Suggested Antigen Peptide Sequences for QPRT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15274

UniProtKB/Swiss-Prot:

NADC_HUMAN :
  • Belongs to the NadC/ModD family.
Family:
  • Belongs to the NadC/ModD family.
genes like me logo Genes that share domains with QPRT: view

No data available for Gene Families for QPRT Gene

Function for QPRT Gene

Molecular function for QPRT Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=21 uM for QA (at 0.1 mM PRPP) {ECO:0000269 PubMed:17868694}; KM=23 uM for QA (at 0.3 mM PRPP) {ECO:0000269 PubMed:17868694}; Vmax=1.2 uM/min/mg enzyme (at 0.3 mM QA and 0.1 mM PRPP) {ECO:0000269 PubMed:17868694}; Vmax=0.93 uM/min/mg enzyme (at 0.3 mM QA and 0.3 mM PRPP) {ECO:0000269 PubMed:17868694};
UniProtKB/Swiss-Prot CatalyticActivity:
Beta-nicotinate D-ribonucleotide + diphosphate + CO(2) = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activity toward QA is slightly repressed by phosphoribosylpyrophosphate (PRPP) in both a competitive and a non-competitive manner.
UniProtKB/Swiss-Prot Function:
Involved in the catabolism of quinolinic acid (QA).

Enzyme Numbers (IUBMB) for QPRT Gene

Gene Ontology (GO) - Molecular Function for QPRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity TAS,IEA --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0016763 transferase activity, transferring pentosyl groups IEA --
GO:0042803 protein homodimerization activity IDA 17868694
genes like me logo Genes that share ontologies with QPRT: view
genes like me logo Genes that share phenotypes with QPRT: view

Animal Model Products

  • Taconic Biosciences Mouse Models for QPRT

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for QPRT Gene

Localization for QPRT Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for QPRT gene
Compartment Confidence
extracellular 5
cytosol 5
plasma membrane 2
mitochondrion 2
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for QPRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with QPRT: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for QPRT Gene

Pathways & Interactions for QPRT Gene

genes like me logo Genes that share pathways with QPRT: view

UniProtKB/Swiss-Prot Q15274-NADC_HUMAN

  • Pathway: Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.

Gene Ontology (GO) - Biological Process for QPRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009435 NAD biosynthetic process IEA --
GO:0019363 pyridine nucleotide biosynthetic process IEA --
GO:0019674 NAD metabolic process TAS --
GO:0034213 quinolinate catabolic process IDA 3409840
GO:0051259 protein oligomerization IDA 17868694
genes like me logo Genes that share ontologies with QPRT: view

No data available for SIGNOR curated interactions for QPRT Gene

Drugs & Compounds for QPRT Gene

(7) Drugs for QPRT Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Niacin Approved, Investigational Nutra Unknown, Agonist, Target, binder 923,923
Carbon dioxide Approved, Vet_approved Pharma 0
Phosphoric acid Approved Pharma 0
Quinolinic acid Experimental Pharma 0
ARI-3037MO Pharma inhibitor, agonist 0

(5) Additional Compounds for QPRT Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
nicotinate beta-D-ribonucleotide
Nicotinic acid mononucleotide
  • 3-Carboxy-1-(5-O-phosphono-b-D-ribofuranosyl)-Pyridinium inner salt
  • 3-Carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)-Pyridinium inner salt
  • 3-Carboxy-1-(5-O-phosphono-beta-delta-ribofuranosyl)-Pyridinium inner salt
  • 3-Carboxy-1-beta-D-ribofuranosylpyridinium hydroxide 5'-phosphate inner salt
  • 3-Carboxy-1-beta-delta-ribofuranosylpyridinium hydroxide 5'-phosphate inner salt
321-02-8
Phosphoribosyl pyrophosphate
  • 5-Phospho-a-D-ribose-1-diphosphate
  • 5-Phospho-a-D-ribosyl pyrophosphate
  • 5-Phospho-alpha-D-ribose 1-diphosphate
  • 5-Phospho-alpha-D-ribose-1-diphosphate
  • 5-Phospho-alpha-D-ribosyl pyrophosphate
7540-64-9
pyridine
  • Azabenzene
  • Azine
  • Piridina
  • Pirydyna
  • Pyridin
110-86-1
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with QPRT: view

Transcripts for QPRT Gene

Unigene Clusters for QPRT Gene

Quinolinate phosphoribosyltransferase:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for QPRT Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
SP1:
SP2:
SP3: - - -
SP4: -
SP5: - - - -

Relevant External Links for QPRT Gene

GeneLoc Exon Structure for
QPRT
ECgene alternative splicing isoforms for
QPRT

Expression for QPRT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for QPRT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for QPRT Gene

This gene is overexpressed in Liver (x8.6), Adrenal Gland (x5.8), and Kidney - Cortex (x5.6).

Protein differential expression in normal tissues from HIPED for QPRT Gene

This gene is overexpressed in Liver, secretome (22.1) and Kidney (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for QPRT Gene



Protein tissue co-expression partners for QPRT Gene

NURSA nuclear receptor signaling pathways regulating expression of QPRT Gene:

QPRT

SOURCE GeneReport for Unigene cluster for QPRT Gene:

Hs.513484

Evidence on tissue expression from TISSUES for QPRT Gene

  • Liver(4.6)
  • Kidney(4.5)
  • Nervous system(4.4)
  • Muscle(4.2)
genes like me logo Genes that share expression patterns with QPRT: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for QPRT Gene

Orthologs for QPRT Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for QPRT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia QPRT 34
  • 98.55 (n)
cow
(Bos Taurus)
Mammalia QPRT 34 35
  • 86.51 (n)
dog
(Canis familiaris)
Mammalia QPRT 34 35
  • 85.41 (n)
mouse
(Mus musculus)
Mammalia Qprt 34 16 35
  • 81.41 (n)
rat
(Rattus norvegicus)
Mammalia Qprt 34
  • 81.07 (n)
oppossum
(Monodelphis domestica)
Mammalia QPRT 35
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia QPRT 35
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia QPRT 35
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495332 34
  • 55.32 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8714 34
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR271W 34
  • 52.43 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BNA6 34 35
  • 51.44 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons QPT 34
  • 45.76 (n)
rice
(Oryza sativa)
Liliopsida Os09g0553600 34
  • 43.91 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU02998 34
  • 54.26 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1371 35
  • 38 (a)
OneToOne
Species where no ortholog for QPRT was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for QPRT Gene

ENSEMBL:
Gene Tree for QPRT (if available)
TreeFam:
Gene Tree for QPRT (if available)

Paralogs for QPRT Gene

Paralogs for QPRT Gene

genes like me logo Genes that share paralogs with QPRT: view

Variants for QPRT Gene

Sequence variations from dbSNP and Humsavar for QPRT Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000048681 -- 29,690,612(+) GATCA(C/T)ACGGC intron-variant
rs1000067898 -- 29,676,943(+) GGGGC(A/G)TGGAG intron-variant
rs1000087710 -- 29,679,003(+) CCCCT(C/T)CTCTG intron-variant, upstream-variant-2KB
rs1000095864 -- 29,671,503(+) TCCAC(C/T)GACCC intron-variant
rs1000177587 -- 29,693,038(+) CCTGG(A/G)CAACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for QPRT Gene

Variant ID Type Subtype PubMed ID
dgv34n68 CNV loss 17160897
esv23737 CNV gain 19812545
esv2758641 CNV gain 17122850
esv3638370 CNV loss 21293372
nsv1063706 CNV gain 25217958
nsv1134520 CNV deletion 24896259
nsv571816 CNV gain 21841781
nsv571817 CNV gain 21841781
nsv833183 CNV loss 17160897

Variation tolerance for QPRT Gene

Residual Variation Intolerance Score: 82.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.81; 66.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for QPRT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
QPRT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for QPRT Gene

Disorders for QPRT Gene

Relevant External Links for QPRT

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
QPRT

No disorders were found for QPRT Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for QPRT Gene

Publications for QPRT Gene

  1. Characterization and functional expression of the cDNA encoding human brain quinolinate phosphoribosyltransferase. (PMID: 9473669) Fukuoka S. … Shibata K. (Biochim. Biophys. Acta 1998) 2 3 4 22 64
  2. Structural and kinetic characterization of quinolinate phosphoribosyltransferase (hQPRTase) from homo sapiens. (PMID: 17868694) Liu H. … Naismith J.H. (J. Mol. Biol. 2007) 3 4 22 64
  3. QPRT: a potential marker for follicular thyroid carcinoma including minimal invasive variant; a gene expression, RNA and immunohistochemical study. (PMID: 19321014) Hinsch N. … Hansmann M.L. (BMC Cancer 2009) 3 22 64
  4. Changes in trigonelline (N-methylnicotinic acid) content and nicotinic acid metabolism during germination of mungbean (Phaseolus aureus) seeds. (PMID: 15837705) Zheng X.Q. … Ashihara H. (J. Exp. Bot. 2005) 22 25 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for QPRT Gene

Sources for QPRT Gene

Content
Loading form....